Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.11
O. V. Usova, O.V. Sologub, N. Ulianytska, O. Yakobson, I. Ushko, A. Sitovskyi, P. D. Haiduchyk
Relevance. One of the human systems, which is particularly acutely affected by external environmental factors is the respiratory system. These disorders in adolescence are especially noticeable when intense and dramatic changes in the child's body on the path to biological maturity occur. Goal. The purpose of our study was to evaluate the functional indexes of the external respiration of adolescents of different medical groups of physical training. Materials and methods. The functionality of the respiratory system was evaluated by the results of pneumothography and respiratory retention. They were evaluated using mathematical statistics using the Medstat program (Yu.E.E., 2006). 76 middle school age pupils (38 boys and 38 girls) were surveyed, which belong to the preparatory group of physical training and 40 peers (20 boys and 20 girls) who attend the main physical education group. For comparison, normal indexes were used according to computer conclusions and scientific literature data Results. The normal performance of the VC according to the results of computer conclusions, registered in 42 % of pupils of the preparatory group of physical education, higher than the norm have 21 % of adolescents, 36 % of adolescents have significant violations of this index. According to the computer's conclusion, 52% of the subjects are characterized by extremely significant changes of FVC. A similar pattern is also noted for the index in the boys of this group. According to the results of computer findings 69% of pupils of the preparatory group have normal indexes of PEF, 21% have a higher then norm, 10% a slight decrease. The results of the functional test of Shtanger (delay in inhalation) showed that in the preparatory group this index is lower than the norm Volumetric indicators of the external respiration of pupils of the preparatory group in more than half of adolescents are significant changes. The volumetric indexes of such adolescents are significantly lower than the norm, by almost 1 liter. The rates of the respiratory system of the MEF 25, 50, 75% are lower than the norm by 1.5 - 2 times, and PEF does not differ from the norm. Conclusions. Indexes of external respiration in more than half of the examined pupils of the preparatory group were changed. The volumetric and flow rates of the respiratory system were significantly lower than the norm. A similar trend was followed by functional respiratory tests.
{"title":"FEATURES OF EXTERNAL RESPIRATION OF ADOLESCENTS OF DIFFERENT MEDICAL GROUPS OF PHYSICAL EDUCATION","authors":"O. V. Usova, O.V. Sologub, N. Ulianytska, O. Yakobson, I. Ushko, A. Sitovskyi, P. D. Haiduchyk","doi":"10.32345/2664-4738.1.2023.11","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.11","url":null,"abstract":"Relevance. One of the human systems, which is particularly acutely affected by external environmental factors is the respiratory system. These disorders in adolescence are especially noticeable when intense and dramatic changes in the child's body on the path to biological maturity occur. \u0000Goal. The purpose of our study was to evaluate the functional indexes of the external respiration of adolescents of different medical groups of physical training. \u0000Materials and methods. The functionality of the respiratory system was evaluated by the results of pneumothography and respiratory retention. They were evaluated using mathematical statistics using the Medstat program (Yu.E.E., 2006). 76 middle school age pupils (38 boys and 38 girls) were surveyed, which belong to the preparatory group of physical training and 40 peers (20 boys and 20 girls) who attend the main physical education group. For comparison, normal indexes were used according to computer conclusions and scientific literature data \u0000Results. The normal performance of the VC according to the results of computer conclusions, registered in 42 % of pupils of the preparatory group of physical education, higher than the norm have 21 % of adolescents, 36 % of adolescents have significant violations of this index. According to the computer's conclusion, 52% of the subjects are characterized by extremely significant changes of FVC. A similar pattern is also noted for the index in the boys of this group. According to the results of computer findings 69% of pupils of the preparatory group have normal indexes of PEF, 21% have a higher then norm, 10% a slight decrease. The results of the functional test of Shtanger (delay in inhalation) showed that in the preparatory group this index is lower than the norm \u0000Volumetric indicators of the external respiration of pupils of the preparatory group in more than half of adolescents are significant changes. The volumetric indexes of such adolescents are significantly lower than the norm, by almost 1 liter. The rates of the respiratory system of the MEF 25, 50, 75% are lower than the norm by 1.5 - 2 times, and PEF does not differ from the norm. \u0000Conclusions. Indexes of external respiration in more than half of the examined pupils of the preparatory group were changed. The volumetric and flow rates of the respiratory system were significantly lower than the norm. A similar trend was followed by functional respiratory tests.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41560312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.01
I. Kuchyn, V. Horoshko
Background. The effectiveness of the use of therapeutic tactics for pain relief at the stages of treatment is important considering the fact that chronic pain is diagnosed in 83.3% of patients with mine-explosive wounds, and in 70% of cases with gunshot wounds. In civilian life, among injured patients, this diagnosis occurs in 11-40% of cases. There is not enough data on the reasons for such a high frequency of chronicity. Thus, the study of the effectiveness of treatment tactics for pain relief in patients with gunshot and mine-explosive wounds at the stages of treatment will play an important role and contribute to improving the results of treatment of this category of patients. Aim: To investigate the effectiveness of therapeutic tactics of analgesia in patients with gunshot and mine-explosive wounds at the stages of treatment. Materials and methods. The treatment of 1166 patients with injuries was analyzed. Pain intensity was diagnosed using a visual analog scale. Group comparisons were performed using the Mann-Whitney test and the chi-square test with allowance for continuity correction, Kruskal-Wallis, and post hoc comparisons were performed using Dunn's test. Results. In patients with gunshot wounds, during the analysis, it was found that VAS data significantly depend on the type of anesthesia. Using regional anesthesia, VAS data are the lowest at all measurement points (p<0.05). In patients who received landmine-explosive injuries, VAS data are weakly dependent on the choice of anesthetic support, however, this indicator still has higher values (p<0.05) when using general anesthesia. Two-factor analysis showed a relationship between the dynamics of VAS data and the type of injury (p<0.001), type of anesthesia (p<0.001). Conclusion. Admission of a patient with a wound to a medical center with subsequent analgesia using regional anesthesia methods has the best outcome in terms of pain management and pain control in such patients.
{"title":"EFFECTIVENESS OF THERAPEUTIC TACTICS FOR ANALGESIA OF PATIENTS WITH GUNSHOT AND MINE-EXPLOSIVE WOUNDS AT THE STAGES OF TREATMENT","authors":"I. Kuchyn, V. Horoshko","doi":"10.32345/2664-4738.1.2023.01","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.01","url":null,"abstract":"Background. The effectiveness of the use of therapeutic tactics for pain relief at the stages of treatment is important considering the fact that chronic pain is diagnosed in 83.3% of patients with mine-explosive wounds, and in 70% of cases with gunshot wounds. In civilian life, among injured patients, this diagnosis occurs in 11-40% of cases. There is not enough data on the reasons for such a high frequency of chronicity. Thus, the study of the effectiveness of treatment tactics for pain relief in patients with gunshot and mine-explosive wounds at the stages of treatment will play an important role and contribute to improving the results of treatment of this category of patients. \u0000Aim: To investigate the effectiveness of therapeutic tactics of analgesia in patients with gunshot and mine-explosive wounds at the stages of treatment. \u0000Materials and methods. The treatment of 1166 patients with injuries was analyzed. Pain intensity was diagnosed using a visual analog scale. Group comparisons were performed using the Mann-Whitney test and the chi-square test with allowance for continuity correction, Kruskal-Wallis, and post hoc comparisons were performed using Dunn's test. \u0000Results. In patients with gunshot wounds, during the analysis, it was found that VAS data significantly depend on the type of anesthesia. Using regional anesthesia, VAS data are the lowest at all measurement points (p<0.05). In patients who received landmine-explosive injuries, VAS data are weakly dependent on the choice of anesthetic support, however, this indicator still has higher values (p<0.05) when using general anesthesia. Two-factor analysis showed a relationship between the dynamics of VAS data and the type of injury (p<0.001), type of anesthesia (p<0.001). \u0000Conclusion. Admission of a patient with a wound to a medical center with subsequent analgesia using regional anesthesia methods has the best outcome in terms of pain management and pain control in such patients.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47884217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.06
V. Gutsulyuk, I. V. Savуtskyi
Background. Peritonitis today continues to be one of the most difficult problems of both abdominal surgery and theoretical pathophysiology. One of the leading pathogenetic mechanisms of peritonitis is disorders in the hemostasis system and the development of dissemination vascular syndrome. Blockade of microcirculation caused by the development of dissemination vascular syndrome leads to tissue hypoxia and, as a result, to dysfunction of organs and body systems. Aim: is to study changes in vascular-platelet and coagulation hemostasis under conditions of experimental fecal peritonitis in rats. Materials and methods. Experimental studies were conducted on 24 non-linear laboratory rats, which were divided into 2 groups: 1 group – intact control (animals received distilled water), 2 group – animals of the control pathology group. According to the "Methodological recommendations for preclinical study of medicinal products", experimental peritonitis was studied on the model of V. A. Lazarenko. Indicators of vascular-platelet and coagulation hemostasis were determined according to generally accepted methods. Results. On the first day of experimental peritonitis, a sharp increase in the rate of blood clotting and changes in the quality properties of platelets were noted, affecting their aggregation ability and retraction of an already formed blood clot. On the 4th day of the experiment, changes in the vascular-platelet link were established, indicating the exhaustion of the platelet potential, due to a decrease in blood clotting time, platelet aggregation ability, and blood clot retraction against the background of a probable increase in the number of blood platelets, which probably by now had time "get" to the bloodstream from the depot. Changes in the coagulation hemostasis system against the background of experimental fecal peritonitis indicate the development of hypercoagulation already on the first day, which is replaced by a hypocoagulation state, which indicates the exhaustion of the enzymatic systems of blood coagulation potential (as early as on the 4th day), which lasted until the end of the experiment. Conclusion. In the development of disorders of the hemostasis system in fecal peritonitis, the key role belongs to both the internal and external mechanisms of activation of the blood coagulation system.
{"title":"STUDY OF THE ROLE OF HEMOCOAGULATION DISBALANCE AS A KEY PATHOGENETIC PREDICTORS IN THE FORMATION OF SYSTEMIC DISORDERS IN EXPERIMENTAL PERITONITIS","authors":"V. Gutsulyuk, I. V. Savуtskyi","doi":"10.32345/2664-4738.1.2023.06","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.06","url":null,"abstract":"Background. Peritonitis today continues to be one of the most difficult problems of both abdominal surgery and theoretical pathophysiology. One of the leading pathogenetic mechanisms of peritonitis is disorders in the hemostasis system and the development of dissemination vascular syndrome. Blockade of microcirculation caused by the development of dissemination vascular syndrome leads to tissue hypoxia and, as a result, to dysfunction of organs and body systems. \u0000Aim: is to study changes in vascular-platelet and coagulation hemostasis under conditions of experimental fecal peritonitis in rats. \u0000Materials and methods. Experimental studies were conducted on 24 non-linear laboratory rats, which were divided into 2 groups: 1 group – intact control (animals received distilled water), 2 group – animals of the control pathology group. According to the \"Methodological recommendations for preclinical study of medicinal products\", experimental peritonitis was studied on the model of V. A. Lazarenko. Indicators of vascular-platelet and coagulation hemostasis were determined according to generally accepted methods. \u0000Results. On the first day of experimental peritonitis, a sharp increase in the rate of blood clotting and changes in the quality properties of platelets were noted, affecting their aggregation ability and retraction of an already formed blood clot. On the 4th day of the experiment, changes in the vascular-platelet link were established, indicating the exhaustion of the platelet potential, due to a decrease in blood clotting time, platelet aggregation ability, and blood clot retraction against the background of a probable increase in the number of blood platelets, which probably by now had time \"get\" to the bloodstream from the depot. Changes in the coagulation hemostasis system against the background of experimental fecal peritonitis indicate the development of hypercoagulation already on the first day, which is replaced by a hypocoagulation state, which indicates the exhaustion of the enzymatic systems of blood coagulation potential (as early as on the 4th day), which lasted until the end of the experiment. \u0000Conclusion. In the development of disorders of the hemostasis system in fecal peritonitis, the key role belongs to both the internal and external mechanisms of activation of the blood coagulation system.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":"41 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41277331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.08
H. Soni, S. Kacker, N. Saboo, J. Sorout
Relevance. Pulmonary function test (PFT) is an important assessment for lung function. The most commonly used method for PFT is Spirometry. It involves the use of a spirometer to measure lung volumes and capacities. Different diseases cause different patterns of abnormalities in a battery of pulmonary function tests. An earlier study suggested that reductions in maximal oxygen consumption (VO2 max) occur reasonably among patients of obstructive and restrictive lung diseases. Objective of this study was to assess the correlation between the parameters of pulmonary function and cardio-respiratory fitness with the amount of physical activity. Material and Methods. This pilot study was conducted in the Department of Physiology, RUHS College of Medical Sciences, in a group of 100 apparently healthy subjects (students) of 18-25 years age group of either sex. Anthropometric parameters (height, weight and BMI), pulmonary function test (PFT), GPAQ, body fat percentage and VO2 max were assessed in standard laboratory settings. Results. The mean±SD for Age, Height, Weight, GPAQ score, FEV1, PEFR, MVV, FEF25-75% and VO2 max was found to be higher in male participants as compared to female participants while BMI and FVC were almost equal in both the genders but Body Fat % and FEV1/FVC were higher in female participants. Correlation of VO2 max with FVC, FEV1. PEFR, MVV and FEF25-75% is moderately positive while correlation of VO2 max with FEV1/FVC is poorly negative in male subjects. In female subjects correlation of VO2 max with FVC, FEV1. PEFR and MVV is poorly positive while with FEV1/FVC and FEF25-75% it is poorly negative. Conclusion. Present study concludes that maximum oxygen consumption (VO2 max) was positively correlated with pulmonary functions except FEV1/FVC ratio in male. While it was poor positive in females except FEV1/FVC ratio and FEF. Study also concludes that observations of PFT parameters vary for male and female subjects. VO2 max i.e. maximum Oxygen Consumption was found to be higher in male participants of the study as compared to female participant’s i.e. male subjects utilizes more amount of Oxygen while exercising than female subjects.
{"title":"A STUDY TO CORRELATE PULMONARY FUNCTION TEST AND MAXIMUM OXYGEN CONSUMPTION IN HEALTHY YOUNG ADULTS","authors":"H. Soni, S. Kacker, N. Saboo, J. Sorout","doi":"10.32345/2664-4738.4.2022.08","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.08","url":null,"abstract":"Relevance. Pulmonary function test (PFT) is an important assessment for lung function. The most commonly used method for PFT is Spirometry. It involves the use of a spirometer to measure lung volumes and capacities. Different diseases cause different patterns of abnormalities in a battery of pulmonary function tests. An earlier study suggested that reductions in maximal oxygen consumption (VO2 max) occur reasonably among patients of obstructive and restrictive lung diseases. \u0000Objective of this study was to assess the correlation between the parameters of pulmonary function and cardio-respiratory fitness with the amount of physical activity. \u0000Material and Methods. This pilot study was conducted in the Department of Physiology, RUHS College of Medical Sciences, in a group of 100 apparently healthy subjects (students) of 18-25 years age group of either sex. Anthropometric parameters (height, weight and BMI), pulmonary function test (PFT), GPAQ, body fat percentage and VO2 max were assessed in standard laboratory settings. \u0000Results. The mean±SD for Age, Height, Weight, GPAQ score, FEV1, PEFR, MVV, FEF25-75% and VO2 max was found to be higher in male participants as compared to female participants while BMI and FVC were almost equal in both the genders but Body Fat % and FEV1/FVC were higher in female participants. Correlation of VO2 max with FVC, FEV1. PEFR, MVV and FEF25-75% is moderately positive while correlation of VO2 max with FEV1/FVC is poorly negative in male subjects. In female subjects correlation of VO2 max with FVC, FEV1. PEFR and MVV is poorly positive while with FEV1/FVC and FEF25-75% it is poorly negative. \u0000Conclusion. Present study concludes that maximum oxygen consumption (VO2 max) was positively correlated with pulmonary functions except FEV1/FVC ratio in male. While it was poor positive in females except FEV1/FVC ratio and FEF. Study also concludes that observations of PFT parameters vary for male and female subjects. VO2 max i.e. maximum Oxygen Consumption was found to be higher in male participants of the study as compared to female participant’s i.e. male subjects utilizes more amount of Oxygen while exercising than female subjects.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44612874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.06
N. Chernetska, L. Dubyk
Relevancy. The combination of chronic obstructive pulmonary disease and type 2 diabetes is studied insufficiently. The incomplete treatment regimen hinders the solution to this problem by including statins in the complex treatment of patients with chronic obstructive pulmonary disease combined with type 2 diabetes mellitus. Objective: to evaluate the effectiveness of including statins in the complex treatment of patients with chronic obstructive pulmonary disease secondary to type 2 diabetes mellitus. Materials and methods. Examination of patients with chronic obstructive pulmonary disease (COPD), including 64 patients with concomitant type 2 diabetes, was conducted on the basis of the pulmonology department of the Chernivtsi Regional Clinical Hospital in 2016-2020. Patients were divided into two groups – the main and the control. Patients with COPD with concomitant type 2 diabetes in the main group (49 patients) were prescribed atorvastatin at a dose of 20-40 mg once a day. The control group (15 COPD patients with concomitant type 2 diabetes) received essential treatment without atorvastatin. Patients received basic therapy depending on the group of patients (A, B, C and D) and the prevalence of shortness of breath or the frequency of exacerbations, long-acting bronchodilators (long-acting β2-agonists and/or long-acting anticholinergic drugs). A separate group of patients received a combination of a long-acting β2-agonist with an inhaled glucocorticosteroid. Some patients were prescribed roflumilast and antibactereal drugs from the group of macrolides (azithromycin or erythromycin). In the presence of sputum, patients were prescribed mucolytic drugs (Lazolvan, ACC, carbocisteine, erdosteine). In case of exacerbation, patients received a short course glucocorticosteroids parenterally, antibacterial drugs (for infectious exacerbation), nebulizer therapy. The effectiveness of therapy was evaluated after six months of treatment using the following diagnostic methods: clinical data (dyspnea, cough, sputum production - according to the BCSS scale; and shortness of breath, cough, sputum production and its color - according to the Paggiaro scale), the number of hospitalizations per year, the number emergency medical calls. Mathematical processing of the obtained data was carried out using programs BioStat 2009 Professional, version 5.8.4.3 (AnalystSoft Inc.), SPSS (Statistical Package for Social Science Statistics) 16.0, Statistisa 10.0 StatSoft Inc., Microsoft Excel 2010. Before testing statistical hypotheses were determined coefficients of asymmetry and kurtosis using the Hahn-Shapiro-Wilkie test to analyze the normality of the distribution of values in randomized samples. Results. When analyzing clinical data in treatment dynamics with atorvastatin, it was found that according to the BCSS, shortness of breath in patients of the main group significantly decreased. Cough in COPD patients with concomitant type 2 diabetes
{"title":"THE USE OF STATINS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND TYPE 2 DIABETES","authors":"N. Chernetska, L. Dubyk","doi":"10.32345/2664-4738.4.2022.06","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.06","url":null,"abstract":"Relevancy. The combination of chronic obstructive pulmonary disease and type 2 diabetes is studied insufficiently. The incomplete treatment regimen hinders the solution to this problem by including statins in the complex treatment of patients with chronic obstructive pulmonary disease combined with type 2 diabetes mellitus. \u0000Objective: to evaluate the effectiveness of including statins in the complex treatment of patients with chronic obstructive pulmonary disease secondary to type 2 diabetes mellitus. \u0000Materials and methods. Examination of patients with chronic obstructive pulmonary disease (COPD), including 64 patients with concomitant type 2 diabetes, was conducted on the basis of the pulmonology department of the Chernivtsi Regional Clinical Hospital in 2016-2020. Patients were divided into two groups – the main and the control. Patients with COPD with concomitant type 2 diabetes in the main group (49 patients) were prescribed atorvastatin at a dose of 20-40 mg once a day. The control group (15 COPD patients with concomitant type 2 diabetes) received essential treatment without atorvastatin. Patients received basic therapy depending on the group of patients (A, B, C and D) and the prevalence of shortness of breath or the frequency of exacerbations, long-acting bronchodilators (long-acting β2-agonists and/or long-acting anticholinergic drugs). A separate group of patients received a combination of a long-acting β2-agonist with an inhaled glucocorticosteroid. Some patients were prescribed roflumilast and antibactereal drugs from the group of macrolides (azithromycin or erythromycin). In the presence of sputum, patients were prescribed mucolytic drugs (Lazolvan, ACC, carbocisteine, erdosteine). In case of exacerbation, patients received a short course glucocorticosteroids parenterally, antibacterial drugs (for infectious exacerbation), nebulizer therapy. The effectiveness of therapy was evaluated after six months of treatment using the following diagnostic methods: clinical data (dyspnea, cough, sputum production - according to the BCSS scale; and shortness of breath, cough, sputum production and its color - according to the Paggiaro scale), the number of hospitalizations per year, the number emergency medical calls. Mathematical processing of the obtained data was carried out using programs BioStat 2009 Professional, version 5.8.4.3 (AnalystSoft Inc.), SPSS (Statistical Package for Social Science Statistics) 16.0, Statistisa 10.0 StatSoft Inc., Microsoft Excel 2010. Before testing statistical hypotheses were determined coefficients of asymmetry and kurtosis using the Hahn-Shapiro-Wilkie test to analyze the normality of the distribution of values in randomized samples. \u0000Results. When analyzing clinical data in treatment dynamics with atorvastatin, it was found that according to the BCSS, shortness of breath in patients of the main group significantly decreased. Cough in COPD patients with concomitant type 2 diabetes","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43452840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.12
V. Zub
Relevance. Cancer remains the biggest medical and socio-economic problem of humanity. International efforts to overcome this global burden of humanity are aimed at the implementation of programs for the prevention and early detection of tumors. Objective: investigation of the effectiveness and level of funding of targeted regional programs to fight cancer, which were implemented in the western regions of Ukraine in the period before the Russian invasion in 2022. Materials and methods. A single point descriptive research was performed on the basis of information provided in 2021 by the Health Departments of the regional state administrations of the western regions of Ukraine, as well as data obtained from the websites of these Health Departments. Statistical methods, structural-logical analysis and a systematic approach were used. Results. The research established the achievement of positive changes in the main indicators of the work of the oncology service regarding the timely diagnosis of oncological pathologies, a reduction in the mortality rates up to a year, as well as the improvement of screening programs for the detection of precancerous conditions. Since most of the final results correspond to the set tasks of the programs, this proves the importance of implementing such programs at the regional level, and, in turn, their proper funding is a catalyst for improving the oncological epidemiological situation and the process of organizing oncological care. Conclusions. Regional target programs should remain a strategic direction of policy implementation in the field of cancer prevention and control.
{"title":"ANALYSIS OF THE EFFECTIVENESS OF CANCER PREVENTION AND CONTROL PROGRAMS IN WESTERN REGIONS OF UKRAINE","authors":"V. Zub","doi":"10.32345/2664-4738.4.2022.12","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.12","url":null,"abstract":"Relevance. Cancer remains the biggest medical and socio-economic problem of humanity. International efforts to overcome this global burden of humanity are aimed at the implementation of programs for the prevention and early detection of tumors. \u0000Objective: investigation of the effectiveness and level of funding of targeted regional programs to fight cancer, which were implemented in the western regions of Ukraine in the period before the Russian invasion in 2022. \u0000Materials and methods. A single point descriptive research was performed on the basis of information provided in 2021 by the Health Departments of the regional state administrations of the western regions of Ukraine, as well as data obtained from the websites of these Health Departments. Statistical methods, structural-logical analysis and a systematic approach were used. \u0000 Results. The research established the achievement of positive changes in the main indicators of the work of the oncology service regarding the timely diagnosis of oncological pathologies, a reduction in the mortality rates up to a year, as well as the improvement of screening programs for the detection of precancerous conditions. Since most of the final results correspond to the set tasks of the programs, this proves the importance of implementing such programs at the regional level, and, in turn, their proper funding is a catalyst for improving the oncological epidemiological situation and the process of organizing oncological care. \u0000 Conclusions. Regional target programs should remain a strategic direction of policy implementation in the field of cancer prevention and control.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42397423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.13
N. Ulianytska, Y. Rebryk, О. Yakobson, I. Ushko, А. Sitovskyi, O. V. Usova
Relevance. Physical and mental health indicators play a major role in assessing patients' quality of life. The quality of life deteriorates with the development of post-traumatic stress disorders (PTSD), and it directly affects patients' health. Objective: to investigate changes in indicators of quality of life among patients with PTSD. Materials and methods. 22 young patients participated in the study. The MOS SF-36 International Quality of Life Questionnaire and the Mississippi Posttraumatic Stress Disorder Rating Scale (civilian version) have been used. Results. According to the results of the Mississippi Scale, the patients were divided into three groups: 1 (n=4) – without PTSD symptoms, 2 (n=13) – with mental disorders, and 3 (n=5) – with PTSD symptoms. In each of the above mentioned groups, the MOS SF-36 quality of life test has been conducted. According to its results, it was determined that group 2 had lower quality of life indicators (physical and mental health components) compared to the first group, but higher compared to the third group. Conclusion. Manifestations of PTSD directly affect the quality of life of patients. Patients with PTSD and mental disorders reported lower indicators of physical and mental components of health.
{"title":"QUALITY ASSESSMENT OF PATIENTS` LIFE WITH POST-TRAUMATIC STRESS DISORDER AND ADJUSTMENT DISORDERS","authors":"N. Ulianytska, Y. Rebryk, О. Yakobson, I. Ushko, А. Sitovskyi, O. V. Usova","doi":"10.32345/2664-4738.4.2022.13","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.13","url":null,"abstract":"Relevance. Physical and mental health indicators play a major role in assessing patients' quality of life. The quality of life deteriorates with the development of post-traumatic stress disorders (PTSD), and it directly affects patients' health. \u0000Objective: to investigate changes in indicators of quality of life among patients with PTSD. \u0000Materials and methods. 22 young patients participated in the study. The MOS SF-36 International Quality of Life Questionnaire and the Mississippi Posttraumatic Stress Disorder Rating Scale (civilian version) have been used. \u0000Results. According to the results of the Mississippi Scale, the patients were divided into three groups: 1 (n=4) – without PTSD symptoms, 2 (n=13) – with mental disorders, and 3 (n=5) – with PTSD symptoms. In each of the above mentioned groups, the MOS SF-36 quality of life test has been conducted. According to its results, it was determined that group 2 had lower quality of life indicators (physical and mental health components) compared to the first group, but higher compared to the third group. \u0000Conclusion. Manifestations of PTSD directly affect the quality of life of patients. Patients with PTSD and mental disorders reported lower indicators of physical and mental components of health.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46357982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.11
S. Hozak, O. Yelizarova, T.V. Stankevych, A. Parats
Relevance. It is widely recognized that COVID-19 disease is significant problem for public health. The COVID-19 pandemic evolves, the long-term health impacts are continually increasing and children health is particular concern. The duration of exposure, heterogeneity and plurality of biopsychosocial factors have to unpredictable consequences on the mental health of vulnerable populations such as children and adolescents. Objective. Determination the significant factors affecting the mental health of schoolchildren during the pandemic in order to further develop the health-saving measures. Methods. During implementation of quarantine measures due to COVID-19 pandemic, we studied the peculiarities of schoolchildren’s life and mental health in 2020-2021 (n=1393) from all regions of Ukraine. Q-RAPH, GPAQ, RCADS-P-25 questionnaires were used. Prior to the pandemic, MH survey of 500 schoolchildren was conducted using “Children’s Neuroses Questionnaire” method. Descriptive statistics, Student's coefficients, univariate and multivariate analysis of variance, followed by a posteriori estimation of mean differences according to the Bonferroni test, conjugation tables, logistic and linear regression models were used. Results. Сonstant stay in an apartment during quarantine leads to an increase in the chances of anxiety-depressive disorders on average by 2.5 times. During the pandemic for the observation period, both duration and frequency of walks were significantly lower for the children with mental disorders. The likelihood of pathological increases in anxiety and depression in school age children without interactive learning is 1.8 times greater. Pairwise comparisons of adjusted means using the Bonferroni test demonstrated that the higher is the BMI - the shorter is the sleep (β=-1.9; p=0.004), the longer is the sedentary behavior duration (β=3.4; p=0.001) - the shorter is MVPA (β =-1,4; p=0,005). It was established that depressive disorders are 2.4 times more common among the children with chronic diseases than among the healthy children (χ2 =51.1; p<0.001). In the course of 3d linear modeling of normalized indicators we can see that a decrease in both light physical activity (LPA) and MVPA leads to deterioration in mental health indicators of the children. Conclusions. Main factors of the negative impact on children's mental health during the COVID-19 pandemic are: permanent stay at home (OR=2.02; CI 1.39-2.93), frequency of walks less than 4 times a week and duration less than 220 minutes per week (OR=1.96; CI 1.12-3.45), non-interactive remote learning (OR=1.78; CI 1.17-2.69), overweight and obesity of schoolchildren (OR=1 .52; CI 1.11-2.08), presence of chronic diseases (OR=2.79; CI 1.99-3.91), anxiety disorders in parents (OR=3.67; CI 1.02-13,25) and their lack of higher education (OR=1,27; CI 1,03-1,56). The obtained results must be taken into account when developing further preventive strategies and tactics for overcoming the pandemic con
{"title":"MAIN FACTORS OF THE NEGATIVE IMPACT OF THE COVID-19 PANDEMIC ON MENTAL HEALTH OF CHILDREN","authors":"S. Hozak, O. Yelizarova, T.V. Stankevych, A. Parats","doi":"10.32345/2664-4738.4.2022.11","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.11","url":null,"abstract":"Relevance. It is widely recognized that COVID-19 disease is significant problem for public health. The COVID-19 pandemic evolves, the long-term health impacts are continually increasing and children health is particular concern. The duration of exposure, heterogeneity and plurality of biopsychosocial factors have to unpredictable consequences on the mental health of vulnerable populations such as children and adolescents. \u0000Objective. Determination the significant factors affecting the mental health of schoolchildren during the pandemic in order to further develop the health-saving measures. \u0000Methods. During implementation of quarantine measures due to COVID-19 pandemic, we studied the peculiarities of schoolchildren’s life and mental health in 2020-2021 (n=1393) from all regions of Ukraine. Q-RAPH, GPAQ, RCADS-P-25 questionnaires were used. Prior to the pandemic, MH survey of 500 schoolchildren was conducted using “Children’s Neuroses Questionnaire” method. Descriptive statistics, Student's coefficients, univariate and multivariate analysis of variance, followed by a posteriori estimation of mean differences according to the Bonferroni test, conjugation tables, logistic and linear regression models were used. \u0000Results. Сonstant stay in an apartment during quarantine leads to an increase in the chances of anxiety-depressive disorders on average by 2.5 times. During the pandemic for the observation period, both duration and frequency of walks were significantly lower for the children with mental disorders. The likelihood of pathological increases in anxiety and depression in school age children without interactive learning is 1.8 times greater. Pairwise comparisons of adjusted means using the Bonferroni test demonstrated that the higher is the BMI - the shorter is the sleep (β=-1.9; p=0.004), the longer is the sedentary behavior duration (β=3.4; p=0.001) - the shorter is MVPA (β =-1,4; p=0,005). It was established that depressive disorders are 2.4 times more common among the children with chronic diseases than among the healthy children (χ2 =51.1; p<0.001). In the course of 3d linear modeling of normalized indicators we can see that a decrease in both light physical activity (LPA) and MVPA leads to deterioration in mental health indicators of the children. \u0000Conclusions. Main factors of the negative impact on children's mental health during the COVID-19 pandemic are: permanent stay at home (OR=2.02; CI 1.39-2.93), frequency of walks less than 4 times a week and duration less than 220 minutes per week (OR=1.96; CI 1.12-3.45), non-interactive remote learning (OR=1.78; CI 1.17-2.69), overweight and obesity of schoolchildren (OR=1 .52; CI 1.11-2.08), presence of chronic diseases (OR=2.79; CI 1.99-3.91), anxiety disorders in parents (OR=3.67; CI 1.02-13,25) and their lack of higher education (OR=1,27; CI 1,03-1,56). \u0000The obtained results must be taken into account when developing further preventive strategies and tactics for overcoming the pandemic con","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47951397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.04
O. Iaremenko, D. Koliadenko
Relevance. The proportion of men among patients with systemic lupus erythematosus (SLE) is only 4-22%, but possible differences in the context of the clinical course and prognosis of the disease in this group of patients require more detailed study. Objective: to assess the spectrum of clinical manifestations, autoantibodies and the level of inflammatory markers in men with SLE. Materials and methods. 371 patients with SLE were examined, including 321 women (86.5%) and 50 men (13.5%). Clinical data, SLEDAI index and SLICC/DI damage, levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) and spectrum of specific autoantibodies (antibodies to dsDNA, Sm, Ro/SSA, La/SSB, RNP, antiphospholipid antibodies) were evaluated. Results. Alopecia (18.0% vs 33.0%; p=0.036) and arthralgia (22.0% vs 40.0%; p=0.016) were significantly less common in men with SLE. In contrast, nephritis with nephrotic syndrome was more than three times more common in male SLE patients (14.3%) than in women (4.1%; p=0.032). There was also a difference in the frequency of serositis: men were significantly more likely to have pleurisy (36.7%) than women (21.6%; p=0.044). Nervous system involvement was less common in men (12.0% vs 29.6%; p=0.007), as well as Raynaud's syndrome (16.0% vs 29.8%; p=0.05) and Sjogren's syndrome (0% vs 8.0%, p=0.023) compared with women. However, trophic ulcers were three times more common in men with SLE (14.3% vs 3.5%; p=0.019). Involvement of the mononuclear phagocyte system, heart, lungs, constitutional symptoms, antiphospholipid syndrome, hematological manifestations did not differ significantly between the representatives of both sexes. There were also no gender differences in SLEDAI indices and SLICC damage, erythrocyte sedimentation rate, C-reactive protein, C3, C4 complement levels. Antibodies to Ro/SSA were significantly less common in male SLE patients than in women (23.1% and 58.5%, respectively, p=0.033). Conclusions. Men with SLE are less likely to have alopecia, arthralgia, Raynaud's syndrome, nervous system involvement and Sjogren's syndrome than women. However, males with SLE are more likely to have kidney disease with nephrotic syndrome, pleuritis and trophic ulcers. Presence of anti-Ro/SSA antibodies in men with SLE is less common than in women.
的相关性。系统性红斑狼疮(SLE)患者中男性的比例仅为4-22%，但该组患者在临床病程和预后方面可能存在的差异需要更详细的研究。目的:探讨男性SLE患者的临床表现、自身抗体及炎症标志物水平。材料和方法。371例SLE患者接受了检查，其中女性321例(86.5%)，男性50例(13.5%)。评估临床资料、SLEDAI指数和SLICC/DI损伤、炎症标志物(红细胞沉降率、c反应蛋白)水平和特异性自身抗体(dsDNA、Sm、Ro/SSA、La/SSB、RNP、抗磷脂抗体)谱。结果。脱发(18.0% vs 33.0%;P =0.036)和关节痛(22.0% vs 40.0%;p=0.016)在SLE患者中较少见。相比之下，肾炎合并肾病综合征在男性SLE患者中的发生率(14.3%)是女性患者的3倍多(4.1%;p = 0.032)。浆膜炎的发生频率也存在差异:男性患胸膜炎的可能性(36.7%)明显高于女性(21.6%);p = 0.044)。神经系统受累在男性中较少见(12.0% vs 29.6%;p=0.007)，雷诺氏综合征(16.0% vs 29.8%;p=0.05)和干燥综合征(0% vs 8.0%， p=0.023)。然而，营养性溃疡在男性SLE患者中的发生率是前者的三倍(14.3% vs 3.5%;p = 0.019)。累及单核吞噬细胞系统、心脏、肺部、体质症状、抗磷脂综合征、血液学表现在两性代表之间无显著差异。SLEDAI指数和SLICC损伤、红细胞沉降率、c反应蛋白、C3、C4补体水平也无性别差异。Ro/SSA抗体在男性SLE患者中的发生率明显低于女性(分别为23.1%和58.5%，p=0.033)。结论。与女性相比，患有SLE的男性患脱发、关节痛、雷诺综合征、神经系统受累和干燥综合征的可能性较小。然而，患有SLE的男性更有可能患有肾病综合征、胸膜炎和营养性溃疡的肾脏疾病。男性SLE患者中存在抗ro /SSA抗体比女性患者少。
{"title":"SPECTRUM OF CLINICAL MANIFESTATIONS, AUTOANTIBODIES AND LEVELS OF INFLAMMATORY MARKERS IN MEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS","authors":"O. Iaremenko, D. Koliadenko","doi":"10.32345/2664-4738.4.2022.04","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.04","url":null,"abstract":"Relevance. The proportion of men among patients with systemic lupus erythematosus (SLE) is only 4-22%, but possible differences in the context of the clinical course and prognosis of the disease in this group of patients require more detailed study. \u0000Objective: to assess the spectrum of clinical manifestations, autoantibodies and the level of inflammatory markers in men with SLE. \u0000Materials and methods. 371 patients with SLE were examined, including 321 women (86.5%) and 50 men (13.5%). Clinical data, SLEDAI index and SLICC/DI damage, levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) and spectrum of specific autoantibodies (antibodies to dsDNA, Sm, Ro/SSA, La/SSB, RNP, antiphospholipid antibodies) were evaluated. \u0000Results. Alopecia (18.0% vs 33.0%; p=0.036) and arthralgia (22.0% vs 40.0%; p=0.016) were significantly less common in men with SLE. In contrast, nephritis with nephrotic syndrome was more than three times more common in male SLE patients (14.3%) than in women (4.1%; p=0.032). There was also a difference in the frequency of serositis: men were significantly more likely to have pleurisy (36.7%) than women (21.6%; p=0.044). Nervous system involvement was less common in men (12.0% vs 29.6%; p=0.007), as well as Raynaud's syndrome (16.0% vs 29.8%; p=0.05) and Sjogren's syndrome (0% vs 8.0%, p=0.023) compared with women. However, trophic ulcers were three times more common in men with SLE (14.3% vs 3.5%; p=0.019). Involvement of the mononuclear phagocyte system, heart, lungs, constitutional symptoms, antiphospholipid syndrome, hematological manifestations did not differ significantly between the representatives of both sexes. There were also no gender differences in SLEDAI indices and SLICC damage, erythrocyte sedimentation rate, C-reactive protein, C3, C4 complement levels. Antibodies to Ro/SSA were significantly less common in male SLE patients than in women (23.1% and 58.5%, respectively, p=0.033). \u0000Conclusions. Men with SLE are less likely to have alopecia, arthralgia, Raynaud's syndrome, nervous system involvement and Sjogren's syndrome than women. However, males with SLE are more likely to have kidney disease with nephrotic syndrome, pleuritis and trophic ulcers. Presence of anti-Ro/SSA antibodies in men with SLE is less common than in women.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44543914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.32345/2664-4738.4.2022.03
T. Panova, O. Myronenko
Relevance. In case of developed alcoholic disease, under conditions of alcoholic hypoglycemia, ketone bodies act as an energy substrate for the brain. However, the role of ketone hunger for maintaining the craving for alcohol has not been established. The assumption of such a connection has a right to exist, since it is alcohol that stimulates the formation of ketone bodies. Therefore, with developed alcoholism, the desire to consume alcohol (and, in fact, "saturate" the brain with ketone bodies) can be considered as a consequence of hypoketonemia. Accordingly, the hunger of the alcoholic is the result of hypoketonemia, but not hypoglycemia. Therefore, it is relevant to conduct a study in which the given variables (controlled by us) were the level of glycemia and the level of ketonemia, and the amount of alcohol consumed voluntarily (under conditions of free choice) was a derivative and dependent value. Objective: to study the relationship between craving for alcohol, and levels of glycemia and ketonemia in alcoholized rats. Materials and methods. Male white rats (n = 40) were forcibly alcoholized with 10% ethanol in 16 weeks. After that, for 30 days, they had a free choice of three types of drinking: clean water, 5% glucose, and 10% ethanol. The volume of consumed liquids was recorded. The criterion for the developed alcohol dependence was the preference of ethanol. At this stage, the animals were divided into 4 groups. Rats were injected per os with 0.8-1.5 ml of: 1.4% unitiol (3.5 mg / kg) to suppress ketonemia – group 1 (n = 10); 40% starch (1.0 g / kg) to eliminate hypoglycemia – group 2 (n = 10); 2.8% unitiol and 80% starch to suppress ketonemia and eliminate hypoglycemia – group 3 (n = 10); 0.9% NaCl as a control – group 4 (n = 10). Blood glucose (from the tail vein) and urine ketone bodies were monitored. The glucose level was determined with a glucometer. Test strips were used to detect ketone bodies in urine. The results were processed with MedStat software. To measure the strength of the correlation between the indicators, Spearman and Pearson tests were used. Results. No ketone bodies were found in the urine of healthy animals; however, after the end of forced alcoholization, varying levels of ketonuria were recorded in all rats: from 0.5 to 10 mmol / L (Spearman's rank correlation test was 0.8). Glycemia in healthy rats was 7.0 ± 1.4 mmol / L. After alcoholization, it decreased (p <0.001) to 3.0 ± 0.7 mmol / l. Ethanol consumption during first 10 days of forced alcoholization was 3.2 ± 0.7 ml per 100 g of animal weight; by the end of the third week - 4.9 ± 1.1 ml; by the end of the sixth week - 6.4 ± 1.4 ml (this was a climax of consumption, since consumption did not increase up to the 16th week). After a 30-day correction, the level of glycemia (mmol / L) was as follows: animals of the 1st group (unitiol) - 4.0 ± 0.8; animals of the 2nd group (enhanced carbohydrate diet) - 7.1 ± 1.2; animals of the 3rd group (unitiol + enhanced
{"title":"INFLUENCE OF KETOSIS AND GLYCEMIA LEVELS ON CRAVING FOR ETHANOL IN ALCOHOLIZED RATS","authors":"T. Panova, O. Myronenko","doi":"10.32345/2664-4738.4.2022.03","DOIUrl":"https://doi.org/10.32345/2664-4738.4.2022.03","url":null,"abstract":"Relevance. In case of developed alcoholic disease, under conditions of alcoholic hypoglycemia, ketone bodies act as an energy substrate for the brain. However, the role of ketone hunger for maintaining the craving for alcohol has not been established. The assumption of such a connection has a right to exist, since it is alcohol that stimulates the formation of ketone bodies. Therefore, with developed alcoholism, the desire to consume alcohol (and, in fact, \"saturate\" the brain with ketone bodies) can be considered as a consequence of hypoketonemia. Accordingly, the hunger of the alcoholic is the result of hypoketonemia, but not hypoglycemia. Therefore, it is relevant to conduct a study in which the given variables (controlled by us) were the level of glycemia and the level of ketonemia, and the amount of alcohol consumed voluntarily (under conditions of free choice) was a derivative and dependent value. \u0000Objective: to study the relationship between craving for alcohol, and levels of glycemia and ketonemia in alcoholized rats. \u0000Materials and methods. Male white rats (n = 40) were forcibly alcoholized with 10% ethanol in 16 weeks. After that, for 30 days, they had a free choice of three types of drinking: clean water, 5% glucose, and 10% ethanol. The volume of consumed liquids was recorded. The criterion for the developed alcohol dependence was the preference of ethanol. At this stage, the animals were divided into 4 groups. Rats were injected per os with 0.8-1.5 ml of: 1.4% unitiol (3.5 mg / kg) to suppress ketonemia – group 1 (n = 10); 40% starch (1.0 g / kg) to eliminate hypoglycemia – group 2 (n = 10); 2.8% unitiol and 80% starch to suppress ketonemia and eliminate hypoglycemia – group 3 (n = 10); 0.9% NaCl as a control – group 4 (n = 10). Blood glucose (from the tail vein) and urine ketone bodies were monitored. The glucose level was determined with a glucometer. Test strips were used to detect ketone bodies in urine. The results were processed with MedStat software. To measure the strength of the correlation between the indicators, Spearman and Pearson tests were used. \u0000Results. No ketone bodies were found in the urine of healthy animals; however, after the end of forced alcoholization, varying levels of ketonuria were recorded in all rats: from 0.5 to 10 mmol / L (Spearman's rank correlation test was 0.8). Glycemia in healthy rats was 7.0 ± 1.4 mmol / L. After alcoholization, it decreased (p <0.001) to 3.0 ± 0.7 mmol / l. Ethanol consumption during first 10 days of forced alcoholization was 3.2 ± 0.7 ml per 100 g of animal weight; by the end of the third week - 4.9 ± 1.1 ml; by the end of the sixth week - 6.4 ± 1.4 ml (this was a climax of consumption, since consumption did not increase up to the 16th week). \u0000After a 30-day correction, the level of glycemia (mmol / L) was as follows: animals of the 1st group (unitiol) - 4.0 ± 0.8; animals of the 2nd group (enhanced carbohydrate diet) - 7.1 ± 1.2; animals of the 3rd group (unitiol + enhanced ","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45046796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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