Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.06
O. Stoyanov, D. Khramtsov, M. Vikarenko, O. Gruzevskyi
Background. The increase in the prevalence of CVZ gives reasons to consider the problem of combating stroke as a priority area of treatment and prevention work of medical workers all over the world. Aim: assessment of the role of changes in markers of neuroimmune disintegration in the acute phase of ischemic stroke. Material and methods. The study was conducted on the basis of the clinical units of the Medical Institute of the Black Sea National University named after Peter Mohyla (Mykolaiv, Odesa) in 2020-2022. At the first stage, a retrospective analysis of 150 disease histories of patients who underwent II and were undergoing rehabilitation at the "Expert Health" medical center was carried out. At the second, prospective stage, 28 patients who had II in the subacute period were examined with an in-depth immunological examination. An analysis of the dynamics of leukogram indicators, CRP, procalcitonin and other markers of inflammation was carried out. At the prospective stage, the blood content of pro-inflammatory cytokines (TNF, IL1, IL2, Il6) and anti-inflammatory cytokines (IL4, IL10) was additionally determined. Statistical processing was carried out by methods of dispersion and correlation analysis using Statistica 14.0 software (TIBCO, USA). Results. According to the retrospective analysis, the severity of changes in leukogram and CRP content correlated with the severity of II (r=0.11-0.29). With an average NIHSS score of 10.8±0.9, the content of lymphocytes in the peripheral pool averaged 17.3±0.4%, while the total content of leukocytes was 9.4±0.2 G/l. 76 (50.7%) patients had records in their medical records regarding the assessment of the CRP level, which averaged 7.7±0.9 mg/l. In 72.7% of patients, manifestations of atherosclerosis of brachiocephalic vessels were determined, including in 31.3% - signs of critical stenosis of the carotid arteries. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). It is shown that in the subacute period at the stage of rehabilitation, the leukogram normalizes, the manifestations of the systemic inflammatory response decrease. At the same time, there are signs of stress on neuroimmune regulatory mechanisms and the need to monitor inflammatory biomarkers both in the acute and subacute stages of stroke. Conclusions. The expressiveness of changes in leukogram and CRP content correlates with the severity of II, and high levels of CRP are a predictor of an adverse clinical outcome. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). With an ischemic stroke, neuroimmune regulatory mechanisms are stressed in the subacute stage of the disease. It is advisable to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.
{"title":"CHANGES IN MARKERS OF NEURO-IMMUNE DISINTEGRATION IN THE SUB-ACUTE PHASE OF ISCHEMIC STROKE","authors":"O. Stoyanov, D. Khramtsov, M. Vikarenko, O. Gruzevskyi","doi":"10.32345/2664-4738.2.2023.06","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.06","url":null,"abstract":"Background. The increase in the prevalence of CVZ gives reasons to consider the problem of combating stroke as a priority area of treatment and prevention work of medical workers all over the world. \u0000Aim: assessment of the role of changes in markers of neuroimmune disintegration in the acute phase of ischemic stroke. \u0000Material and methods. The study was conducted on the basis of the clinical units of the Medical Institute of the Black Sea National University named after Peter Mohyla (Mykolaiv, Odesa) in 2020-2022. At the first stage, a retrospective analysis of 150 disease histories of patients who underwent II and were undergoing rehabilitation at the \"Expert Health\" medical center was carried out. At the second, prospective stage, 28 patients who had II in the subacute period were examined with an in-depth immunological examination. An analysis of the dynamics of leukogram indicators, CRP, procalcitonin and other markers of inflammation was carried out. At the prospective stage, the blood content of pro-inflammatory cytokines (TNF, IL1, IL2, Il6) and anti-inflammatory cytokines (IL4, IL10) was additionally determined. Statistical processing was carried out by methods of dispersion and correlation analysis using Statistica 14.0 software (TIBCO, USA). \u0000Results. According to the retrospective analysis, the severity of changes in leukogram and CRP content correlated with the severity of II (r=0.11-0.29). With an average NIHSS score of 10.8±0.9, the content of lymphocytes in the peripheral pool averaged 17.3±0.4%, while the total content of leukocytes was 9.4±0.2 G/l. 76 (50.7%) patients had records in their medical records regarding the assessment of the CRP level, which averaged 7.7±0.9 mg/l. In 72.7% of patients, manifestations of atherosclerosis of brachiocephalic vessels were determined, including in 31.3% - signs of critical stenosis of the carotid arteries. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). \u0000It is shown that in the subacute period at the stage of rehabilitation, the leukogram normalizes, the manifestations of the systemic inflammatory response decrease. At the same time, there are signs of stress on neuroimmune regulatory mechanisms and the need to monitor inflammatory biomarkers both in the acute and subacute stages of stroke. \u0000Conclusions. The expressiveness of changes in leukogram and CRP content correlates with the severity of II, and high levels of CRP are a predictor of an adverse clinical outcome. When comparing the levels of CRP and the severity of the atherosclerotic process, a positive correlation of average strength was found (r=0.31). With an ischemic stroke, neuroimmune regulatory mechanisms are stressed in the subacute stage of the disease. It is advisable to monitor inflammatory biomarkers both in the acute and subacute stages of stroke.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44624886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.16
V. Vasylevskyi, V. Glagovych, N. Liutianska, R. Koval, O. Plavkov, D. Charniuk, M. Soputnyak
Background. Investigating the medical-biological and socio-economic impacts of PTSD on a country's population is essential, as PTSD can cause serious mental and somatic health issues, affect work capacity and overall quality of life, and have long-term consequences for veterans and survivors. Understanding and studying the causes and consequences of PTSD is crucial for developing effective prevention and treatment strategies and ensuring national security and sustainable development of the country. Aim: To analyze the medical-biological and socio-economic consequences of PTSD on veterans and the population as a whole. Materials and methods. A data analysis was conducted using information obtained from online database searches in "PubMed," "National Institute on Alcohol Abuse and Alcoholism," "ScienceDirect," and "Psychiatrist.com," with keywords such as "post-traumatic stress disorder," "civilian population," "military," "veterans," "comorbid conditions," "alcoholism," "drug addiction," "economic burden," "disability," "costs," "socio-economic status," "combat operations," and "support for survivors." Results. PTSD is a significant societal and economic challenge. Negative trends of these consequences are most acutely manifested in countries experiencing recent or ongoing military conflicts, where the dynamics of PTSD are increasing. Timely diagnosis and active public education are extremely important for preventing the development of chronic conditions and avoiding limitations on the functioning of survivors. Real-world practice demonstrates that support for individuals with PTSD often includes not only professional medical therapy but also assistance in employment, housing, and social adaptation. Conclusion. PTSD is a serious problem for veterans and civilian populations, requiring attention and support from the government and society. Further research and the development of effective treatment and support methods for people suffering from PTSD are needed to improve their quality of life and promote social integration.
{"title":"MEDICO-BIOLOGICAL AND SOCIO-ECONOMIC IMPACT OF POST-TRAUMATIC STRESS DISORDER ON THE POPULATION IN THE CONDITIONS OF HOSTILITIES","authors":"V. Vasylevskyi, V. Glagovych, N. Liutianska, R. Koval, O. Plavkov, D. Charniuk, M. Soputnyak","doi":"10.32345/2664-4738.2.2023.16","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.16","url":null,"abstract":"Background. Investigating the medical-biological and socio-economic impacts of PTSD on a country's population is essential, as PTSD can cause serious mental and somatic health issues, affect work capacity and overall quality of life, and have long-term consequences for veterans and survivors. Understanding and studying the causes and consequences of PTSD is crucial for developing effective prevention and treatment strategies and ensuring national security and sustainable development of the country. \u0000Aim: To analyze the medical-biological and socio-economic consequences of PTSD on veterans and the population as a whole. \u0000Materials and methods. A data analysis was conducted using information obtained from online database searches in \"PubMed,\" \"National Institute on Alcohol Abuse and Alcoholism,\" \"ScienceDirect,\" and \"Psychiatrist.com,\" with keywords such as \"post-traumatic stress disorder,\" \"civilian population,\" \"military,\" \"veterans,\" \"comorbid conditions,\" \"alcoholism,\" \"drug addiction,\" \"economic burden,\" \"disability,\" \"costs,\" \"socio-economic status,\" \"combat operations,\" and \"support for survivors.\" \u0000Results. PTSD is a significant societal and economic challenge. Negative trends of these consequences are most acutely manifested in countries experiencing recent or ongoing military conflicts, where the dynamics of PTSD are increasing. Timely diagnosis and active public education are extremely important for preventing the development of chronic conditions and avoiding limitations on the functioning of survivors. Real-world practice demonstrates that support for individuals with PTSD often includes not only professional medical therapy but also assistance in employment, housing, and social adaptation. \u0000Conclusion. PTSD is a serious problem for veterans and civilian populations, requiring attention and support from the government and society. Further research and the development of effective treatment and support methods for people suffering from PTSD are needed to improve their quality of life and promote social integration.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41604171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.17
M. Shevchuk, L. Volos
Background. Cannabidiol (CBD), found in Cannabis sativa (hemp), is a non-psychoactive phytochemical substance that has gained considerable popularity over the past decade. Cannabidiol is the main phytocannabinoid, its share in the plant extract can reach 40%. Cannabidiol does not have any of the psychoactive properties that tetrahydrocannabinol (THC) and has a significant advantage for clinical use. Studies of cannabidiol involve studies of cognitive, anxiety and movement disorders, and chronic pain, but there is a lack of high-quality evidence that cannabidiol is effective for these conditions, such as safety and precise dose ranges for each disorder. Aim: to analyze the main achievements in the development of experimental and clinical use of cannabidiol. Materials and methods. We conducted a search for scientific studies related to the therapeutic use of cannabidiol. The included studies were selected based on a search of the online databases PubMed, Web of Science, Scopus, Google Scholar for documents related to the history of research and use of cannabidiol (cannabis, cannabidiol, tetrahydrocannabinol, endocannabinoid system, cannabinoid receptors were used as keywords). The search was carried out by two independent authors and 158 sources were selected for analysis, of which 61 were used that met the search criteria. Results. Based on the analysis of experimental and clinical studies, it was established that cannabidiol has various properties, including antiapoptotic, antioxidant, anti-inflammatory, antipsychotic and neuroprotective. In addition, basic and clinical studies of the effects of cannabidiol have been conducted in the context of many other health conditions, including its potential use in epilepsy, depression, neurodystrophic diseases, schizophrenia, and social phobia. Conclusion. Therefore, cannabidiol is a non-psychoactive phytochemical compound that can help patients with a different clinical condition. Despite the achievements, further studies are needed to determine the administration regimen and dose, likely side effects with long-term use, particularly in clinical settings.
背景。大麻二酚(CBD)，在大麻(大麻)中发现，是一种非精神活性的植物化学物质，在过去的十年中得到了相当大的普及。大麻二酚是主要的植物大麻素，其在植物提取物中的含量可达40%。大麻二酚不具有四氢大麻酚(THC)的任何精神活性特性，具有临床应用的显着优势。大麻二酚的研究涉及对认知、焦虑和运动障碍以及慢性疼痛的研究，但缺乏高质量的证据表明大麻二酚对这些疾病有效，例如每种疾病的安全性和精确剂量范围。目的:分析大麻二酚实验和临床应用发展的主要成果。材料和方法。我们搜索了与大麻二酚治疗用途相关的科学研究。纳入的研究是通过在线数据库PubMed、Web of Science、Scopus、谷歌Scholar检索与大麻二酚研究和使用历史相关的文献(以大麻、大麻二酚、四氢大麻酚、内源性大麻素系统、大麻素受体为关键词)来选择的。搜索由两位独立作者进行，并选择了158个来源进行分析，其中61个来源符合搜索标准。结果。通过实验和临床研究分析，确定了大麻二酚具有抗凋亡、抗氧化、抗炎、抗精神病和神经保护等多种特性。此外，在许多其他健康状况的背景下，对大麻二酚的影响进行了基础和临床研究，包括其在癫痫、抑郁症、神经营养不良疾病、精神分裂症和社交恐惧症中的潜在用途。结论。因此，大麻二酚是一种非精神活性的植物化学化合物，可以帮助患有不同临床疾病的患者。尽管取得了这些成就，但需要进一步的研究来确定给药方案和剂量，以及长期使用可能产生的副作用，特别是在临床环境中。
{"title":"THERAPEUTIC POTENTIAL OF CANNABIDIOL: THE MOST IMPORTANT ACHIEVEMENTS ON THE WAY TO A NEW ERA","authors":"M. Shevchuk, L. Volos","doi":"10.32345/2664-4738.2.2023.17","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.17","url":null,"abstract":"Background. Cannabidiol (CBD), found in Cannabis sativa (hemp), is a non-psychoactive phytochemical substance that has gained considerable popularity over the past decade. Cannabidiol is the main phytocannabinoid, its share in the plant extract can reach 40%. Cannabidiol does not have any of the psychoactive properties that tetrahydrocannabinol (THC) and has a significant advantage for clinical use. Studies of cannabidiol involve studies of cognitive, anxiety and movement disorders, and chronic pain, but there is a lack of high-quality evidence that cannabidiol is effective for these conditions, such as safety and precise dose ranges for each disorder. \u0000Aim: to analyze the main achievements in the development of experimental and clinical use of cannabidiol. \u0000Materials and methods. We conducted a search for scientific studies related to the therapeutic use of cannabidiol. The included studies were selected based on a search of the online databases PubMed, Web of Science, Scopus, Google Scholar for documents related to the history of research and use of cannabidiol (cannabis, cannabidiol, tetrahydrocannabinol, endocannabinoid system, cannabinoid receptors were used as keywords). The search was carried out by two independent authors and 158 sources were selected for analysis, of which 61 were used that met the search criteria. \u0000Results. Based on the analysis of experimental and clinical studies, it was established that cannabidiol has various properties, including antiapoptotic, antioxidant, anti-inflammatory, antipsychotic and neuroprotective. In addition, basic and clinical studies of the effects of cannabidiol have been conducted in the context of many other health conditions, including its potential use in epilepsy, depression, neurodystrophic diseases, schizophrenia, and social phobia. \u0000Conclusion. Therefore, cannabidiol is a non-psychoactive phytochemical compound that can help patients with a different clinical condition. Despite the achievements, further studies are needed to determine the administration regimen and dose, likely side effects with long-term use, particularly in clinical settings.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48346128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.07
Y. Saldan, Y. Panchenko, N. Malachkova
Background. Age-related macular degeneration is one of the most common causes of blindness in developed countries, especially in people over 60 years old. The incidence of AMD is projected to increase to 288 million in 2040 compared to 196 million in 2020. Cardiovascular factors, smoking, alcohol consumption, overweight, genetic factors, and metabolic disorders are risk factors for the development of AMD. There are disorders of lipid metabolism, as well as hyperreactivity of platelet purine receptors may be associated with the progression of AMD. The AREDS2 formula is currently used to treat AMD. New therapeutic strategies aimed to correct metabolic disorders are needed to decrease the development of the late stages of AMD. Aim: to investigate the effectiveness of improving pathogenetically directed method of prevention and treatment of age-related macular degeneration. Materials and methods. We observed 40 patients (80 eyes), aged 50-85 years, with AMD of category 3 (intermediate AMD), who were divided into 2 groups. The main group included 20 patients (40 eyes), 14 women and 6 men, who have prescribed a complex drug according to the standard AREDS2 scheme, as well as fenofibrate (200 mg) and clopidogrel bisulfate (75 mg). The control group included 20 patients (40 eyes), 13 women and 7 men. These patients received AREDS2 standard treatment. Progression was evaluated according to the results of OCT of the macular area according to the AREDS classification and control of corrected visual acuity (CVA). The observation period was 2 years. Results. No signs of progression were noted in patients of both observation groups within 6 months from the start of the prescribed therapy. In the patients of the control group, the progression of the disease was recorded after 1 year of observation according to both defined criteria. Changes in OCT were observed in 7,5% of patients in the control group, and a decrease in CVA- in 5%. In the patients of the main group who used the extended therapeutic regimen, after 1 year of follow-up, progression according to OCT signs was noted in 2,5% of cases, but there was no worsening of CVA. After 2 years of observation, signs of progression according to OST were recorded in the main group by 50% less than in the control group. According to CVA, disease progression was detected in 15% of the main group and 30% of the control group. Conclusions. This study complemented already existing therapeutic strategies for the preventive treatment of AMD.
{"title":"PATHOGENETICALLY DIRECTED METHOD OF PREVENTION AND TREATMENT OF AGE-MACULAR DEGENERATION","authors":"Y. Saldan, Y. Panchenko, N. Malachkova","doi":"10.32345/2664-4738.2.2023.07","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.07","url":null,"abstract":"Background. Age-related macular degeneration is one of the most common causes of blindness in developed countries, especially in people over 60 years old. The incidence of AMD is projected to increase to 288 million in 2040 compared to 196 million in 2020. Cardiovascular factors, smoking, alcohol consumption, overweight, genetic factors, and metabolic disorders are risk factors for the development of AMD. There are disorders of lipid metabolism, as well as hyperreactivity of platelet purine receptors may be associated with the progression of AMD. The AREDS2 formula is currently used to treat AMD. New therapeutic strategies aimed to correct metabolic disorders are needed to decrease the development of the late stages of AMD. \u0000Aim: to investigate the effectiveness of improving pathogenetically directed method of prevention and treatment of age-related macular degeneration. \u0000Materials and methods. We observed 40 patients (80 eyes), aged 50-85 years, with AMD of category 3 (intermediate AMD), who were divided into 2 groups. The main group included 20 patients (40 eyes), 14 women and 6 men, who have prescribed a complex drug according to the standard AREDS2 scheme, as well as fenofibrate (200 mg) and clopidogrel bisulfate (75 mg). The control group included 20 patients (40 eyes), 13 women and 7 men. These patients received AREDS2 standard treatment. Progression was evaluated according to the results of OCT of the macular area according to the AREDS classification and control of corrected visual acuity (CVA). The observation period was 2 years. \u0000Results. No signs of progression were noted in patients of both observation groups within 6 months from the start of the prescribed therapy. In the patients of the control group, the progression of the disease was recorded after 1 year of observation according to both defined criteria. Changes in OCT were observed in 7,5% of patients in the control group, and a decrease in CVA- in 5%. In the patients of the main group who used the extended therapeutic regimen, after 1 year of follow-up, progression according to OCT signs was noted in 2,5% of cases, but there was no worsening of CVA. After 2 years of observation, signs of progression according to OST were recorded in the main group by 50% less than in the control group. According to CVA, disease progression was detected in 15% of the main group and 30% of the control group. \u0000Conclusions. This study complemented already existing therapeutic strategies for the preventive treatment of AMD.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47898319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.02
V. Horoshko, I. Kuchyn
Background. In combatants with gunshot wounds, the frequency of pain chronicization is observed in 63.4-78.5% of cases. The reason for this high frequency of chronicization may be a neuropathic component. However, this hypothesis remains unexplored. Aim: To study the frequency of neuropathic pain in combatants after gunshot wounds. Materials and methods. We analyzed the treatment of 769 combatants after gunshot wounds. The neuropathic component of pain was identified using the Douleur Neuropathique 4 questions. The statistical analysis was performed using the Shapiro-Wilk, Friedman, chi-square, and Bonferroni correction. Results. The obtained data indicate that all combatants with chronic pain after gunshot wounds have a neuropathic component of pain (DN4 - from 4 to 5 points). Moreover, the results between the groups did not differ after 1 month - p=0.918, and after 3 months - 0.713, 6 months - p=0.824 and 12 months - p=0.911. Conclusion. Combatants who sustained gunshot wounds have a high risk of chronic pain. It was found that the neuropathic component of pain is present in all patients in this category, so it may be one of the key components of such a high frequency of pain chronicity, which requires further research.
{"title":"PAIN WITH A NEUROPATHIC COMPONENT IN COMBATANTS AFTER GUNSHOT WOUNDS","authors":"V. Horoshko, I. Kuchyn","doi":"10.32345/2664-4738.2.2023.02","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.02","url":null,"abstract":"Background. In combatants with gunshot wounds, the frequency of pain chronicization is observed in 63.4-78.5% of cases. The reason for this high frequency of chronicization may be a neuropathic component. However, this hypothesis remains unexplored. \u0000Aim: To study the frequency of neuropathic pain in combatants after gunshot wounds. \u0000Materials and methods. We analyzed the treatment of 769 combatants after gunshot wounds. The neuropathic component of pain was identified using the Douleur Neuropathique 4 questions. The statistical analysis was performed using the Shapiro-Wilk, Friedman, chi-square, and Bonferroni correction. \u0000Results. The obtained data indicate that all combatants with chronic pain after gunshot wounds have a neuropathic component of pain (DN4 - from 4 to 5 points). Moreover, the results between the groups did not differ after 1 month - p=0.918, and after 3 months - 0.713, 6 months - p=0.824 and 12 months - p=0.911. \u0000Conclusion. Combatants who sustained gunshot wounds have a high risk of chronic pain. It was found that the neuropathic component of pain is present in all patients in this category, so it may be one of the key components of such a high frequency of pain chronicity, which requires further research.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47916539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.03
Priyanshi Chauhan, N. Gaur, Gangadhar Reddy Akula, S. Kodidala
Background. Covid-19, conjointly referred to as severe acute metabolism syndrome appeared in December 2019 by a new Corona virus. The virus originated from Wuhan, the capital of China’s Hubei Province and unfold everywhere the globe and have become a worldwide pandemic due to lack of cure. Aim:To study the association of ABO Blood Group, Rh, Age and gender with and COVID-19 infection. Material and methods. This retrospective study was conducted after the approval college research committee of Teerthanker Mahaveer medical college and research center. The study period of this study is from 12 March 2021 to 12 March 2022. The current research included 3000 Covid-19 patients confirmed by RTPCR test and admitted in the Teerthanker Mahaveer University Hospital, Moradabad. Covid -19 positive patient’s age, gender, ABO blood group, Rh factor and personal data was collected from the medical record department. Results. The most common blood group affected was B+ (1,119, 37.3%) followed by O+ (729, 24.3%), A+ (653, 21.8%), AB+ (330, 11.0%), B- (77, 2.6%), O- (36, 1.2%), A-(36, 1.2%) and AB- (20, 0.7%). Among study population, 69 (2.3%) belonged to 1-10 years, 157 (5.2%) belonged to 11-20 years, 727 (24.2%) belonged to 21-30 years, 479 (16.0%) belonged to 31-40 years, 455 (15.2%) belonged to 41-50 years, 584 (19.5%) belonged to 51-60 years, 377 (12.6%) belonged to 61-70 years, 114 (3.8%) belonged to 71-80 years and 38 (1.3%) belonged to above 80 years. The study population consisted of 1,811 (60.4%) males and 1,189 (39.6%) females. Conclusions. The findings of this study are In our study we found that age group that was most vulnerable was 21-30 years. We also observed that Males were affected more as compared to females and the blood group that was affected most was B positive and least numbers of patients affected are of AB negative blood group.
{"title":"CORRELATION BETWEEN BLOOD GROUP, AGE & GENDER WITH COVID-19 INFECTION","authors":"Priyanshi Chauhan, N. Gaur, Gangadhar Reddy Akula, S. Kodidala","doi":"10.32345/2664-4738.2.2023.03","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.03","url":null,"abstract":"Background. Covid-19, conjointly referred to as severe acute metabolism syndrome appeared in December 2019 by a new Corona virus. The virus originated from Wuhan, the capital of China’s Hubei Province and unfold everywhere the globe and have become a worldwide pandemic due to lack of cure. \u0000Aim:To study the association of ABO Blood Group, Rh, Age and gender with and COVID-19 infection. \u0000Material and methods. This retrospective study was conducted after the approval college research committee of Teerthanker Mahaveer medical college and research center. The study period of this study is from 12 March 2021 to 12 March 2022. The current research included 3000 Covid-19 patients confirmed by RTPCR test and admitted in the Teerthanker Mahaveer University Hospital, Moradabad. Covid -19 positive patient’s age, gender, ABO blood group, Rh factor and personal data was collected from the medical record department. \u0000Results. The most common blood group affected was B+ (1,119, 37.3%) followed by O+ (729, 24.3%), A+ (653, 21.8%), AB+ (330, 11.0%), B- (77, 2.6%), O- (36, 1.2%), A-(36, 1.2%) and AB- (20, 0.7%). Among study population, 69 (2.3%) belonged to 1-10 years, 157 (5.2%) belonged to 11-20 years, 727 (24.2%) belonged to 21-30 years, 479 (16.0%) belonged to 31-40 years, 455 (15.2%) belonged to 41-50 years, 584 (19.5%) belonged to 51-60 years, 377 (12.6%) belonged to 61-70 years, 114 (3.8%) belonged to 71-80 years and 38 (1.3%) belonged to above 80 years. The study population consisted of 1,811 (60.4%) males and 1,189 (39.6%) females. \u0000Conclusions. The findings of this study are In our study we found that age group that was most vulnerable was 21-30 years. We also observed that Males were affected more as compared to females and the blood group that was affected most was B positive and least numbers of patients affected are of AB negative blood group.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43978954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.32345/2664-4738.2.2023.10
Y. Marushko, T.V. Shipelik, T. Hyschak, S. Kramarev, T. Kryuchko, A. Pisarev, S. Kryvopustov
Background. The urgency of the problem is due to the rapid spread of the coronavirus infection in the world, as well as the frequent occurrence of a wide range of post-coronavirus complications in children, which significantly affect the quality of life. These changes also remain in the post-Covid period. Assessment of the quality of life in children with post-covid syndrome in Ukraine is at the stage of formation, therefore, methodologically, the creation and validation of children's questionnaires with subsequent assessment of the quality of life remains an urgent problem. Aim: to summarize data from the literature regarding the study of health-related quality of life in children with SARS-CoV-2 infection and post-covid syndrome. Materials and methods. An assessment of literature data on the frequency and course of coronavirus infection, its manifestations, damage to the respiratory system and other organs and systems in children, and asthenic manifestations was carried out. Results. Based on the analysis of the scientific literature, the possibilities of using the quality of life assessment method in pediatric practice, in particular in children with COVID-19 and the consequences of the infection, were considered. One of the most frequently used questionnaires for assessing the quality of life in children is the PedsQL 4.0 questionnaire, which, due to good psychometric qualities, the availability of parallel forms for children and parents, a wide age range, simplicity and ease of filling out, can be recommended for determining the health-related quality of life in children. It is shown how the study of the quality of life related to health allows to study the impact of the disease and treatment on the components of the child's health. Conclusions. Research on quality of life allows monitoring the condition of a child with post-covid syndrome during treatment and rehabilitation, as well as evaluating the effectiveness of these measures.
{"title":"METHODOLOGY FOR ASSESSMENT OF THE QUALITY OF LIFE OF CHILDREN WITH CORONA VIRUS INFECTION AND THE POST-VIDAL SYNDROME","authors":"Y. Marushko, T.V. Shipelik, T. Hyschak, S. Kramarev, T. Kryuchko, A. Pisarev, S. Kryvopustov","doi":"10.32345/2664-4738.2.2023.10","DOIUrl":"https://doi.org/10.32345/2664-4738.2.2023.10","url":null,"abstract":"Background. The urgency of the problem is due to the rapid spread of the coronavirus infection in the world, as well as the frequent occurrence of a wide range of post-coronavirus complications in children, which significantly affect the quality of life. These changes also remain in the post-Covid period. Assessment of the quality of life in children with post-covid syndrome in Ukraine is at the stage of formation, therefore, methodologically, the creation and validation of children's questionnaires with subsequent assessment of the quality of life remains an urgent problem. \u0000Aim: to summarize data from the literature regarding the study of health-related quality of life in children with SARS-CoV-2 infection and post-covid syndrome. \u0000Materials and methods. An assessment of literature data on the frequency and course of coronavirus infection, its manifestations, damage to the respiratory system and other organs and systems in children, and asthenic manifestations was carried out. \u0000Results. Based on the analysis of the scientific literature, the possibilities of using the quality of life assessment method in pediatric practice, in particular in children with COVID-19 and the consequences of the infection, were considered. One of the most frequently used questionnaires for assessing the quality of life in children is the PedsQL 4.0 questionnaire, which, due to good psychometric qualities, the availability of parallel forms for children and parents, a wide age range, simplicity and ease of filling out, can be recommended for determining the health-related quality of life in children. It is shown how the study of the quality of life related to health allows to study the impact of the disease and treatment on the components of the child's health. \u0000Conclusions. Research on quality of life allows monitoring the condition of a child with post-covid syndrome during treatment and rehabilitation, as well as evaluating the effectiveness of these measures.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44332433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.02
O. Mozyrskaya
Background. The distribution of sensitization among children and adolescence with allergic rhinitis (AR) and asthma and their impact on various allergic symptoms have been analyzed. Aim: investigate the distribution of sensitization among children with AR and asthma of the Ukrainian population. Material and methods. The study involved 280 children with AR and asthma aged 2–18 years. They were tested for sIgE on the most common allergens among Ukrainians - Dermatophagoides pteronyssinus, Dermatophagoides farinae, dog, cat, cockroach, birch (t03, Bet v1, Bet v2, Bet v4), plane tree, timothy (g06, Phl p1, Phl , Phl p6, Phl p7, Phl p12), ragweed, mugwort and Alternaria. Measurements of sIgE were performed by Western blotting according to the manufacturer's protocol (Simesta-Medivis, Ukraine-Germany). Results. Among the sensitized subjects, 165 were sensitive to pollen allergens, sIgE was positive to birch in 64 subjects (22.5%), to mugwort ‒ 65 subjects (25.4%), ragweed ‒ 110 subjects (42.5%), timothy ‒ 69 subjects (24.6%), plane tree ‒ 12 subjects (5%). Positive sIgE to feline allergen was found in 114 (43.3%), dogs ‒ 77 (32.1%), Dermatophagoides pteronyssinus ‒ 66 (24.6%), Dermatophagoides farinae ‒ 32 (12%), Alternaria ‒ 38 (15 %), cockroaches ‒ 25 (10%). Conclusions. Sensitization to airborne allergens is significantly associated with asthma and AR. The most important inhalant allergens consist of pollens (trees, grasses, and weeds), house dust mites, molds and animal dander. Among sensitive subjects to pollen allergens, allergy to ragweed was most spread.
{"title":"PREVALENCE OF SENSITIZATION TO AIRBORNE ALLERGENS IN PATIENTS WITH ALLERGIC RHINITIS AND ASTHMA IN UKRAINE","authors":"O. Mozyrskaya","doi":"10.32345/2664-4738.1.2023.02","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.02","url":null,"abstract":"Background. The distribution of sensitization among children and adolescence with allergic rhinitis (AR) and asthma and their impact on various allergic symptoms have been analyzed. \u0000Aim: investigate the distribution of sensitization among children with AR and asthma of the Ukrainian population. \u0000Material and methods. The study involved 280 children with AR and asthma aged 2–18 years. They were tested for sIgE on the most common allergens among Ukrainians - Dermatophagoides pteronyssinus, Dermatophagoides farinae, dog, cat, cockroach, birch (t03, Bet v1, Bet v2, Bet v4), plane tree, timothy (g06, Phl p1, Phl , Phl p6, Phl p7, Phl p12), ragweed, mugwort and Alternaria. Measurements of sIgE were performed by Western blotting according to the manufacturer's protocol (Simesta-Medivis, Ukraine-Germany). \u0000Results. Among the sensitized subjects, 165 were sensitive to pollen allergens, sIgE was positive to birch in 64 subjects (22.5%), to mugwort ‒ 65 subjects (25.4%), ragweed ‒ 110 subjects (42.5%), timothy ‒ 69 subjects (24.6%), plane tree ‒ 12 subjects (5%). Positive sIgE to feline allergen was found in 114 (43.3%), dogs ‒ 77 (32.1%), Dermatophagoides pteronyssinus ‒ 66 (24.6%), Dermatophagoides farinae ‒ 32 (12%), Alternaria ‒ 38 (15 %), cockroaches ‒ 25 (10%). \u0000Conclusions. Sensitization to airborne allergens is significantly associated with asthma and AR. The most important inhalant allergens consist of pollens (trees, grasses, and weeds), house dust mites, molds and animal dander. Among sensitive subjects to pollen allergens, allergy to ragweed was most spread.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41497609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.12
T. Hrydina, R. Khoma, A. Fedchuk, O. А. Hruzevskyi, H. Shevchuk, Yu. V. Ishkov
Background. The spread of a new strain of SARS-CoV-2 and the pandemic that caused it has led to huge changes around the world. So, it reminded us again about the importance of developing measures for the prevention of infections that transmitted by air droplets. Aim: investigation of the antimicrobial activity of aminomethanesulfonic acid (AMSA) and its derivatives (N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA) and N-(tert-butyl)-(t-BuAMSA)) which impregnated on filtering fibrous material and can be used for the manufacture of anti-aerosol elements of individual respiratory protection against strains of Staphylococcus aureus with different level of antibiotics resistance. Materials and methods. The standard method of Kirby and Bauer disks is used for the investigation of the specific activity of antimicrobial drugs. The 24-hour cultures of microorganisms that contained (1.2+0.2)x109 CFU/ml were diluted according to the turbidity standard. The results were detected after 18-20 hours of incubation at 37°C. The 0.5 cm diameter filter fibrous discs contained the following compounds: AMSA, HEAMSA, BzAMSA, t-BuAMSA and streptocide (sulfanilamide) as a reference with active compound content (Q) at a final concentration of 0.047 and 0.236 mmol/g. Results. All test samples with aminomethanesulfonic acids at a final concentration of 0.236 mmol/g that were applied to the filter fibrous material had a higher level of inhibition of the growth of the microorganisms than the prototype using streptocide (sulfanilamide) e against the strains of Staphylococcus aureus 2781 and Staphylococcus aureus Kunda. Conclusions. Samples based on HEAMSA showed the greatest antimicrobial activity against the studied strains of Staphylococcus aureus from all research samples of filter fibrous material with YAMSA. They were characterized by the maximum hydrophilicity and the minimum value of the empirical pKa function lgPow. AMSA and HEAMSA were characterized by the smallest particle sizes on the surface of lavsan fiber according to electron microscopy analysis. This provides the largest boundary of contact between the phases of these biocides in the composition of the filtering fibrous material with bio aerosols during respiratory air purification.
{"title":"ANTIMICROBIAL PROPERTIES OF FILTERING FIBROUS MATERIALS IMPREGNATED BY AMINOMETHANESULPHONIC ACIDS","authors":"T. Hrydina, R. Khoma, A. Fedchuk, O. А. Hruzevskyi, H. Shevchuk, Yu. V. Ishkov","doi":"10.32345/2664-4738.1.2023.12","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.12","url":null,"abstract":"Background. The spread of a new strain of SARS-CoV-2 and the pandemic that caused it has led to huge changes around the world. So, it reminded us again about the importance of developing measures for the prevention of infections that transmitted by air droplets. \u0000Aim: investigation of the antimicrobial activity of aminomethanesulfonic acid (AMSA) and its derivatives (N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA) and N-(tert-butyl)-(t-BuAMSA)) which impregnated on filtering fibrous material and can be used for the manufacture of anti-aerosol elements of individual respiratory protection against strains of Staphylococcus aureus with different level of antibiotics resistance. \u0000Materials and methods. The standard method of Kirby and Bauer disks is used for the investigation of the specific activity of antimicrobial drugs. The 24-hour cultures of microorganisms that contained (1.2+0.2)x109 CFU/ml were diluted according to the turbidity standard. The results were detected after 18-20 hours of incubation at 37°C. The 0.5 cm diameter filter fibrous discs contained the following compounds: AMSA, HEAMSA, BzAMSA, t-BuAMSA and streptocide (sulfanilamide) as a reference with active compound content (Q) at a final concentration of 0.047 and 0.236 mmol/g. \u0000Results. All test samples with aminomethanesulfonic acids at a final concentration of 0.236 mmol/g that were applied to the filter fibrous material had a higher level of inhibition of the growth of the microorganisms than the prototype using streptocide (sulfanilamide) e against the strains of Staphylococcus aureus 2781 and Staphylococcus aureus Kunda. \u0000Conclusions. Samples based on HEAMSA showed the greatest antimicrobial activity against the studied strains of Staphylococcus aureus from all research samples of filter fibrous material with YAMSA. They were characterized by the maximum hydrophilicity and the minimum value of the empirical pKa function lgPow. AMSA and HEAMSA were characterized by the smallest particle sizes on the surface of lavsan fiber according to electron microscopy analysis. This provides the largest boundary of contact between the phases of these biocides in the composition of the filtering fibrous material with bio aerosols during respiratory air purification.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47096573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.32345/2664-4738.1.2023.10
I. Noenko, O. Pavlenko, I. Mochalov
Background. Dental caries is a widespread worldwide disease of multifactorial genesis. The leading mechanism of its development is a long-term imbalance of the physiological balance between the inorganic component of the teeth hard tissues and the liquid biofilm formed on their surface, the predominance of the demineralization processes in hard tissues over the processes of remineralization. The use of dental enamel sealants has proven to be effective in preventing and reducing the intensity of dental caries. Modern bioactive polymer sealants for enamel contain such remineralizing agents as sodium fluoride, nanoamorphous calcium phosphate, beta-tricalcium phosphate, and particles of bioactive glass. For all dental composite filling materials, mechanical stability is one of the prerequisites for the long-term clinical success of restorations and fillings, and accordingly, temporary protective structures made of sealants. Aim: to compare the flexural strength and modulus of elasticity of three modern photocomposite enamel sealants. Materials and methods. In laboratory conditions for three modern photocomposite dental materials for sealing fissures and pits of enamel "Fissurit FX" (VOCO), "Clinpro™ Sealant" (3M™ ESPE™) and "Jen-Fissufil" (Jendental-Ukraine LLC) a flexural strength (three-point test) and elastic modulus were determined in accordance with the requirements of the international standard ISO 4049:2019. 6 samples of each material, polymerized and kept for a day in humid conditions, were examined. Results. The highest elastic modulus and flexural strength were in "Fissurit FX" – 5.17±0.80 GPa (M=5.00 GPa) and 130.07±7.75 MPa (M=127.81 MPa), respectively. In "Clinpro™ Sealant" the elastic modulus was 2.97±0.12 GPa (М=3.00 GPa), the flexural strength was 100.01±14.33 (М=96.73) MPa. In "Jen-Fissufil" the elastic modulus was 3.47±0.52 GPa (M=3.17 GPa), the flexural strength was 90.91±6.66 MPa (M=93.02 MPa). The studied indicators of all three materials exceeded the requirements of the international standard ISO 4049:2019. Conclusion. The performed studies showed high mechanical properties of all three dental sealants for enamel and that they have the potential to withstand long-term periodic masticatory load when functioning on the surface of teeth.
{"title":"COMPARATIVE STUDY OF FLEXURAL STRENGTH OF PHOTOCOMPOSITE DENTAL ENAMEL SEALANTS","authors":"I. Noenko, O. Pavlenko, I. Mochalov","doi":"10.32345/2664-4738.1.2023.10","DOIUrl":"https://doi.org/10.32345/2664-4738.1.2023.10","url":null,"abstract":"Background. Dental caries is a widespread worldwide disease of multifactorial genesis. The leading mechanism of its development is a long-term imbalance of the physiological balance between the inorganic component of the teeth hard tissues and the liquid biofilm formed on their surface, the predominance of the demineralization processes in hard tissues over the processes of remineralization. The use of dental enamel sealants has proven to be effective in preventing and reducing the intensity of dental caries. Modern bioactive polymer sealants for enamel contain such remineralizing agents as sodium fluoride, nanoamorphous calcium phosphate, beta-tricalcium phosphate, and particles of bioactive glass. For all dental composite filling materials, mechanical stability is one of the prerequisites for the long-term clinical success of restorations and fillings, and accordingly, temporary protective structures made of sealants. \u0000Aim: to compare the flexural strength and modulus of elasticity of three modern photocomposite enamel sealants. \u0000Materials and methods. In laboratory conditions for three modern photocomposite dental materials for sealing fissures and pits of enamel \"Fissurit FX\" (VOCO), \"Clinpro™ Sealant\" (3M™ ESPE™) and \"Jen-Fissufil\" (Jendental-Ukraine LLC) a flexural strength (three-point test) and elastic modulus were determined in accordance with the requirements of the international standard ISO 4049:2019. 6 samples of each material, polymerized and kept for a day in humid conditions, were examined. \u0000Results. The highest elastic modulus and flexural strength were in \"Fissurit FX\" – 5.17±0.80 GPa (M=5.00 GPa) and 130.07±7.75 MPa (M=127.81 MPa), respectively. In \"Clinpro™ Sealant\" the elastic modulus was 2.97±0.12 GPa (М=3.00 GPa), the flexural strength was 100.01±14.33 (М=96.73) MPa. In \"Jen-Fissufil\" the elastic modulus was 3.47±0.52 GPa (M=3.17 GPa), the flexural strength was 90.91±6.66 MPa (M=93.02 MPa). The studied indicators of all three materials exceeded the requirements of the international standard ISO 4049:2019. \u0000Conclusion. The performed studies showed high mechanical properties of all three dental sealants for enamel and that they have the potential to withstand long-term periodic masticatory load when functioning on the surface of teeth.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48867426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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