Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.04
V. Moskaliuk, I. Rudan
Relevance. Today, there are controversies regarding the influence of hepatitis B and C viruses on the course of HIV infection. Objective assess the course and outcomes of chronic hepatitis B and C in HIV-infected patients, as well as to analyze the causes of death of such patients. Materials and methods. A retrospective pseudorandomized study was conducted with a depth of 5 years. 114 medical records of inpatients (HIV infection in association with hepatitis B and C) were selected. The analysis of the causes of death in patients with HIV infection was carried out based on the study of autopsy materials of 21 patients. Results. It was established that the frequency of CHV exacerbation in III-IV clinical stages of HIV infection is significantly higher, and remission is lower than in I-II stages - (36.8±4.5) versus (7.0±2.4)% and (35.1±4.5) and (7.9±2.5)%, respectively (p<0.001). The frequency of liver cirrhosis was characterized by a clear tendency to increase with the deepening of immunodeficiency. The calculation of the frequency of findings in liver cirrhosis showed that in the I-II clinical stage of HIV infection, this value was equal to 0.17, and in the III-IV stage - 0.33. The relative risk of developing liver cirrhosis in HIV-infected patients was 0.52. Moreover, the probability of a fatal outcome in cirrhosis of the liver in HIV-infected patients in the I-II clinical stage was equal to 0.16, and in the III-IV stage - 0.29, with a relative risk of 0.63. The reduction in the relative risk of a fatal outcome taking into account the stage of HIV infection is 0.32. The average life expectancy of patients from the moment of detection of HIV antibodies was (3.4±0.6) years (from 4 months to 9 years). Such a short average life expectancy of HIV-infected patients was caused by a large number of patients diagnosed for the first time already in the IV clinical stage. In more than half (13 out of 21) the causes of death were AIDS-related diseases (61.9 %). Conclusions. A retrospective pseudorandomized study showed that cirrhosis of the liver in the early stages of HIV infection was registered 2.7 times less often than in patients with HIV infection in the stage of secondary diseases. Exacerbation of chronic hepatitis B and C is significantly more often established in the III-IV clinical stage of concomitant HIV infection. Under the same circumstances, signs of cirrhosis of the liver are more often registered, and fatal outcomes occupy one of the leading places in patients with HIV infection. This indicates the need to revise the tactics of clinical management of this category of patients. In 61.9 % of cases, the causes of death were AIDS-indicative diseases. Tuberculosis turned out to be the leading cause of death (46.1 %) of HIV-infected patients and was mainly in a generalized form. Toxoplasmosis (30.8 %) with damage to the brain and other organs takes the second place in terms of the frequency of fatal AIDS-indicative diseases. Meningoencepha
{"title":"INVESTIGATIONS OF CHRONIC HEPATITIS B and C IN HIV-INFECTION","authors":"V. Moskaliuk, I. Rudan","doi":"10.32345/2664-4738.3.2022.04","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.04","url":null,"abstract":"Relevance. Today, there are controversies regarding the influence of hepatitis B and C viruses on the course of HIV infection. \u0000Objective assess the course and outcomes of chronic hepatitis B and C in HIV-infected patients, as well as to analyze the causes of death of such patients. \u0000Materials and methods. A retrospective pseudorandomized study was conducted with a depth of 5 years. 114 medical records of inpatients (HIV infection in association with hepatitis B and C) were selected. The analysis of the causes of death in patients with HIV infection was carried out based on the study of autopsy materials of 21 patients. \u0000Results. It was established that the frequency of CHV exacerbation in III-IV clinical stages of HIV infection is significantly higher, and remission is lower than in I-II stages - (36.8±4.5) versus (7.0±2.4)% and (35.1±4.5) and (7.9±2.5)%, respectively (p<0.001). The frequency of liver cirrhosis was characterized by a clear tendency to increase with the deepening of immunodeficiency. \u0000The calculation of the frequency of findings in liver cirrhosis showed that in the I-II clinical stage of HIV infection, this value was equal to 0.17, and in the III-IV stage - 0.33. The relative risk of developing liver cirrhosis in HIV-infected patients was 0.52. Moreover, the probability of a fatal outcome in cirrhosis of the liver in HIV-infected patients in the I-II clinical stage was equal to 0.16, and in the III-IV stage - 0.29, with a relative risk of 0.63. The reduction in the relative risk of a fatal outcome taking into account the stage of HIV infection is 0.32. \u0000The average life expectancy of patients from the moment of detection of HIV antibodies was (3.4±0.6) years (from 4 months to 9 years). Such a short average life expectancy of HIV-infected patients was caused by a large number of patients diagnosed for the first time already in the IV clinical stage. In more than half (13 out of 21) the causes of death were AIDS-related diseases (61.9 %). \u0000Conclusions. A retrospective pseudorandomized study showed that cirrhosis of the liver in the early stages of HIV infection was registered 2.7 times less often than in patients with HIV infection in the stage of secondary diseases. \u0000Exacerbation of chronic hepatitis B and C is significantly more often established in the III-IV clinical stage of concomitant HIV infection. Under the same circumstances, signs of cirrhosis of the liver are more often registered, and fatal outcomes occupy one of the leading places in patients with HIV infection. This indicates the need to revise the tactics of clinical management of this category of patients. \u0000In 61.9 % of cases, the causes of death were AIDS-indicative diseases. Tuberculosis turned out to be the leading cause of death (46.1 %) of HIV-infected patients and was mainly in a generalized form. Toxoplasmosis (30.8 %) with damage to the brain and other organs takes the second place in terms of the frequency of fatal AIDS-indicative diseases. Meningoencepha","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47706965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.09
О.М. Misiura, V. Sova, O. V. Anoprienko, O.S. Sudyka, А.І. Merkotan, M. Khaitovych
Relevance. The infliction of war and military aggression is a violation of children's basic rights, because during war children gain experiences that are in stark contrast to their needs to grow up in a physically and emotionally safe and predictable environment. Objective of the work was to establish the frequency and manifestations of emotional disorders in children who lived in the occupied territory of Ukraine in February-March 2022. Material and methods. In May-July 2022, 184 children aged 3-17 years who lived in February-March 2022 in Kyiv and Chernihiv regions in the territories occupied by Russian troops were examined. Psychological and psychiatric counseling of 119 children was carried out. The "Child's Dream" method was used to identify themes of disturbing thoughts (the child was asked to draw a sleeping child and a dream that she had). Parents of 81 children were also surveyed using the Pediatric Symptom Checklist-17 (PSC-17): 29 children from May 3 to May 17 (Group I); 17 children from May 19 to May 31 (II group); 35 children from June 6 to July 14 (III group). Results. Anxiety disorders were detected in 27.7% of children, and conditions associated with high anxiety (insomnia, phobias, post-traumatic stress disorder, behavioral disorders) were found in another 24.4%. In 72.4% of the children of the I group, 29.4% of the children of the II group, and 17.1% of the children of the III group, internalization disorders were found; disorders of attention and externalization were found only in children of I (55.2% and 51.7%, respectively) and II groups (20.4% and 11.8%, respectively). Conclusions. More than half of the children who lived in the occupied territory were found to have psychoemotional disorders with a predominance of anxiety. 3 months after experiencing acute stress, internalization problems remain in 17% of children. These emotional disorders indicate the need to develop psychological correction measures.
{"title":"EMOTIONAL STATE OF CHILDREN OF UKRAINE WHO WERE AFFECTED BY WAR FACTORS IN THE OCCUPIED TERRITORY","authors":"О.М. Misiura, V. Sova, O. V. Anoprienko, O.S. Sudyka, А.І. Merkotan, M. Khaitovych","doi":"10.32345/2664-4738.3.2022.09","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.09","url":null,"abstract":"Relevance. The infliction of war and military aggression is a violation of children's basic rights, because during war children gain experiences that are in stark contrast to their needs to grow up in a physically and emotionally safe and predictable environment. \u0000Objective of the work was to establish the frequency and manifestations of emotional disorders in children who lived in the occupied territory of Ukraine in February-March 2022. \u0000Material and methods. In May-July 2022, 184 children aged 3-17 years who lived in February-March 2022 in Kyiv and Chernihiv regions in the territories occupied by Russian troops were examined. Psychological and psychiatric counseling of 119 children was carried out. The \"Child's Dream\" method was used to identify themes of disturbing thoughts (the child was asked to draw a sleeping child and a dream that she had). Parents of 81 children were also surveyed using the Pediatric Symptom Checklist-17 (PSC-17): 29 children from May 3 to May 17 (Group I); 17 children from May 19 to May 31 (II group); 35 children from June 6 to July 14 (III group). \u0000Results. Anxiety disorders were detected in 27.7% of children, and conditions associated with high anxiety (insomnia, phobias, post-traumatic stress disorder, behavioral disorders) were found in another 24.4%. In 72.4% of the children of the I group, 29.4% of the children of the II group, and 17.1% of the children of the III group, internalization disorders were found; disorders of attention and externalization were found only in children of I (55.2% and 51.7%, respectively) and II groups (20.4% and 11.8%, respectively). \u0000Conclusions. More than half of the children who lived in the occupied territory were found to have psychoemotional disorders with a predominance of anxiety. 3 months after experiencing acute stress, internalization problems remain in 17% of children. These emotional disorders indicate the need to develop psychological correction measures.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48212404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.13
I.V. Ibrahimova, O. Vavrinevych, A. Antonenko, S. Omelchuk, V. Bardov
Relevance. The priorities of modern agricultural production are the application of new pesticides that are highly effective, safe for humans and do not have a negative impact on environmental objects. The most promising is the synthesis of substances from natural materials or their synthetic analogues (pesticides of biological origin). These include avermectin class substance – milbemectin. Objective of the work was the toxicological and hygienic evaluation of the new active ingredient of the aversectins class - milbemectin and the formulation based on it Milbeknok 1%, CE, substantiation of the acceptable daily dose (ADD) of milbemectin. Materials and methods. Expert-analytical, toxicological and hygienic methods, analysis of literature data were used during the research. The hygienic assessment of the toxicity of milbemectin and the formulation based on it was carried out in accordance with State Standard 8.8.1.002-98 “Hygienic classification of pesticides by degree of hazard”. Results. The analysis of the acute toxicity of the formulation and its active ingredient showed that Milbeknok 1%, CE, according to State Standard 8.8.1.002-98, belongs to the 3rd class of hazard, and milbemectin – to the 2nd class, according to the limiting criterion – acute inhalation toxicity. In short-term and long-term experiments with rats, mice and dogs, the main effect of milbemectin exposure was general toxicity and hepatotoxicity. According to carcinogenicity, reproductive and embryotoxicity, milbemectin is pertained to the 3rd class of hazard. Substantiating the ADD of milbemectin we used the smallest NO(A)EL value of 3 mg/kg, established for the general toxic effect in the experiment to study the chronic effect on dogs and safety factor of 1000 (taking into account the lack of a study of developmental neurotoxicity and limited data on reproductive toxicity of the compound): ADD = 3/1000 = 0.003 mg/kg. Conclusions. It was established that the Milbeknok 1%, CE pertains to the 3rd class, and its active substance - to the 2nd class of hazard, according to the limiting criterion – acute inhalation toxicity. The substantiated ADD value of milbemectin is 0.003 mg/kg.
{"title":"TOXICOLOGICAL AND HYGIENIC ASSESSMENT OF THE NEW ACTIVE INGREDIENT OF THE AVERSECTINS CLASS - MILBEMECTIN AND THE FORMULATION BASED ON IT MILBEKNOK 1%, CE","authors":"I.V. Ibrahimova, O. Vavrinevych, A. Antonenko, S. Omelchuk, V. Bardov","doi":"10.32345/2664-4738.3.2022.13","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.13","url":null,"abstract":"Relevance. The priorities of modern agricultural production are the application of new pesticides that are highly effective, safe for humans and do not have a negative impact on environmental objects. The most promising is the synthesis of substances from natural materials or their synthetic analogues (pesticides of biological origin). These include avermectin class substance – milbemectin. \u0000Objective of the work was the toxicological and hygienic evaluation of the new active ingredient of the aversectins class - milbemectin and the formulation based on it Milbeknok 1%, CE, substantiation of the acceptable daily dose (ADD) of milbemectin. \u0000Materials and methods. Expert-analytical, toxicological and hygienic methods, analysis of literature data were used during the research. The hygienic assessment of the toxicity of milbemectin and the formulation based on it was carried out in accordance with State Standard 8.8.1.002-98 “Hygienic classification of pesticides by degree of hazard”. \u0000Results. The analysis of the acute toxicity of the formulation and its active ingredient showed that Milbeknok 1%, CE, according to State Standard 8.8.1.002-98, belongs to the 3rd class of hazard, and milbemectin – to the 2nd class, according to the limiting criterion – acute inhalation toxicity. \u0000In short-term and long-term experiments with rats, mice and dogs, the main effect of milbemectin exposure was general toxicity and hepatotoxicity. According to carcinogenicity, reproductive and embryotoxicity, milbemectin is pertained to the 3rd class of hazard. \u0000Substantiating the ADD of milbemectin we used the smallest NO(A)EL value of 3 mg/kg, established for the general toxic effect in the experiment to study the chronic effect on dogs and safety factor of 1000 (taking into account the lack of a study of developmental neurotoxicity and limited data on reproductive toxicity of the compound): ADD = 3/1000 = 0.003 mg/kg. \u0000Conclusions. It was established that the Milbeknok 1%, CE pertains to the 3rd class, and its active substance - to the 2nd class of hazard, according to the limiting criterion – acute inhalation toxicity. The substantiated ADD value of milbemectin is 0.003 mg/kg.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48317790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.10
О. Temirova, M. Khaitovych, Julia Krat
Relevance. Acne is the most common dermatological problem, the treatment of which requires a personalized approach for each patient. However, many patients refer to self-medication. Objective. To analyze the role of pharmaceutical care in dispensing medicines for the prevention and treatment of acne according to the results of a questionnaire survey. Materials and methods. 100 pharmacy workers were surveyed according to a single specially developed protocol, considering issues related to the dispensing of anti-acne drugs. Standardization, an anonymous questionnaire, statistical and graphic methods were used. Results. It was found that 89% of the surveyed pharmacy workers recommend drugs for the treatment/prevention of acne to visitors. In particular, azelaic acid (74%), salicylic acid (31%), clindamycin (49%), and benzoyl peroxide (37%) are more frequent recommendations. More than half of the respondents, mostly employees with 4-6 years of work experience (р<0.05), recommend visitors to take sorbents in combination with anti-acne drugs. It is important to note that almost 20% of pharmaceutical workers were contacted by visitors with the appearance of side reactions after using anti-acne drugs. Visitors note such complications as dryness (31.4%) and redness of the skin (19.6%), increased rash (21.6%). It has been established that most pharmacy workers provide visitors with information on medicines for responsible self-treatment and acne prevention. However, more than 30% of pharmacists do not use the "Prevention and symptomatic treatment of acne" protocol. Conclusions. Therefore, the provision of pharmaceutical care is a necessary condition for ensuring effective and safe pharmacotherapy of acne. While high-quality pharmaceutical care is possible if the pharmacy employees follow the pharmacist's protocol. Postgraduate training of pharmacists in pharmaceutical care in dermatology is important.
{"title":"SOCIOLOGICAL STUDY OF THE ROLE OF PHARMACEUTICAL CARE IN THE DISPENSING OF MEDICINES FOR THE PREVENTION AND TREATMENT OF ACNE","authors":"О. Temirova, M. Khaitovych, Julia Krat","doi":"10.32345/2664-4738.3.2022.10","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.10","url":null,"abstract":"Relevance. Acne is the most common dermatological problem, the treatment of which requires a personalized approach for each patient. However, many patients refer to self-medication. \u0000Objective. To analyze the role of pharmaceutical care in dispensing medicines for the prevention and treatment of acne according to the results of a questionnaire survey. \u0000Materials and methods. 100 pharmacy workers were surveyed according to a single specially developed protocol, considering issues related to the dispensing of anti-acne drugs. Standardization, an anonymous questionnaire, statistical and graphic methods were used. \u0000Results. It was found that 89% of the surveyed pharmacy workers recommend drugs for the treatment/prevention of acne to visitors. In particular, azelaic acid (74%), salicylic acid (31%), clindamycin (49%), and benzoyl peroxide (37%) are more frequent recommendations. More than half of the respondents, mostly employees with 4-6 years of work experience (р<0.05), recommend visitors to take sorbents in combination with anti-acne drugs. It is important to note that almost 20% of pharmaceutical workers were contacted by visitors with the appearance of side reactions after using anti-acne drugs. Visitors note such complications as dryness (31.4%) and redness of the skin (19.6%), increased rash (21.6%). It has been established that most pharmacy workers provide visitors with information on medicines for responsible self-treatment and acne prevention. However, more than 30% of pharmacists do not use the \"Prevention and symptomatic treatment of acne\" protocol. \u0000Conclusions. Therefore, the provision of pharmaceutical care is a necessary condition for ensuring effective and safe pharmacotherapy of acne. While high-quality pharmaceutical care is possible if the pharmacy employees follow the pharmacist's protocol. Postgraduate training of pharmacists in pharmaceutical care in dermatology is important.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45200546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.12
А. Antonenko, O. Vavrinevych, B. I. Shpak, I. Tkachenko, S. Omelchuk
Relevance. In order to conduct agriculture and comply with food standards, it is necessary to create effective systems for controlling the content of pesticides active ingredients in agricultural crops, the food products quality, and assessing the risk of consuming food that may contain pesticide residues.Objective: forecasting and assessment of the risk of consuming products contaminated with avermectin insecticides hazardous effect on human health.Materials and methods. The actual content of abamectin and emamectin benzoate in vegetable, grain, stone fruits, berries, grapes, soybeans and green mass of plants was determined by the methods of gas chromatography and high-performance liquid chromatography. The τ50 of the studied insecticides and the integral index of danger when using products contaminated by them were calculated. Results. According to its stability in agricultural crops (grapes, cabbage, peaches, cherries) emamectin benzoate pertained to the 4th hazardous class (not stable); abamectin – to class 3 (moderately stable compounds) in grapes, pears, nuts, strawberries, apples, tomatoes; to the 4th class (non-persistent compound) – in cucumbers, eggplants, soybeans. Abamectin and emamectin belong to the 2nd hazardous class according to integral index of danger when using pesticide-contaminated products value – dangerous. This is due to its high toxicity for warm-blooded animals and humans and a wide range of crops on which formulations based on the studied compounds are allowed to be used.Conclusion. It was established that abamectin and emamectin benzoate belong to moderately persistent (3rd hazard class) and non-persistent (4th hazard class) pesticides according to their persistence in agricultural plants, respectively, and according to the value of integral index of danger when using pesticide-contaminated products value, both studied compounds belong to the 2nd class (dangerous).
{"title":"PREDICTION OF THE AVERMECTIN INSECTICIDES HAZARDOUS EFFECT ON HUMAN HEALTH WHEN CONSUMING PLANT PRODUCTS GROWN WITH THE APPLICATION OF FORMULATIONS BASED ON THEM","authors":"А. Antonenko, O. Vavrinevych, B. I. Shpak, I. Tkachenko, S. Omelchuk","doi":"10.32345/2664-4738.3.2022.12","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.12","url":null,"abstract":"Relevance. In order to conduct agriculture and comply with food standards, it is necessary to create effective systems for controlling the content of pesticides active ingredients in agricultural crops, the food products quality, and assessing the risk of consuming food that may contain pesticide residues.Objective: forecasting and assessment of the risk of consuming products contaminated with avermectin insecticides hazardous effect on human health.Materials and methods. The actual content of abamectin and emamectin benzoate in vegetable, grain, stone fruits, berries, grapes, soybeans and green mass of plants was determined by the methods of gas chromatography and high-performance liquid chromatography. The τ50 of the studied insecticides and the integral index of danger when using products contaminated by them were calculated. \u0000Results. According to its stability in agricultural crops (grapes, cabbage, peaches, cherries) emamectin benzoate pertained to the 4th hazardous class (not stable); abamectin – to class 3 (moderately stable compounds) in grapes, pears, nuts, strawberries, apples, tomatoes; to the 4th class (non-persistent compound) – in cucumbers, eggplants, soybeans. \u0000Abamectin and emamectin belong to the 2nd hazardous class according to integral index of danger when using pesticide-contaminated products value – dangerous. This is due to its high toxicity for warm-blooded animals and humans and a wide range of crops on which formulations based on the studied compounds are allowed to be used.Conclusion. It was established that abamectin and emamectin benzoate belong to moderately persistent (3rd hazard class) and non-persistent (4th hazard class) pesticides according to their persistence in agricultural plants, respectively, and according to the value of integral index of danger when using pesticide-contaminated products value, both studied compounds belong to the 2nd class (dangerous).","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.07
О. Stoyanov, R. Vastyanov, A. Son, V. Kalashnikov, О.А. Hruzevskyi, V. Dariy, S. Oliinyk
Relevance. Mnestic functions in patients after stroke and coronavirus infection are not restored completely. Nowadays, the search for ways to overcome in such patients is actual. Objective: to find out the possibility of cognitive deficiency’ overcoming in persons after stroke who have suffered from COVID-19 by Phenibut pharmacocorrection and magnetic therapy. Materials and methods. 46 patients aged 40-60 years who had COVID-19 in anamnesis and ischemic stroke in the post-covid period were divided into 3 groups at the stage of comprehensive rehabilitation. In the 1st group (n=15) - the control group - no nootropic drugs and physiotherapeutic procedures were not asdministered; in group 2 (n=15), magnet stimulation procedures were performed for 20 days (frequency of basic impulses 180-195 Hz, frequency of a group of impulses 12,5-29 Hz, average induction of magnetic fields within 100 μT); group 3 (n=16) took Phenibut (β-Phenyl-GABA) one tablet (250 mg) 3 times a day for three months. The study of cognitive functions was carried out with the help of a short mental state scale - MMSE, a set of tests for the study of frontal dysfunction - FAB, a test for memorizing of 10 words according to the A.R. Luria’s method and clock drawing testing All groups were tested twice: at the beginning of the study and after three months. The obtained data were processed statistically; an ordinal logistic regression model was applied, in particular logistic regression with a cumulative relationship. The results. In group 2 the result of the subtest "Voluntary attention" improved (3,8±0,3 points vs. 3,1±0,2 in the control) and the FAB test (15, 2±1,2 points vs. 11,3±0,4 in control). In group 3, the cognitive functions in the MMSE (26,1±0,8 points vs. 21,2±0,6 in the control) and FAB (16,3±0,6 points vs. 11,3±0,4) tests probably improved. The results of the subtests "Discretionary attention" (3,8±0,1 points vs. 3,1±0,1) and "Memory" (2,6±0,2 points vs. 2,0±0,1) improved. In the test for 10 words memorizing, the difference in indicators, compared to the control, was in each subsequent presentation: 1,0±0,05; 1,1±0,09; 1,7±0,10 words, in delayed presentation 1,75±0,05 (in all cases p<0.05). Conclusions. The use of Phenibut and magnetic therapy in patients who have suffered a stroke after COVID-19 leads to regression of cognitive deficiency and depressive symptoms. The effect of Phenibut turned out to be better - the odds ratio, compared to the control, was 13,1.
{"title":"POSSIBILITIES FOR CORRECTING COGNITIVE DEFICITS IN STROKE IN PEOPLE WHO HAVE HAD COVID-19","authors":"О. Stoyanov, R. Vastyanov, A. Son, V. Kalashnikov, О.А. Hruzevskyi, V. Dariy, S. Oliinyk","doi":"10.32345/2664-4738.3.2022.07","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.07","url":null,"abstract":"Relevance. Mnestic functions in patients after stroke and coronavirus infection are not restored completely. Nowadays, the search for ways to overcome in such patients is actual. \u0000Objective: to find out the possibility of cognitive deficiency’ overcoming in persons after stroke who have suffered from COVID-19 by Phenibut pharmacocorrection and magnetic therapy. \u0000Materials and methods. 46 patients aged 40-60 years who had COVID-19 in anamnesis and ischemic stroke in the post-covid period were divided into 3 groups at the stage of comprehensive rehabilitation. In the 1st group (n=15) - the control group - no nootropic drugs and physiotherapeutic procedures were not asdministered; in group 2 (n=15), magnet stimulation procedures were performed for 20 days (frequency of basic impulses 180-195 Hz, frequency of a group of impulses 12,5-29 Hz, average induction of magnetic fields within 100 μT); group 3 (n=16) took Phenibut (β-Phenyl-GABA) one tablet (250 mg) 3 times a day for three months. \u0000The study of cognitive functions was carried out with the help of a short mental state scale - MMSE, a set of tests for the study of frontal dysfunction - FAB, a test for memorizing of 10 words according to the A.R. Luria’s method and clock drawing testing All groups were tested twice: at the beginning of the study and after three months. \u0000The obtained data were processed statistically; an ordinal logistic regression model was applied, in particular logistic regression with a cumulative relationship. \u0000The results. In group 2 the result of the subtest \"Voluntary attention\" improved (3,8±0,3 points vs. 3,1±0,2 in the control) and the FAB test (15, 2±1,2 points vs. 11,3±0,4 in control). \u0000In group 3, the cognitive functions in the MMSE (26,1±0,8 points vs. 21,2±0,6 in the control) and FAB (16,3±0,6 points vs. 11,3±0,4) tests probably improved. The results of the subtests \"Discretionary attention\" (3,8±0,1 points vs. 3,1±0,1) and \"Memory\" (2,6±0,2 points vs. 2,0±0,1) improved. In the test for 10 words memorizing, the difference in indicators, compared to the control, was in each subsequent presentation: 1,0±0,05; 1,1±0,09; 1,7±0,10 words, in delayed presentation 1,75±0,05 (in all cases p<0.05). \u0000Conclusions. The use of Phenibut and magnetic therapy in patients who have suffered a stroke after COVID-19 leads to regression of cognitive deficiency and depressive symptoms. The effect of Phenibut turned out to be better - the odds ratio, compared to the control, was 13,1.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46587917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.08
D. Khramtsov, О. Stoyanov, О.А. Hruzevskyi, H.Yu. Shaevchuk
Relevance. There are studies on the positive effect of electric current on neuronal excitability and activity of the cerebral cortex, depending on the chosen mode. But it is not known whether there will be a positive clinical effect from transcranial electrical stimulation of the brain in patients who have suffered an ischemic stroke. Objective: evaluation of the clinical effectiveness of the complex method of neurorehabilitation of post-stroke patients. Material and methods. Treatment of 150 patients with ischemic type of acute violation of cerebral circulation was carried out. The total sample was randomly divided into four clinical groups: І (n=30) – traditional therapy, ІІ (n=40) – application against the background of traditional therapy of neuroprotection in the acute and early recovery period with peptidergic compounds (cerebrolysin 40 ml per day), ІІІ ( n=40) – application of traditional therapy with transcranial micropolarization of the brain, IV (n=40) – application against the background of traditional therapy of combined neuroprotection in the acute and early recovery period with peptidergic compounds in combination with micropolarization of the brain. All patients during the observation period were repeatedly assessed the motor function of the upper limb using the Action Research Arm Test (ARAT), in its own modification with the assessment of the extension function of the fingers of the hand. Additionally, functional recovery after a stroke was assessed using the STREAM (Stroke Rehabilitation Assessment of Movement) scale, assessment of the function of the upper limb using the Fugl-Meyer FMA-UE test and the lower limb using the FMA-LE test. Disturbances in the motor-coordination sphere were additionally assessed using the stabilometry method on the ST-150 platform, using the following subtests: Romberg test, combined coordination-motor test, static test, dynamic test, as well as the foot reception test. Statistical processing was performed by the method of variance analysis. Results. As a result of rehabilitation measures, locomotion function and fine motility of the upper limb are restored in all patients. Recovery of upper extremity fine motility and stato-dynamic indicators in patients who received neuroprotective effects during the treatment of stroke is permanent. Positive dynamics are monitored throughout the entire period of catamnetic observation. The use of peptidergic drugs has a greater neurorehabilitation effect than the isolated use of micropolarization. The combined use of micropolarization and peptidergic metabolic support in patients with ischemic stroke significantly improves the functional results of rehabilitation at all stages of observation. According to the FMA-UE test, statistically significant differences compared to controls were observed in the subtests of mobility in the carpal joint and fingers of the hand, as well as voluntary movements with synergy. In patients of the I group, the score on the AII
{"title":"COMPLEX NEUROREHABILITATION OF POST-STROKE PATIENTS","authors":"D. Khramtsov, О. Stoyanov, О.А. Hruzevskyi, H.Yu. Shaevchuk","doi":"10.32345/2664-4738.3.2022.08","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.08","url":null,"abstract":"Relevance. There are studies on the positive effect of electric current on neuronal excitability and activity of the cerebral cortex, depending on the chosen mode. But it is not known whether there will be a positive clinical effect from transcranial electrical stimulation of the brain in patients who have suffered an ischemic stroke. \u0000Objective: evaluation of the clinical effectiveness of the complex method of neurorehabilitation of post-stroke patients. \u0000Material and methods. Treatment of 150 patients with ischemic type of acute violation of cerebral circulation was carried out. The total sample was randomly divided into four clinical groups: І (n=30) – traditional therapy, ІІ (n=40) – application against the background of traditional therapy of neuroprotection in the acute and early recovery period with peptidergic compounds (cerebrolysin 40 ml per day), ІІІ ( n=40) – application of traditional therapy with transcranial micropolarization of the brain, IV (n=40) – application against the background of traditional therapy of combined neuroprotection in the acute and early recovery period with peptidergic compounds in combination with micropolarization of the brain. \u0000All patients during the observation period were repeatedly assessed the motor function of the upper limb using the Action Research Arm Test (ARAT), in its own modification with the assessment of the extension function of the fingers of the hand. Additionally, functional recovery after a stroke was assessed using the STREAM (Stroke Rehabilitation Assessment of Movement) scale, assessment of the function of the upper limb using the Fugl-Meyer FMA-UE test and the lower limb using the FMA-LE test. \u0000Disturbances in the motor-coordination sphere were additionally assessed using the stabilometry method on the ST-150 platform, using the following subtests: Romberg test, combined coordination-motor test, static test, dynamic test, as well as the foot reception test. Statistical processing was performed by the method of variance analysis. \u0000Results. As a result of rehabilitation measures, locomotion function and fine motility of the upper limb are restored in all patients. Recovery of upper extremity fine motility and stato-dynamic indicators in patients who received neuroprotective effects during the treatment of stroke is permanent. Positive dynamics are monitored throughout the entire period of catamnetic observation. \u0000The use of peptidergic drugs has a greater neurorehabilitation effect than the isolated use of micropolarization. The combined use of micropolarization and peptidergic metabolic support in patients with ischemic stroke significantly improves the functional results of rehabilitation at all stages of observation. \u0000According to the FMA-UE test, statistically significant differences compared to controls were observed in the subtests of mobility in the carpal joint and fingers of the hand, as well as voluntary movements with synergy. In patients of the I group, the score on the AII","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44150967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.11
O. V. Usova, O.V. Sologub, N. Ulianytska, О. Yakobson, I. Ushko, А. Sitovskyi, T. Shevchuk
Relevance. The health of teenagers should be assessed not only by their morphometric data, but also by the functional state of the main organs and systems that provide adaptive reserve potential. Objective. The purpose of our study was to evaluate the functional capabilities of the cardiovascular system of teenagers according to biomechanical indexes of blood circulation. Methods and materials. 272 teenagers aged 13–14 (176 boys and 96 girls) participated in the study. Among the boys, there are 104 pupils of the basic medical group of physical education and 72 of the preparatory group (2nd health group). There were 48 primary and 48 preparatory group pupils among the girls. The results of Kubicek rheography and rheovasography were used to study the biomechanical parameters of the cardiovascular system. They were evaluated using the methods of mathematical statistics (the MedStat program (Ye. Lyakh, 2006)). Results. There were no any statistically significant differences between most of the rheovasographic parameters of the students of the preparatory and basic medical groups of physical education. Instead, there are certain distinctive features of the peripheral blood flow of pupils of the preparatory group of physical education (with reduced functional capabilities). Thus, the , indexes of the rapid filling timing in the pupils of the preparatory group of physical education are lower than in the main group.In the boys of the preparatory group of physical education on both hands and in the girls of this group on the left hand, the blood flow time for the forearms is slightly increased. Greater deviations from the norm for the amplitude of rheograms were found in pupils of the preparatory group of physical education. The number of pupils with asymmetric blood supply to the forearms in the preparatory group of physical education is more than in the main group. A decrease in the blood supply of the vessels of the forearms is registered more often in teenagers who are assigned to the preparatory group of physical education. In the boys of the preparatory group of physical education, the blood vessels of the shins are worse. Conclusions. Some distinctive features for the state of peripheral blood flow of teenagers in the preparatory group of physical education were revealed. Thus, the indexes of the rapid filling timing, the amplitude of the rheograms were lower, and the time of propagation of the pulse wave was higher than normal. Asymmetry and decreased blood flow in the vessels of the upper and lower extremities were noted in most teenagers with impaired
{"title":"BIOMECHANICS OF BLOOD CIRCULATION OF TEENAGERS IN DIFFERENT MEDICAL GROUPS OF PHYSICAL EDUCATION","authors":"O. V. Usova, O.V. Sologub, N. Ulianytska, О. Yakobson, I. Ushko, А. Sitovskyi, T. Shevchuk","doi":"10.32345/2664-4738.3.2022.11","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.11","url":null,"abstract":"Relevance. The health of teenagers should be assessed not only by their morphometric data, but also by the functional state of the main organs and systems that provide adaptive reserve potential. \u0000Objective. The purpose of our study was to evaluate the functional capabilities of the cardiovascular system of teenagers according to biomechanical indexes of blood circulation. \u0000Methods and materials. 272 teenagers aged 13–14 (176 boys and 96 girls) participated in the study. Among the boys, there are 104 pupils of the basic medical group of physical education and 72 of the preparatory group (2nd health group). There were 48 primary and 48 preparatory group pupils among the girls. The results of Kubicek rheography and rheovasography were used to study the biomechanical parameters of the cardiovascular system. They were evaluated using the methods of mathematical statistics (the MedStat program (Ye. Lyakh, 2006)). \u0000Results. There were no any statistically significant differences between most of the rheovasographic parameters of the students of the preparatory and basic medical groups of physical education. Instead, there are certain distinctive features of the peripheral blood flow of pupils of the preparatory group of physical education (with reduced functional capabilities). Thus, the , indexes of the rapid filling timing in the pupils of the preparatory group of physical education are lower than in the main group.In the boys of the preparatory group of physical education on both hands and in the girls of this group on the left hand, the blood flow time for the forearms is slightly increased. Greater deviations from the norm for the amplitude of rheograms were found in pupils of the preparatory group of physical education. \u0000The number of pupils with asymmetric blood supply to the forearms in the preparatory group of physical education is more than in the main group. A decrease in the blood supply of the vessels of the forearms is registered more often in teenagers who are assigned to the preparatory group of physical education. In the boys of the preparatory group of physical education, the blood vessels of the shins are worse. \u0000Conclusions. Some distinctive features for the state of peripheral blood flow of teenagers in the preparatory group of physical education were revealed. Thus, the indexes of the rapid filling timing, the amplitude of the rheograms were lower, and the time of propagation of the pulse wave was higher than normal. Asymmetry and decreased blood flow in the vessels of the upper and lower extremities were noted in most teenagers with impaired","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42871711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.02
O. Mozyrskaya, N.A. Slusar
Relevance. Food allergy is one of the most common chronic diseases in children. Toll-like receptors may be unique in the development of food allergies due to their expression by intestinal epithelial and dendritic cells. Objective. The aim of this study was to investigate the relationship between the rs4696480 polymorphism in TLR2 and the presence of food allergy in children with atopic dermatitis. Material and methods. The study included 103 patients with atopic dermatitis and 84 healthy children. Polymorphism genotyping was performed in the group of patients and the control group using real-time PCR. Food sensitization was determined by presence sIgE to food allergens by the immunochemiluminescent method using an ImmunoCAP 100 (Thermo Fisher Scientific Inc., Phadia, Sweden). The presence of food allergy was determined by a detailed clinical history and review of clinical records. Results. In the subgroup of children with food allergies, 9 children had the AA genotype, 7 patients had the heterozygous variant, and 3 children had the TT genotype. Among patients without food allergy, 20 patients had the AA genotype, 39 were heterozygotes, and 25 had the TT genotype. The OR assessment demonstrated that the AA genotype of the rs4696480 polymorphism is reliably associated with the development of food allergy in children with atopic dermatitis, OR=2,880 (1,0271-8,0757). Conclusion. The rs4696480 polymorphism in TLR2 gene is associated with the development of food allergy in Ukrainian children with atopic dermatitis.
{"title":"SIGNIFICANCE OF TOLL-LIKE RECEPTOR-2 POLYMORPHISM rs4696480 FOR THE DEVELOPMENT OF FOOD ALLERGY IN CHILDREN WITH ATOPIC DERMATITIS","authors":"O. Mozyrskaya, N.A. Slusar","doi":"10.32345/2664-4738.3.2022.02","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.02","url":null,"abstract":"Relevance. Food allergy is one of the most common chronic diseases in children. Toll-like receptors may be unique in the development of food allergies due to their expression by intestinal epithelial and dendritic cells. \u0000Objective. The aim of this study was to investigate the relationship between the rs4696480 polymorphism in TLR2 and the presence of food allergy in children with atopic dermatitis. \u0000Material and methods. The study included 103 patients with atopic dermatitis and 84 healthy children. Polymorphism genotyping was performed in the group of patients and the control group using real-time PCR. Food sensitization was determined by presence sIgE to food allergens by the immunochemiluminescent method using an ImmunoCAP 100 (Thermo Fisher Scientific Inc., Phadia, Sweden). The presence of food allergy was determined by a detailed clinical history and review of clinical records. \u0000Results. In the subgroup of children with food allergies, 9 children had the AA genotype, 7 patients had the heterozygous variant, and 3 children had the TT genotype. Among patients without food allergy, 20 patients had the AA genotype, 39 were heterozygotes, and 25 had the TT genotype. The OR assessment demonstrated that the AA genotype of the rs4696480 polymorphism is reliably associated with the development of food allergy in children with atopic dermatitis, OR=2,880 (1,0271-8,0757). \u0000Conclusion. The rs4696480 polymorphism in TLR2 gene is associated with the development of food allergy in Ukrainian children with atopic dermatitis.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42847590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.32345/2664-4738.3.2022.05
A. K. Rushai, M. Baida, A. Martinchuk, O. Musienko
Relevance. To date, there is no final solution to the theoretical and practical issues of the problem of external fixation in the treatment of long bone fractures. Objective. To determine the rational methods of completing ring retainer (RF) in the treatment of nonunions of the shin bones after fractures of long bones on the basis of clinical and experimental substantiation of the choice, taking into account the peculiarities of the assembly of the apparatus and the implementation of the connection "apparatus-fragments of non-union". Materials and methods. In the experimental part, Sawbones® synthetic composite bone was used. The rigidity of fixation of bone fragments of the RF of the wire-rod type was studied. We tested and compared 5 different options for fixation of bone fragments in RF. The samples were tested in 4 modes: compression along the axis of the bone; compression on the head of the bone; twisting; bending. The strength and deformation characteristics of the materials were determined with a maximum force of up to 5 kN using the TIRATEST-2151 universal testing machine. They chose the most optimal configuration of the RF. Then, in the clinical part, the clinical effectiveness of the optimal structures was evaluated based on the analysis of their use in 12 patients with non-union of the shin bones. Results. Optimal structures have been determined from the point of view of integral rigidity of the structure. The greatest rigidity was the RF system No. 3, in which 3 spokes are used: 2 of them are held at an angle, 1 - in the plane of the ring. In the case of an increase in the number of spokes, the stiffness of the system increased. When tested in compression along the axis of the bone, the stiffness of System No. 3 is 6.5% greater than that of System No. 2 and 12.5 % greater than System No. 1, in which only 2 spokes are used. Fixing the spokes at an angle to the plane of the ring also increases the rigidity of the system. When tested in compression along the axis of the bone, the stiffness of System No. 3 is 6.5 % greater than that of System No. 2. The stiffening rib affects the stiffness of the entire system. But the bend became the most sensitive. Flexural stiffness decreased by 23 % and compression by 8.5 %. Debris removal during bending increased by 1.5-1.8 times. Conclusion. The best indicators of fixation rigidity have options for the arrangement of spokes with a cross not only in the frontal, but also in the sagittal planes. The stability of the fixation of the rod is significantly increased by mounting the "stiffness triangle". The obtained clinical data indicate the promising application of improved ring fixators.
{"title":"STIFFNESS PARAMETERS OF VARIOUS MODIFICATIONS OF RING FIXATOR","authors":"A. K. Rushai, M. Baida, A. Martinchuk, O. Musienko","doi":"10.32345/2664-4738.3.2022.05","DOIUrl":"https://doi.org/10.32345/2664-4738.3.2022.05","url":null,"abstract":"Relevance. To date, there is no final solution to the theoretical and practical issues of the problem of external fixation in the treatment of long bone fractures. \u0000Objective. To determine the rational methods of completing ring retainer (RF) in the treatment of nonunions of the shin bones after fractures of long bones on the basis of clinical and experimental substantiation of the choice, taking into account the peculiarities of the assembly of the apparatus and the implementation of the connection \"apparatus-fragments of non-union\". \u0000Materials and methods. In the experimental part, Sawbones® synthetic composite bone was used. The rigidity of fixation of bone fragments of the RF of the wire-rod type was studied. We tested and compared 5 different options for fixation of bone fragments in RF. The samples were tested in 4 modes: compression along the axis of the bone; compression on the head of the bone; twisting; bending. The strength and deformation characteristics of the materials were determined with a maximum force of up to 5 kN using the TIRATEST-2151 universal testing machine. They chose the most optimal configuration of the RF. Then, in the clinical part, the clinical effectiveness of the optimal structures was evaluated based on the analysis of their use in 12 patients with non-union of the shin bones. \u0000Results. Optimal structures have been determined from the point of view of integral rigidity of the structure. The greatest rigidity was the RF system No. 3, in which 3 spokes are used: 2 of them are held at an angle, 1 - in the plane of the ring. In the case of an increase in the number of spokes, the stiffness of the system increased. When tested in compression along the axis of the bone, the stiffness of System No. 3 is 6.5% greater than that of System No. 2 and 12.5 % greater than System No. 1, in which only 2 spokes are used. Fixing the spokes at an angle to the plane of the ring also increases the rigidity of the system. When tested in compression along the axis of the bone, the stiffness of System No. 3 is 6.5 % greater than that of System No. 2. The stiffening rib affects the stiffness of the entire system. But the bend became the most sensitive. Flexural stiffness decreased by 23 % and compression by 8.5 %. Debris removal during bending increased by 1.5-1.8 times. \u0000Conclusion. The best indicators of fixation rigidity have options for the arrangement of spokes with a cross not only in the frontal, but also in the sagittal planes. The stability of the fixation of the rod is significantly increased by mounting the \"stiffness triangle\". The obtained clinical data indicate the promising application of improved ring fixators.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48788395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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