Pub Date : 2016-01-02DOI: 10.1080/10590501.2015.1131539
Se-Jung Park, B. Yi, Ho-Sun Lee, Woo-Yeon Oh, Hyun-Kyung Na, M. Lee, Mihi Yang
ABSTRACT Tobacco smoking is currently on the rise among women, and can pose a greater health risk. In order to understand the nature of the increase in smoking prevalence among women, we focused on the vulnerability of women to smoking behaviors—smoking cessation or tobacco addiction—and performed a systematic review of the socioeconomic and intrinsic factors as well as tobacco ingredients that affect women's susceptibility to smoking tobacco. We observed that nicotine and other tobacco components including cocoa-relatives, licorice products, and menthol aggravate tobacco addiction in women rather than in men. Various genetic and epigenetic alterations in dopamine pathway and the pharmaco-kinetics and -dynamic factors of nicotine also showed potential evidences for high susceptibility to tobacco addiction in women. Therefore, we suggest systemic approaches to prevent tobacco smoking–related health risks, considering gene–environment–gender interaction.
{"title":"To quit or not: Vulnerability of women to smoking tobacco","authors":"Se-Jung Park, B. Yi, Ho-Sun Lee, Woo-Yeon Oh, Hyun-Kyung Na, M. Lee, Mihi Yang","doi":"10.1080/10590501.2015.1131539","DOIUrl":"https://doi.org/10.1080/10590501.2015.1131539","url":null,"abstract":"ABSTRACT Tobacco smoking is currently on the rise among women, and can pose a greater health risk. In order to understand the nature of the increase in smoking prevalence among women, we focused on the vulnerability of women to smoking behaviors—smoking cessation or tobacco addiction—and performed a systematic review of the socioeconomic and intrinsic factors as well as tobacco ingredients that affect women's susceptibility to smoking tobacco. We observed that nicotine and other tobacco components including cocoa-relatives, licorice products, and menthol aggravate tobacco addiction in women rather than in men. Various genetic and epigenetic alterations in dopamine pathway and the pharmaco-kinetics and -dynamic factors of nicotine also showed potential evidences for high susceptibility to tobacco addiction in women. Therefore, we suggest systemic approaches to prevent tobacco smoking–related health risks, considering gene–environment–gender interaction.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"34 1","pages":"33 - 56"},"PeriodicalIF":2.5,"publicationDate":"2016-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2015.1131539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-02DOI: 10.1080/10590501.2015.1135593
Xiaobo He, Q. Xia, Liang Ma, P. Fu
ABSTRACT Pyrrolizidine alkaloids (PAs) require metabolic activation to exert cytotoxicity, genotoxicity, and tumorigenicity. We previously reported that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts are responsible for PA-induced liver tumor formation in rats. In this study, we determined that metabolism of riddelliine and monocrotaline by human or rat liver microsomes produced 7-cysteine-DHP and DHP. The metabolism of 7-glutathionyl-DHP by human and rat liver microsomes also generated 7-cysteine-DHP. Further, reaction of 7-cysteine-DHP with calf thymus DNA in aqueous solution yielded the described DHP-derived DNA adducts. This study represents the first report that 7-cysteine-DHP is a new PA metabolite that can lead to DNA adduct formation.
{"title":"7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids","authors":"Xiaobo He, Q. Xia, Liang Ma, P. Fu","doi":"10.1080/10590501.2015.1135593","DOIUrl":"https://doi.org/10.1080/10590501.2015.1135593","url":null,"abstract":"ABSTRACT Pyrrolizidine alkaloids (PAs) require metabolic activation to exert cytotoxicity, genotoxicity, and tumorigenicity. We previously reported that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts are responsible for PA-induced liver tumor formation in rats. In this study, we determined that metabolism of riddelliine and monocrotaline by human or rat liver microsomes produced 7-cysteine-DHP and DHP. The metabolism of 7-glutathionyl-DHP by human and rat liver microsomes also generated 7-cysteine-DHP. Further, reaction of 7-cysteine-DHP with calf thymus DNA in aqueous solution yielded the described DHP-derived DNA adducts. This study represents the first report that 7-cysteine-DHP is a new PA metabolite that can lead to DNA adduct formation.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"34 1","pages":"57 - 76"},"PeriodicalIF":2.5,"publicationDate":"2016-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2015.1135593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-02DOI: 10.1080/10590501.2014.990744
{"title":"Ed Board EOV","authors":"","doi":"10.1080/10590501.2014.990744","DOIUrl":"https://doi.org/10.1080/10590501.2014.990744","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"32 1","pages":"ebi - ebi"},"PeriodicalIF":2.5,"publicationDate":"2014-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2014.990744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-01DOI: 10.1080/10590501.2013.859915
{"title":"Editorial Board EOV","authors":"","doi":"10.1080/10590501.2013.859915","DOIUrl":"https://doi.org/10.1080/10590501.2013.859915","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"31 1","pages":"ebi - ebi"},"PeriodicalIF":2.5,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2013.859915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.1080/10590501.2012.749767
{"title":"Editorial Board EOV","authors":"","doi":"10.1080/10590501.2012.749767","DOIUrl":"https://doi.org/10.1080/10590501.2012.749767","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"30 1","pages":"ebi - ebi"},"PeriodicalIF":2.5,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2012.749767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-10-01DOI: 10.1080/10590501.2011.639172
{"title":"Editorial Board (EOV)","authors":"","doi":"10.1080/10590501.2011.639172","DOIUrl":"https://doi.org/10.1080/10590501.2011.639172","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"29 1","pages":"ebi - ebi"},"PeriodicalIF":2.5,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2011.639172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.1080/10590500600945566
D. Lai
{"title":"A Review of: “Voices from the Gathering Storm: The Web of Ecological-Societal Crisis”","authors":"D. Lai","doi":"10.1080/10590500600945566","DOIUrl":"https://doi.org/10.1080/10590500600945566","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"24 1","pages":"285 - 287"},"PeriodicalIF":2.5,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590500600945566","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"This Issue is Dedicated to the Memory of Dr. Joseph C. Arcos","authors":"","doi":"10.1081/gnc-200055844","DOIUrl":"https://doi.org/10.1081/gnc-200055844","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"23 1","pages":"1 - 2"},"PeriodicalIF":2.5,"publicationDate":"2005-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/gnc-200055844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60146355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carbon disulfide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on the results of epidemiological studies of workers exposed to carbon disulfide and supporting data from experiments conducted on animals, the nervous system appears to be the critical target for carbon disulfide-induced toxicity, manifested most often as reduced conduction velocity in the peripheral nerves and impaired performance in psychomotor testing. Other effects for which there is considerable weight of evidence in humans exposed to carbon disulfide include alterations in serum lipids and blood pressure that are associated with increased risk of heart disease, damage to the blood vessels of the retina and (with higher exposures) increased mortality from heart disease. A tolerable concentration of 100 μg/m3 has been derived, based upon the benchmark concentration associated with a 5% adverse response for the most sensitive response variable (i.e., peroneal motor nerve conduction velocity at 20 mg/m3) in an epidemiological study of an occupationally exposed population.
{"title":"CARBON DISULFIDE: HAZARD CHARACTERIZATION AND EXPOSURE-RESPONSE ANALYSIS","authors":"R. Newhook, M. E. Meek, M. Walker","doi":"10.1081/GNC-100103583","DOIUrl":"https://doi.org/10.1081/GNC-100103583","url":null,"abstract":"Carbon disulfide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on the results of epidemiological studies of workers exposed to carbon disulfide and supporting data from experiments conducted on animals, the nervous system appears to be the critical target for carbon disulfide-induced toxicity, manifested most often as reduced conduction velocity in the peripheral nerves and impaired performance in psychomotor testing. Other effects for which there is considerable weight of evidence in humans exposed to carbon disulfide include alterations in serum lipids and blood pressure that are associated with increased risk of heart disease, damage to the blood vessels of the retina and (with higher exposures) increased mortality from heart disease. A tolerable concentration of 100 μg/m3 has been derived, based upon the benchmark concentration associated with a 5% adverse response for the most sensitive response variable (i.e., peroneal motor nerve conduction velocity at 20 mg/m3) in an epidemiological study of an occupationally exposed population.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"19 1","pages":"125 - 160"},"PeriodicalIF":2.5,"publicationDate":"2001-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/GNC-100103583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60144512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.
{"title":"ETHYLENE OXIDE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS","authors":"R. Liteplo, M. E. Meek, W. Bruce","doi":"10.1081/GNC-100103586","DOIUrl":"https://doi.org/10.1081/GNC-100103586","url":null,"abstract":"Ethylene oxide has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based on studies in animals, cancer is considered the critical endpoint for effects of ethylene oxide on human health. In inhalation studies, ethylene oxide has induced a wide range of tumours, with a strong likelihood that the mode of action involves direct interaction with genetic material. Tumorigenic Concentration05s (i.e., concentrations associated with a 5% increase in tumour incidence above background), derived from a study in animals with optimal characterization of exposure–response, ranged from 2.2 to 31.0 mg/m3.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"19 1","pages":"219 - 265"},"PeriodicalIF":2.5,"publicationDate":"2001-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/GNC-100103586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60144777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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