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Effects of SETD2 on telomere length and malignant transformation property of Met-5A after one-month crocidolite exposure. SETD2对青石棉暴露一个月后Met-5A端粒长度和恶性转化特性的影响。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-12-13 DOI: 10.1080/26896583.2023.2271822
Min Yu, Dan Yang, Chiyun Chen, Hailing Xia

Crocidolite is a carcinogen contributing to the pathogenesis of malignant mesothelioma. This study aimed to characterize the possible telomere-related events mediating the malignant transformation of mesothelial cells with and without SETD2 under crocidolite exposure. The crocidolite concentration resulting in 90% viable SETD2 knockout Met-5A (Met-5ASETD2-KO) and Met-5A were estimated to be 0.71 μg/cm2 and 1.8 μg/cm2, respectively, during 72 h of exposure, which was further employed in chronical crocidolite exposure during a 72 h exposure interval per time up to 1 month. Chronical crocidolite-exposed Met-5ASETD2-KO (chronical Cro-Met-5ASETD2-KO) had higher colony formation and increased telomerase reverse transcriptase (TERT) protein levels than chronical crocidolite-exposed Met-5A (chronical Cro-Met-5A) and Met-5ASETD2-KO. Chronical Cro-Met-5ASETD2-KO had longer telomere length (TL) than chronical Cro-Met-5A, although there were no changes in TL for either chronical Cro-Met-5A or chronical Cro-Met-5ASETD2-KO compared with their corresponding cells without crocidolite exposure. BIBR 1532, an inhibitor targeting TERT, partially reduced colony formation and TL for chronical Cro-Met-5ASETD2-KO, while BIBR 1532 reduced TL but had no effect on colony formation for chronical Cro-Met-5A. Therefore, SETD2 deficient mesothelial cells are susceptible to malignant transformation during chronical crocidolite exposure, and TERT-dependent TL modification likely partially drives SETD2 loss-mediated early onset of mesothelial malignant transformation.

青石棉是一种致癌物质,有助于恶性间皮瘤的发病机制。本研究旨在表征在青石棉暴露下,介导具有和不具有SETD2的间皮细胞恶性转化的端粒相关事件。导致90%可行SETD2敲除Met-5A(Met-5ASETD2-KO)和Met-5A的青石棉浓度估计为0.71 μg/cm2和1.8 在72 暴露小时,在72 h每次曝光间隔,最多1 月与慢性青石棉暴露的Met-5A(慢性Cro-Met-5A)和Met-5ASETD2-KO相比,慢性青石棉接触的Met-5ASTD2-KO(慢性Cro-Mat-5ASETD2-KO)具有更高的集落形成和增加的端粒酶逆转录酶(TERT)蛋白水平。慢性Cro-Met-5ASETD2-KO比慢性Cro-Met-5A具有更长的端粒长度(TL),尽管与没有青石棉暴露的相应细胞相比,慢性Cro-Met-5A或慢性Cro-Met-5ASETO2-KO的TL没有变化。BIBR 1532,一种靶向TERT的抑制剂,部分减少了慢性Cro-Met-5ASETD2-KO的集落形成和TL,而BIBR 1532减少了慢性Cro-Met-5A的TL,但对集落形成没有影响。因此,SETD2缺陷的间皮细胞在长期青石棉暴露期间易发生恶性转化,TERT依赖性TL修饰可能部分驱动SETD2缺失介导的间皮恶性转化的早期发生。
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引用次数: 0
A systematic review and meta-analysis of radon risk exposure from drinking water resources in Nigeria. 尼日利亚饮用水资源氡风险暴露的系统审查和荟萃分析。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-12-13 DOI: 10.1080/26896583.2023.2278957
Adamu Usman Mohammed, Ahmad Zaharin Aris, Mohammad Firuz Ramli, Noorain Mohd Isa, Abdullahi Suleiman Arabi, Muyiwa Michael Orosun

Elevated radon concentrations in drinking water pose an increased risk of cancer among nonsmokers. A Monte-Carlo Simulation was employed to assess the effective dose and cancer risk associated with radon exposure in humans, utilizing a systematic review and meta-analysis of related studies. These studies were sourced from databases including PubMed, Web of Science, Scopus, Science Direct, and Google Scholar, focusing on drinking water from Nigeria's six geopolitical zones. The random effects models revealed a 222Rn concentration in drinking water of Nigeria at 25.01, with 95% confidence intervals (CI) of 7.62 and 82.09, indicating significant heterogeneity of (I2 = 100%; p < 0.001). The probabilistic risk of effective dose revealed a best-scenario (P 5%) at Kundiga and Magiro that exceeded the World Health Organization's (WHO) recommended effective dose limit of 200 µSv/y. Conversely, the worst-case scenario (P 95%) indicated concentrations surpassing the recommended limit at Kundiga, Edbe, Magiro, Ekiti, and Abeokuta. Excess Life Cancer Risk for infants, children, and adults attributed to the ingestion and inhalation of radon from various drinking water sources exceeded the recommended values of 0.2 x 10-3 established by the International Commission on Radiological Protection (ICRP) and the United Nations Scientific Committee on the Effect of Atomic Radiation (UNSCEAR). It underscores the necessity for treating radon-polluted water, employing methos such as aeration and granular activated carbon (GAC) processes.

饮用水中氡浓度升高会增加非吸烟者患癌症的风险。利用相关研究的系统回顾和荟萃分析,采用蒙特卡罗模拟来评估与人类氡暴露相关的有效剂量和癌症风险。这些研究来自PubMed、Web of Science、Scopus、Science Direct和Google Scholar等数据库,重点关注尼日利亚六个地缘政治区域的饮用水。随机效应模型显示尼日利亚饮用水中222Rn浓度为25.01,95%置信区间(CI)分别为7.62和82.09,异质性显著(I2 = 100%;p -3是由国际辐射防护委员会(辐射防护委员会)和联合国原子辐射效应科学委员会(辐射科委会)设立的。它强调了处理氡污染水的必要性,采用曝气和颗粒活性炭(GAC)工艺等方法。
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引用次数: 0
Determination of the genotoxic effects of sweeteners, mannitol and lactitol. 甜味剂、甘露醇和乳醇基因毒性作用的测定。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-12-13 DOI: 10.1080/26896583.2023.2275984
Ebru Eker-Kartal, Ece Avuloglu-Yilmaz

The changes in dietary habit around the world have led to an increased use of additives in the food. The safety of food additives has been a main focus of research for many years due to the ongoing debate on their potential effects on health. In this study, the in vitro genotoxic effects of mannitol and lactitol, polyols used as sweetener food additives, were evaluated using chromosomal aberrations (CAs) and micronucleus (MN) assays in human peripheral lymphocytes. Additionally, the effects of these sweeteners on the mitotic index (MI) and nuclear division index (NDI) were investigated. Concentrations of 500, 1000, 2000, 4000, and 8000 μg/mL for mannitol and 250, 500, 1000, 2000, and 4000 μg/mL for lactitol were used. The results indicated that both polyols did not affect CA and MN frequency, and did not cause a significant change in NDI at all treatment concentratoins. However, mannitol (except at concentrations of 500 and 1000 μg/mL) and lactitol (except at 250 μg/mL) significantly decreased the MI compared to the control at almost all concentrations and treatment times. In conclusion, it was observed that mannitol and lactitol did not have a significant genotoxic effect at the concentrations used in human lymphocytes in vitro.

世界各地饮食习惯的变化导致食品中添加剂的使用增加。由于食品添加剂对健康的潜在影响一直存在争议,因此食品添加剂的安全性多年来一直是研究的主要焦点。本研究采用人外周血淋巴细胞染色体畸变(CAs)和微核(MN)检测方法,对甘露醇和乳醇这两种作为甜味剂食品添加剂的多元醇进行了体外遗传毒性评价。此外,还研究了这些甜味剂对核分裂指数(MI)和核分裂指数(NDI)的影响。甘露醇浓度分别为500、1000、2000、4000、8000 μg/mL,乳醇浓度分别为250、500、1000、2000、4000 μg/mL。结果表明,两种多元醇均不影响CA和MN频率,并且在所有处理浓度下均未引起NDI的显著变化。然而,甘露醇(除500和1000 μg/mL浓度外)和乳醇(除250 μg/mL浓度外)在几乎所有浓度和处理时间下均较对照组显著降低心肌梗死。综上所述,甘露醇和乳醇在体外培养的人淋巴细胞中没有显著的遗传毒性作用。
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引用次数: 0
Genotoxic effects of caffeine in female mice exposed during pregnancy and lactation period and their offspring. 咖啡因对孕期和哺乳期接触咖啡因的雌性小鼠及其后代的遗传毒性影响
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-05-26 DOI: 10.1080/26896583.2023.2213613
Marina Lummertz Magenis, Pamela Souza de Marcos, Adriani Paganini Damiani, Anderson Ricardo Cantareli da Silva, Luiza Martins Longaretti, Ive Bahia Franca, Juliana Da Silva, Carina Rodrigues Boeck, Vanessa Moraes de Andrade

Caffeine is a widely consumed substance, and there is a discussion about its effects when ingested by women during pregnancy and lactation. We aimed to identify the genotoxic effects of caffeine in female mice that consumed it during pregnancy and lactation periods and its consequences in their offspring. Thirty-six couples of Swiss mice received water or caffeine (0.3 and 1.0 mg/mL) treatment during pregnancy and lactation. The male and female offspring were divided into 12 groups according to the treatment administered to the female mice. Genotoxicity was assessed using the comet assay and the micronucleus test. Both doses of caffeine showed genotoxic effects in pregnant and lactating mice groups compared to groups not administered caffeine. In relation to offspring, it can be observed that females and males of the offspring had low weight in early life. In both female and male offspring, genotoxicity was detected in the blood, liver, and kidney tissues. Thus, from the present study, we can suggest that the caffeine consumed by female mice during the periods of pregnancy and lactation led to genotoxic effects in their offspring.

咖啡因是一种被广泛摄入的物质,关于它对妊娠期和哺乳期妇女的影响也有讨论。我们的目的是确定咖啡因对妊娠期和哺乳期摄入咖啡因的雌性小鼠的遗传毒性影响及其对后代的影响。36对瑞士小鼠在孕期和哺乳期接受了水或咖啡因(0.3和1.0毫克/毫升)处理。根据雌性小鼠所接受的处理,雄性和雌性后代被分为 12 组。使用彗星试验和微核试验评估遗传毒性。与未施用咖啡因的小鼠组相比,两种剂量的咖啡因都会对怀孕和哺乳期小鼠组产生遗传毒性影响。在后代方面,可以观察到雌性和雄性后代早期体重偏低。在雌性和雄性后代的血液、肝脏和肾脏组织中都检测到了遗传毒性。因此,本研究表明,雌性小鼠在孕期和哺乳期摄入咖啡因会对其后代产生基因毒性影响。
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引用次数: 0
Health risk assessment of exposure to triclosan in pregnant women using Monte Carlo simulation techniques: based on biomonitoring data. 利用蒙特卡洛模拟技术对孕妇接触三氯生的健康风险进行评估:基于生物监测数据。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-06-27 DOI: 10.1080/26896583.2023.2226587
Elham Attarian, Farzaneh Mohammadi, Karim Ebrahimpour, Malihe Moazeni, Mohammadreza Maracy, Afshin Ebrahimi, Roya Kelishadi

This study aimed to assess the triclosan (TCS) health risk in an Iranian pregnant women sample by Monte Carlo simulation (MCS). The urinary TCS of 99 women after the 28th week of pregnancy was detected by gas chromatography/mass spectrometry detector (GC/MS), and the MCS model implemented a health risk assessment. The corresponding hazard quotient (HQ) and the sensitivity analysis were calculated. TCS was measured in 100% of the urine samples with a median concentration of 2.89 µg/L. The median of HQ was obtained at 1.93 × 10-4. The TCS exposure risk in the studied population was lower than the allowable limit. A comparison between HQ values in the two weight subgroups of pregnant women showed that the risk level is almost equal, and there was minimal health risk in pregnant women from exposure to TCS.

本研究旨在通过蒙特卡罗模拟(MCS)评估伊朗孕妇样本中三氯生(TCS)的健康风险。通过气相色谱/质谱检测器(GC/MS)检测了 99 名怀孕 28 周后的孕妇尿液中的三氯生(TCS),并利用 MCS 模型进行了健康风险评估。计算了相应的危害商数(HQ)和敏感性分析。100%的尿样中都检测到了三氯氢硅,浓度中位数为 2.89 微克/升。HQ 的中位数为 1.93 × 10-4。研究人群接触三氯氢硅的风险低于允许限值。对孕妇两个体重分组的 HQ 值进行比较后发现,风险水平几乎相等,孕妇接触三氯苯酚对健康造成的风险极小。
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引用次数: 0
Understanding the connections between climate change, air pollution, and human health in Africa: Insights from a literature review. 了解非洲气候变化、空气污染和人类健康之间的联系:来自文献综述的见解。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-01 Epub Date: 2023-12-13 DOI: 10.1080/26896583.2023.2267332
Daniel A Ayejoto, Johnson C Agbasi, Vincent E Nwazelibe, Johnbosco C Egbueri, Joseph O Alao

Climate change and air pollution are two interconnected global challenges that have profound impacts on human health. In Africa, a continent known for its rich biodiversity and diverse ecosystems, the adverse effects of climate change and air pollution are particularly concerning. This review study examines the implications of air pollution and climate change for human health and well-being in Africa. It explores the intersection of these two factors and their impact on various health outcomes, including cardiovascular disease, respiratory disorders, mental health, and vulnerable populations such as children and the elderly. The study highlights the disproportionate effects of air pollution on vulnerable groups and emphasizes the need for targeted interventions and policies to protect their health. Furthermore, it discusses the role of climate change in exacerbating air pollution and the potential long-term consequences for public health in Africa. The review also addresses the importance of considering temperature and precipitation changes as modifiers of the health effects of air pollution. By synthesizing existing research, this study aims to shed light on complex relationships and highlight the key findings, knowledge gaps, and potential solutions for mitigating the impacts of climate change and air pollution on human health in the region. The insights gained from this review can inform evidence-based policies and interventions to mitigate the adverse effects on human health and promote sustainable development in Africa.

气候变化和空气污染是两个相互关联的全球挑战,对人类健康产生深远影响。非洲大陆以其丰富的生物多样性和多样化的生态系统而闻名,气候变化和空气污染的不利影响尤其令人担忧。这项综述研究考察了空气污染和气候变化对非洲人类健康和福祉的影响。它探讨了这两个因素的交叉点及其对各种健康结果的影响,包括心血管疾病、呼吸系统疾病、心理健康以及儿童和老年人等弱势群体。该研究强调了空气污染对弱势群体的不成比例的影响,并强调需要有针对性的干预措施和政策来保护他们的健康。此外,它还讨论了气候变化在加剧空气污染方面的作用以及对非洲公共卫生的潜在长期后果。该综述还谈到了将温度和降水变化视为空气污染对健康影响的调节剂的重要性。通过综合现有研究,本研究旨在阐明复杂的关系,并强调关键发现、知识差距和缓解气候变化和空气污染对该地区人类健康影响的潜在解决方案。从这次审查中获得的见解可以为循证政策和干预措施提供信息,以减轻对人类健康的不利影响,促进非洲的可持续发展。
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引用次数: 0
The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells. 人b淋巴母细胞样TK6细胞II期药物代谢酶的表达。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2022-01-01 Epub Date: 2022-03-11 DOI: 10.1080/26896583.2022.2044242
Xilin Li, Yuxi Li, Kylie G Ning, Si Chen, Lei Guo, Jessica A Bonzo, Nan Mei

In vitro genotoxicity testing plays an important role in chemical risk assessment. The human B-lymphoblastoid cell line TK6 is widely used as a standard cell line for regulatory safety evaluations. Like many other mammalian cell lines, TK6 cells have limited metabolic capacity; therefore, usually require a source of exogenous metabolic activation for use in genotoxicity testing. Previously, we developed a set of TK6-derived cell lines that individually express one of fourteen cytochrome P450s (CYPs). In the present study, we surveyed a panel of major Phase II drug-metabolizing enzymes to characterize their baseline expression in TK6 cells. These results may serve as a reference enzymatic profile of this commonly used cell line.

体外遗传毒性检测在化学品风险评估中起着重要作用。人b淋巴母细胞样细胞系TK6被广泛用作监管安全性评估的标准细胞系。像许多其他哺乳动物细胞系一样,TK6细胞的代谢能力有限;因此,通常需要外源性代谢激活源用于遗传毒性试验。此前,我们开发了一组tk6衍生的细胞系,这些细胞系分别表达14种细胞色素p450 (CYPs)中的一种。在本研究中,我们调查了一组主要的II期药物代谢酶,以表征它们在TK6细胞中的基线表达。这些结果可以作为这种常用细胞系的参考酶谱。
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引用次数: 1
Bystander effect of ultraviolet A radiation protects A375 melanoma cells by induction of antioxidant defense. 紫外线A辐射的旁观者效应通过诱导抗氧化防御来保护A375黑色素瘤细胞。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2022-01-01 Epub Date: 2021-12-13 DOI: 10.1080/26896583.2021.1994820
Surajit Hansda, Rita Ghosh

Ultraviolet (UV) irradiated cells release factors that result in varied responses by non-irradiated cells via bystander effects (BE). The UV-BE is dependent on the cell types involved and on the wavelength of the radiation. Using conditioned medium from UVA-irradiated A375 human melanoma cells (UVA-CM), UVA-bystander response was evaluated on the viability of naïve A375 cells. UVA-CM treatment itself did not alter cell viability; however, UVA-CM treated bystander cells were more resistant to the lethal action of UVA, UVB, UVC or H2O2. Effects of UVA-CM on cell proliferation, mechanism of cell death, DNA damage, malondialdehyde formation, generation of reactive oxygen species (ROS) and antioxidant status were studied in A375 cells. We observed that UVA-CM triggered antioxidant defenses to elicit protective responses through elevation of antioxidant enzyme activities in cells, which persisted until 5 h after exposure to UVA-CM. This was possibly responsible for decreased generation of ROS and diminished DNA and membrane damage in cells. These bystander cells were resistant to killing when exposed to different genotoxic agents. Damaged nuclei, induction of apoptosis and autophagic death were also lowered in these cells. The influence of UVA-CM on cancer stem cells side population was assessed.Highlights:UVA radiation induced bystander effects in A375 cellsDamage by genotoxicants is suppressed due to lower ROS generation on UVA-CM treatmentUVA-CM exposure enhanced higher activities of CAT and GPxResistance to genotoxic agents in such cells was due to elevated antioxidant defenceUVA-bystander phenomenon was a protective response.

紫外线(UV)照射细胞释放因子,通过旁观者效应(BE)引起未照射细胞的不同反应。UV-BE取决于所涉及的细胞类型和辐射的波长。使用uva辐照的A375人黑色素瘤细胞(UVA-CM)的条件培养基,评估uva旁观者反应对naïve A375细胞活力的影响。UVA-CM处理本身不改变细胞活力;然而,UVA- cm处理的旁观者细胞对UVA、UVB、UVC和H2O2的致死作用更有抵抗力。研究了UVA-CM对A375细胞增殖、细胞死亡机制、DNA损伤、丙二醛生成、活性氧(ROS)生成和抗氧化状态的影响。我们观察到UVA-CM通过提高细胞中抗氧化酶活性触发抗氧化防御,从而引发保护反应,这种反应持续到暴露于UVA-CM后5小时。这可能是细胞中ROS生成减少、DNA和膜损伤减少的原因。当暴露于不同的基因毒性物质时,这些旁观者细胞对杀伤具有抵抗力。细胞核损伤、细胞凋亡诱导和自噬死亡均降低。评估UVA-CM对肿瘤干细胞侧群的影响。重点:UVA辐射诱导A375细胞的旁观者效应UVA- cm处理时,由于ROS的产生减少,基因毒物的损伤受到抑制,UVA- cm暴露增强了CAT和gpx的活性,这些细胞对基因毒物的抗性是由于抗氧化防御的增强,va -旁观者现象是一种保护性反应。
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引用次数: 3
Association between lower-level of environmental lead exposure and reactive and proactive aggression in youth: Sex differences. 青少年较低水平的环境铅暴露与被动和主动攻击行为之间的关系:性别差异
IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2022-01-01 Epub Date: 2023-01-20 DOI: 10.1080/26896583.2022.2157183
Andrea L Glenn, Yuli Li, Jianghong Liu

Lead exposure during childhood has been associated with a variety of negative outcomes, including antisocial/aggressive behavior. However, different subtypes of antisocial behavior have been found to have different neurobiological correlates, and it is unclear whether lead exposure is related to specific subtypes of aggressive behavior. The objective of the study was to examine relationships between childhood blood lead levels (BLL) and proactive and reactive aggression. Further, given prior findings of sex differences in the effects of lead exposure, we examine whether there are sex differences in these relationships. In a sample of 818 youth (47.2% girls) ages 10-13 in China, we assessed BLL and administered the Reactive Proactive Aggression Questionnaire. Results show that BLLs were associated with reactive, but not proactive aggression. There was a significant interaction between BLL and sex in predicting aggression; boys with higher BLL scored higher in both proactive and reactive aggression than boys with lower BLL, but these differences were not present for girls. These findings suggest that lead exposure may have broad effects on antisocial behavior, but that boys may be more susceptible than girls. These findings may provide insights to identifying protective factors that could be potential targets for intervention.

童年时期的铅暴露与包括反社会/攻击行为在内的多种不良后果有关。然而,不同亚型的反社会行为具有不同的神经生物学相关性,目前尚不清楚铅暴露是否与特定亚型的攻击性行为有关。本研究旨在探讨儿童期血铅水平(BLL)与主动和被动攻击行为之间的关系。此外,鉴于之前的研究发现铅暴露的影响存在性别差异,我们还研究了这些关系中是否存在性别差异。我们对中国 818 名 10-13 岁青少年(47.2% 为女孩)进行了血铅含量评估,并发放了 "反应性攻击问卷"。结果显示,BLL 与反应性攻击相关,但与主动性攻击无关。在预测攻击行为方面,铅中毒水平与性别之间存在明显的交互作用;铅中毒水平较高的男孩在主动和被动攻击行为方面的得分均高于铅中毒水平较低的男孩,但女孩则不存在这些差异。这些研究结果表明,铅暴露可能会对反社会行为产生广泛影响,但男孩可能比女孩更容易受到影响。这些发现可为确定潜在干预目标的保护性因素提供启示。
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引用次数: 0
Degradation of isoniazid by anodic oxidation and subcritical water oxidation methods: Application of Box-Behnken design. 阳极氧化和亚临界水氧化法降解异烟肼:Box-Behnken设计的应用。
IF 2.5 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2022-01-01 Epub Date: 2022-01-24 DOI: 10.1080/26896583.2022.2026192
Özkan Görmez, Selda Doğan Çalhan, Belgin Gözmen

Pharmaceutical compounds released into the aquatic environment are known to cause toxic effects on the environment. Isoniazid is widely used in the treatment of tuberculosis and is, therefore, frequently encountered in environmental waters. In this study, the degradation of isoniazid was investigated by anodic oxidation and subcritical water oxidation method which are members of Advanced Oxidation Processes. The Box-Behnken Design was used to determine the effects of current, initial concentration, and electrolysis time on mineralization in the anodic oxidation process, which carried out a cell with a Pt cathode and boron-doped diamond anode. The highest mineralization value of 78.14% was achieved at optimal conditions of 300 mA, 3 h, and 100 mg/L initial concentration. The degradation of Isoniazid was also investigated under subcritical water conditions using an ecological oxidizing agent, H2O2. The maximum mineralization rate of 72.23% was obtained when 100 mM H2O2 was used for a 90 min treatment at 125 °C for 100 mg/L Isoniazid solution in the subcritical water oxidation process. The LC-MS results showed that the degradation products obtained by AO and SWO methods were different from each other. Finally, possible degradation mechanisms are proposed according to the degradation products obtained for both processes.

已知释放到水生环境中的药物化合物会对环境造成毒性作用。异烟肼广泛用于治疗结核病,因此在环境水体中经常遇到。研究了高级氧化法中的阳极氧化法和亚临界水氧化法对异烟肼的降解。采用Box-Behnken设计来确定电流、初始浓度和电解时间对阳极氧化过程中矿化的影响,以铂阴极和掺硼金刚石阳极为电池。在300 mA、3 h、100 mg/L初始浓度条件下,矿化率最高,达78.14%。在亚临界水条件下,采用生态氧化剂H2O2对异烟肼进行了降解研究。100 mg/L异烟肼溶液在亚临界水氧化过程中,以100 mM H2O2在125℃下处理90 min,矿化率达到72.23%。LC-MS结果表明,AO法和SWO法得到的降解产物存在差异。最后,根据两种工艺的降解产物,提出了可能的降解机理。
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引用次数: 1
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