eJournal of Oral Maxillofacial Research最新文献

Objectives: This systematic review aims to evaluate the diagnostic utility of direct and indirect immunofluorescence of oral lesions in comparison with conventional diagnostic aids.

Material and methods: The diagnostic utility of immunofluorescence in various oral lesions was evaluated. Relevant data from 37 studies, including study characteristics, patient population, test details, and outcomes, were systematically extracted. The search was performed analysing studies across multiple electronic databases including MEDLINE (PubMed), Embase, Scopus and Google Scholar, published from January 15, 2024 until May 15, 2024. Risk of bias was assessed using a modified QUADAS-2 tool.

Results: Most studies demonstrated a low risk of bias in most domains, indicating overall methodological rigor. Comparative analysis showed that direct immunofluorescence (DIF) consistently outperformed indirect immunofluorescence. DIF exhibited high sensitivity and specificity for pemphigus vulgaris (87.8% and 100%), mucous membrane pemphigoid (92% and 98%), and desquamative gingivitis oral ulcers overlapping with oral lichen planus (OLP) (81% and 98.9%). For OLP, DIF showed moderate sensitivity (64.3%) and high specificity (88%).

Conclusions: This review highlights the superior diagnostic utility of direct immunofluorescence over indirect immunofluorescence in evaluating oral lesions. Direct immunofluorescence's higher performance makes it the preferred technique for conditions requiring direct visualization of tissue-bound immune deposits. The combined use of direct immunofluorescence and indirect immunofluorescence can enhance the evaluation and management of various oral pathologies.

Objectives: Recently surface modification techniques have been introduced to dental implants to improve osseointegration, bone formation at the implant surface, and to reduce the occurrence of mucositis and peri-implantitis. The aim of this systematic literature review was to investigate the dependence of the risk of inflammation of the tissues surrounding the implant on different implant alloys and surface coating materials.

Material and methods: The search for the systematic review of the scientific literature was performed between November 28, 2023, and February 5, 2024. Articles were retrieved using the PRISMA screening system from MEDLINE (PubMed), EMBASE (ScienceDirect), Cochrane Central Register of Controlled Trials (the Cochrane Library), Springer Link, and Google Scholar databases. The literature review included publications in English, randomized controlled clinical trials assessing bleeding on probing, pocket depth, and marginal bone level around the implant.

Results: A total of 41 full-text articles were selected after removing duplicates, of which 5 were included in this systematic literature review. The data from the studies were structured and presented in summary tables. Statistically significant differences in marginal bone level loss were observed using fluoride and sandblasting with large grit and acid-etching methods for implant surface modification. However, the effects of other surface coating materials and different implant alloys on bone loss, bleeding on probing, and pocket depth were not found to be significant.

Conclusions: Despite the limitations of this literature review, it can be concluded that implant alloys and surface coating materials are potential risk factors for the development of inflammation in the tissues surrounding the implant.

Objectives: The objective of this retrospective study was to evaluate clinicopathologic profile and collagen type I expression in oral leukoplakia and oral squamous cell carcinoma to elucidate stromal alterations in malignant transformation.

Material and methods: The sample consisted of 40 cases, of which 20 oral leukoplakia (OL) were classified according to World Health Organization and binary systems for grading oral epithelial dysplasia (OED) as well as 20 oral squamous cell carcinoma (OSCC), moderately or poorly differentiated. Type I collagen was analysed by immunohistochemistry, Fisher's exact test and chi-square test evaluated the clinical data. One-way ANOVA and Tukey's test were applied to analyse type I collagen expression between groups. Associations between data were analysed by two-way ANOVA with Sidak's multiple comparison test.

Results: Men were most affected with OSCC (90%) and 60% of OL were in women (P = 0.0022). Type I collagen expression was higher in mild (P = 0.04) and moderate (P = 0.03) OED than moderately differentiated OSCC. Severe OED had a lower expression when compared with moderate OED (P = 0.01) and well differentiated OSCC (P = 0.02). The binary system showed that low-risk had more collagen expression than high-risk (P = 0.03) and severe OED (P = 0.03).

Conclusions: The binary system allows more effective correlations to be established between stromal changes and oral epithelial dysplasia. The higher expression of collagen in the benign lesions may represent changes in the microenvironment that will favour the process of epithelial transformation and the establishment of a more aggressive disease.

Objectives: This cross-sectional study aimed to measure the distance between the buccal and lingual cortical bones and its relation with the mandibular canal roof of third molars classified as III-C position according to Winter, Pell and Gregory classifications in cone-beam computed tomography.

Material and methods: A total of 140 lower third molars were classified according to Winter, Pell and Gregory. The distance between the buccal external cortex and the lingual external cortex was measured at 25%, 50% and 75% of the distance to the roof of the mandibular canal in parasagittal sections of teeth classified in horizontal III-C position. The presence or absence of lesions associated with the elements in this position was observed. Descriptive statistical analysis was performed and the intra-examiner agreement was calculated using the Bland-Altman and t-test methods (0.88 and 0.91, respectively). The significance level used was 5% (P ≤ 0.05).

Results: Seventy patients (29.4 [SD 8.8] years, 54% women and 46% men) were included. Fourteen (10%) third molars were classified in horizontal III-C position. The average measurements taken were 1.78, 1.1 and 1.53 mm for the distances between the buccal external cortex and lingual external cortex, at 25%, 50% and 75% of the distance to the roof of the mandibular canal, respectively. No pathological conditions associated with the included elements were observed.

Conclusions: Analysis of cone-beam computed tomography parasagittal sections of third molars classified in horizontal III-C position, revealed proximity of impacted teeth to the mandibular canal roof, mainly in the midline between the buccal and lingual external cortices.

Objectives: The aim of this case-control study was to examine upper airway by acoustic reflection in class II children with large horizontal maxillary overjet compared to children with neutral occlusion.

Material and methods: The study group included children of 9 to 14 years with class II and large horizontal maxillary overjet (≥ 6 mm) compared to children with neutral occlusion (controls). Acoustic pharyngometry and rhinometry were performed in natural head position. Differences between groups were tested by chi-square test, general linear model (adjusted for age, gender and body mass index [BMI]), and Mann-Whitney test.

Results: The study and control group consisted of 37 (boys: 19, girls: 18) and 32 (boys: 16, girls: 16) participants, respectively. No significant differences in age, gender, and BMI were found between the groups. For the acoustic rhinometry measurements significantly increased resistance (P = 0.04), reduced volume (P = 0.03) and distance to minimal cross-section area (MCA) (P = 0.035) were found in the study group, but only for the right nostril. However, significantly reduced MCA for both nostrils was found in the study group (P = 0.025 to 0.04). No significant differences in acoustic pharyngometry measurements were found.

Conclusions: Nasal airway dimensions were significantly reduced, and nasal resistance was significantly increased in the study group compared to controls. Thus, class II and large overjet with indication for growth adaptive treatment may be a risk factor for sleep-disordered breathing. In the future, orthodontic paediatric patients may benefit from non-invasive risk assessment of narrow upper airway using acoustic reflection.

Objectives: This cross-sectional study aimed to evaluate the factors that determine the choice of oral surgeons and periodontists to perform immediate dental implant placement.

Material and methods: An anonymous survey was carried out from January 6, 2024 to February 29, 2024. The questionnaire was distributed online to Lithuanian specialists - oral surgeons and periodontists, who perform implantation procedures. A total of 186 professionals were included in this survey. Chi-square test, its degrees of freedom was used for the analysis of variables.

Results: The main reason for refusing immediate implant placement is a periapical lesion greater than 5 mm, reported by 91.7% of oral surgeons and 96.9% of periodontists. Good aesthetics and preservation of anatomical structures are identified as an advantage by 99.2% of oral surgeons and 92.3% of periodontists. In the aesthetic zone, for periodontists, the main criterion for choosing a method is the quantitative and qualitative indicators of the soft tissue of the extraction socket 96.9%, and for oral surgeons - the morphology of the bone walls of the socket 87.6%. Only 43.1% of periodontists and 33.9% of oral surgeons are familiar with and use extraction socket morphology assessment classifications for immediate dental implant placement.

Conclusions: Taking into account study's results, it is recommended to adjust the teaching programs at Universities and to increase the knowledge of specialists performing dental implantation procedures, by carrying out continuous educational programs.

Objectives: This systematic review aims to critically assess the impact of platelet-rich fibrin on maxillary sinus floor augmentation and outline the specific aspects of new bone formation, bone height, implant stability quotient, and Schneiderian membrane thickness.

Material and methods: A systematic review and meta-analysis were conducted, analysing studies from MEDLINE (PubMed), the Cochrane Library, and ScienceDirect databases, published from January 29, 2018 until January 29, 2024 that compared maxillary sinus floor augmentation (MSFA) using bone graft material with and without platelet-rich fibrin (PRF). This review focused on patients 18 years and older who undergone MSFA before the dental implant placement. It systematically examined five studies, encompassing randomized controlled trials, and reported on 112 MSFA procedures conducted in 84 patients.

Results: The meta-analysis reveals a marginal significance in new bone formation with PRF, suggesting a trend towards beneficial outcomes that were not statistically significant. No significant impact on bone height was observed. However, a notable improvement in implant stability quotient (ISQ) was recorded, indicating enhanced implant stability with PRF. The Schneiderian membrane thickness did not show significant changes post-treatment with PRF.

Conclusions: While platelet-rich fibrin shows promise in enhancing implant stability, its effects on new bone formation and Schneiderian membrane thickness are inconclusive, highlighting the need for further research. Platelet-rich fibrin did not significantly affect bone height. The findings support platelet-rich fibrin's potential as a beneficial adjunct in maxillary sinus floor augmentation, particularly for implant stability.

Objectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about the specific behavioural characteristics of odontogenic keratocysts at the molecular level.

Material and methods: Forty dentigerous cysts (DC) and forty odontogenic keratocysts (OKC) tissue samples were examined using immunohistochemical staining to detect cytoplasmic activation/proliferation - associated protein-1 (CAPRIN-1) antibodies. Nuclear and/or cytoplasmic staining was evaluated as "positive". Cell staining rate (%) and cell staining intensity were determined, and a staining intensity distribution (SID) score was calculated for each sample. Cases were considered "negative" if they showed no staining for CAPRIN-1 antibodies, thus were given a SID score of zero. According to the SID scores, the expression levels were rated as negative, mild, moderate, or high.

Results: Of 80 samples, 16 that could adversely affect immunohistochemical evaluation were excluded. Ten negative, 21 positive and three negative, 30 positive CAPRIN-1 expressions were observed in DC and OKC groups, respectively. The difference between the negative and positive cases within groups was significant only in the OKC group (P = 0.000). The SID score range and mean were 0 to 160 and 31.1 (SD 35.7) for DC and 0 to 160 and 57.3 (SD 42.3) for OKC groups. CAPRIN-1 expression was significantly higher in the OKC group (P = 0.043).

Conclusions: The molecular basis for increased mitotic activity, high recurrence rates or presence of satellite cysts in odontogenic keratocysts may be attributed to the expression of cytoplasmic activation/proliferation - associated protein-1.

Objectives: This systematic review and meta-analysis aim to provide detailed insights into the clinical performance of short and longer dental implants placed simultaneously with bone augmentation.

Material and methods: The search for literature was performed across MEDLINE (PubMed), ScienceDirect and the Cochrane Library databases, adhering to specific selection criteria and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only articles published in English between 2014 and 2024 were considered for data collection. Primary outcomes were survival rate (SR), marginal bone loss (MBL) and complications. Clinical outcomes were as follows: bleeding on probing (BOP), periodontal pocket depth (PPD), and implant stability quotient (ISQ). Quality and risk of bias assessment were evaluated by the Critical Appraisal Checklist tool for randomized controlled trials developed by the Joanna Briggs Institute.

Results: A total of 14678 articles were screened, with 9 meeting the inclusion criteria and being utilized for this systematic review and meta-analysis. A total of 495 patients with 984 implants (491 short and 493 longer implants) showing a SR of 93.91% for the short implants and 91.83% for the longer implants. Meta-analysis revealed statistically significant difference between short implants and longer implants simultaneously placed with alveolar bone augmentation in relation to MBL (-0.513 mm, 95% CI = -0.93 to -0.096; P = 0.02), and in PPD (-0.247, 95% CI = -0.515 to 0.022; P = 0.07).

Conclusions: When comparing the results of treatment with short and longer dental implants combined with alveolar bone augmentation, short implants showed better clinical results regarding the parameters of survival rate, marginal bone loss and complications.

Objectives: This retrospective study aims to identify incidental findings in cone-beam computed tomography scans of patients irradiated for preoperative evaluation for implant placement and obtained using the same imaging unit as well as the same field of view. The incidence of each incidental finding, as well as the overall incidence, were calculated and the findings were ranked according to their clinical significance.

Material and methods: A total of 741 cone-beam computed tomography (CBCT) examinations with extended field of view (15 x 15 cm) were retrospectively evaluated for incidental findings (IFs). These were identified, recorded, classified as to their location, and ranked according to their clinical significance.

Results: The vast majority of CBCT examinations presented at least one IF, resulting in a surprisingly high prevalence in total. If extreme anatomical variants are considered (nasal septum deviation, sinus septations etc.), the cumulative prevalence exceeds 99%. IFs of major significance, that may require immediate attention, are beyond 10% in frequency.

Conclusions: We found high prevalence of incidental findings on cone-beam computed tomography examinations performed for preoperative evaluation for implant placement (99.5% if anatomical variants included). Most incidental findings were of minor significance. Although the number of incidental findings that require immediate attention is relatively low, there is a considerable number of cases that need periodic evaluation and/or referral.