Introduction: This study aims to investigate the clinical characteristics, therapeutic approaches, and factors influencing length of hospital stay of pneumothorax (PNO) cases. Materials & methods: This study employed a retrospective approach. Data were collected from January 2019 to April 2023, encompassing sociodemographic information, toxic habits, medical history, clinical signs, PNO characteristics, treatment modalities, evolution, and complications. Results: The study encompassed 158 PNO cases, predominantly males (89.2%) with a median age of 51 years [33-62]. Primary spontaneous pneumothorax accounted for 62.0% of cases, while secondary spontaneous pneumothorax (PSS) constituted 33.5% with chronic obstructive pulmonary disease as the leading cause (34.0%), followed by tuberculosis (20.8%). Drainage was the primary treatment (91.8%), with favorable outcomes in 84.2% of cases. PSS cases were associated with unfavorable evolution and longer hospital stays. Factors associated with prolonged hospitalization included female gender, PSS, total PNO, and surgical treatment. Conclusions: This study provides valuable insights into factors influencing prolonged hospitalization of PNO cases in Souss Massa Region. Understanding these factors can aid healthcare professionals in optimizing patient management and improving outcomes.
{"title":"Clinical characteristics and hospitalization factors in pneumothorax patients: Clinical and therapeutic perspectives from Souss Massa Region","authors":"Fatima Es-Sabir, Aicha Lehiany, Safiya Mahlaq, Hicham Blaak, Naima Eddib, Zaineb Ichou, Ghizlane El Laaroussi, Majdouline Obtel","doi":"10.29333/jcei/14695","DOIUrl":"https://doi.org/10.29333/jcei/14695","url":null,"abstract":"Introduction: This study aims to investigate the clinical characteristics, therapeutic approaches, and factors influencing length of hospital stay of pneumothorax (PNO) cases.\u0000Materials & methods: This study employed a retrospective approach. Data were collected from January 2019 to April 2023, encompassing sociodemographic information, toxic habits, medical history, clinical signs, PNO characteristics, treatment modalities, evolution, and complications.\u0000Results: The study encompassed 158 PNO cases, predominantly males (89.2%) with a median age of 51 years [33-62]. Primary spontaneous pneumothorax accounted for 62.0% of cases, while secondary spontaneous pneumothorax (PSS) constituted 33.5% with chronic obstructive pulmonary disease as the leading cause (34.0%), followed by tuberculosis (20.8%). Drainage was the primary treatment (91.8%), with favorable outcomes in 84.2% of cases. PSS cases were associated with unfavorable evolution and longer hospital stays. Factors associated with prolonged hospitalization included female gender, PSS, total PNO, and surgical treatment.\u0000Conclusions: This study provides valuable insights into factors influencing prolonged hospitalization of PNO cases in Souss Massa Region. Understanding these factors can aid healthcare professionals in optimizing patient management and improving outcomes.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"124 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Stojanovic, N. Barisic, Milica Dragan Jaric, Luka Zoran Vujovic, M. Milojkovic, Sladjana Lazar Lazin, J. D. Djuran
Introduction: In recent years, saliva has been frequently tested as an alternative biological sample for diagnosing various diseases. Various substances reach the saliva through endogenous synthesis in acinar cells or from plasma. Passive diffusion, transudation, diffusion, or selective transport are how these substances cross from plasma to saliva. There are a small number of studies in children and adults that have examined renal function and the ratio of serum and salivary creatinine. To date, no study has been conducted that examined the existence of this correlation in neonates. Our study aimed to examine whether there is a correlation between serum and salivary creatinine values in preterm infants. Methods: We conducted a prospective study that included 30 neonates, in whom serum and salivary creatinine levels were measured simultaneously in two-time spots. Results: The mean value of salivary to serum creatinine (sCr) ratio was 0.700. Salivary to sCr ratio was statistically significantly higher in newborns of gestational age (GA)<28 gestational weeks (mean value 0.825), compared to children with GA≥28 gestational weeks (mean value 0.566), student t-test; p=0.003. Logistic regression showed that the correlation between serum and salivary creatinine levels was more coherent in newborns with GA<28 weeks. Conclusions: In this study, it was examined for the first time whether there is a correlation between the values of serum and salivary creatinine in preterm infants. We found that the correlation between serum and salivary creatinine levels is strong in newborns with GA<28 weeks.
{"title":"Comparison of serum and salivary creatinine levels in preterm neonates","authors":"V. Stojanovic, N. Barisic, Milica Dragan Jaric, Luka Zoran Vujovic, M. Milojkovic, Sladjana Lazar Lazin, J. D. Djuran","doi":"10.29333/jcei/14452","DOIUrl":"https://doi.org/10.29333/jcei/14452","url":null,"abstract":"Introduction: In recent years, saliva has been frequently tested as an alternative biological sample for diagnosing various diseases. Various substances reach the saliva through endogenous synthesis in acinar cells or from plasma. Passive diffusion, transudation, diffusion, or selective transport are how these substances cross from plasma to saliva. There are a small number of studies in children and adults that have examined renal function and the ratio of serum and salivary creatinine. To date, no study has been conducted that examined the existence of this correlation in neonates. Our study aimed to examine whether there is a correlation between serum and salivary creatinine values in preterm infants.\u0000Methods: We conducted a prospective study that included 30 neonates, in whom serum and salivary creatinine levels were measured simultaneously in two-time spots.\u0000Results: The mean value of salivary to serum creatinine (sCr) ratio was 0.700. Salivary to sCr ratio was statistically significantly higher in newborns of gestational age (GA)<28 gestational weeks (mean value 0.825), compared to children with GA≥28 gestational weeks (mean value 0.566), student t-test; p=0.003. Logistic regression showed that the correlation between serum and salivary creatinine levels was more coherent in newborns with GA<28 weeks.\u0000Conclusions: In this study, it was examined for the first time whether there is a correlation between the values of serum and salivary creatinine in preterm infants. We found that the correlation between serum and salivary creatinine levels is strong in newborns with GA<28 weeks.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Yıldırım, G. T. Alp, Hikmet Kilicarslan, I. Vasi, H. Kucuk
Introduction: To investigate the significance of high mobility group box 1 (HMGB1) levels as both an immune and inflammatory mediator in systemic sclerosis (SSC) patients with interstitial lung disease (SSC-ILD) and whether HMGB1 levels could be a biomarker for progression and disease activity. Materials & methods: Our study included 27 patients diagnosed with SSC according to the 2013 ACR/EULAR classification criteria, along with 12 healthy controls (HC). Among the patients with a diagnosis of SSC, they were further categorized into two groups based on the presence of ILD with 19 patients having lung involvement and eight patients without. In ILD-positive group, the activity of the involvement was assessed using the simple Goh algorithm. Serum levels of HMGB1 were evaluated in all groups using ELISA method. Results: Significantly higher serum HMGB1 levels were found in patients with SSC-ILD active disease when compared to those with inactive ILD involvement and HC (14.01 mg/dl vs. 7.87 mg/dl and 8.04 mg/dl). Conclusions: Serum HMGB1 levels reflect the disease activity in SSC-ILD. HMGB1 could be used for a potential biomarker for detecting active lung disease.
{"title":"High mobility box protein-1 may be a new biomarker in active interstitial lung disease of systemic sclerosis","authors":"D. Yıldırım, G. T. Alp, Hikmet Kilicarslan, I. Vasi, H. Kucuk","doi":"10.29333/jcei/14364","DOIUrl":"https://doi.org/10.29333/jcei/14364","url":null,"abstract":"Introduction: To investigate the significance of high mobility group box 1 (HMGB1) levels as both an immune and inflammatory mediator in systemic sclerosis (SSC) patients with interstitial lung disease (SSC-ILD) and whether HMGB1 levels could be a biomarker for progression and disease activity.\u0000Materials & methods: Our study included 27 patients diagnosed with SSC according to the 2013 ACR/EULAR classification criteria, along with 12 healthy controls (HC). Among the patients with a diagnosis of SSC, they were further categorized into two groups based on the presence of ILD with 19 patients having lung involvement and eight patients without. In ILD-positive group, the activity of the involvement was assessed using the simple Goh algorithm. Serum levels of HMGB1 were evaluated in all groups using ELISA method.\u0000Results: Significantly higher serum HMGB1 levels were found in patients with SSC-ILD active disease when compared to those with inactive ILD involvement and HC (14.01 mg/dl vs. 7.87 mg/dl and 8.04 mg/dl).\u0000Conclusions: Serum HMGB1 levels reflect the disease activity in SSC-ILD. HMGB1 could be used for a potential biomarker for detecting active lung disease.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niya Atanasova Gecheva, R. Kehayov, Hristo Dimitrov Georgiev
Objectives: Patellar instability is one of the most common pathologies in children and adolescents. The objective of this study is to present the functional and diagnostic results after performing modified Roux-Goldthwait procedure for habitual patellar dislocation in pediatric population. Materials & methods: A retrospective analysis was performed on 17 patients, under the age of 18 years, from September 2007 to March 2023. For diagnostic results were evaluated congruence angle, sulcus angle and Caton-Deschamps index. Functional results were evaluated by modified Lysholm score and Cox grading system. Results: Excellent and good results were reported for 82%, fair and poor results for 18%. No statistical significance was reported on the topic of congruence angle and sulcus angle. Conclusions: Modified Roux-Goldthwait procedure for habitual patellar dislocation in pediatric population is safe and effective as it is entirely soft tissue operation that leaves the growth plate intact.
{"title":"Modified Roux-Goldthwait procedure for habitual patellar dislocation in pediatric population","authors":"Niya Atanasova Gecheva, R. Kehayov, Hristo Dimitrov Georgiev","doi":"10.29333/jcei/13897","DOIUrl":"https://doi.org/10.29333/jcei/13897","url":null,"abstract":"Objectives: Patellar instability is one of the most common pathologies in children and adolescents. The objective of this study is to present the functional and diagnostic results after performing modified Roux-Goldthwait procedure for habitual patellar dislocation in pediatric population. Materials & methods: A retrospective analysis was performed on 17 patients, under the age of 18 years, from September 2007 to March 2023. For diagnostic results were evaluated congruence angle, sulcus angle and Caton-Deschamps index. Functional results were evaluated by modified Lysholm score and Cox grading system. Results: Excellent and good results were reported for 82%, fair and poor results for 18%. No statistical significance was reported on the topic of congruence angle and sulcus angle. Conclusions: Modified Roux-Goldthwait procedure for habitual patellar dislocation in pediatric population is safe and effective as it is entirely soft tissue operation that leaves the growth plate intact.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"28 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139129257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Due to the increased consumption of packaged foods, exposure to food additives is also increasing. Sodium benzoate (SB), a frequently used food additive, is generally used in alcoholic beverages, fruit, and vegetable juices, carbonated soft drinks, canned food, and various sauces. It is used to inhibit the formation of mold, yeast, and bacteria. This study was carried out to investigate the effects of SB exposure on angiogenesis and oxidant-antioxidant balance. Materials & methods: Three different concentrations of SB, bevacizumab, and empty pellets were prepared, placed on chorioallantoic membrane (CAM), and examined for anti-angiogenesis. Total antioxidant capacity (TAC) and total oxidant capacity (TOC) measurements were made in the albumen samples, and oxidative stress index (OSI) value was calculated. Results: The control group had no anti-angiogenic effect, but the bevacizumab group had a strong anti-angiogenic effect.10-3 M SB had a weak anti-angiogenic effect, but 10-4 M SB and 10-5 M SB showed no anti-angiogenic effect. TOC levels increased with SB in a dose-dependent manner. TAC levels decreased depending on the dose in the experimental groups with SB application. OSI levels increased depending on the dose increase in SB. Conclusions: SB exposure caused a dose-dependent increase in oxidative stress and anti-angiogenic effect in CAM model.
{"title":"Anti-angiogenic and oxidative effects of sodium benzoate at different concentrations in chorioallantoic membrane model","authors":"Elina Dinc, Mehmet Enes Sozen, Hasan Basri Savas","doi":"10.29333/jcei/13893","DOIUrl":"https://doi.org/10.29333/jcei/13893","url":null,"abstract":"<b>Aim:</b> Due to the increased consumption of packaged foods, exposure to food additives is also increasing. Sodium benzoate (SB), a frequently used food additive, is generally used in alcoholic beverages, fruit, and vegetable juices, carbonated soft drinks, canned food, and various sauces. It is used to inhibit the formation of mold, yeast, and bacteria. This study was carried out to investigate the effects of SB exposure on angiogenesis and oxidant-antioxidant balance.<br /> <b>Materials &amp; methods:</b> Three different concentrations of SB, bevacizumab, and empty pellets were prepared, placed on chorioallantoic membrane (CAM), and examined for anti-angiogenesis. Total antioxidant capacity (TAC) and total oxidant capacity (TOC) measurements were made in the albumen samples, and oxidative stress index (OSI) value was calculated.<br /> <b>Results:</b> The control group had no anti-angiogenic effect, but the bevacizumab group had a strong anti-angiogenic effect.10<sup>-3</sup> M SB had a weak anti-angiogenic effect, but 10<sup>-4</sup> M SB and 10<sup>-5</sup> M SB showed no anti-angiogenic effect. TOC levels increased with SB in a dose-dependent manner. TAC levels decreased depending on the dose in the experimental groups with SB application. OSI levels increased depending on the dose increase in SB.<br /> <b>Conclusions:</b> SB exposure caused a dose-dependent increase in oxidative stress and anti-angiogenic effect in CAM model.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"10 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trends in number of patients undergoing gastrostomy between 2010 and 2022 in Japan","authors":"Yusaku Kajihara","doi":"10.29333/jcei/13777","DOIUrl":"https://doi.org/10.29333/jcei/13777","url":null,"abstract":"<jats:p xml:lang=\"en\">N/A</jats:p>","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135968131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The benefits of vitamin C treatment for erectile functions during prepubertal crude oil-contaminated water (CCW) ingestion are unknown. We currently considered the import of vitamin C supplement during prepubertal crude oil-contaminated water ingestion on adult erectile mechanisms in Wistar rats. Materials and methods: 18 prepubertal male rats were divided into three groups and given saline, 2.5 ml CCW, and 2.5 ml CCW + vitamin C (10 mg/kg), separately, until adulthood. Cavernosa tissue responses to phenylephrine, acetylcholine, potassium chloride, and responses after incubation with glibenclamide, nifedipine, methyl blue, and indomethacin were investigated. Serum testosterone and the cavernosa oxidative biomarkers were determined. Results: Testosterone and catalase activity were significantly reduced in CCW group, while malondialdehyde activity was significantly increased. Potassium significantly increased cavernosa contraction in CCW-treated group. Incubation of the cavernosa with nifedipine and indomethacin reduced the percentage of relaxation in CCW group. When compared to the vitamin C-supplemented groups, incubating the cavernosa with methyl blue and glibenclamide markedly reduced relaxation in CCW. Conclusions: Prepubertal CCW ingestion impaired adult cavernosa ATP-sensitive K+ channels, receptor and voltage-operated calcium channels, guanylate cyclase, and prostaglandin activity. Vitamin C administration reduced contractile impairments by increasing antioxidant activity in the cavernosa.
{"title":"Adult erectile functions and prepubertal role of vitamin C supplementation during crude oil-contaminated water ingestion","authors":"Shakiru Ademola Salami, Grace Temitope Omojuwa, Michael Olabode Allen, Hussein Mofomosara Salahdeen, Babatunde Adekunle Murtala","doi":"10.29333/jcei/13751","DOIUrl":"https://doi.org/10.29333/jcei/13751","url":null,"abstract":"<b>Background:</b> The benefits of vitamin C treatment for erectile functions during prepubertal crude oil-contaminated water (CCW) ingestion are unknown. We currently considered the import of vitamin C supplement during prepubertal crude oil-contaminated water ingestion on adult erectile mechanisms in Wistar rats.<br /> <b>Materials and methods: </b>18 prepubertal male rats were divided into three groups and given saline, 2.5 ml CCW, and 2.5 ml CCW + vitamin C (10 mg/kg), separately, until adulthood. Cavernosa tissue responses to phenylephrine, acetylcholine, potassium chloride, and responses after incubation with glibenclamide, nifedipine, methyl blue, and indomethacin were investigated. Serum testosterone and the cavernosa oxidative biomarkers were determined.<br /> <b>Results:</b> Testosterone and catalase activity were significantly reduced in CCW group, while malondialdehyde activity was significantly increased. Potassium significantly increased cavernosa contraction in CCW-treated group. Incubation of the cavernosa with nifedipine and indomethacin reduced the percentage of relaxation in CCW group. When compared to the vitamin C-supplemented groups, incubating the cavernosa with methyl blue and glibenclamide markedly reduced relaxation in CCW.<br /> <b>Conclusions:</b> Prepubertal CCW ingestion impaired adult cavernosa ATP-sensitive K+ channels, receptor and voltage-operated calcium channels, guanylate cyclase, and prostaglandin activity. Vitamin C administration reduced contractile impairments by increasing antioxidant activity in the cavernosa.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135831344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In Qatar, laparoscopic gastric sleeve (LGS) is a key surgical method for obesity treatment. This study assessed its impact on the lipid profiles of 863 obese patients, some with hyperlipidemia. Spanning five years (2015-2020), the research monitored metrics like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). Post-LGS, TC, and LDL levels decreased after three months, increased, and then significantly dropped from the 2nd to the 5th year. TG levels consistently declined over five years, while HDL saw a marked rise from six months to five years post-surgery. In conclusion, LGS positively influenced lipid profiles during certain post-operative periods.
在卡塔尔，腹腔镜胃袖术(LGS)是肥胖症治疗的关键手术方法。这项研究评估了它对863名肥胖患者血脂谱的影响，其中一些患有高脂血症。该研究历时五年(2015-2020年)，监测了总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)和高密度脂蛋白胆固醇(HDL)等指标。lgs后，TC和LDL水平在3个月后下降，然后上升，然后从2<sup>和</sup>5< supt; the </ supt;的一年。手术后6个月至5年内，TG水平持续下降，而HDL水平显著上升。综上所述，LGS对术后某些时期的脂质谱有积极影响。
{"title":"Does laparoscopic gastric sleeve improve lipid profile in obese patients? A five-year retrospective study","authors":"Aysha Saqer Mustafa, Zumin Shi, Marios Hadjicharalambous, Mohammad Mollazehi, Manar AlDweik, Ayat Alshaer, Usama ALAlami, Norshafarina Shari","doi":"10.29333/jcei/13719","DOIUrl":"https://doi.org/10.29333/jcei/13719","url":null,"abstract":"In Qatar, laparoscopic gastric sleeve (LGS) is a key surgical method for obesity treatment. This study assessed its impact on the lipid profiles of 863 obese patients, some with hyperlipidemia. Spanning five years (2015-2020), the research monitored metrics like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). Post-LGS, TC, and LDL levels decreased after three months, increased, and then significantly dropped from the 2<sup>nd</sup> to the 5<sup>th</sup> year. TG levels consistently declined over five years, while HDL saw a marked rise from six months to five years post-surgery. In conclusion, LGS positively influenced lipid profiles during certain post-operative periods.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135925950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mutiu Alani Jimoh, Ganiyu Olatunbosun Arinola, Abbas Abdus-Salam, Adeniyi Adenipekun
Background: Several blood cell ratios have emerged as easy and minimally evasive inflammatory markers of cancer progression and management. Systemic inflammation response index (SIRI) and aggregate inflammation systemic index (AISI), which are reliable indicators of inflammation because they are calculated using more than two immune cells, have not been widely studied. The present study is particularly important in delineating gender-based cancers and to suggest inflammation based therapy. Methods: SIRI and AISI were calculated from differential white blood cell counts using automatic hematology analyzer in 50 cervical patients, 50 prostate cancer patients and 61 corresponding controls. Results: Mean values of SIRI and AISI were significantly raised in cervical cancer patients and prostate cancer patients compared with corresponding control. The mean white blood cell and neutrophil counts were significantly raised while SIRI, monocyte counts and AISI were significantly reduced in prostate cancer patients compared with cervical cancer patients. Conclusions: This study suggests that inflammation is a phenomenon in cervical- and prostate- cancer patients but the impact of inflammation might be more in cervical cancer patients, suggesting that sex hormones might limit the efficacy of broad spectrum single cancer immunotherapy for both sexes.
{"title":"Systemic inflammation response index and aggregate inflammation systemic index in male and female cancers: Implication for gender based immunotherapy","authors":"Mutiu Alani Jimoh, Ganiyu Olatunbosun Arinola, Abbas Abdus-Salam, Adeniyi Adenipekun","doi":"10.29333/jcei/13704","DOIUrl":"https://doi.org/10.29333/jcei/13704","url":null,"abstract":"<b>Background:</b> Several blood cell ratios have emerged as easy and minimally evasive inflammatory markers of cancer progression and management. Systemic inflammation response index (SIRI) and aggregate inflammation systemic index (AISI), which are reliable indicators of inflammation because they are calculated using more than two immune cells, have not been widely studied. The present study is particularly important in delineating gender-based cancers and to suggest inflammation based therapy.<br /> <b>Methods: </b>SIRI and AISI were calculated from differential white blood cell counts using automatic hematology analyzer in 50 cervical patients, 50 prostate cancer patients and 61 corresponding controls.<br /> <b>Results</b>: Mean values of SIRI and AISI were significantly raised in cervical cancer patients and prostate cancer patients compared with corresponding control. The mean white blood cell and neutrophil counts were significantly raised while SIRI, monocyte counts and AISI were significantly reduced in prostate cancer patients compared with cervical cancer patients.<br /> <b>Conclusions</b>: This study suggests that inflammation is a phenomenon in cervical- and prostate- cancer patients but the impact of inflammation might be more in cervical cancer patients, suggesting that sex hormones might limit the efficacy of broad spectrum single cancer immunotherapy for both sexes.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135059704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Massive antibiotic therapy, even with the most powerful modern drugs, does not lead to a cure for the disease with a carbuncle of the kidney without opening and draining the purulent-necrotic focus. Establishing the diagnosis of carbuncle of the kidney provides for urgent surgical intervention.
{"title":"Difficulties of management of a pregnant patient with renal carbuncles","authors":"Dauren Zhantleu, Zhannat Nurmakhanova, Daniyar Sultankulov","doi":"10.29333/jcei/13683","DOIUrl":"https://doi.org/10.29333/jcei/13683","url":null,"abstract":"Massive antibiotic therapy, even with the most powerful modern drugs, does not lead to a cure for the disease with a carbuncle of the kidney without opening and draining the purulent-necrotic focus. Establishing the diagnosis of carbuncle of the kidney provides for urgent surgical intervention.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"26-27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134912655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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