M. Ohe, Hideaki Minami, H. Shida, K. Furuya, Mitsuru Sugiura, S. Ando
{"title":"A Case of B-Cell Lymphoma Diagnosed by Bone Marrow Aspiration","authors":"M. Ohe, Hideaki Minami, H. Shida, K. Furuya, Mitsuru Sugiura, S. Ando","doi":"10.29333/jcei/11515","DOIUrl":"https://doi.org/10.29333/jcei/11515","url":null,"abstract":"","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41789977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leishmania Recidivans Could Be Induced by Intralesional Infiltration of Cutaneous Leishmaniasis by Sodium Stibogluconate, with New Therapeutic Trial","authors":"K. Sharquie, Raed I. Jabbar","doi":"10.29333/jcei/11516","DOIUrl":"https://doi.org/10.29333/jcei/11516","url":null,"abstract":"","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41446553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The War between the Brain and the Body Caused by Stress","authors":"Hasret Balcioglu","doi":"10.29333/jcei/11513","DOIUrl":"https://doi.org/10.29333/jcei/11513","url":null,"abstract":"","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44325726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Socio-Economic Manifestation Dealing with a Proven Green Pit Viper (Cryptelytrops sp.) Envenomation- A Case from Nalagad Municipality, Jajarkot, Karnali Province, Nepal","authors":"B. Baral, G. Magar, K. B. Shah","doi":"10.29333/jcei/11514","DOIUrl":"https://doi.org/10.29333/jcei/11514","url":null,"abstract":"","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49246508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obstructive Sleep Apnoea Syndrome (OSAS) and obesity are linked by a bidirectional causality, where the effects of one affect the other. The factors most involved in the association between OSAS and obesity are oxidative stress, systemic inflammation, and gut microbiota. Moreover, there is a potential link between reduced lung function due to sharing common or similar inflammatory processes and the risk of non-alcoholic fatty liver disease (NAFLD). Therefore, we hypothesize that decreased lung function could be a contributory factor to the development of NAFLD. Electronegative LDL (L5), a promising clinical biomarker for cardiovascular disease, has an important role in (cardiovascular disease) CVD risk assessment. So, L5 may be a potential biomarker for such dual organ interactions and related diseases, too.
{"title":"Electronegative LDL: Could it be a Potential Biomarker for Organ Interactions?","authors":"H. Vural, S. Akyol","doi":"10.29333/jcei/11271","DOIUrl":"https://doi.org/10.29333/jcei/11271","url":null,"abstract":"Obstructive Sleep Apnoea Syndrome (OSAS) and obesity are linked by a bidirectional causality, where the effects of one affect the other. The factors most involved in the association between OSAS and obesity are oxidative stress, systemic inflammation, and gut microbiota. Moreover, there is a potential link between reduced lung function due to sharing common or similar inflammatory processes and the risk of non-alcoholic fatty liver disease (NAFLD). Therefore, we hypothesize that decreased lung function could be a contributory factor to the development of NAFLD. Electronegative LDL (L5), a promising clinical biomarker for cardiovascular disease, has an important role in (cardiovascular disease) CVD risk assessment. So, L5 may be a potential biomarker for such dual organ interactions and related diseases, too.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Email: hide.soomyung@gmail.com Dear Editor, An 83-year old bedridden man with constipation and hemiparalysis due to subarachnoid hemorrhage was admitted for further examination of anemia and thrombocytopenia. On admission, a Foley urinary catheter, made of 100% silicon, had been placed to measure urine output. Moreover, the urine bag was made of medical-grade polyvinyl chloride. Regarding anemia and thrombocytopenia, the myelodysplastic syndrome was diagnosed based on the dysplasia of erythroblast, megakaryocyte, and chromosomal abnormality in bone marrow aspiration. Consequently, purple urine was first observed at 3 months after urinary catheterization. Urinalysis revealed a pH of 8.5, positive nitrites, and numerous leukocytes and bacteria. Microorganisms like Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli were found growing in the urine culture. Thus, the diagnosis of purple urine bag syndrome (PUBS) was made based on the aforementioned characteristic findings. Moreover, the patient had no fever or lower urinary tract symptoms. Furthermore, laboratory findings showed normal leukocyte count and C-reactive protein level. Therefore, no antibiotics were given. PUBS occurs as a result of a chemical reaction in the urine bag. Tryptophan is the metabolite of dietary protein that is catabolized to indole by the intestinal bacteria, absorbed from the intestinal tract, and then converted into indoxyl-sulfate in the liver. Indoxyl-sulfate is excreted into the urine and converted into indoxyl by sulfarase-producing bacteria (e.g., K. pneumonia, Proteus mirabilis, P. aeruginosa, E. coli, Providencia species, and Morganella morganii) (1). Moreover, indoxyl is oxidated into indigo (blue pigment) and indirubin (red pigment) in the presence of alkaline urine. These two pigments do not make the urine purple until they react with the urine bag and tubing.
{"title":"An Elderly Man with Purple Urine","authors":"Hideaki Minami, M. Ohe, K. Furuya","doi":"10.29333/jcei/11266","DOIUrl":"https://doi.org/10.29333/jcei/11266","url":null,"abstract":"Email: hide.soomyung@gmail.com Dear Editor, An 83-year old bedridden man with constipation and hemiparalysis due to subarachnoid hemorrhage was admitted for further examination of anemia and thrombocytopenia. On admission, a Foley urinary catheter, made of 100% silicon, had been placed to measure urine output. Moreover, the urine bag was made of medical-grade polyvinyl chloride. Regarding anemia and thrombocytopenia, the myelodysplastic syndrome was diagnosed based on the dysplasia of erythroblast, megakaryocyte, and chromosomal abnormality in bone marrow aspiration. Consequently, purple urine was first observed at 3 months after urinary catheterization. Urinalysis revealed a pH of 8.5, positive nitrites, and numerous leukocytes and bacteria. Microorganisms like Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli were found growing in the urine culture. Thus, the diagnosis of purple urine bag syndrome (PUBS) was made based on the aforementioned characteristic findings. Moreover, the patient had no fever or lower urinary tract symptoms. Furthermore, laboratory findings showed normal leukocyte count and C-reactive protein level. Therefore, no antibiotics were given. PUBS occurs as a result of a chemical reaction in the urine bag. Tryptophan is the metabolite of dietary protein that is catabolized to indole by the intestinal bacteria, absorbed from the intestinal tract, and then converted into indoxyl-sulfate in the liver. Indoxyl-sulfate is excreted into the urine and converted into indoxyl by sulfarase-producing bacteria (e.g., K. pneumonia, Proteus mirabilis, P. aeruginosa, E. coli, Providencia species, and Morganella morganii) (1). Moreover, indoxyl is oxidated into indigo (blue pigment) and indirubin (red pigment) in the presence of alkaline urine. These two pigments do not make the urine purple until they react with the urine bag and tubing.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47398600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that can be located in any part of the gastrointestinal system. Most often they occur in the stomach and in 20-30% of cases they occur in the small intestine. About 30% of all GISTs are malignant. We report a case of a 54-year-old patient with malignant GIST located in the small intestine and liver. The patient complained of discomfort and heaviness in the abdomen and parts of the abdomen were hard on palpation. Family physician performed an ultrasound of the abdomen which showed a large mass in the right hemiabdomen. CT scan of the abdomen showed a tumour mass of approximately 13x19x20 cm and GIST was suspected. Biopsy was performed and histopathological finding spoke in favour of GIST. GIST resection and Meckel diverticulum resection were performed. Histopathological finding confirmed it was a malignant GIST. After nine months, a control ultrasound showed an oval formation of the liver and excision was performed. The patient was discharged home and histopathological finding confirmed that liver formations were also GIST. GIST should be considered as a possible cause of abdominal difficulties and the treatment of choice is surgery.
{"title":"Gastrointestinal Stromal Tumour of the Small Intestine – Case Report","authors":"Ema Dejhalla, T. Zavidić","doi":"10.29333/jcei/11270","DOIUrl":"https://doi.org/10.29333/jcei/11270","url":null,"abstract":"Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that can be located in any part of the gastrointestinal system. Most often they occur in the stomach and in 20-30% of cases they occur in the small intestine. About 30% of all GISTs are malignant. We report a case of a 54-year-old patient with malignant GIST located in the small intestine and liver. The patient complained of discomfort and heaviness in the abdomen and parts of the abdomen were hard on palpation. Family physician performed an ultrasound of the abdomen which showed a large mass in the right hemiabdomen. CT scan of the abdomen showed a tumour mass of approximately 13x19x20 cm and GIST was suspected. Biopsy was performed and histopathological finding spoke in favour of GIST. GIST resection and Meckel diverticulum resection were performed. Histopathological finding confirmed it was a malignant GIST. After nine months, a control ultrasound showed an oval formation of the liver and excision was performed. The patient was discharged home and histopathological finding confirmed that liver formations were also GIST. GIST should be considered as a possible cause of abdominal difficulties and the treatment of choice is surgery.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47145544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to examine the effect of postural drainage and deep breathing-coughing exercises on oxygen saturation, triflo volume and pulmonary function test applied to patients with chronic obstructive pulmonary disease. Methods: Postural drainage and deep breathing-coughing exercises were performed twice a day, morning and evening for 7 days. Hemodynamic parameters were recorded four times a day, pre-exercise and post-exercise. The forced vital capacity (FVC), forced expiratory volume (FEV1) and FEV1 / FVC values obtained during the Pulmonary Function Test (PFT) were assessed at the end of the first day of the study before the exercise and at the end of the 7th day. Results: As a result of the analyzes performed, there was a statistically significant difference in the oxygen saturation, triflo volume and pulmonary function test of the patients on all days before and after exercise. Conclusions: Postural drainage and deep breathing-coughing exercises are effective in increasing oxygen saturation, triflo volume, pulmonary function tests.
{"title":"Effect of Postural Drainage and Deep Breathing-Cough Exercises on Oxygen Saturation, Triflo Volume and Pulmonary Function Test in Patients with COPD","authors":"Kıvan Çevik, Selma Arık","doi":"10.29333/jcei/11269","DOIUrl":"https://doi.org/10.29333/jcei/11269","url":null,"abstract":"Objective: The aim of this study was to examine the effect of postural drainage and deep breathing-coughing exercises on oxygen saturation, triflo volume and pulmonary function test applied to patients with chronic obstructive pulmonary disease.\u0000Methods: Postural drainage and deep breathing-coughing exercises were performed twice a day, morning and evening for 7 days. Hemodynamic parameters were recorded four times a day, pre-exercise and post-exercise. The forced vital capacity (FVC), forced expiratory volume (FEV1) and FEV1 / FVC values obtained during the Pulmonary Function Test (PFT) were assessed at the end of the first day of the study before the exercise and at the end of the 7th day.\u0000Results: As a result of the analyzes performed, there was a statistically significant difference in the oxygen saturation, triflo volume and pulmonary function test of the patients on all days before and after exercise.\u0000Conclusions: Postural drainage and deep breathing-coughing exercises are effective in increasing oxygen saturation, triflo volume, pulmonary function tests.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46948557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The study was aimed to compare the performance of three different approaches (temocillin disc diffusion test (TDD), immunochromatographic assay, OXA-48 K-SET, and chromogenic assay containing ChromID OXA-48 media) with PCR in a collection of K. pneumoniae producing OXA-48. Materials and methods: A total of 45 carbapenem resistant K. pneumoniae isolates (27 were OXA-48 positive) were included in the study. Polymerase chain reaction (PCR), TDD, OXA-48 K-SET, ChromID OXA-48 media were applied to all isolates. Results: The OXA-48 K-SET was found to be 100% compatible with gold standard PCR for the identification of OXA-48 positive Klebsiella pneumoniae strains. 100% sensitivity and 88.8% specificity were found with the ChromID OXA-48 medium method. Sensitivity and specificity of the TDD assay were found 100% and 77.8%, respectively. Conclusion: The OXA-48 K-Set had excellent performance for detecting OXA-48 carbapenemase and can be used easily and reliably in the routine clinical microbiology laboratory for rapid detection of OXA-48 producing K. pneumoniae isolates, particularly in endemic regions. ChromID media and temocillin disc diffusion testing can be applied in laboratories as part of the identification and screening of carbapenemase-positive Klebsiella pneumoniae.
{"title":"Comparison of Chromogenic Culture Media, Rapid Immunochromatographic Test and Temocillin Resistance for The Detection of OXA-48 Carbapenemase-Positive Klebsiella Pneumonia Strains","authors":"Erkan Sanmak, S. Aksaray","doi":"10.29333/jcei/11267","DOIUrl":"https://doi.org/10.29333/jcei/11267","url":null,"abstract":"Objectives: The study was aimed to compare the performance of three different approaches (temocillin disc diffusion test (TDD), immunochromatographic assay, OXA-48 K-SET, and chromogenic assay containing ChromID OXA-48 media) with PCR in a collection of K. pneumoniae producing OXA-48.\u0000Materials and methods: A total of 45 carbapenem resistant K. pneumoniae isolates (27 were OXA-48 positive) were included in the study. Polymerase chain reaction (PCR), TDD, OXA-48 K-SET, ChromID OXA-48 media were applied to all isolates.\u0000Results: The OXA-48 K-SET was found to be 100% compatible with gold standard PCR for the identification of OXA-48 positive Klebsiella pneumoniae strains. 100% sensitivity and 88.8% specificity were found with the ChromID OXA-48 medium method. Sensitivity and specificity of the TDD assay were found 100% and 77.8%, respectively.\u0000Conclusion: The OXA-48 K-Set had excellent performance for detecting OXA-48 carbapenemase and can be used easily and reliably in the routine clinical microbiology laboratory for rapid detection of OXA-48 producing K. pneumoniae isolates, particularly in endemic regions. ChromID media and temocillin disc diffusion testing can be applied in laboratories as part of the identification and screening of carbapenemase-positive Klebsiella pneumoniae.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49103281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Sahin, Ferruh Acet, E. T. Tavmergen Goker, E. Tavmergen
{"title":"Live Birth Rates After Assisted Reproductive Techniques of Women Aged 42 and Over","authors":"G. Sahin, Ferruh Acet, E. T. Tavmergen Goker, E. Tavmergen","doi":"10.29333/jcei/11214","DOIUrl":"https://doi.org/10.29333/jcei/11214","url":null,"abstract":"","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45673868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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