Pub Date : 2021-08-31DOI: 10.31487/j.cei.2021.01.02
Neeraj Kumar, Subhajit Ghosh
{"title":"The Mindset of Postgraduate Trainee to Face the First Suspected COVID-19 Patient: An Anxious Experience","authors":"Neeraj Kumar, Subhajit Ghosh","doi":"10.31487/j.cei.2021.01.02","DOIUrl":"https://doi.org/10.31487/j.cei.2021.01.02","url":null,"abstract":"<jats:p />","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77547994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-14DOI: 10.20944/PREPRINTS202107.0321.V1
M. Galib, Yusha Araf, I. B. Naser, Salman Khan Promon
Cancer cachexia is a multifactorial syndrome that is identified by ongoing muscle atrophy, along with functional impairment, anorexia, weakness, fatigue, anemia, reduced tolerance to antitumor treatments. Thus, reducing the patients’ quality of life. Cachexia alone causes about 22-25% of cancer deaths. This review covers the symptoms, mediators, available treatment, and prospects of 3D bioprinting for cancer cachexia. Studies about cachexia have shown several factors that drive this disease – protein breakdown, inflammatory cytokines activation, and mitochondrial alteration. Even with proper nutrition, physical exercises, anti-inflammatory agents, chemotherapy, and grafting attempts, standard treatment has been unsuccessful for cachexia. But the use of 3D bioprinting shows much promise compared to conventional methods by attempting to fabricate 3D constructs mimicking the native muscle tissues. In this review, some 3D bioprinting techniques with their advantages and drawbacks, along with their achievements and challenges in in-vivo applications have been discussed. Constructs with neural integration or muscle-tendon units aim to repair muscle atrophy. But it is still difficult to properly bio-print these complex muscles. Although progress can be made by developing new bio-inks or 3D printers to fabricate high-resolution constructs. Using secondary data, this review study shows prospects of why 3D bioprinting can be a good alternate approach to fight cachexia.
{"title":"Prospects of 3D Bioprinting as a Possible Treatment for Cancer Cachexia","authors":"M. Galib, Yusha Araf, I. B. Naser, Salman Khan Promon","doi":"10.20944/PREPRINTS202107.0321.V1","DOIUrl":"https://doi.org/10.20944/PREPRINTS202107.0321.V1","url":null,"abstract":"Cancer cachexia is a multifactorial syndrome that is identified by ongoing muscle atrophy, along with functional impairment, anorexia, weakness, fatigue, anemia, reduced tolerance to antitumor treatments. Thus, reducing the patients’ quality of life. Cachexia alone causes about 22-25% of cancer deaths. This review covers the symptoms, mediators, available treatment, and prospects of 3D bioprinting for cancer cachexia. Studies about cachexia have shown several factors that drive this disease – protein breakdown, inflammatory cytokines activation, and mitochondrial alteration. Even with proper nutrition, physical exercises, anti-inflammatory agents, chemotherapy, and grafting attempts, standard treatment has been unsuccessful for cachexia. But the use of 3D bioprinting shows much promise compared to conventional methods by attempting to fabricate 3D constructs mimicking the native muscle tissues. In this review, some 3D bioprinting techniques with their advantages and drawbacks, along with their achievements and challenges in in-vivo applications have been discussed. Constructs with neural integration or muscle-tendon units aim to repair muscle atrophy. But it is still difficult to properly bio-print these complex muscles. Although progress can be made by developing new bio-inks or 3D printers to fabricate high-resolution constructs. Using secondary data, this review study shows prospects of why 3D bioprinting can be a good alternate approach to fight cachexia.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48111770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Atherosclerosis and thrombotic disorders disrupts distal limb perfusion and threatens organ viability. The distal flow should be provided with interventional or surgical procedures. However, it is not possible every time due to the loss of normal anatomical conditions. Extra-anatomic ways can be used for providing distal blood supply in such these conditions. In current study we aimed to present our extra-anatomic bypass applications in cases who has not chance for anatomical revascularization. Method: Extra-anatomic bypass intervention was applied to medical cases in our clinic between 2010 and 2018. Age, sex and accompanying diseases were recorded retrospectively. The polytetrafluoroethylene (PTFE) or otogenous saphenous vein graft was used for extra-anatomic revascularization. Results: Nine (75%) of the patients were male and 3 of them (25%) were female. The mean age of the patients was 56.08 years. Lower extremity revascularization was performed in all cases. For the lower extremity, a femoro-femoral bypass in eight cases, an axillo-femoral bypass in two cases, and femoro-infrapopliteal bypass 18 in two cases were performed respectively. Two (18%) complications were encountered in the immediate postoperative period. Late-period mortality was not observed during the follow-up period. In terms of late-period morbidity (6 months after surgery), graft thrombosis was observed in one case. Conclusion: Although the increase in the number of endovascular interventions in recent years restricts surgical intervention, extra-anatomic bypass procedures should be considered as an alternative surgical approach in cases with co-morbidity factors such as previous vascular bypass surgery, diabetes, and obesity etc.
{"title":"Single-Center Experience on Extra-Anatomic Arterial Revascularisation Applications","authors":"İ. Kaya","doi":"10.29333/JCEI/10961","DOIUrl":"https://doi.org/10.29333/JCEI/10961","url":null,"abstract":"Objective: Atherosclerosis and thrombotic disorders disrupts distal limb perfusion and threatens organ viability. The distal flow should be provided with interventional or surgical procedures. However, it is not possible every time due to the loss of normal anatomical conditions. Extra-anatomic ways can be used for providing distal blood supply in such these conditions. In current study we aimed to present our extra-anatomic bypass applications in cases who has not chance for anatomical revascularization.\u0000Method: Extra-anatomic bypass intervention was applied to medical cases in our clinic between 2010 and 2018. Age, sex and accompanying diseases were recorded retrospectively. The polytetrafluoroethylene (PTFE) or otogenous saphenous vein graft was used for extra-anatomic revascularization.\u0000Results: Nine (75%) of the patients were male and 3 of them (25%) were female. The mean age of the patients was 56.08 years. Lower extremity revascularization was performed in all cases. For the lower extremity, a femoro-femoral bypass in eight cases, an axillo-femoral bypass in two cases, and femoro-infrapopliteal bypass 18 in two cases were performed respectively. Two (18%) complications were encountered in the immediate postoperative period. Late-period mortality was not observed during the follow-up period. In terms of late-period morbidity (6 months after surgery), graft thrombosis was observed in one case.\u0000Conclusion: Although the increase in the number of endovascular interventions in recent years restricts surgical intervention, extra-anatomic bypass procedures should be considered as an alternative surgical approach in cases with co-morbidity factors such as previous vascular bypass surgery, diabetes, and obesity etc.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"12 1","pages":"em00775"},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47764396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Peripheral artery disease (PAD) is the name given to blocked blood flow in major arteries other than cerebral and coronary circulation. The diagnosis and treatment of PAD is very important because of the high frequency of PAD. In this study, it was aimed to investigate the possible change in next generation oxidative stress-antioxidant status indicators as a biochemical parameter that may be useful in the diagnosis and follow-up of PAD. Method: Forty healthy controls and 40 male and female patients with peripheral artery disease who applied to the Alanya Alaaddin Keykubat University Research and Training Hospital were enrolled in the study on a voluntary basis. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia modified albumin (IMA) and Thiol balance were studied with the colorimetric method. Results: The TOS (p <0.001), OSI (p <0.001), IMA (p = 0.027), total thiol (0.004) levels were higher in the peripheral artery patients compared to the control group, while the TAS (p <0.001) and native thiol / total thiol ratio (index 3) (p = 0.018) values were significantly lower. Conclusion: The increase in TOS and IMA levels may be used as an indicator of peripheral artery disease. There is an increase in inflammation in the ischemia and atherosclerosis processes. An ischemia-specific protein called ischemia-modified albumin may be used as a rapid and practical laboratory marker in common peripheral artery disease.
{"title":"Ischemia Modified Albumin as a Novel Biochemical Indicator in Peripheral Artery Patients","authors":"H. Savaş, M. Etli","doi":"10.29333/JCEI/10960","DOIUrl":"https://doi.org/10.29333/JCEI/10960","url":null,"abstract":"Objective: Peripheral artery disease (PAD) is the name given to blocked blood flow in major arteries other than cerebral and coronary circulation. The diagnosis and treatment of PAD is very important because of the high frequency of PAD. In this study, it was aimed to investigate the possible change in next generation oxidative stress-antioxidant status indicators as a biochemical parameter that may be useful in the diagnosis and follow-up of PAD.\u0000Method: Forty healthy controls and 40 male and female patients with peripheral artery disease who applied to the Alanya Alaaddin Keykubat University Research and Training Hospital were enrolled in the study on a voluntary basis. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia modified albumin (IMA) and Thiol balance were studied with the colorimetric method.\u0000Results: The TOS (p <0.001), OSI (p <0.001), IMA (p = 0.027), total thiol (0.004) levels were higher in the peripheral artery patients compared to the control group, while the TAS (p <0.001) and native thiol / total thiol ratio (index 3) (p = 0.018) values were significantly lower.\u0000Conclusion: The increase in TOS and IMA levels may be used as an indicator of peripheral artery disease. There is an increase in inflammation in the ischemia and atherosclerosis processes. An ischemia-specific protein called ischemia-modified albumin may be used as a rapid and practical laboratory marker in common peripheral artery disease.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"12 1","pages":"em00774"},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49066510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Kawuki, Q. Sserwanja, N. Obore, Zixin Wang, J. Lau
COVID-19 being a rapidly evolving pandemic, early lessons from the first deaths must be learnt to help feed into the public health guidelines. This article, therefore, aims to present the first two deaths due to COVID-19 in Uganda and their public health relevance. This is a case study of the first two COVID-19 deaths reported in Uganda, and the events were prospectively documented. The first case was a 34-year-old female and support staff at a health center II. She first presented with COVID-19 like symptoms before dying on 21st July 2020. The second case was an 80 years old female, who also presented with COVID-19 like symptoms before dying on 24th July 2020. The postmortem samples of both cases were confirmed positive for COVID-19. This study identifies a need for timely identification and testing of COVID-19 suspects, strengthening of health center capacity, as well as more awareness for effective prevention and control of COVID-19.
{"title":"Reflecting on the First Two COVID-19 Deaths in Uganda: A Public Health Perspective","authors":"J. Kawuki, Q. Sserwanja, N. Obore, Zixin Wang, J. Lau","doi":"10.29333/JCEI/10878","DOIUrl":"https://doi.org/10.29333/JCEI/10878","url":null,"abstract":"COVID-19 being a rapidly evolving pandemic, early lessons from the first deaths must be learnt to help feed into the public health guidelines. This article, therefore, aims to present the first two deaths due to COVID-19 in Uganda and their public health relevance. This is a case study of the first two COVID-19 deaths reported in Uganda, and the events were prospectively documented. The first case was a 34-year-old female and support staff at a health center II. She first presented with COVID-19 like symptoms before dying on 21st July 2020. The second case was an 80 years old female, who also presented with COVID-19 like symptoms before dying on 24th July 2020. The postmortem samples of both cases were confirmed positive for COVID-19. This study identifies a need for timely identification and testing of COVID-19 suspects, strengthening of health center capacity, as well as more awareness for effective prevention and control of COVID-19.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"12 1","pages":"em00773"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46114137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Ünal, U. Demirkılıç, İ. Balık, K. Aydin, M. Zor, A. Bozkurt
Objective and background: Light-based antimicrobials, mainly ultraviolet C (UVC) and laser light irradiation, have a potential to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of our study was to evaluate the effect of transbronchial and intravenous application of UVC and laser light irradiation on treatment of patients with severe COVID-19. Methods: The clinical outcome of six patients (age 42-69 years) with severe COVID-19 infection who were directly applied UVC (254 nm) transbronchially, and UVC plus green (630 nm) and red laser (535 nm) lights to the blood circulation in addition to standard pharmacotherapy (UVC group) were prospectively evaluated in comparison to six patients (age 50-69 years) treated only with pharmacotherapy (standard treatment group). Results: The patients in UVC group had shorter stay in intensive care unit (median length of stay 1 vs. 8.5 days; p=0.015), more negative PCR results after treatment (5/6 vs. 0/6 patients; p=0.003), higher discharge rate (5/6 vs. 3/6 patients), and lower mortality (1/6 vs. 3/6 patients), as compared to patients in standard treatment group. Serum D-dimer level, which reached up to 2500 ng/mL (six times of baseline value) seven days after treatment in standard treatment group, was much lower in UVC group (1000 ng/mL). Serum ferritin level was 1.5 to 1.9-fold higher and CRP level was up to 1.7-fold higher in standard treatment group during ten days after treatment as compared to UVC group. No adverse effects have been observed. Conclusions: Combined transbronchial and intravenous UVC and laser irradiation may improve outcome of severe COVID-19 cases.
{"title":"Pilot Study of Application of Combined Transbronchial and Intravenous Ultraviolet C (UVC) and Laser Beam Application for the Treatment of Critical COVID-19 Infection","authors":"Y. Ünal, U. Demirkılıç, İ. Balık, K. Aydin, M. Zor, A. Bozkurt","doi":"10.29333/JCEI/10811","DOIUrl":"https://doi.org/10.29333/JCEI/10811","url":null,"abstract":"Objective and background: Light-based antimicrobials, mainly ultraviolet C (UVC) and laser light irradiation, have a potential to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of our study was to evaluate the effect of transbronchial and intravenous application of UVC and laser light irradiation on treatment of patients with severe COVID-19.\u0000Methods: The clinical outcome of six patients (age 42-69 years) with severe COVID-19 infection who were directly applied UVC (254 nm) transbronchially, and UVC plus green (630 nm) and red laser (535 nm) lights to the blood circulation in addition to standard pharmacotherapy (UVC group) were prospectively evaluated in comparison to six patients (age 50-69 years) treated only with pharmacotherapy (standard treatment group).\u0000Results: The patients in UVC group had shorter stay in intensive care unit (median length of stay 1 vs. 8.5 days; p=0.015), more negative PCR results after treatment (5/6 vs. 0/6 patients; p=0.003), higher discharge rate (5/6 vs. 3/6 patients), and lower mortality (1/6 vs. 3/6 patients), as compared to patients in standard treatment group. Serum D-dimer level, which reached up to 2500 ng/mL (six times of baseline value) seven days after treatment in standard treatment group, was much lower in UVC group (1000 ng/mL). Serum ferritin level was 1.5 to 1.9-fold higher and CRP level was up to 1.7-fold higher in standard treatment group during ten days after treatment as compared to UVC group. No adverse effects have been observed.\u0000Conclusions: Combined transbronchial and intravenous UVC and laser irradiation may improve outcome of severe COVID-19 cases.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49370554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-25DOI: 10.31487/J.CEI.2021.01.01
A. Panagiota, Polyxeni Ntaountaki, A. Drigas
The current paper examines the role of Information and Communication Technologies (ICTs) in the inclusion of students with sensory and physical disabilities. Our main goal is to present the importance of ICTs and highlight their contribution to the smooth and equal inclusion of these children in the educational system and society. Thus, the research team of this paper presents specific examples of ICTs that aid children with visual and hearing impairments and physical disabilities. We followed the method of bibliographic review of articles, focusing on articles from the last five years. However, we considered it necessary to include also some older articles for a more complete and accurate review of the topic. According to the results of the research, ICTs provide an attractive and supportive environment for the students with special needs as well as equal opportunities regarding their inclusion. Since we live in the world of information and the digital revolution, we have to adapt to modern reality and prioritize the use of ICTs in education. Lastly, ICTs help the students with sensory and physical disabilities to overcome the barriers that exist in traditional educational systems which would lead to the reduction of social exclusion.
{"title":"ICTs in Inclusive Education for Sensory and Physical Disabilities","authors":"A. Panagiota, Polyxeni Ntaountaki, A. Drigas","doi":"10.31487/J.CEI.2021.01.01","DOIUrl":"https://doi.org/10.31487/J.CEI.2021.01.01","url":null,"abstract":"The current paper examines the role of Information and Communication Technologies (ICTs) in the inclusion of students with sensory and physical disabilities. Our main goal is to present the importance of ICTs and highlight their contribution to the smooth and equal inclusion of these children in the educational system and society. Thus, the research team of this paper presents specific examples of ICTs that aid children with visual and hearing impairments and physical disabilities. We followed the method of bibliographic review of articles, focusing on articles from the last five years. However, we considered it necessary to include also some older articles for a more complete and accurate review of the topic. According to the results of the research, ICTs provide an attractive and supportive environment for the students with special needs as well as equal opportunities regarding their inclusion. Since we live in the world of information and the digital revolution, we have to adapt to modern reality and prioritize the use of ICTs in education. Lastly, ICTs help the students with sensory and physical disabilities to overcome the barriers that exist in traditional educational systems which would lead to the reduction of social exclusion.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"2017 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73899605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the spread of SARS-CoV2 continues to increase globally, newer information gets reported every day. We are learning more and more about the presentation, symptoms and treatment of this infection. Earlier cardinal symptoms of COVID-19 had been fever, cough, and shortness of breath. New findings in its symptoms are now being reported some of which includes neurological symptoms, dizziness and diarrhoea. Of recent skin manifestations due to COVID-19 have drawn the attention of medical experts. The presence of a livedoid pattern (red mottled-net like coloration) rash and a rare skin lesion at the extremities also known as acro-ischemia in patients diagnosed with COVID-19 or patients presenting with symptoms of COVID-19 is now on a surge. Though the correlation between acute acro-ischemia, skin rash and COVID-19 is yet to be fully documented these dermatological and clinical observations in patients might just be another possible key indicator for the presence of the COVID-19 disease.
{"title":"Is COVID-19 Expanding its Symptom List? The Case of Acute Acro-ischemia and Skin Rash","authors":"Teh Exodus Akwa, A. Jalloh","doi":"10.29333/JCEI/10774","DOIUrl":"https://doi.org/10.29333/JCEI/10774","url":null,"abstract":"As the spread of SARS-CoV2 continues to increase globally, newer information gets reported every day. We are learning more and more about the presentation, symptoms and treatment of this infection. Earlier cardinal symptoms of COVID-19 had been fever, cough, and shortness of breath. New findings in its symptoms are now being reported some of which includes neurological symptoms, dizziness and diarrhoea. Of recent skin manifestations due to COVID-19 have drawn the attention of medical experts. The presence of a livedoid pattern (red mottled-net like coloration) rash and a rare skin lesion at the extremities also known as acro-ischemia in patients diagnosed with COVID-19 or patients presenting with symptoms of COVID-19 is now on a surge. Though the correlation between acute acro-ischemia, skin rash and COVID-19 is yet to be fully documented these dermatological and clinical observations in patients might just be another possible key indicator for the presence of the COVID-19 disease.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44534991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A web-based cross-sectional study was conducted among 1072 Bangladeshi young adults to identify the prevalence and correlates of depressive symptoms due to COVID-19 pandemic. The 9-item patient health questionnaire (PHQ-9) was used to measure depressive symptoms. Kruskal-Wallis H test and ordered logistic regression were employed to identify the drivers correlated with the levels of depressive symptoms. The estimated prevalence rates of moderate to severe depressive symptoms were 54.1%. Older age, residing urban area, not having stable family income, having relatives or acquaintances infected with COVID-19, being worried about educational delays or jobs, having the disturbance of daily activities, and being worried about social support were significantly associated with the levels of depressive symptoms among Bangladeshi young adults due to COVID-19 pandemic.
{"title":"Prevalence and Correlates of Depressive Symptoms among Bangladeshi Young Adults due to COVID-19 Outbreak","authors":"Md. Ayatullah Khan","doi":"10.29333/JCEI/9766","DOIUrl":"https://doi.org/10.29333/JCEI/9766","url":null,"abstract":"A web-based cross-sectional study was conducted among 1072 Bangladeshi young adults to identify the prevalence and correlates of depressive symptoms due to COVID-19 pandemic. The 9-item patient health questionnaire (PHQ-9) was used to measure depressive symptoms. Kruskal-Wallis H test and ordered logistic regression were employed to identify the drivers correlated with the levels of depressive symptoms. The estimated prevalence rates of moderate to severe depressive symptoms were 54.1%. Older age, residing urban area, not having stable family income, having relatives or acquaintances infected with COVID-19, being worried about educational delays or jobs, having the disturbance of daily activities, and being worried about social support were significantly associated with the levels of depressive symptoms among Bangladeshi young adults due to COVID-19 pandemic.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45048649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Prayitno, R. Oetari, Idin Shahiddin, Aldissa Yova Elmanda, Anita Dwi Septiarini, Hasriyani Hasriyani, Luky Dharmayanti, Yuneka Saristiana, Yunita Sari
Introduction: Hyperglycemic triggers various complications, some organs that damage can occur due to the oxidation by oxidant of proteins both structural and non-structural, such as eyes, kidneys, heart, nerves and blood vessels. α-mangosteen as antioxidant can suppress cell damage so that blood sugar can be transported back into the cell and be found in Garcinia mangostana Linn. The purpose of this study was to explains the effect of α-mangosteen in increasing blood insulin and reducing blood sugar levels in hyperglycemic rat. Method: This study uses 9 rat treatment groups. Group I as control, group II as negative control (hyperglycemic), group III as positive control (hyperglycemia + Glybenclamide), group IV-VI treated with extract mangosteen in ethanol rind (EEMR) and group VII-IX treated with isolate α-mangosteen rind (IAMR). After 28 days peripheral blood was taken and measurements the insulin and glucose blood serum level. Results: Mean insulin control is 19.08µU/mL, after administration of STZ-NA is 6.18µU/mL, after administration with Glibenclamide is 11.58µU/m, after administration with EEMR is 18.69µU/mL. and after administration with IAMR is 17.81µU/mL. Mean glycemic control is 99.90mg/dl, after administration of STZ-NA is 259.90 mg/dl, after administration with Glibenclamide is 123.39 mg/dl, after administration with EEMR is 108.87mg/dl. and after administration with IAMR is 92.52 mg/dl. Showed an increase in insulin serum levels after administration with extract mangosteen and isolate α-mangosteen. Anova Test, showed there was a very significant difference between control and treatment in insulin levels (p=0.001). Conclusion: α-mangosteen can increasing blood insulin and reduce blood sugar levels in hyperglycemic rat.
{"title":"α-Mangosteen from Garcinia Mangostana Linn and its Effect in Blood Insulin and Sugar Levels in Hyperglycemic Rat","authors":"A. Prayitno, R. Oetari, Idin Shahiddin, Aldissa Yova Elmanda, Anita Dwi Septiarini, Hasriyani Hasriyani, Luky Dharmayanti, Yuneka Saristiana, Yunita Sari","doi":"10.29333/JCEI/9767","DOIUrl":"https://doi.org/10.29333/JCEI/9767","url":null,"abstract":"Introduction: Hyperglycemic triggers various complications, some organs that damage can occur due to the oxidation by oxidant of proteins both structural and non-structural, such as eyes, kidneys, heart, nerves and blood vessels. α-mangosteen as antioxidant can suppress cell damage so that blood sugar can be transported back into the cell and be found in Garcinia mangostana Linn. The purpose of this study was to explains the effect of α-mangosteen in increasing blood insulin and reducing blood sugar levels in hyperglycemic rat.\u0000Method: This study uses 9 rat treatment groups. Group I as control, group II as negative control (hyperglycemic), group III as positive control (hyperglycemia + Glybenclamide), group IV-VI treated with extract mangosteen in ethanol rind (EEMR) and group VII-IX treated with isolate α-mangosteen rind (IAMR). After 28 days peripheral blood was taken and measurements the insulin and glucose blood serum level.\u0000Results: Mean insulin control is 19.08µU/mL, after administration of STZ-NA is 6.18µU/mL, after administration with Glibenclamide is 11.58µU/m, after administration with EEMR is 18.69µU/mL. and after administration with IAMR is 17.81µU/mL. Mean glycemic control is 99.90mg/dl, after administration of STZ-NA is 259.90 mg/dl, after administration with Glibenclamide is 123.39 mg/dl, after administration with EEMR is 108.87mg/dl. and after administration with IAMR is 92.52 mg/dl. Showed an increase in insulin serum levels after administration with extract mangosteen and isolate α-mangosteen. Anova Test, showed there was a very significant difference between control and treatment in insulin levels (p=0.001).\u0000Conclusion: α-mangosteen can increasing blood insulin and reduce blood sugar levels in hyperglycemic rat.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47704307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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