Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12803
H. Rumbo
Abstract: Uncontrolled high blood pressure can lead to stroke, heart attack, kidney failure, memory and vision disfunction, and also erectile dysfunction. Globally, data shows that 1.28 billon adults aged 30 – 79 years has hypertension and estimated only 46% of adults with hypertension are diagnosed and treated. In Indonesia, based on national survey in 2019, an estimated 34.11% of the population aged 18 years above has hypertension. Division of Disease Control and Environmental health in Central Sulawesi Province proofed that only 0.12 % of hypertensive patients have been recorded to get treatment or visited to the health Center in Parigi Moutong District. This study aims to identify the determinant factors of uncontrolled hypertension among hypertensive patients in Taniuge, Parigi Moutong District. Community- based cross sectional study design was conducted 25 July to 6 August 2021. Total sampling method was used to select 30 sample. Data was collected using the structured questionnaire. Chi-square test was used to identify the relationship between the variables. The results show that, there is relationship between life style and uncontrolled hypertension (p = 0.029); there were no relationship between genetic, family support and health center availability and uncontrolled hypertension (p = 0.6; p = 1.0; p = 0.5, sequentially). The conclusion is to control blood pressure, patients are recommended to take medication regularly, and also apply the Healthy Living Community Movement (GERMAS). All people are encouraged to adopt a healthy lifestyle, such as not smoking, consuming balanced nutrition, daily physical activity for at least 30 minutes; in order to reduce risk factors for hypertension.Keywords: Hypertension; Uncontrolled; Adult; Life-style
{"title":"DETERMINANT FACTORS OF UNCONTROLLED HYPERTENSION AMONG ADULT","authors":"H. Rumbo","doi":"10.20527/jbk.v18i1.12803","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12803","url":null,"abstract":"Abstract: Uncontrolled high blood pressure can lead to stroke, heart attack, kidney failure, memory and vision disfunction, and also erectile dysfunction. Globally, data shows that 1.28 billon adults aged 30 – 79 years has hypertension and estimated only 46% of adults with hypertension are diagnosed and treated. In Indonesia, based on national survey in 2019, an estimated 34.11% of the population aged 18 years above has hypertension. Division of Disease Control and Environmental health in Central Sulawesi Province proofed that only 0.12 % of hypertensive patients have been recorded to get treatment or visited to the health Center in Parigi Moutong District. This study aims to identify the determinant factors of uncontrolled hypertension among hypertensive patients in Taniuge, Parigi Moutong District. Community- based cross sectional study design was conducted 25 July to 6 August 2021. Total sampling method was used to select 30 sample. Data was collected using the structured questionnaire. Chi-square test was used to identify the relationship between the variables. The results show that, there is relationship between life style and uncontrolled hypertension (p = 0.029); there were no relationship between genetic, family support and health center availability and uncontrolled hypertension (p = 0.6; p = 1.0; p = 0.5, sequentially). The conclusion is to control blood pressure, patients are recommended to take medication regularly, and also apply the Healthy Living Community Movement (GERMAS). All people are encouraged to adopt a healthy lifestyle, such as not smoking, consuming balanced nutrition, daily physical activity for at least 30 minutes; in order to reduce risk factors for hypertension.Keywords: Hypertension; Uncontrolled; Adult; Life-style","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41894255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12783
B. Budiyanto
Abstract: Background: Diarrhea still become one of the leading causes of morbidity and mortality in children, especially under 5 years. Anthropogenic climate change, mainly due to global warming process, is expected to change the epidemiological pattern of infectious diseases, including diarrhea. COVID-19 pandemic that has occurred globally since March 2020 may also have an impact. Banjarmasin as a city in a wetland area with tropical savanna climate that also affected by COVID-19 pandemic is also at risk. We conducted a research to study the influence of climate factors on diarrhea cases in children under 5 years before and after the COVID-19 pandemic in Banjarmasin.Methods: Data of monthly diarrhea cases in children under 5 years at public health centers from Banjarmasin City Health Office and monthly climate data (amount of rainfall, number of rain days, temperature, humidity, sunshine duration, wind speed) from BMKG and BPS between January 2010 to April 2021 were collected. Statistical analysis was carried out to determine the correlation between climate factors and diarrhea cases before and after COVID-19 pandemic.Results: There was a decrease in the average monthly visits of children under five years with diarrhea before (497 ±47.4) and after (132 ±45.8) COVID-19 pandemic. Among climate factors, amount of rainfall (r=-0.753; p=0.005), number of rain days (r=-0.774; p=0.003), and humidity (r=-0.590; p=0.044) were negatively correlated, while sunshine duration (r=0.674; p=0.016) was positively correlated with diarrhea cases in the period before COVID-19 pandemic. No correlation was found between any climate factor and diarrhea cases in the subsequent period.Conclusion: Diarrhea cases in children under 5 years in Banjarmasin tend to increase in dry season, however during COVID-19 pandemic there were some changes in society, such as working from home, reluctance to go to health facilities which might affect the usual trend. Keywords: Anthropogenic climate change; Climate factors; COVID-19 pandemic; Diarrhea under 5 years; Wetland
{"title":"THE INFLUENCE OF CLIMATE FACTORS ON DIARRHEA CASES IN CHILDREN UNDER FIVE YEARS BEFORE AND AFTER THE COVID-19 PANDEMIC IN BANJARMASIN","authors":"B. Budiyanto","doi":"10.20527/jbk.v18i1.12783","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12783","url":null,"abstract":"Abstract: Background: Diarrhea still become one of the leading causes of morbidity and mortality in children, especially under 5 years. Anthropogenic climate change, mainly due to global warming process, is expected to change the epidemiological pattern of infectious diseases, including diarrhea. COVID-19 pandemic that has occurred globally since March 2020 may also have an impact. Banjarmasin as a city in a wetland area with tropical savanna climate that also affected by COVID-19 pandemic is also at risk. We conducted a research to study the influence of climate factors on diarrhea cases in children under 5 years before and after the COVID-19 pandemic in Banjarmasin.Methods: Data of monthly diarrhea cases in children under 5 years at public health centers from Banjarmasin City Health Office and monthly climate data (amount of rainfall, number of rain days, temperature, humidity, sunshine duration, wind speed) from BMKG and BPS between January 2010 to April 2021 were collected. Statistical analysis was carried out to determine the correlation between climate factors and diarrhea cases before and after COVID-19 pandemic.Results: There was a decrease in the average monthly visits of children under five years with diarrhea before (497 ±47.4) and after (132 ±45.8) COVID-19 pandemic. Among climate factors, amount of rainfall (r=-0.753; p=0.005), number of rain days (r=-0.774; p=0.003), and humidity (r=-0.590; p=0.044) were negatively correlated, while sunshine duration (r=0.674; p=0.016) was positively correlated with diarrhea cases in the period before COVID-19 pandemic. No correlation was found between any climate factor and diarrhea cases in the subsequent period.Conclusion: Diarrhea cases in children under 5 years in Banjarmasin tend to increase in dry season, however during COVID-19 pandemic there were some changes in society, such as working from home, reluctance to go to health facilities which might affect the usual trend. Keywords: Anthropogenic climate change; Climate factors; COVID-19 pandemic; Diarrhea under 5 years; Wetland","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49225171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12818
I. Hadning, Muhammad Heyqal Wirakarsa, Muhamad Rinaldhi Tandah
Abstract: The increase in the number of chronic kidney disease (CKD) sufferers and the expensive financing of this disease, the economic burden borne will certainly increase. This study aimed to determine the cost of illness of CKD patients undergoing hemodialysis, as well as to find out the comparison of real costs with INA-CBG’s rates. This was a pharmacoeconomic research, used the cost of illness method according to a societal perspective. The study was conducted in a type B government hospitals in Yogyakarta from January to March 2020. The population in this study were all CKD patients undergoing hemodialysis in need to mention the hospital at first. The research instruments were medical records, hospital financial data, and patient interviews. The complete data were analyzed statistically with the descriptive method and the Mann Whitney test. The number of samples was 65 patients. The results revealed the average cost of illness was 6,224,277.00 IDR for one month of treatment. The cost component that dominates was hemodialysis rate. The average real cost was 836,686 IDR for one procedure. It can be concluded that the average real cost of CKD patients with hemodialysis in the type B government hospital were significantly smaller than the INA-CBG’s rate.Keywords: Chronic Kidney Disease; Hemodialysis; Cost Of Illness; INA-CBG’s Rate
{"title":"COST OF ILLNESS FOR CHRONIC KIDNEY DISEASE TREATMENT WITH HEMODIALYSIS IN YOGYAKARTA","authors":"I. Hadning, Muhammad Heyqal Wirakarsa, Muhamad Rinaldhi Tandah","doi":"10.20527/jbk.v18i1.12818","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12818","url":null,"abstract":"Abstract: The increase in the number of chronic kidney disease (CKD) sufferers and the expensive financing of this disease, the economic burden borne will certainly increase. This study aimed to determine the cost of illness of CKD patients undergoing hemodialysis, as well as to find out the comparison of real costs with INA-CBG’s rates. This was a pharmacoeconomic research, used the cost of illness method according to a societal perspective. The study was conducted in a type B government hospitals in Yogyakarta from January to March 2020. The population in this study were all CKD patients undergoing hemodialysis in need to mention the hospital at first. The research instruments were medical records, hospital financial data, and patient interviews. The complete data were analyzed statistically with the descriptive method and the Mann Whitney test. The number of samples was 65 patients. The results revealed the average cost of illness was 6,224,277.00 IDR for one month of treatment. The cost component that dominates was hemodialysis rate. The average real cost was 836,686 IDR for one procedure. It can be concluded that the average real cost of CKD patients with hemodialysis in the type B government hospital were significantly smaller than the INA-CBG’s rate.Keywords: Chronic Kidney Disease; Hemodialysis; Cost Of Illness; INA-CBG’s Rate ","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48502851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12794
D. Prakoso, Alya’ Laudza, Yusuf Oka Mahendra, N. Hanif, Fitria Nurul Hidayah
Abstract: One of the consequences of the Covid-19 pandemic is the adaptation process and changes in the education process. During the Covid-19 crisis, the Indonesian Ministry of Education and Culture implemented a policy to aid in preventing Covid-19 spread through regulations governing the implementation of "Learning from Home" education. The implementation of this program which has been going on for quite a long time can create additional life burdens that produce a psychological impact on parents such as stress, anxiety, and depression. The purpose of this study is to determine the prevalence of stress, depression, and anxiety in parents of children who are "Learning from Home" as a response of the Covid-19 epidemic. An online survey was conducted from August 2020 until September 2020 among parents who have a minimum of one child with the age of children or adolescents. The Google Form was used to create a structured self-reported e-questionnaire, and the link was shared through WhatsApp. Respondents completed a survey measuring socio-demographic variables and the DASS-42 (Depression, Anxiety, Stress Scale) to measure stress, depression, and anxiety, after giving informed consent. Researchers received 225 online responses. Microsoft Excel and SPSS 21 were used to perform a univariate analysis on the data collection. Stress, depression, and anxiety were found to be prevalent among parents of “Learning from Home” children in 43.56%, 13.78%, and 18.22%, respectively. This research showed that during the Covid-19 pandemic, a significant number of parents of "Learning from Home" children encountered stress, anxiety, and depression symptomsKeywords: Stress-depression-anxiety; Learning from home; Parents; Covid-19
{"title":"STRESS, DEPRESSION AND ANXIETY LEVELS AMONG PARENTS OF “LEARNING FROM HOME” DURING COVID-19 PANDEMIC","authors":"D. Prakoso, Alya’ Laudza, Yusuf Oka Mahendra, N. Hanif, Fitria Nurul Hidayah","doi":"10.20527/jbk.v18i1.12794","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12794","url":null,"abstract":"Abstract: One of the consequences of the Covid-19 pandemic is the adaptation process and changes in the education process. During the Covid-19 crisis, the Indonesian Ministry of Education and Culture implemented a policy to aid in preventing Covid-19 spread through regulations governing the implementation of \"Learning from Home\" education. The implementation of this program which has been going on for quite a long time can create additional life burdens that produce a psychological impact on parents such as stress, anxiety, and depression. The purpose of this study is to determine the prevalence of stress, depression, and anxiety in parents of children who are \"Learning from Home\" as a response of the Covid-19 epidemic. An online survey was conducted from August 2020 until September 2020 among parents who have a minimum of one child with the age of children or adolescents. The Google Form was used to create a structured self-reported e-questionnaire, and the link was shared through WhatsApp. Respondents completed a survey measuring socio-demographic variables and the DASS-42 (Depression, Anxiety, Stress Scale) to measure stress, depression, and anxiety, after giving informed consent. Researchers received 225 online responses. Microsoft Excel and SPSS 21 were used to perform a univariate analysis on the data collection. Stress, depression, and anxiety were found to be prevalent among parents of “Learning from Home” children in 43.56%, 13.78%, and 18.22%, respectively. This research showed that during the Covid-19 pandemic, a significant number of parents of \"Learning from Home\" children encountered stress, anxiety, and depression symptomsKeywords: Stress-depression-anxiety; Learning from home; Parents; Covid-19","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47530734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12843
Seno Dwi Prasetyo, L. Rosita, Utami Mulyaningrum
Abstrak: The incidence of CKD in the world is more than 500 million patients and up to 1.5 million patients need to undergo renal replacement therapy in the form of hemodialysis. Chronic kidney disease is inseparable from several complications, one of which is anemia. Confirmation of the diagnosis of anemia in CKD patients can be confirmed through various examinations such as the classic examination of serum ferritine levels, but ferritine is known to be involved in the inflammatory process that occurs in CKD. The aims of this study were to determine the relationship between the percentage of hypochromic erythrocytes and ferritine levels, to determine the average percentage of hypochromic erythrocytes and to determine the average ferritin level in CKD patients undergoing hemodiliasis at PKU Bantul Hospital. This study was conducted using a cross-sectional method involving 50 CKD patients at PKU Bantul Hospital. Blood samples were taken to check ferritine levels and hypochromic erythrocyte percentage. Data analysis was carried out with two types, univariate analysis and bivariate analysis which were carried out with the Spearman correlation test. Based on the results of univariate analysis, the median percentage of hypochromic erythrocytes of the research subjects was 0.95%. The median ferritine in research subjects was 105.5 ng/mL. based on the results of bivariate analysis, there was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels (p=0.130, r=-0.217). There was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels. Keywords: anemia; ferritine serum, chronic kidney disease, reticulocytes hemoglobin
{"title":"CORRELATION BETWEEN THE PERCENTAGE OF HYPOCHROMIC ERYTHROCYTES AND FERRITINE LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS IN PKU BANTUL HOSPITAL","authors":"Seno Dwi Prasetyo, L. Rosita, Utami Mulyaningrum","doi":"10.20527/jbk.v18i1.12843","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12843","url":null,"abstract":"Abstrak: The incidence of CKD in the world is more than 500 million patients and up to 1.5 million patients need to undergo renal replacement therapy in the form of hemodialysis. Chronic kidney disease is inseparable from several complications, one of which is anemia. Confirmation of the diagnosis of anemia in CKD patients can be confirmed through various examinations such as the classic examination of serum ferritine levels, but ferritine is known to be involved in the inflammatory process that occurs in CKD. The aims of this study were to determine the relationship between the percentage of hypochromic erythrocytes and ferritine levels, to determine the average percentage of hypochromic erythrocytes and to determine the average ferritin level in CKD patients undergoing hemodiliasis at PKU Bantul Hospital. This study was conducted using a cross-sectional method involving 50 CKD patients at PKU Bantul Hospital. Blood samples were taken to check ferritine levels and hypochromic erythrocyte percentage. Data analysis was carried out with two types, univariate analysis and bivariate analysis which were carried out with the Spearman correlation test. Based on the results of univariate analysis, the median percentage of hypochromic erythrocytes of the research subjects was 0.95%. The median ferritine in research subjects was 105.5 ng/mL. based on the results of bivariate analysis, there was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels (p=0.130, r=-0.217). There was no significant relationship between the percentage of hypochromic erythrocytes and ferritine levels. Keywords: anemia; ferritine serum, chronic kidney disease, reticulocytes hemoglobin","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41251087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12850
Putu Martha Gerynda Sukma, W. Budianti, Sari Chairunnisa, R. Astriningrum
Abstract: The phenomenon of “sensitive skin” is a relatively recent terminology in certain populations reporting sensory complaints that are more intense and more frequent than the normal population, especially after using cosmetic products. The incidence of sensitive skin is increasing along with the rapid widespread of skin care products availability. Various studies have been conducted but the pathophysiology of sensitive skin is still unclear. Physiological changes in sensitive skin are influenced by two main factors such as dysfunction in skin barrier and neurosensory. There are various quantitative sensory tests that can be done to determine skin sensitivity. Until now, there is no guideline for treating sensitive skin. Contributing factors, quantitative sensory tests, relation to skin diseases, and managements will be discussed in this literature review.Keywords: Dysfunction; Neurosensory; Sensitive skin; Skin barrier
{"title":"SENSITIVE SKIN: A NEW ENTITY PERSPECTIVE","authors":"Putu Martha Gerynda Sukma, W. Budianti, Sari Chairunnisa, R. Astriningrum","doi":"10.20527/jbk.v18i1.12850","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12850","url":null,"abstract":"Abstract: The phenomenon of “sensitive skin” is a relatively recent terminology in certain populations reporting sensory complaints that are more intense and more frequent than the normal population, especially after using cosmetic products. The incidence of sensitive skin is increasing along with the rapid widespread of skin care products availability. Various studies have been conducted but the pathophysiology of sensitive skin is still unclear. Physiological changes in sensitive skin are influenced by two main factors such as dysfunction in skin barrier and neurosensory. There are various quantitative sensory tests that can be done to determine skin sensitivity. Until now, there is no guideline for treating sensitive skin. Contributing factors, quantitative sensory tests, relation to skin diseases, and managements will be discussed in this literature review.Keywords: Dysfunction; Neurosensory; Sensitive skin; Skin barrier","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42568381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12830
fitrialrasi fitri, Marisa Riliani, Edward Syam
Abstract: Cadaver rigidity due to formalin preservation often intricates students' understanding in anatomical learning. Various solutions have been trial, but there were no satisfactory results. In this study, acetic acid solution was used to restore the motion flexibility motion of small joint in the hand. Investigated the difference in motion angle of articulatio metacarpophalangeal 1 after being given acetic acid in cadaver post formalin preservation. A pair of cadaver hands conserved by formalin from the same body, were exposed to 5% acetic acid for 4 months. Angular measurements performed on flexion and extension before and after exposure. The flexibility of metacarpophalangeal joints 1 increased in the form of angular reduction in flexion movement (22.8° reduced, p<0.05) and the addition of angle to the extension movement (9.85° increased, p<0.05). Administration of acetic acid for 4 months may increase the motion flexibility of small joint like articulatio metacarpophalangeal 1 in cadaver post-formalin preservation. This result may help students to have better anatomical understanding in cadaver at anatomy laboratory. Keywords: Acetic acid; Articulatio metacarpophalangeal 1; Cadaver; Flexibility; Restoration
{"title":"FLEXIBILITY RESTORATION OF ARTICULATIO METACARPOPHALANGEAL 1 IN CADAVER PRESERVED BY FORMALIN WITH ACETIC ACID EXPOSURE","authors":"fitrialrasi fitri, Marisa Riliani, Edward Syam","doi":"10.20527/jbk.v18i1.12830","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12830","url":null,"abstract":"Abstract: Cadaver rigidity due to formalin preservation often intricates students' understanding in anatomical learning. Various solutions have been trial, but there were no satisfactory results. In this study, acetic acid solution was used to restore the motion flexibility motion of small joint in the hand. Investigated the difference in motion angle of articulatio metacarpophalangeal 1 after being given acetic acid in cadaver post formalin preservation. A pair of cadaver hands conserved by formalin from the same body, were exposed to 5% acetic acid for 4 months. Angular measurements performed on flexion and extension before and after exposure. The flexibility of metacarpophalangeal joints 1 increased in the form of angular reduction in flexion movement (22.8° reduced, p<0.05) and the addition of angle to the extension movement (9.85° increased, p<0.05). Administration of acetic acid for 4 months may increase the motion flexibility of small joint like articulatio metacarpophalangeal 1 in cadaver post-formalin preservation. This result may help students to have better anatomical understanding in cadaver at anatomy laboratory. Keywords: Acetic acid; Articulatio metacarpophalangeal 1; Cadaver; Flexibility; Restoration","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41868387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.11829
Isnaini Isnaini, I. Oktaviyanti, E. Suhartono
UV radiation are divided into 3, namely UV A (400 – 315 nm), UV B (315-280 nm), UV C (280 – 100 nm). UV C radiation have the greatest effect on skin damage compared to UV A and UV B. UV radiation can reach the earth's surface, that can cause burning of the skin with signs such as redness of the skin (erythema), pain, blistering and peeling of the skin. Until now there has been no research on the effect of long exposure of UV C radiation on the erythema and melanin index, so aim this research is know about the effect of long exposure of UV C radiation on the erythema and melanine index. This research was conducted by giving exposure to rat that had been shaved with variations in exposure time, namely 5 minutes, 10 minutes, 15 minutes and 20 minutes. The skin that has been exposed with UV radiation will be photographed for color analysis using a chromometer. The results showed that exposure of UV radiation for 10 minutes caused the greatest increase in the melanin and erythema index
{"title":"THE EFFECT OF LONG EXPOSURE OF UV RADIATION ON ERYTHEMA AND MELANIN INDEX","authors":"Isnaini Isnaini, I. Oktaviyanti, E. Suhartono","doi":"10.20527/jbk.v18i1.11829","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.11829","url":null,"abstract":"UV radiation are divided into 3, namely UV A (400 – 315 nm), UV B (315-280 nm), UV C (280 – 100 nm). UV C radiation have the greatest effect on skin damage compared to UV A and UV B. UV radiation can reach the earth's surface, that can cause burning of the skin with signs such as redness of the skin (erythema), pain, blistering and peeling of the skin. Until now there has been no research on the effect of long exposure of UV C radiation on the erythema and melanin index, so aim this research is know about the effect of long exposure of UV C radiation on the erythema and melanine index. This research was conducted by giving exposure to rat that had been shaved with variations in exposure time, namely 5 minutes, 10 minutes, 15 minutes and 20 minutes. The skin that has been exposed with UV radiation will be photographed for color analysis using a chromometer. The results showed that exposure of UV radiation for 10 minutes caused the greatest increase in the melanin and erythema index","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47984921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12863
Winardi Budiwinata, Abdurahman Maman, Azhar Raden Yohana
Abstrak: Breast cancer is the most common carcinoma in women in the world. Anti-Mullerian Hormone (AMH) is a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to ovarian follicles is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study aims to determine the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study employed a prospective cohort study design. Inclusion criteria were breast carcinoma, premenopausal, and history of chemotherapy (-). Exclusion criteria were history of ovarian surgery, pelvic radiation, GnRH-agonist therapy, smoking for ≥10 years, obesity, and chemotherapy dropout. Subjects were examined for AMH before the 1st chemotherapy and after the 4th chemotherapy. Statistical test was done with Wilcoxon test, significant if p≤0.05. The average AMH level before FAC chemotherapy was 1.51±1.957; the average AMH level after the 4th FAC chemotherapy was 0.24±0.587. The result of the Wilcoxon test comparing AMH levels before and after 4th FAC chemotherapy was p<0.0001. FAC chemotherapy reduces AMH patients with premenopausal breast carcinoma.Keywords: Breast carcinoma, chemotherapy, AMH.
{"title":"EFFECTS OF FAC CHEMOTHERAPY ON ANTI MULLERIAN HORMONE IN PREMENOPAUSAL BREAST CARCINOMA","authors":"Winardi Budiwinata, Abdurahman Maman, Azhar Raden Yohana","doi":"10.20527/jbk.v18i1.12863","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12863","url":null,"abstract":"Abstrak: Breast cancer is the most common carcinoma in women in the world. Anti-Mullerian Hormone (AMH) is a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to ovarian follicles is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study aims to determine the effect of FAC chemotherapy on AMH in premenopausal breast carcinoma patients. This study employed a prospective cohort study design. Inclusion criteria were breast carcinoma, premenopausal, and history of chemotherapy (-). Exclusion criteria were history of ovarian surgery, pelvic radiation, GnRH-agonist therapy, smoking for ≥10 years, obesity, and chemotherapy dropout. Subjects were examined for AMH before the 1st chemotherapy and after the 4th chemotherapy. Statistical test was done with Wilcoxon test, significant if p≤0.05. The average AMH level before FAC chemotherapy was 1.51±1.957; the average AMH level after the 4th FAC chemotherapy was 0.24±0.587. The result of the Wilcoxon test comparing AMH levels before and after 4th FAC chemotherapy was p<0.0001. FAC chemotherapy reduces AMH patients with premenopausal breast carcinoma.Keywords: Breast carcinoma, chemotherapy, AMH.","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47456722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-21DOI: 10.20527/jbk.v18i1.12801
Ellen Ayuningtyas Pratidina, E. Suhartono, B. Setiawan
Abstract: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative impacts in the field of health such as the disruption of the glycolysis process in humans. The purpose of this study was determine the interaction of heavy metals which is cadmium and mercury against hexokinase enzymes using hexokinase enzymes type I, II, III with PDB ID : 4F9O, 2NZT, 3HM8 taken from Protein Data Bank and using the molecular docking website MIB: Metal Ion Binding Site Prediction and Docking server. Docking results will be visualized using chimera app version 1.15. Molecular docking of the heavy metals cadmium and mercury can interact with all three types of hexokinase enzymes. Cadmium metal ions bind hydrophobicly to amino acid residues of hexokinase enzymes type I, II, and III, while mercury metal ions bind covalently coordinate with amino acid residues of hexokinase enzymes type I and III. Mercury metal ions bind more strongly than cadmium metal ions. Of the three types of hexokinase enzymes, mercury metal ions bind most strongly with hexokinase enzyme type II because mercury ions bind to the active site of the three amino acid residues of hexokinase enzymes type II.Keywords: Cadmium ; hexokinase enzyme ; mercury ; molecular docking
{"title":"IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY","authors":"Ellen Ayuningtyas Pratidina, E. Suhartono, B. Setiawan","doi":"10.20527/jbk.v18i1.12801","DOIUrl":"https://doi.org/10.20527/jbk.v18i1.12801","url":null,"abstract":"Abstract: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative impacts in the field of health such as the disruption of the glycolysis process in humans. The purpose of this study was determine the interaction of heavy metals which is cadmium and mercury against hexokinase enzymes using hexokinase enzymes type I, II, III with PDB ID : 4F9O, 2NZT, 3HM8 taken from Protein Data Bank and using the molecular docking website MIB: Metal Ion Binding Site Prediction and Docking server. Docking results will be visualized using chimera app version 1.15. Molecular docking of the heavy metals cadmium and mercury can interact with all three types of hexokinase enzymes. Cadmium metal ions bind hydrophobicly to amino acid residues of hexokinase enzymes type I, II, and III, while mercury metal ions bind covalently coordinate with amino acid residues of hexokinase enzymes type I and III. Mercury metal ions bind more strongly than cadmium metal ions. Of the three types of hexokinase enzymes, mercury metal ions bind most strongly with hexokinase enzyme type II because mercury ions bind to the active site of the three amino acid residues of hexokinase enzymes type II.Keywords: Cadmium ; hexokinase enzyme ; mercury ; molecular docking","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48772236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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