首页 > 最新文献

Human Antibodies最新文献

英文 中文
COVID-19 pandemic: Insights into genetic susceptibility to SARS-CoV-2 and host genes implications on virus spread, disease severity and outcomes. COVID-19大流行:对SARS-CoV-2的遗传易感性和宿主基因对病毒传播、疾病严重程度和结局的影响
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-211506
Saba Dastar, Jalal Gharesouran, Deniz Mortazavi, Hassan Hosseinzadeh, Seyed Jalal Kian, Mohammad Taheri, Soudeh Ghafouri-Fard, Elena Jamali, Maryam Rezazadeh

The outbreak of the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world has caused global public health emergencies, international concern and economic crises. The systemic SARS-CoV-2 disease (COVID-19) can lead to death through causing unrestrained cytokines-storm and subsequent pulmonary shutdown among the elderly and patients with pre-existing comorbidities. Additionally, in comparison with poor nations without primary health care services, in developed countries with advanced healthcare system we can witness higher number of infections per one million people. In this review, we summarize the latest studies on genes associated with SARS-CoV-2 pathogenesis and propose possible mechanisms of the virus replication cycle and its triggered signaling pathways to encourage researchers to investigate genetic and immune profiles of the disease and try strategies for its treatment. Our review shows that immune response in people with different genetic background might vary as African and then Asian populations have lowest number of affected cases compared with European and American nations. Considering SARS-CoV-2 pathogenesis, we put forward some potentially important genetic gateways to COVID-19 infection including genes involved in the entry and replication of SARS-CoV-2 and the regulation of host immune response which might represent explanation for its spread, severity, and morality. Finally, we suggest that genetic alterations within these gateways could be critical factors in influencing geographical discrepancies of the virus, so it is essential to fully study them and design appropriated and reliable therapeutic agents against COVID-19.

新出现的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)在全球范围内爆发,引发了全球性突发公共卫生事件、国际关注和经济危机。系统性SARS-CoV-2疾病(COVID-19)可在老年人和已有合并症的患者中引起无节制的细胞因子风暴和随后的肺关闭,从而导致死亡。此外,与没有初级卫生保健服务的贫穷国家相比,在拥有先进卫生保健系统的发达国家,我们可以看到每百万人的感染人数更高。本文综述了与SARS-CoV-2发病机制相关基因的最新研究,提出了病毒复制周期的可能机制及其触发的信号通路,以鼓励研究人员研究该疾病的遗传和免疫特征,并尝试治疗策略。我们的综述显示,不同遗传背景的人的免疫反应可能会有所不同,因为与欧洲和美洲国家相比,非洲和亚洲人群的感染病例数量最少。考虑到SARS-CoV-2的发病机制,我们提出了涉及SARS-CoV-2进入和复制以及宿主免疫反应调控的一些潜在的重要遗传通道,这可能解释了其传播、严重和道德的原因。最后,我们认为这些通道内的遗传改变可能是影响病毒地理差异的关键因素,因此有必要对它们进行充分研究,并设计合适和可靠的治疗药物来对抗COVID-19。
{"title":"COVID-19 pandemic: Insights into genetic susceptibility to SARS-CoV-2 and host genes implications on virus spread, disease severity and outcomes.","authors":"Saba Dastar,&nbsp;Jalal Gharesouran,&nbsp;Deniz Mortazavi,&nbsp;Hassan Hosseinzadeh,&nbsp;Seyed Jalal Kian,&nbsp;Mohammad Taheri,&nbsp;Soudeh Ghafouri-Fard,&nbsp;Elena Jamali,&nbsp;Maryam Rezazadeh","doi":"10.3233/HAB-211506","DOIUrl":"https://doi.org/10.3233/HAB-211506","url":null,"abstract":"<p><p>The outbreak of the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world has caused global public health emergencies, international concern and economic crises. The systemic SARS-CoV-2 disease (COVID-19) can lead to death through causing unrestrained cytokines-storm and subsequent pulmonary shutdown among the elderly and patients with pre-existing comorbidities. Additionally, in comparison with poor nations without primary health care services, in developed countries with advanced healthcare system we can witness higher number of infections per one million people. In this review, we summarize the latest studies on genes associated with SARS-CoV-2 pathogenesis and propose possible mechanisms of the virus replication cycle and its triggered signaling pathways to encourage researchers to investigate genetic and immune profiles of the disease and try strategies for its treatment. Our review shows that immune response in people with different genetic background might vary as African and then Asian populations have lowest number of affected cases compared with European and American nations. Considering SARS-CoV-2 pathogenesis, we put forward some potentially important genetic gateways to COVID-19 infection including genes involved in the entry and replication of SARS-CoV-2 and the regulation of host immune response which might represent explanation for its spread, severity, and morality. Finally, we suggest that genetic alterations within these gateways could be critical factors in influencing geographical discrepancies of the virus, so it is essential to fully study them and design appropriated and reliable therapeutic agents against COVID-19.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Transcript levels of cytokine coding genes in peripheral blood and tissues of patients with periodontitis. 牙周炎患者外周血和组织中细胞因子编码基因的转录水平。
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-211507
Mohammad Taheri, Leila Gholami, Fwad Nicknafs, Bashdar Mahmud Hussen, Shahram Arsang-Jang, Arezou Sayad, Soudeh Ghafouri-Fard

Periodontal diseases are common conditions in almost all age groups and a public health problem. Numerous risk factors have been demonstrated for this condition. The main mechanism of tissue destruction in the periodontitis is the functional interactions between microbial pathogens and host immune responses, thus cytokines have crucial roles in the pathogenesis periodontitis. Our previous study has demonstrated the susceptibility role of HLA-DRB1*04 allele in development of this disease. So, the individuals who were positive for HLA-DRB1*04 allele were excluded. We aimed to appraise the function of cytokines in the pathogenesis of periodontitis via assessment of tissue and blood levels of a number of cytokine coding genes, namely IL-1B, CXCL8, IL-17, IFNG, TGFB and TNFA1. Expressions of IFNG, IL-17, TGFB and TNFA1 were significantly higher in the peripheral blood of individuals with periodontitis compared with unaffected persons (Posterior beta = 1.91, P value = 0.043; Posterior beta = 1.84, P value = 0.033; Posterior beta = 0.713, P value = 0.009 and Posterior beta = 2.85, P value = 0.001, respectively). Moreover, expression of IL-17 was higher in females compared with males (Posterior beta = 1.47, P value = 0.036). As the interaction effect between gender and group was remarkable for IL-17 expression, we further conducted subgroup analysis within gender group. Expression of IL-17 was higher in male patients compared with unaffected males (Posterior beta = 1.9, P value = 0.048). We did not detect any significant difference in the expression of these cytokines in tissues obtained from affected individuals and unaffected controls. Therefore, our results imply dysregulation of cytokine coding genes in patients with periodontitis and warrant further mechanistical studies.

牙周病是几乎所有年龄组的常见病,也是一个公共卫生问题。许多危险因素已被证明会导致这种情况。牙周炎组织破坏的主要机制是病原微生物与宿主免疫应答的功能相互作用,因此细胞因子在牙周炎发病中起着至关重要的作用。我们之前的研究已经证实了HLA-DRB1*04等位基因在本病发生中的易感性作用。因此,排除HLA-DRB1*04等位基因阳性的个体。我们旨在通过评估组织和血液中一些细胞因子编码基因的水平,即IL-1B、CXCL8、IL-17、IFNG、TGFB和TNFA1,来评估细胞因子在牙周炎发病机制中的功能。牙周炎患者外周血中IFNG、IL-17、TGFB和TNFA1的表达明显高于正常人群(后验β = 1.91, P值= 0.043;后验贝塔系数= 1.84,P值= 0.033;后验β = 0.713, P值= 0.009;后验β = 2.85, P值= 0.001)。IL-17在女性中的表达高于男性(Posterior beta = 1.47, P值= 0.036)。由于性别和组间对IL-17表达的交互作用显著,我们进一步在性别组内进行亚组分析。男性患者IL-17的表达高于正常男性(后验β = 1.9, P值= 0.048)。我们没有发现从受影响个体和未受影响的对照组获得的组织中这些细胞因子的表达有任何显著差异。因此,我们的结果暗示牙周炎患者的细胞因子编码基因失调,需要进一步的机制研究。
{"title":"Transcript levels of cytokine coding genes in peripheral blood and tissues of patients with periodontitis.","authors":"Mohammad Taheri,&nbsp;Leila Gholami,&nbsp;Fwad Nicknafs,&nbsp;Bashdar Mahmud Hussen,&nbsp;Shahram Arsang-Jang,&nbsp;Arezou Sayad,&nbsp;Soudeh Ghafouri-Fard","doi":"10.3233/HAB-211507","DOIUrl":"https://doi.org/10.3233/HAB-211507","url":null,"abstract":"<p><p>Periodontal diseases are common conditions in almost all age groups and a public health problem. Numerous risk factors have been demonstrated for this condition. The main mechanism of tissue destruction in the periodontitis is the functional interactions between microbial pathogens and host immune responses, thus cytokines have crucial roles in the pathogenesis periodontitis. Our previous study has demonstrated the susceptibility role of HLA-DRB1*04 allele in development of this disease. So, the individuals who were positive for HLA-DRB1*04 allele were excluded. We aimed to appraise the function of cytokines in the pathogenesis of periodontitis via assessment of tissue and blood levels of a number of cytokine coding genes, namely IL-1B, CXCL8, IL-17, IFNG, TGFB and TNFA1. Expressions of IFNG, IL-17, TGFB and TNFA1 were significantly higher in the peripheral blood of individuals with periodontitis compared with unaffected persons (Posterior beta = 1.91, P value = 0.043; Posterior beta = 1.84, P value = 0.033; Posterior beta = 0.713, P value = 0.009 and Posterior beta = 2.85, P value = 0.001, respectively). Moreover, expression of IL-17 was higher in females compared with males (Posterior beta = 1.47, P value = 0.036). As the interaction effect between gender and group was remarkable for IL-17 expression, we further conducted subgroup analysis within gender group. Expression of IL-17 was higher in male patients compared with unaffected males (Posterior beta = 1.9, P value = 0.048). We did not detect any significant difference in the expression of these cytokines in tissues obtained from affected individuals and unaffected controls. Therefore, our results imply dysregulation of cytokine coding genes in patients with periodontitis and warrant further mechanistical studies.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"47-55"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon gamma, interleukin 6 and tissue necrosis factor alpha levels among asymptomatic HIV patients in Benin City, Nigeria. 尼日利亚贝宁市无症状HIV患者的干扰素γ、白细胞介素6和组织坏死因子α水平
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-220014
Godwin Aigbedo Aikpitanyi-Iduitua, Isaiah Nnana Ibeh, Nosakhare Lawrence Idemudia, Rosemary Osamede Aikpitanyi-Iduitua, Richard Omoregie

Background: Morbidity and mortality associated with HIV infection is immune-mediated, and an understanding of HIV immunology will be beneficial in the management of HIV infectionOBJECTIVE: The objective of this research was to measure the levels of TNF-α, IL-6 and IFN-γ in asymptomatic HIV patients and non-HIV subjects, as well as their relationship with CD4 count.

Method: Blood samples were collected from 173 subjects, consisting of 125 asymptomatic HIV patients (44 HAART-naïve and 81 on HAART) and 48 non-HIV subjects. The IFN-, IL-6, and TNF- levels in the blood were determined using enzyme-linked immunosorbent assays, and the CD4 count of all participants was determined using flow cytometry.

Results: Regardless of treatment status, the IFN-γ levels of non-HIV subjects were significantly higher than those of HIV patients (p< 0.001). The opposite was true for IL-6, as the levels of IL-6 in non-HIV subjects were significantly lower than those in HAART-naïve HIV patients (p< 0.001) and those on HAART (p< 0.01). TNF-α levels did not differ between HIV patients and their non-HIV counterparts. Generally, the levels of these cytokines was not affected (p> 0.05) by immunosuppression (measured by CD4 count < 200 cells/μL) and there was no significant correlation between CD4 count and these cytokines (p> 0.05).

Conclusion: In conclusion, asymptomatic HIV infection decreased IFN-γ, increased IL-6, and had no effect on TNF-α levels, regardless of treatment status. Immunosuppression had no impact on these cytokine levels, and there was no relationship between them and CD4 counts.

背景:与HIV感染相关的发病率和死亡率是免疫介导的,了解HIV免疫学将有助于HIV感染的管理。目的:本研究的目的是测量无症状HIV患者和非HIV受试者中TNF-α、IL-6和IFN-γ的水平,以及它们与CD4计数的关系。方法:采集173例患者血样,其中无症状HIV患者125例(HAART-naïve 44例,HAART治疗81例),非HIV患者48例。采用酶联免疫吸附法测定血液中的IFN-、IL-6和TNF-水平,采用流式细胞术测定所有参与者的CD4计数。结果:无论治疗状态如何,非HIV受试者的IFN-γ水平均显著高于HIV患者(p< 0.001)。IL-6的情况正好相反,非HIV受试者的IL-6水平显著低于HAART-naïve HIV患者(p< 0.001)和HAART患者(p< 0.01)。TNF-α水平在HIV患者和非HIV患者之间没有差异。免疫抑制(CD4计数< 200 cells/μL)对上述细胞因子水平无显著影响(p> 0.05), CD4计数与上述细胞因子之间无显著相关性(p> 0.05)。结论:综上所述,无论治疗状态如何,无症状HIV感染均可降低IFN-γ,升高IL-6,对TNF-α水平无影响。免疫抑制对这些细胞因子水平没有影响,它们与CD4计数之间没有关系。
{"title":"Interferon gamma, interleukin 6 and tissue necrosis factor alpha levels among asymptomatic HIV patients in Benin City, Nigeria.","authors":"Godwin Aigbedo Aikpitanyi-Iduitua,&nbsp;Isaiah Nnana Ibeh,&nbsp;Nosakhare Lawrence Idemudia,&nbsp;Rosemary Osamede Aikpitanyi-Iduitua,&nbsp;Richard Omoregie","doi":"10.3233/HAB-220014","DOIUrl":"https://doi.org/10.3233/HAB-220014","url":null,"abstract":"<p><strong>Background: </strong>Morbidity and mortality associated with HIV infection is immune-mediated, and an understanding of HIV immunology will be beneficial in the management of HIV infectionOBJECTIVE: The objective of this research was to measure the levels of TNF-α, IL-6 and IFN-γ in asymptomatic HIV patients and non-HIV subjects, as well as their relationship with CD4 count.</p><p><strong>Method: </strong>Blood samples were collected from 173 subjects, consisting of 125 asymptomatic HIV patients (44 HAART-naïve and 81 on HAART) and 48 non-HIV subjects. The IFN-, IL-6, and TNF- levels in the blood were determined using enzyme-linked immunosorbent assays, and the CD4 count of all participants was determined using flow cytometry.</p><p><strong>Results: </strong>Regardless of treatment status, the IFN-γ levels of non-HIV subjects were significantly higher than those of HIV patients (p< 0.001). The opposite was true for IL-6, as the levels of IL-6 in non-HIV subjects were significantly lower than those in HAART-naïve HIV patients (p< 0.001) and those on HAART (p< 0.01). TNF-α levels did not differ between HIV patients and their non-HIV counterparts. Generally, the levels of these cytokines was not affected (p> 0.05) by immunosuppression (measured by CD4 count < 200 cells/μL) and there was no significant correlation between CD4 count and these cytokines (p> 0.05).</p><p><strong>Conclusion: </strong>In conclusion, asymptomatic HIV infection decreased IFN-γ, increased IL-6, and had no effect on TNF-α levels, regardless of treatment status. Immunosuppression had no impact on these cytokine levels, and there was no relationship between them and CD4 counts.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 4","pages":"177-182"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9464902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of HIV on the risk of COVID-19 death among hospitalized patients. HIV对住院患者COVID-19死亡风险的影响
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-220011
Mehdi Azizmohammad Looha, Nazanin Taraghikhah, Maedeh Amini, Pegah Salimi Pormehr, Negin Talaei, Mahmood Khodadoost, Saeid Gholamzadeh, Reza Vafaee, Gohar Mohammadi

Background: Little is known about the association between Human Immunodeficiency Virus (HIV) infection and risk of death among hospitalized COVID-19 patients. We aimed to investigate this association using a multicenter study.

Material and methods: This multicenter study was conducted using the registry database of Coronavirus Control Operations Headquarter from March 21, 2021 to January 18, 2020 in the province of Tehran, Iran. The interest outcome was COVID-19 death among hospitalized patients living with and without HIV. The Cox regression models with robust standard error were used to estimate the association between HIV infection and risk of COVID-19 death. The subgroup and interaction analysis were also performed in this study.

Results: 326052 patients with COVID-19 were included in the study, of whom 127 (0.04%) were living with HIV. COVID-19 patients with HIV were more likely to be female, older, and to have symptoms such as fever, muscular pain, dyspnea and cough. The death proportion due to COVID-19 was 18 (14.17%) and 21595 (6.63%) among HIV and non-HIV patients, respectively. Patients living with HIV had lower mean survival time compared to those without HIV (26.49 vs. 15.31 days, P-value = 0.047). Crude risk of COVID-19 death was higher among HIV patients than in non-HIV group (hazard ratio[HR]: 1.60, 1.08-2.37). Compared to those without HIV, higher risk of COVID-19 death was observed among patients with HIV after adjusting for sex (1.60, 1.08-2.36), comorbidities (1.49, 1.01-2.19), cancer (1.59, 1.08-2.33), and PO2 (1.68, 1.12-2.50). However, the risk of COVID-19 death was similar in patients with and without HIV after adjusting for age (1.46, 0.98-2.16) and ward (1.30, 0.89-1.89).

Conclusion: We found no strong evidence of association between HIV infection and higher risk of COVID-19 death among hospitalized patients. To determine the true impact of HIV on the risk of COVID-19 death, factors such as age, comorbidities, hospital ward, viral load, CD4 count, and antiretroviral treatment should be considered.

背景:人类免疫缺陷病毒(HIV)感染与住院COVID-19患者死亡风险之间的关系尚不清楚。我们的目的是通过一项多中心研究来调查这种关联。材料和方法:本多中心研究于2021年3月21日至2020年1月18日在伊朗德黑兰省利用冠状病毒控制行动总部的登记数据库进行。感兴趣的结局是感染和不感染艾滋病毒的住院患者中COVID-19死亡。使用具有稳健标准误差的Cox回归模型来估计HIV感染与COVID-19死亡风险之间的关联。本研究还进行了亚组分析和相互作用分析。结果:共纳入326052例COVID-19患者,其中127例(0.04%)为HIV感染者。COVID-19感染艾滋病毒的患者更有可能是女性、年龄较大,并出现发烧、肌肉疼痛、呼吸困难和咳嗽等症状。在HIV和非HIV患者中,因COVID-19死亡的比例分别为18例(14.17%)和21595例(6.63%)。HIV感染者的平均生存时间比未感染HIV的患者低(26.49天比15.31天,p值= 0.047)。HIV患者的COVID-19粗死亡风险高于非HIV组(风险比:1.60,1.08-2.37)。经性别(1.60,1.08-2.36)、合并症(1.49,1.01-2.19)、癌症(1.59,1.08-2.33)和PO2(1.68, 1.12-2.50)校正后,HIV患者的COVID-19死亡风险高于未感染HIV的患者。然而,在调整年龄(1.46,0.98-2.16)和病房(1.30,0.89-1.89)后,感染和未感染艾滋病毒的患者的COVID-19死亡风险相似。结论:我们未发现住院患者中HIV感染与COVID-19死亡风险较高之间存在强有力的关联。要确定艾滋病毒对COVID-19死亡风险的真正影响,应考虑年龄、合并症、医院病房、病毒载量、CD4计数和抗逆转录病毒治疗等因素。
{"title":"The impact of HIV on the risk of COVID-19 death among hospitalized patients.","authors":"Mehdi Azizmohammad Looha,&nbsp;Nazanin Taraghikhah,&nbsp;Maedeh Amini,&nbsp;Pegah Salimi Pormehr,&nbsp;Negin Talaei,&nbsp;Mahmood Khodadoost,&nbsp;Saeid Gholamzadeh,&nbsp;Reza Vafaee,&nbsp;Gohar Mohammadi","doi":"10.3233/HAB-220011","DOIUrl":"https://doi.org/10.3233/HAB-220011","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the association between Human Immunodeficiency Virus (HIV) infection and risk of death among hospitalized COVID-19 patients. We aimed to investigate this association using a multicenter study.</p><p><strong>Material and methods: </strong>This multicenter study was conducted using the registry database of Coronavirus Control Operations Headquarter from March 21, 2021 to January 18, 2020 in the province of Tehran, Iran. The interest outcome was COVID-19 death among hospitalized patients living with and without HIV. The Cox regression models with robust standard error were used to estimate the association between HIV infection and risk of COVID-19 death. The subgroup and interaction analysis were also performed in this study.</p><p><strong>Results: </strong>326052 patients with COVID-19 were included in the study, of whom 127 (0.04%) were living with HIV. COVID-19 patients with HIV were more likely to be female, older, and to have symptoms such as fever, muscular pain, dyspnea and cough. The death proportion due to COVID-19 was 18 (14.17%) and 21595 (6.63%) among HIV and non-HIV patients, respectively. Patients living with HIV had lower mean survival time compared to those without HIV (26.49 vs. 15.31 days, P-value = 0.047). Crude risk of COVID-19 death was higher among HIV patients than in non-HIV group (hazard ratio[HR]: 1.60, 1.08-2.37). Compared to those without HIV, higher risk of COVID-19 death was observed among patients with HIV after adjusting for sex (1.60, 1.08-2.36), comorbidities (1.49, 1.01-2.19), cancer (1.59, 1.08-2.33), and PO2 (1.68, 1.12-2.50). However, the risk of COVID-19 death was similar in patients with and without HIV after adjusting for age (1.46, 0.98-2.16) and ward (1.30, 0.89-1.89).</p><p><strong>Conclusion: </strong>We found no strong evidence of association between HIV infection and higher risk of COVID-19 death among hospitalized patients. To determine the true impact of HIV on the risk of COVID-19 death, factors such as age, comorbidities, hospital ward, viral load, CD4 count, and antiretroviral treatment should be considered.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 4","pages":"165-175"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of anti-thyroid peroxidase and anti-thyroglobulin antibodies on the gestational outcome of euthyroid pregnancies: A retrospective study. 抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体对甲状腺功能正常妊娠结局的影响:一项回顾性研究。
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-220010
Kemal Beksac, Hanife Guler Donmez, Murat Cagan, Mehmet Sinan Beksac

Background: Thyroglobulin (anti-TG) and/or thyroid peroxidase (anti-TPO) autoantibodies are associated with higher rates of poor gestational outcomes.

Objective: To demonstrate the impact of anti-TPO and anti-TG autoantibodies on the gestational outcomes of euthyroid pregnant women with a history of poor gestational outcome and thyroid gland disorders.

Methods: This retrospective study included totally 75 euthyroid pregnant, 30 of women with high thyroid autoantibodies (Anti-TPO/Thyroglobulin-positive group) and 45 of them without autoantibodies (control group).

Results: We could not demonstrate significant differences between two groups in terms of risk factors/co-morbidities, obstetric complications, gestational outcomes, and birth data (p> 0.05). However, enhanced miscarriage rates were observed among the Anti-TPO/Thyroglobulin-positive and control groups without significance (36.7% and 17.8% respectively, p= 0.116). High neonatal intensive care unit (NICU) admission rates were found for control and Anti-TPO/Thyroglobulin-positive groups (16.2% and 21.1%, respectively) (p= 0.720). Clinically, we compared the two groups in terms of the existence and the types of goiter (diffuse and nodular), and demonstrated that nodular goiter was statistically more frequent in the control group (40.0% vs. 8.7%, p= 0.015). Alongside, relatively high hereditary thrombophilia and type-2 diabetes mellitus rates were found in the Anti-TPO/Thyroglobulin-positive group (20.0% and 20.0%).

Conclusion: Thyroid autoantibody positivity is likely a risk factor for early pregnancy loss and NICU admission.

背景:甲状腺球蛋白(抗tg)和/或甲状腺过氧化物酶(抗tpo)自身抗体与妊娠结局不良的高发率相关。目的:探讨抗tpo和抗tg自身抗体对有不良妊娠结局和甲状腺疾病史的甲状腺功能正常孕妇妊娠结局的影响。方法:回顾性研究75例甲状腺功能正常的孕妇,其中甲状腺自身抗体高的孕妇30例(抗tpo /甲状腺球蛋白阳性组),无自身抗体的孕妇45例(对照组)。结果:我们无法证明两组在危险因素/合并症、产科并发症、妊娠结局和出生数据方面存在显著差异(p> 0.05)。抗tpo /甲状腺球蛋白阳性组与对照组流产率增高,差异无统计学意义(分别为36.7%和17.8%,p= 0.116)。对照组和抗tpo /甲状腺球蛋白阳性组新生儿重症监护病房(NICU)入院率较高(分别为16.2%和21.1%)(p= 0.720)。临床比较两组甲状腺肿的存在及类型(弥漫性和结节性),发现对照组结节性甲状腺肿发生率更高(40.0%比8.7%,p= 0.015)。此外,抗tpo /甲状腺球蛋白阳性组的遗传性血栓病和2型糖尿病发生率相对较高(20.0%和20.0%)。结论:甲状腺自身抗体阳性可能是早期妊娠流产和新生儿重症监护病房住院的危险因素。
{"title":"Impact of anti-thyroid peroxidase and anti-thyroglobulin antibodies on the gestational outcome of euthyroid pregnancies: A retrospective study.","authors":"Kemal Beksac,&nbsp;Hanife Guler Donmez,&nbsp;Murat Cagan,&nbsp;Mehmet Sinan Beksac","doi":"10.3233/HAB-220010","DOIUrl":"https://doi.org/10.3233/HAB-220010","url":null,"abstract":"<p><strong>Background: </strong>Thyroglobulin (anti-TG) and/or thyroid peroxidase (anti-TPO) autoantibodies are associated with higher rates of poor gestational outcomes.</p><p><strong>Objective: </strong>To demonstrate the impact of anti-TPO and anti-TG autoantibodies on the gestational outcomes of euthyroid pregnant women with a history of poor gestational outcome and thyroid gland disorders.</p><p><strong>Methods: </strong>This retrospective study included totally 75 euthyroid pregnant, 30 of women with high thyroid autoantibodies (Anti-TPO/Thyroglobulin-positive group) and 45 of them without autoantibodies (control group).</p><p><strong>Results: </strong>We could not demonstrate significant differences between two groups in terms of risk factors/co-morbidities, obstetric complications, gestational outcomes, and birth data (p> 0.05). However, enhanced miscarriage rates were observed among the Anti-TPO/Thyroglobulin-positive and control groups without significance (36.7% and 17.8% respectively, p= 0.116). High neonatal intensive care unit (NICU) admission rates were found for control and Anti-TPO/Thyroglobulin-positive groups (16.2% and 21.1%, respectively) (p= 0.720). Clinically, we compared the two groups in terms of the existence and the types of goiter (diffuse and nodular), and demonstrated that nodular goiter was statistically more frequent in the control group (40.0% vs. 8.7%, p= 0.015). Alongside, relatively high hereditary thrombophilia and type-2 diabetes mellitus rates were found in the Anti-TPO/Thyroglobulin-positive group (20.0% and 20.0%).</p><p><strong>Conclusion: </strong>Thyroid autoantibody positivity is likely a risk factor for early pregnancy loss and NICU admission.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mini-review: The market growth of diagnostic and therapeutic monoclonal antibodies - SARS CoV-2 as an example. 小回顾:诊断和治疗单克隆抗体的市场增长——以SARS CoV-2为例。
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-211513
Yasmine El Abd, Ashraf Tabll, Robert Smolic, Martina Smolic

Background: The emergence of novel viruses poses severe challenges to global public health highlighting the crucial necessity for new antivirals.

Main body: Monoclonal antibodies (mAbs) are immunoglobulins that bind to a single epitope. Mouse mAbs are generated by classic hybridoma technology and are mainly used for immunodiagnostics. For immunotherapy, it is critical to use monoclonal antibodies in their human form to minimize adverse reactions. They have been successfully used to treat numerous illnesses, accordingly, an increasing number of mAbs, with high potency against emerging viruses is the target of every biopharmaceutical company. The diagnostic and therapeutic mAbs market grows rapidly into a multi-billion-dollar business. Biopharmaceuticals are innovative resolutions which revolutionized the treatment of significant chronic diseases and malignancies. Currently, a variety of therapeutic options that include antiviral medications, monoclonal antibodies, and immunomodulatory agents are available for the management of COVID-19.

Short conclusion: The invasion of mAbs in new medical sectors will increase the market magnitude as it is expected to generate revenue of about 300 billion $ by 2025. In the current mini-review, the applications of monoclonal antibodies in immune-diagnosis and immunotherapy will be demonstrated, particularly for COVID-19 infection and will focus mainly on monoclonal antibodies in the market.

背景:新型病毒的出现给全球公共卫生带来了严峻的挑战,强调了开发新型抗病毒药物的必要性。主体:单克隆抗体(mab)是一种结合单一表位的免疫球蛋白。小鼠单克隆抗体是由经典杂交瘤技术产生的,主要用于免疫诊断。对于免疫治疗,关键是使用单克隆抗体的人的形式,以尽量减少不良反应。它们已经成功地用于治疗许多疾病,因此,越来越多的单克隆抗体,对新出现的病毒具有高效力,是每个生物制药公司的目标。诊断和治疗单克隆抗体市场迅速成长为数十亿美元的业务。生物制药是革命性的解决方案,它彻底改变了重大慢性疾病和恶性肿瘤的治疗。目前,包括抗病毒药物、单克隆抗体和免疫调节剂在内的多种治疗方案可用于COVID-19的管理。简短的结论:单抗在新医疗领域的入侵将增加市场规模,预计到2025年将产生约3000亿美元的收入。在本次迷你综述中,将展示单克隆抗体在免疫诊断和免疫治疗中的应用,特别是在COVID-19感染方面的应用,并将主要关注市场上的单克隆抗体。
{"title":"Mini-review: The market growth of diagnostic and therapeutic monoclonal antibodies - SARS CoV-2 as an example.","authors":"Yasmine El Abd,&nbsp;Ashraf Tabll,&nbsp;Robert Smolic,&nbsp;Martina Smolic","doi":"10.3233/HAB-211513","DOIUrl":"https://doi.org/10.3233/HAB-211513","url":null,"abstract":"<p><strong>Background: </strong>The emergence of novel viruses poses severe challenges to global public health highlighting the crucial necessity for new antivirals.</p><p><strong>Main body: </strong>Monoclonal antibodies (mAbs) are immunoglobulins that bind to a single epitope. Mouse mAbs are generated by classic hybridoma technology and are mainly used for immunodiagnostics. For immunotherapy, it is critical to use monoclonal antibodies in their human form to minimize adverse reactions. They have been successfully used to treat numerous illnesses, accordingly, an increasing number of mAbs, with high potency against emerging viruses is the target of every biopharmaceutical company. The diagnostic and therapeutic mAbs market grows rapidly into a multi-billion-dollar business. Biopharmaceuticals are innovative resolutions which revolutionized the treatment of significant chronic diseases and malignancies. Currently, a variety of therapeutic options that include antiviral medications, monoclonal antibodies, and immunomodulatory agents are available for the management of COVID-19.</p><p><strong>Short conclusion: </strong>The invasion of mAbs in new medical sectors will increase the market magnitude as it is expected to generate revenue of about 300 billion $ by 2025. In the current mini-review, the applications of monoclonal antibodies in immune-diagnosis and immunotherapy will be demonstrated, particularly for COVID-19 infection and will focus mainly on monoclonal antibodies in the market.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"15-24"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39878194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Comparison of some hematological parameters between male and female patients infected with COVID-19. 新型冠状病毒肺炎(COVID-19)男女患者血液学指标比较
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-220006
Hayder H Abed, Ahmed Ghdhban Al-Ziaydi, Ihab Abbas Taher, Ahmed K Al Dulaimi

Background: COVID-19 is a highly contagious virus that is rapidly spreading across the world. As the number of COVID-19 patients is quickly rising, and certain nations and areas, such as the third world countries, lack the medical resources, it is critical to track and monitor a patient's status using blood parameters on regular testing. The aim of this study is to compare the serum D-dimer levels, Ferritin, CRP, WBCs, Lymphocytes, and Neutrophils in male and female patients infected with COVID-19.

Objective and methods: The study procedure includes evaluating the D-dimer level, Ferritin, CRP, WBCs, lymphocytes, and neutrophils in 116 patients infected with COVID-19 (48 Females and 68 Males).

Result: The result of this study shows a significant increase in the D-dimer level in males 1618 ± 247.7 ng/ml compared to females 684.5 ± 53.69 ng/ml and a significant increase in Ferritin level in males 525.6 ± 69.55 μg/L compared to females 254.1 ± 33.73 μg/L. However, no other significant change is seen in the other parameters (CRP, LDH, and WBCs, L, and N) although all of these parameters are abnormal, compared to the normal reference values.

Conclusion: This study concludes that there is a significant increase in the D-dimer and Ferritin concentrations in male patients compared to female patients, who were infected with COVID-19. Also there are no significant differences in other parameters (CRP, LDH, WBCs, L, and N) between male and female patients.

背景:COVID-19是一种高度传染性的病毒,正在全球迅速传播。随着新冠肺炎患者数量的迅速增加,第三世界国家等某些国家和地区缺乏医疗资源,利用定期检测的血液参数跟踪和监测患者的状况至关重要。本研究的目的是比较男性和女性感染COVID-19患者的血清d -二聚体水平、铁蛋白、CRP、白细胞、淋巴细胞和中性粒细胞。目的和方法:研究程序包括评估116例COVID-19感染患者(女性48例,男性68例)的d -二聚体水平、铁蛋白、CRP、白细胞、淋巴细胞和中性粒细胞。结果:本研究结果显示,雄性d -二聚体水平(1618±247.7 ng/ml)显著高于雌性(684.5±53.69 ng/ml);雄性铁蛋白水平(525.6±69.55 μg/L)显著高于雌性(254.1±33.73 μ L)。然而,与正常参考值相比,其他参数(CRP、LDH、wbc、L和N)均不正常,但未见其他显著变化。结论:与女性患者相比,男性患者的d -二聚体和铁蛋白浓度明显升高。其他参数(CRP、LDH、wbc、L、N)在男女患者之间也无显著差异。
{"title":"Comparison of some hematological parameters between male and female patients infected with COVID-19.","authors":"Hayder H Abed,&nbsp;Ahmed Ghdhban Al-Ziaydi,&nbsp;Ihab Abbas Taher,&nbsp;Ahmed K Al Dulaimi","doi":"10.3233/HAB-220006","DOIUrl":"https://doi.org/10.3233/HAB-220006","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 is a highly contagious virus that is rapidly spreading across the world. As the number of COVID-19 patients is quickly rising, and certain nations and areas, such as the third world countries, lack the medical resources, it is critical to track and monitor a patient's status using blood parameters on regular testing. The aim of this study is to compare the serum D-dimer levels, Ferritin, CRP, WBCs, Lymphocytes, and Neutrophils in male and female patients infected with COVID-19.</p><p><strong>Objective and methods: </strong>The study procedure includes evaluating the D-dimer level, Ferritin, CRP, WBCs, lymphocytes, and neutrophils in 116 patients infected with COVID-19 (48 Females and 68 Males).</p><p><strong>Result: </strong>The result of this study shows a significant increase in the D-dimer level in males 1618 ± 247.7 ng/ml compared to females 684.5 ± 53.69 ng/ml and a significant increase in Ferritin level in males 525.6 ± 69.55 μg/L compared to females 254.1 ± 33.73 μg/L. However, no other significant change is seen in the other parameters (CRP, LDH, and WBCs, L, and N) although all of these parameters are abnormal, compared to the normal reference values.</p><p><strong>Conclusion: </strong>This study concludes that there is a significant increase in the D-dimer and Ferritin concentrations in male patients compared to female patients, who were infected with COVID-19. Also there are no significant differences in other parameters (CRP, LDH, WBCs, L, and N) between male and female patients.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"151-155"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40470317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误表。
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-229000
{"title":"Erratum.","authors":"","doi":"10.3233/HAB-229000","DOIUrl":"10.3233/HAB-229000","url":null,"abstract":"","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"57"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39769267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of molecular apoptosis signaling pathways and its correlation with EBV viral load in SLE patients using systems biology approach. 应用系统生物学方法评估SLE患者分子凋亡信号通路及其与EBV病毒载量的相关性
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-211505
Soad Ghabeshi, Ali Najafi, Batol Zamani, Mozhdeh Soltani, Amanuel Godana Arero, Shim Izadi, Ahmad Piroozmand

Background: Considerable evidence supports that SLE could be related to apoptotic cells and EBV infection.

Objective: The aim of this study was to identify the transcriptional signature of EBV infection in SLE patients for survey of the molecular apoptosis signaling pathways.

Methods: The PBMCs gene expression profiles of healthy control and SLE patients were obtained from GEO. Functional annotation and signaling pathway enrichment were carried out using DAVID, KEGG. To validate bioinformatics analysis the changes in genes expression of some of obtained genes, Real time PCR was performed on PBMCs from 28 SLE patients and 18 controls.

Results: We found that mean viral load was 6013 ± 390.1 copy/μg DNA from PBMCs in all patients. QRT-PCR results showed that the expression of the DUSP1 and LAMP3 genes which had most changes in the logFC among 4 candidate genes, increased significantly in comparison with control. The consistent expression of LMP2 as viral latency gene involve in apoptosis signaling pathways was detected in SLE patients with EBV viral load and some controls.

Conclusions: The study indicated that some cellular genes may have an important role in pathogenesis of SLE through apoptosis signaling pathways. Beside, EBV infection as an environmental risk factor for SLE may affect the dysfunction of apoptosis.

背景:大量证据支持SLE可能与细胞凋亡和EBV感染有关。目的:本研究的目的是鉴定EBV感染SLE患者的转录特征,以调查分子凋亡信号通路。方法:从GEO获取健康对照和SLE患者的PBMCs基因表达谱。使用DAVID、KEGG进行功能注释和信号通路富集。为了验证生物信息学分析中部分基因表达变化的有效性,我们对28例SLE患者和18例对照组的pbmc进行了Real time PCR检测。结果:所有患者外周血单核细胞的平均病毒载量为6013±390.1拷贝/μg DNA。QRT-PCR结果显示,4个候选基因中logFC变化最大的DUSP1和LAMP3基因的表达量较对照显著升高。LMP2作为参与细胞凋亡信号通路的病毒潜伏期基因,在EBV病毒载量的SLE患者和部分对照组中表达一致。结论:本研究提示一些细胞基因可能通过凋亡信号通路在SLE发病中起重要作用。此外,EBV感染作为SLE的环境危险因素可能影响细胞凋亡功能障碍。
{"title":"Evaluation of molecular apoptosis signaling pathways and its correlation with EBV viral load in SLE patients using systems biology approach.","authors":"Soad Ghabeshi,&nbsp;Ali Najafi,&nbsp;Batol Zamani,&nbsp;Mozhdeh Soltani,&nbsp;Amanuel Godana Arero,&nbsp;Shim Izadi,&nbsp;Ahmad Piroozmand","doi":"10.3233/HAB-211505","DOIUrl":"https://doi.org/10.3233/HAB-211505","url":null,"abstract":"<p><strong>Background: </strong>Considerable evidence supports that SLE could be related to apoptotic cells and EBV infection.</p><p><strong>Objective: </strong>The aim of this study was to identify the transcriptional signature of EBV infection in SLE patients for survey of the molecular apoptosis signaling pathways.</p><p><strong>Methods: </strong>The PBMCs gene expression profiles of healthy control and SLE patients were obtained from GEO. Functional annotation and signaling pathway enrichment were carried out using DAVID, KEGG. To validate bioinformatics analysis the changes in genes expression of some of obtained genes, Real time PCR was performed on PBMCs from 28 SLE patients and 18 controls.</p><p><strong>Results: </strong>We found that mean viral load was 6013 ± 390.1 copy/μg DNA from PBMCs in all patients. QRT-PCR results showed that the expression of the DUSP1 and LAMP3 genes which had most changes in the logFC among 4 candidate genes, increased significantly in comparison with control. The consistent expression of LMP2 as viral latency gene involve in apoptosis signaling pathways was detected in SLE patients with EBV viral load and some controls.</p><p><strong>Conclusions: </strong>The study indicated that some cellular genes may have an important role in pathogenesis of SLE through apoptosis signaling pathways. Beside, EBV infection as an environmental risk factor for SLE may affect the dysfunction of apoptosis.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":"30 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer. 程序性死亡-1和程序性死亡配体-1蛋白在乳腺癌中的预后意义。
Q3 Medicine Pub Date : 2022-01-01 DOI: 10.3233/HAB-220001
Imtiaz Mahmood Tahir, Abdur Rauf, Huma Mehboob, Samia Sadaf, Muhammad Shaiful Alam, Fadia Kalsoom, Abdelhakim Bouyahya, Aicha El Allam, Nasreddine El Omari, Saad Bakrim, Muhammad Akram, Syed Kashif Raza, Talha Bin Emran, Yahia N Mabkhot, Gokhan Zengin, Marina Derkho, Suray Natalya, Mohammad Ali Shariati

In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer. Our inclusion criteria included studies showing the synergy between the expression of PD-L1 and PD-1 in primary breast cancers as prognostic markers and this research was limited to humans only. We included review articles, original research, letters to the editor, case reports, and short communications in our study, published in English. We focused our work on PD-L1 mRNA expression in breast cancer cell lines. PD-L1 expression has been decisively demonstrated to be a high-risk factor for breast cancer with a bad prognosis.

在许多与肿瘤预后相关的研究中,程序性死亡配体1 (programmed death-ligand 1, PD-L1)已被确定为一种生物标志物。这项工作旨在确定PD-L1在乳腺癌预后中的重要性。我们检索了PubMed、Google scholar、出版集团主页、医学、临床和制药科学期刊等电子数据库,以及其他相关来源,以发现PD-1和PD-L1表达在乳腺癌治疗和复发中的重要性。搜索中使用的关键词是自身免疫、程序性细胞死亡、PD-L1或PD-1和乳腺癌。我们的纳入标准包括了显示PD-L1和PD-1在原发性乳腺癌中作为预后标志物的表达之间的协同作用的研究,并且这项研究仅限于人类。在我们的研究中,我们包括了评论文章、原始研究、给编辑的信、病例报告和简短的交流,这些都是用英语发表的。我们的工作重点是PD-L1 mRNA在乳腺癌细胞系中的表达。PD-L1表达已被明确证明是乳腺癌预后不良的高危因素。
{"title":"Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer.","authors":"Imtiaz Mahmood Tahir,&nbsp;Abdur Rauf,&nbsp;Huma Mehboob,&nbsp;Samia Sadaf,&nbsp;Muhammad Shaiful Alam,&nbsp;Fadia Kalsoom,&nbsp;Abdelhakim Bouyahya,&nbsp;Aicha El Allam,&nbsp;Nasreddine El Omari,&nbsp;Saad Bakrim,&nbsp;Muhammad Akram,&nbsp;Syed Kashif Raza,&nbsp;Talha Bin Emran,&nbsp;Yahia N Mabkhot,&nbsp;Gokhan Zengin,&nbsp;Marina Derkho,&nbsp;Suray Natalya,&nbsp;Mohammad Ali Shariati","doi":"10.3233/HAB-220001","DOIUrl":"https://doi.org/10.3233/HAB-220001","url":null,"abstract":"<p><p>In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer. Our inclusion criteria included studies showing the synergy between the expression of PD-L1 and PD-1 in primary breast cancers as prognostic markers and this research was limited to humans only. We included review articles, original research, letters to the editor, case reports, and short communications in our study, published in English. We focused our work on PD-L1 mRNA expression in breast cancer cell lines. PD-L1 expression has been decisively demonstrated to be a high-risk factor for breast cancer with a bad prognosis.</p>","PeriodicalId":53564,"journal":{"name":"Human Antibodies","volume":" ","pages":"131-150"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40593062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Human Antibodies
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1