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Robot-assistance in revision thoracolumbar fusion surgeries – Prospective study of 64 patients 机器人辅助翻修胸腰椎融合手术- 64例患者的前瞻性研究
Q2 Medicine Pub Date : 2025-10-29 DOI: 10.1016/j.jcot.2025.103247
Balamurugan Thirugnanam , Vidyadhara Srinivasa , Abhishek Soni , Akhil Xavier Joseph , R Dinesh Iyer

Background

Robot-assisted spine surgery is currently gaining popularity in thoracolumbar spine instrumentation because of enhanced precision and safety. Revision spine surgeries present unique challenges by virtue of abnormal anatomical bony landmarks, broken implants/bone cement in-situ and loose implant tracts, posing difficulties in re-implantation of screws. We evaluated the usefulness of Robot-assistance in Revision Spine Surgeries for varied pathologies.

Methods

We prospectively analysed 64 consecutive patients undergoing Revision Thoracolumbar Spine Instrumented Fusion Surgeries over one-year. The causes of revision surgery were broken implants (20), adjacent segment disease (19), revision deformity surgeries (12), surgical site infection with implant loosing (8) and failed back syndrome secondary to cement augmentation (5). The O-arm time, cut to close time, radiation dose, robot time, time per screw, operative time, blood loss, screw accuracy, and intraoperative complications were noted.

Results

Robot-assisted revision pedicle screw placement was successfully performed for 388 screws in 64 patients. The mean O-arm time was 10.3 ± 2.2 min, cut to close time was 157.9 ± 45.8 min, and radiation dose was 16.6 ± 3.7 mGy, robot time was 18.2 ± 3.7 min, time per screw was 3.1 ± 1.3 min, and blood loss was 538.8 ± 156.9 mL. No intraoperative complications were reported. Two out of 388 revised screws was misplaced without clinical implications

Conclusions

Robot-assisted revision thoracolumbar spine surgery offers alternate safe bony corridors for placement of screws in revision spine surgeries with loose/broken implants/bone cement with accuracy and safety. It demonstrated acceptable operative time, blood loss, and radiation exposure with high screw placement accuracy and no intraoperative complications.
机器人辅助脊柱手术目前在胸腰椎内固定中越来越受欢迎,因为它提高了精度和安全性。脊柱翻修手术面临着独特的挑战,因为解剖性骨标记异常,植入物/原位骨水泥断裂,植入物束松动,给螺钉的再植入带来了困难。我们评估了机器人辅助在脊柱翻修手术中对不同病理的有用性。方法前瞻性分析64例连续1年接受改良胸腰椎内固定融合手术的患者。翻修手术的原因包括假体断裂(20例)、邻近节段疾病(19例)、翻修畸形手术(12例)、手术部位感染导致假体松动(8例)和骨水泥增强后继发背部综合征(5例)。观察o型臂时间、切断至闭合时间、辐射剂量、机器人时间、每颗螺钉时间、手术时间、出血量、螺钉精度、术中并发症。结果64例患者共388枚机器人辅助翻修椎弓根螺钉置入成功。平均o臂时间为10.3±2.2 min,切至闭合时间为157.9±45.8 min,放射剂量为16.6±3.7 mGy,机器人时间为18.2±3.7 min,每颗螺钉时间为3.1±1.3 min,出血量538.8±156.9 mL,无术中并发症报告。结论机器人辅助的胸腰椎翻修手术为使用松动/破碎植入物/骨水泥翻修脊柱手术中的螺钉放置提供了安全的替代骨通道,具有准确性和安全性。手术时间、出血量、放射线暴露均可接受,置钉精度高,无术中并发症。
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引用次数: 0
Machine-learning prediction of 90-day readmission following primary TKA: Insights from 2,123 cases in the Michigan arthroplasty registry 机器学习预测原发性TKA后90天再入院:来自密歇根州关节置换术登记处2123例的见解
Q2 Medicine Pub Date : 2025-10-28 DOI: 10.1016/j.jcot.2025.103250
Usher Khan , Zachary Crespi , Fong Nham , Chaoyang Chen , Bryan Little , Hussein Darwiche

Background

Despite peri-operative advances, unplanned 90-day readmission after total knee arthroplasty (TKA) remains a costly quality metric. We leveraged statewide registry data and machine-learning analytics to quantify contemporary risk and uncover modifiable drivers.

Methods

We retrospectively reviewed all primary TKAs performed between 2016 and 2024 at a MARCQI-participating academic hospital. Demographics, comorbidities, peri-operative factors, and medication use were compared between patients with and without 90-day readmission. A multilayer perceptron neural network (MPNN) incorporating 10 routinely collected variables (age, sex, race, marital status, length of stay [LOS], smoking, alcohol, bleeding disorder, prior DVT/PE, ASA class) was trained (70 %) and validated (30 %) to predict readmission; model performance was assessed by accuracy, AUC, and variable importance.

Results

Among 2123 TKAs, 86 patients (4.1 %) were readmitted. Compared with non-readmitted patients, those readmitted had higher ASA scores (2.92 ± 0.49 vs 2.72 ± 0.48), longer LOS (2.97 ± 1.43 vs 2.32 ± 1.30 days), more prior DVT/PE (11.9 % vs 5.8 %), and greater pre-operative opioid use (5.0 % vs 3.2 %) (all p ≤ .036). LOS (ρ = 0.10) ranked highest on correlation analysis, while home/self-care discharge correlated negatively (ρ = −0.06). The MPNN achieved 96.0 % accuracy and AUC 0.704; LOS was the strongest predictor (importance 100 %), followed by ASA class, race, prior DVT/PE, and bleeding disorders.

Conclusions

Although uncommon, 90-day readmission after primary TKA is chiefly associated with prolonged LOS, elevated ASA status, prior thromboembolism, opioid exposure, and non-home discharge. Targeted enhancements -- aggressive VTE prophylaxis, opioid-sparing analgesia, and streamlined discharge pathways promoting safe home return -- may further curb readmissions and related costs.
尽管围手术期有进展,但全膝关节置换术(TKA)后90天的意外再入院仍然是一个代价高昂的质量指标。我们利用全州注册数据和机器学习分析来量化当代风险,并发现可修改的驱动因素。方法回顾性分析2016年至2024年在一家参与marcqi的学术医院进行的所有原发性tka。统计数据、合并症、围手术期因素和药物使用在有和没有90天再入院的患者之间进行比较。一个多层感知器神经网络(MPNN)包含10个常规收集的变量(年龄、性别、种族、婚姻状况、住院时间[LOS]、吸烟、酒精、出血性疾病、既往DVT/PE、ASA等级)进行训练(70%)和验证(30%)来预测再入院;通过准确性、AUC和变量重要性来评估模型的性能。结果2123例tka患者中有86例(4.1%)再次入院。与非再入院患者相比,再入院患者ASA评分较高(2.92±0.49 vs 2.72±0.48),LOS较长(2.97±1.43 vs 2.32±1.30天),既往DVT/PE较多(11.9% vs 5.8%),术前阿片类药物使用较多(5.0% vs 3.2%)(均p≤0.036)。在相关分析中,LOS (ρ = 0.10)最高,而居家/自我护理出院(ρ = - 0.06)呈负相关。MPNN的准确率为96.0%,AUC为0.704;LOS是最强的预测因子(重要性100%),其次是ASA等级、种族、既往DVT/PE和出血性疾病。结论原发性TKA术后90天再入院主要与LOS延长、ASA状态升高、既往血栓栓塞、阿片类药物暴露和非居家出院有关。有针对性的增强措施——积极的静脉血栓栓塞预防、阿片类药物节约镇痛和促进安全回家的流线型出院途径——可能进一步抑制再入院和相关费用。
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引用次数: 0
Precision of preoperative planning in medial opening wedge high tibial osteotomy: A retrospective study 胫骨内侧开口楔形高位截骨术术前计划精度的回顾性研究
Q2 Medicine Pub Date : 2025-10-28 DOI: 10.1016/j.jcot.2025.103254
Ana Suarez-Quintero , Javier Olmedo Palma , Ramon Alvarez de Manzaneda

Background

Medial opening wedge high tibial osteotomy (HTO) is a valid treatment for unicompartmental osteoarthritis due to varus alignment. This study aimed to examine the relationships between preoperative planning, intraoperative opening, and postoperative measurements, focusing on the correction of the mechanical axis.

Methods

Radiological measurements, including HKA, mPTA, mLDFA, JLCA, and %WBL, were compared in 21 patients before and after surgery. The osteotomy size was calculated manually using the Miniaci method. A regression analysis determined which variables influenced successful correction (%WBL postoperative 45–55 %).

Results

The mean age was 40 years. The difference between the intraoperative opening and the Miniaci-calculated size was 0.45 ± 1.05 mm (p = 0.048). Postoperative corrections were significant for HKA, mMPTA, and %WBL (p < 0.001). Preoperative HKA and Miniaci values negatively predicted successful correction.

Conclusions

The Miniaci method tends to underestimate intraoperative opening size, but still allows for sufficient correction of the mechanical axis to the joint center.
背景:内侧开口楔形胫骨高位截骨术(HTO)是治疗内翻对准引起的单室骨关节炎的有效方法。本研究旨在探讨术前计划、术中开放和术后测量之间的关系,重点关注机械轴的校正。方法对21例患者手术前后的HKA、mPTA、mLDFA、JLCA、WBL %等影像学指标进行比较。采用Miniaci方法人工计算截骨大小。回归分析确定哪些变量影响成功矫正(术后WBL % 45 - 55%)。结果患者平均年龄40岁。术中开口与miniaci计算的开口大小的差异为0.45±1.05 mm (p = 0.048)。术后矫正对HKA、mMPTA和%WBL有显著意义(p < 0.001)。术前HKA和Miniaci值负向预测矫正成功。结论Miniaci方法往往会低估术中开口的大小,但仍然允许机械轴到关节中心的足够修正。
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引用次数: 0
Predictive variables influencing intraoperative blood loss during single-stage posterior spinal fusion in severe idiopathic scoliosis: Analysis of 126 cases 影响严重特发性脊柱侧凸单期后路融合术中出血量的预测变量:126例分析
Q2 Medicine Pub Date : 2025-10-27 DOI: 10.1016/j.jcot.2025.103248
Y. Mihara , S.Y. Lee , C.Y.W. Chan , C.K. Chiu , M.S. Hasan , M.K. Kwan

Background

Despite the clinical importance, few studies have specifically addressed intraoperative blood loss in patients with severe idiopathic scoliosis undergoing posterior spinal fusion (PSF). Therefore, this study seeks to investigate independent predictors of intraoperative bleeding during single-stage PSF in this high-risk population.

Methods

A retrospective analysis was conducted on 126 patients with severe IS (defined as a major Cobb angle ≥90°) who underwent single-stage PSF without osteotomy procedures. Key parameters collected included preoperative Cobb angle (Pre Cobb), postoperative Cobb angle (Post Cobb), correction rate (CR), side-bending Cobb angle (SB Cobb), side-bending flexibility (SBF), side-bending correction index (SBCI), total number of fusion levels, number of pedicle screws utilized, and operative time (Op Time). The estimated total intraoperative blood loss (EBL) was quantified. Multiple regression analysis was employed to identify independent predictors of intraoperative blood loss.

Results

The mean pre Cobb was 103.0 + 12.4° and post Cobb was 45.1 + 14.0°. The mean CR was 56.1 + 12.8 %. The mean SB Cobb and flexibility were 65.0 + 19.4° and 37.7 + 13.7 %. Average SBCI was 1.8 + 1.2. The mean fusion levels and number of screws used were 13.3 + 1.3 and 16.3 + 1.6, respectively. The mean Op time in this study was 185.9 + 49.3 min. The mean EBL was 1493.0 + 841.0 mL, EBL/EBV ratio was 51.6 + 29.1 %, and EBL/level fused was 112.0 ± 62.0 mL. Multiple regression analysis identified Op time, gender, and pre Cobb as the independent predictors for EBL (R2 0.281; p < 0.05). The derived predictive formula was EBL = −1747.0 + (5.6 x Op time) + (13.9 x pre Cobb) + (697.0 x G), where G = 2 for male and G = 1 for female.

Conclusions

Operative time, male gender, and preoperative major Cobb angle were the significant predictive factors for EBL in single-stage PSF surgery for severe IS patients.
背景:尽管具有重要的临床意义,但很少有研究专门针对严重特发性脊柱侧凸后路脊柱融合术(PSF)患者术中失血的问题。因此,本研究旨在探讨这一高危人群单期PSF术中出血的独立预测因素。方法回顾性分析126例重度IS患者(定义为Cobb角≥90°),均行单期PSF,未行截骨术。收集的关键参数包括术前Cobb角(Pre Cobb)、术后Cobb角(Post Cobb)、矫正率(CR)、侧弯Cobb角(SB Cobb)、侧弯柔韧性(SBF)、侧弯矫正指数(SBCI)、融合度总数、椎弓根螺钉使用数量、手术时间(Op time)。估计术中总失血量(EBL)被量化。采用多元回归分析确定术中出血量的独立预测因素。结果术前Cobb平均为103.0 + 12.4°,术后Cobb平均为45.1 + 14.0°。平均CR为56.1 + 12.8%。平均SB Cobb和柔韧性分别为65.0 + 19.4°和37.7 + 13.7%。平均SBCI为1.8 + 1.2。平均融合度为13.3 + 1.3,螺钉数量为16.3 + 1.6。本研究的平均手术时间为185.9 + 49.3 min。平均EBL为1493.0 + 841.0 mL, EBL/EBV比值为51.6 + 29.1%,EBL/融合水平为112.0±62.0 mL。多元回归分析发现,手术时间、性别、前Cobb是EBL的独立预测因子(R2 0.281; p < 0.05)。推导出的预测公式为EBL = - 1747.0 + (5.6 x操作时间)+ (13.9 x预Cobb) + (697.0 x G),其中男性G = 2,女性G = 1。结论手术时间、男性、术前Cobb大角是严重IS患者单期PSF手术中EBL发生的重要预测因素。
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引用次数: 0
Elastic stable intramedullary nailing for pediatric forearm fractures: A review article 弹性稳定髓内钉治疗儿童前臂骨折:综述文章
Q2 Medicine Pub Date : 2025-10-25 DOI: 10.1016/j.jcot.2025.103249
Esha Reddy , Aakanksha Sriwastwa , Saral Patel , Rajul Gupta , Shital N. Parikh
Fractures of the shaft of the radius and ulna are common injuries in children and adolescents. Undisplaced fractures and fractures that are stable after closed reduction, can be treated with cast immobilization and an interosseous mold. Healing is reliable in children and remodeling would help to correct any residual malunion at the fracture site. However, in older children and adolescents, where the healing and remodeling potential is limited, and for unstable fractures, surgical intervention may be necessary. Intramedullary nailing using elastic nails, also known as elastic stable intramedullary nailing (ESIN) is the gold standard for surgical treatment of forearm fractures in children and adolescents, as it is physeal-sparing, safe, reliable and minimally invasive. There are several pearls and pitfalls related to the surgical technique of ESIN which would be discussed in this article. It does require a second surgery for removal of the nails once fracture is healed. The overall outcomes of ESIN of forearm shaft fracture are very satisfactory. Most of the complications are technique-related and can be avoided by meticulous attention to details. The aim of this narrative review article is to provide an overview of the indications, surgical techniques, clinical outcomes and potential complications of ESIN of forearm shaft fractures. It is important for orthopaedic surgeons who treat these fractures in children to master the art of ESIN.
桡骨和尺骨干骨折是儿童和青少年常见的损伤。未移位骨折和闭合复位后稳定的骨折可采用石膏固定和骨间模塑治疗。儿童愈合是可靠的,重建将有助于纠正骨折部位的任何残留畸形愈合。然而,在年龄较大的儿童和青少年中,愈合和重塑潜力有限,对于不稳定的骨折,手术干预可能是必要的。弹性钉髓内钉,又称弹性稳定髓内钉(ESIN),是儿童和青少年前臂骨折手术治疗的金标准,具有节省肢体、安全、可靠、微创等优点。有几个珍珠和陷阱相关的ESIN手术技术将讨论在这篇文章。一旦骨折愈合,需要进行第二次手术来移除指甲。ESIN治疗前臂干骨折的总体效果令人满意。大多数并发症与技术有关,通过对细节的细致关注可以避免。本文旨在综述ESIN治疗前臂干骨折的适应症、手术技术、临床结果和潜在并发症。对于治疗这些儿童骨折的骨科医生来说,掌握ESIN的艺术是很重要的。
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引用次数: 0
Oral antibiotics demonstrate superior success and fewer complications compared to parenteral antibiotics for pediatric bone and joint Infections:A systematic review and meta-analysis 与肠外抗生素相比,口服抗生素治疗儿童骨关节感染的成功率更高,并发症更少:一项系统综述和荟萃分析
Q2 Medicine Pub Date : 2025-10-25 DOI: 10.1016/j.jcot.2025.103245
Gabriella Schreiner , Alexis Driscoll , Jesus Mejia , Stephen Fucaloro , Laura Krivicich , Matthew Salzler

Background

Effective antimicrobial therapy for bone and joint infections (BJIs) in the pediatric population is essential to prevent serious sequelae. As literature continues to evaluate the best therapeutic route, discussions centered upon the efficacy of oral antibiotics compared to parenteral have demonstrated promising results. This study aims to provide a statistical appraisal of literature comparing oral antibiotic therapy to parenteral treatment success and complications in treating pediatric BJIs.

Methods

After PROSPERO registration (ID: CRD42023463451), PubMed, Embase, and Web of Science databases were queried for articles comparing oral and parenteral antibiotic therapies for pediatric BJIs. Studies were included if parenteral and oral regimens were used for the entire treatment duration, or if the parenteral control group was compared against an “early switch” group, where the therapeutic route was switched from parenteral to oral antibiotics within 11 days. Data for all included studies was collected, pooled, and analyzed using DerSimonian-Laird Random-effects modeling, with statistical significance defined as p-value less than 0.05.

Results

Meta-analysis of six early switch studies demonstrated higher odds of success for the early switch group (OR = 2.27 [1.53–3.36], I2 = 9.20 %, p < 0.01). Five oral-only studies demonstrated higher odds of success for the oral group (OR = 2.64 [1.10–6.34], I2 = 66.22 %, p < 0.01). Meta-analysis demonstrated significantly higher odds of uncomplicated treatment for the early switch and oral-only groups compared to parenteral groups, though heterogeneity was significant for these analyses.

Conclusion

The findings of this meta-analysis, limited by high heterogeneity and primarily observational data, demonstrate early switch to antibiotics had higher success rates and fewer complications compared to parenteral antibiotics. Future high-quality randomized controlled trials in specific pediatric subgroups and varied resource settings are needed.

Level of evidence

Level III, systematic review of one randomized controlled trial, one case-control study and six retrospective comparative studies.

Mesh terms

Osteomyelitis; Antibiotics; Anti-Bacterial Agents; Bone Diseases, Infectious; Septic Arthritis; Pediatrics.
背景:儿童骨和关节感染(BJIs)的有效抗菌治疗对于预防严重的后遗症至关重要。随着文献继续评估最佳治疗途径,围绕口服抗生素与非注射抗生素的疗效的讨论已经显示出有希望的结果。本研究旨在对治疗儿童BJIs的口服抗生素治疗与非肠外治疗的成功率和并发症的文献进行统计评估。方法在PROSPERO注册(ID: CRD42023463451)后,查询PubMed、Embase和Web of Science数据库中比较口服和肠外抗生素治疗小儿BJIs的文章。如果在整个治疗期间使用肠外和口服方案,或者将肠外对照组与“早期转换”组进行比较,则研究包括在内,在“早期转换”组中,治疗途径在11天内从肠外切换到口服抗生素。采用dersimonan - laird随机效应模型对所有纳入研究的数据进行收集、汇总和分析,p值小于0.05定义为统计学显著性。结果6项早期切换研究的meta分析显示,早期切换组的成功率更高(OR = 2.27 [1.53-3.36], I2 = 9.20%, p < 0.01)。5项仅口服组的研究显示,口服组的成功率更高(OR = 2.64 [1.10-6.34], I2 = 66.22%, p < 0.01)。荟萃分析显示,与肠外注射组相比,早期转换组和口服组的简单治疗几率明显更高,尽管这些分析存在显著的异质性。结论:该荟萃分析的结果受到高异质性和主要观察性数据的限制,表明与肠外抗生素相比,早期改用抗生素具有更高的成功率和更少的并发症。未来需要针对特定儿科亚组和不同资源环境的高质量随机对照试验。证据水平:III级,系统评价1项随机对照试验、1项病例对照研究和6项回顾性比较研究。网termsOsteomyelitis;抗生素;抗菌代理人;骨病,传染病;脓毒性关节炎;儿科。
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引用次数: 0
Does approach for radial head repair in Bado II Monteggia variants affect outcome? 桡骨头修复的入路是否影响治疗效果?
Q2 Medicine Pub Date : 2025-10-24 DOI: 10.1016/j.jcot.2025.103246
Matthew W. Sgaglione, Sanjit R. Konda, Philipp Leucht, Nirmal C. Tejwani, Kenneth A. Egol

Background

This study compares outcomes and complications of patients with Bado II Monteggia fracture-dislocations that required radial head fixation or replacement based upon approach to the radial head.

Methods

A retrospective review was performed of 159 consecutive patients with proximal ulna fractures and a radial head dislocation or fracture (Monteggia Variant). Injuries were classified by Bado type. Forty-one patients with Bado II Monteggia injuries treated with either a radial head replacement or fixation with complete follow up were included. Demographics, injury information, surgical details, and follow up information including elbow range of motion (ROM) and complications were collected. A trans-osseous posterior (TOP) approach working through the ulna fracture to address the radial head first was used in 19 patients, while 22 patients had their radial head treated via a separate lateral (Kocher) interval after ulnar fixation. Ulnar plate fixation was performed for all patients. Comparisons were made using independent t-tests.

Results

Forty-one Monteggia lesions treated through TOP (19, 46 %) or Kocher (22, 64 %) approaches underwent a radial head replacement (33, 80.5 %) or fracture repair (8, 19.5 %) with a mean final follow-up of 15.3 months. At all post-operative visits, groups displayed similar rates of functional elbow ROM. At latest follow-up rates of patient-reported pain, ultimate elbow ROM, time to radiographic healing were equivalent. No significant differences were observed in ulna non-union, joint malalignment, post-operative nerve injury, post-operative infection, heterotopic ossification, incidence of hardware failure, patient-reported pain, and rate of removal of symptomatic hardware. Sub-analysis of radial head replacement versus fixation revealed equivalent percentage of patients with full ROM at each post-operative time point.

Conclusion

For Bado II Monteggia fracture-dislocations, the surgical approach to the radial head—TOP versus Kocher—does not influence ultimate patient outcomes or complication rates. Radial head replacement and fixation provide comparable results.

Level of evidence

III.
本研究比较了Bado II型Monteggia骨折脱位患者在桡骨头入路基础上需要桡骨头固定或置换的结果和并发症。方法对159例尺近端骨折合并桡骨头脱位或骨折(Monteggia变异型)患者进行回顾性分析。损伤按Bado型分类。41例接受桡骨头置换术或固定治疗的Bado II型Monteggia损伤患者进行了完整的随访。收集了人口统计学、损伤信息、手术细节和随访信息,包括肘关节活动范围(ROM)和并发症。19例患者首先采用经骨后路(TOP)通过尺骨骨折治疗桡骨头,22例患者在尺骨固定后通过单独的外侧(Kocher)间隔治疗桡骨头。所有患者均行尺钢板固定。采用独立t检验进行比较。结果经TOP入路(19.46%)或Kocher入路(22.64%)治疗的41例Monteggia病变行桡骨头置换术(33.80.5%)或骨折修复术(8.19.5%),最终平均随访15.3个月。在所有的术后随访中,各组显示出相似的功能性肘关节活动度。在最近的随访中,患者报告的疼痛率、肘关节活动度、放射治疗愈合时间是相同的。在尺骨不连、关节错位、术后神经损伤、术后感染、异位骨化、硬体失效发生率、患者报告的疼痛和有症状硬体移除率方面,两组无显著差异。桡骨头置换术与内固定的亚分析显示,在每个术后时间点,完全ROM患者的百分比相等。结论对于Bado II型Monteggia骨折脱位,桡骨头手术入路(top)与kocher手术入路(kocher)不影响患者的最终预后或并发症发生率。桡骨头置换术和内固定术提供了类似的结果。证据水平ii。
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引用次数: 0
The effects of multiple myeloma on total knee arthroplasty outcomes: A retrospective study 多发性骨髓瘤对全膝关节置换术结果的影响:一项回顾性研究
Q2 Medicine Pub Date : 2025-10-23 DOI: 10.1016/j.jcot.2025.103190
Sushrruti Varatharaj, Senthil Sambandam, Sruthi Priyavadhana Ramanan, Clarissa Meza, Gatik Senthil

Background

Total knee arthroplasty (TKA) is a common orthopedic procedure, yet outcomes in patients with multiple myeloma (MM) remain poorly understood since there are limited studies. As a result, the aim was to assess how MM affects outcomes of patients undergoing TKA.

Methods

In this retrospective cohort study, patients with MM who underwent TKA were identified using a TriNetX national database from 2005 to 2024. These patients were matched to controls without MM using propensity score matching based on age, sex and relevant comorbidities. Postoperative complication rates, readmission, revision surgery, and mortality were analyzed over a one-year follow-up.

Results

A total of 237, 007 patients who had TKR were matched to 353 patients with MM who had TKR. MM patients were older, male (mean age 70.3 vs 67 years) and had a higher incidence of comorbidities at baseline. MM patients had significantly higher rates of wound dehiscence (1.98 % vs 0.52 %, p = .003), periprosthetic infection (2.27 % vs 0.81 %, p = .009), acute renal failure (5.95 % vs 1.96 %, p < .001), blood loss anemia (15.01 % vs 6.53 %, p < .001),DVT (2.55 % vs 1.27 p = .049), myocardial infarction (0.85 % vs 0.21 %, p = .040), pulmonary embolism (3.12 % vs 0.84 %, p < .001) and pneumonia. However, one-year mortality rates did not differ significantly between groups.

Conclusion

MM is associated with an increased risk of postoperative complications following TKA compared to control patients but not mortality. This study highlights multispecialty tailored perioperative care protocols for MM patients undergoing TKA to decrease complications.
背景:全膝关节置换术(TKA)是一种常见的骨科手术,但由于研究有限,对多发性骨髓瘤(MM)患者的预后仍然知之甚少。因此,目的是评估MM如何影响TKA患者的预后。方法在这项回顾性队列研究中,使用TriNetX国家数据库从2005年至2024年确定了接受TKA的MM患者。使用基于年龄、性别和相关合并症的倾向评分匹配将这些患者与没有MM的对照组进行匹配。术后并发症发生率、再入院、翻修手术和死亡率在一年的随访期间进行了分析。结果237,007例TKR患者与353例合并TKR的MM患者相匹配。MM患者年龄较大,男性(平均年龄70.3 vs 67岁),基线时合并症发生率较高。MM患者的伤口裂开(1.98% vs 0.52%, p = 0.003)、假体周围感染(2.27% vs 0.81%, p = 0.009)、急性肾功能衰竭(5.95% vs 1.96%, p < 0.001)、失血性贫血(15.01% vs 6.53%, p < 0.001)、DVT (2.55% vs 1.27%, p = 0.049)、心肌梗死(0.85% vs 0.21%, p = 0.040)、肺栓塞(3.12% vs 0.84%, p < 001)和肺炎的发生率均显著高于MM患者。然而,两组之间一年的死亡率没有显著差异。结论与对照组相比,mm与TKA术后并发症风险增加有关,但与死亡率无关。本研究强调了多专业定制的MM患者接受TKA的围手术期护理方案,以减少并发症。
{"title":"The effects of multiple myeloma on total knee arthroplasty outcomes: A retrospective study","authors":"Sushrruti Varatharaj,&nbsp;Senthil Sambandam,&nbsp;Sruthi Priyavadhana Ramanan,&nbsp;Clarissa Meza,&nbsp;Gatik Senthil","doi":"10.1016/j.jcot.2025.103190","DOIUrl":"10.1016/j.jcot.2025.103190","url":null,"abstract":"<div><h3>Background</h3><div>Total knee arthroplasty (TKA) is a common orthopedic procedure, yet outcomes in patients with multiple myeloma (MM) remain poorly understood since there are limited studies. As a result, the aim was to assess how MM affects outcomes of patients undergoing TKA.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, patients with MM who underwent TKA were identified using a TriNetX national database from 2005 to 2024. These patients were matched to controls without MM using propensity score matching based on age, sex and relevant comorbidities. Postoperative complication rates, readmission, revision surgery, and mortality were analyzed over a one-year follow-up.</div></div><div><h3>Results</h3><div>A total of 237, 007 patients who had TKR were matched to 353 patients with MM who had TKR. MM patients were older, male (mean age 70.3 vs 67 years) and had a higher incidence of comorbidities at baseline. MM patients had significantly higher rates of wound dehiscence (1.98 % vs 0.52 %, p = .003), periprosthetic infection (2.27 % vs 0.81 %, p = .009), acute renal failure (5.95 % vs 1.96 %, p &lt; .001), blood loss anemia (15.01 % vs 6.53 %, p &lt; .001),DVT (2.55 % vs 1.27 p = .049), myocardial infarction (0.85 % vs 0.21 %, p = .040), pulmonary embolism (3.12 % vs 0.84 %, p &lt; .001) and pneumonia. However, one-year mortality rates did not differ significantly between groups.</div></div><div><h3>Conclusion</h3><div>MM is associated with an increased risk of postoperative complications following TKA compared to control patients but not mortality. This study highlights multispecialty tailored perioperative care protocols for MM patients undergoing TKA to decrease complications.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"71 ","pages":"Article 103190"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Masquelet technique combined with gentamicin-cement-coated rigid nails in the treatment of infected bone defects: A retrospective review Masquelet技术联合庆大霉素水泥包覆硬钉治疗感染性骨缺损的疗效回顾
Q2 Medicine Pub Date : 2025-10-22 DOI: 10.1016/j.jcot.2025.103242
Germán Garabano , Andres Juri , Leonel Perez Alamino , Joaquín Rodriguez , Cesar Angel Pesciallo

Background

This study aimed to describe the bone healing, infection recurrence, and failure rates in patients with infected bone defects (IBD) of the femur and tibia in whom we combined the Masquelet technique with gentamicin-cement-coated rigid nails from the first stage.

Methods

We conducted a retrospective review of fourteen consecutive patients with IBD treated between June 2015 and December 2022 with the Masquelet technique and a gentamicin cement-coated rigid nail. Eleven patients were male; the median age was 40.5 years. Six defects were located in the femur and eight in the tibia. We analyzed the bone healing, infection recurrence, and failure rates (nonunions, graft resorption, amputations). We used the Lower Extremity Functional Scale (LEFS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to assess the functional outcomes.

Results

One patient needed additional debridement after the first stage. The mean time between stages was 10.28 (range 6–28) weeks. The mean LEFS score before the second stage was 62.57 ± 5.66 points. The median defect length was 6.8 cm (range 3.5–12). All the patients achieved bone healing within a median of eight months. No infection recurrences or failures were recorded. At the study closure, the mean LEFS and WOMAC were 62.07 ± 4.17, and 77.92 ± 10.89, respectively. The median follow-up was 31.71 months (range 12–80).

Conclusion

The combination of gentamicin cement-coated rigid nails with Masquelet's technique was associated with excellent bone healing and infection control in the treatment of infected bone defects in this small series. Further research is needed to validate the effectiveness of this method.
本研究旨在描述股骨和胫骨感染性骨缺损(IBD)患者的骨愈合、感染复发和失败率,我们将Masquelet技术与庆大霉素水泥包被的第一阶段硬钉相结合。方法:我们对2015年6月至2022年12月期间连续使用Masquelet技术和庆大霉素水泥包覆刚性钉治疗的14例IBD患者进行回顾性分析。男性11例;中位年龄为40.5岁。6个缺损位于股骨,8个缺损位于胫骨。我们分析了骨愈合、感染复发和失败率(骨不连、移植物吸收、截肢)。我们使用下肢功能量表(LEFS)和西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)来评估功能结果。结果1例患者在一期手术后需要进一步清创。两期之间的平均时间为10.28周(范围6-28周)。第二阶段前的平均LEFS评分为62.57±5.66分。中位缺损长度为6.8 cm(范围3.5-12)。所有患者均在平均8个月内实现骨愈合。无感染复发或失败记录。研究结束时,平均LEFS和WOMAC分别为62.07±4.17和77.92±10.89。中位随访时间为31.71个月(12-80个月)。结论庆大霉素水泥包被硬钉联合Masquelet技术治疗感染性骨缺损具有良好的骨愈合和感染控制效果。该方法的有效性有待进一步研究验证。
{"title":"Outcomes of Masquelet technique combined with gentamicin-cement-coated rigid nails in the treatment of infected bone defects: A retrospective review","authors":"Germán Garabano ,&nbsp;Andres Juri ,&nbsp;Leonel Perez Alamino ,&nbsp;Joaquín Rodriguez ,&nbsp;Cesar Angel Pesciallo","doi":"10.1016/j.jcot.2025.103242","DOIUrl":"10.1016/j.jcot.2025.103242","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to describe the bone healing, infection recurrence, and failure rates in patients with infected bone defects (IBD) of the femur and tibia in whom we combined the Masquelet technique with gentamicin-cement-coated rigid nails from the first stage.</div></div><div><h3>Methods</h3><div>We conducted a retrospective review of fourteen consecutive patients with IBD treated between June 2015 and December 2022 with the Masquelet technique and a gentamicin cement-coated rigid nail. Eleven patients were male; the median age was 40.5 years. Six defects were located in the femur and eight in the tibia. We analyzed the bone healing, infection recurrence, and failure rates (nonunions, graft resorption, amputations). We used the Lower Extremity Functional Scale (LEFS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to assess the functional outcomes.</div></div><div><h3>Results</h3><div>One patient needed additional debridement after the first stage. The mean time between stages was 10.28 (range 6–28) weeks. The mean LEFS score before the second stage was 62.57 ± 5.66 points. The median defect length was 6.8 cm (range 3.5–12). All the patients achieved bone healing within a median of eight months. No infection recurrences or failures were recorded. At the study closure, the mean LEFS and WOMAC were 62.07 ± 4.17, and 77.92 ± 10.89, respectively. The median follow-up was 31.71 months (range 12–80).</div></div><div><h3>Conclusion</h3><div>The combination of gentamicin cement-coated rigid nails with Masquelet's technique was associated with excellent bone healing and infection control in the treatment of infected bone defects in this small series. Further research is needed to validate the effectiveness of this method.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"71 ","pages":"Article 103242"},"PeriodicalIF":0.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monteggia fractures and the Bado CLASSIFICATION: AN urban trauma center experience 蒙特吉亚骨折和巴多分类:城市创伤中心的经验
Q2 Medicine Pub Date : 2025-10-21 DOI: 10.1016/j.jcot.2025.103244
Olivia Jagiella-Lodise , Anna Meyer, Nicholas Cantu , Adam Boissonneault, Thomas Large

Background

There are conflicting reports regarding the incidence of Monteggia fractures by Bado type and their associated risks of nerve and vascular injury and other complications.

Methods

A registry was queried at a level I trauma center for Monteggia fracture codes. A retrospective chart and radiographic review were then conducted to correctly identify Monteggia fractures. The primary outcome was incidence by Bado type with secondary outcomes being associated injuries.

Results

69 patients sustained Bado I (42), Bado II (15), Bado III (8), and Bado IV (4) injuries. 83 % had a high-energy mechanism. 7 % had vascular injuries, 32 % were open, 13 % had a radial head fracture, 10 % had neurological deficits, 0 % had compartment syndrome, 1 % required open reduction of the radiocapitellar joint, 1 % developed malunion, and 9 % developed nonunion. 61 % were Bado I injuries. However, it was more common for Bado III fractures to be open (p = 0.018), and for Bado II fractures to involve radial head fractures (p = 0.008). Neurologic deficits were seen in Bado I, II, and IV injuries with 5/7 of these injuries in Bado I patients, although not significant (p = 0.600). Three nerve injuries were transections without recovery. Five vascular injuries were seen, none required revascularization. One Bado I required open reduction of the radiocapitellar dislocation. Malunion and nonunion were significant for Bado II (p = 0.031).

Conclusion

Bado I are the most common type in this mostly high-energy cohort. There were no significant differences in the incidence of associated neurologic or vascular injuries between Bado types. There were significantly more nonunion/malunion and radial head fractures in Bado II and greater percentage of open injuries in Bado III. No patients developed compartment syndrome. Twelve patients had nerve or vascular injuries, 32 % were open fractures, and 6 had nonunions, underscoring that this is not a benign injury.
关于巴多型蒙氏骨折的发生率及其相关的神经和血管损伤及其他并发症的风险,有相互矛盾的报道。方法在某一级创伤中心对注册表进行蒙氏骨折编码查询。回顾性图表和影像学检查,然后进行正确识别蒙氏骨折。主要结局是Bado型的发病率,次要结局是相关损伤。结果69例患者发生Bado I型损伤42例,Bado II型损伤15例,Bado III型损伤8例,Bado IV型损伤4例。83%有高能量机制。7%为血管损伤,32%为切开骨折,13%为桡骨头骨折,10%为神经功能缺损,0%为隔室综合征,1%需要切开复位桡肱关节,1%为骨不连,9%为骨不连。61%为Bado I型损伤。然而,Bado III型骨折多为开放性骨折(p = 0.018), Bado II型骨折多为桡骨头骨折(p = 0.008)。Bado I、II和IV型损伤均出现神经功能缺损,其中5/7为Bado I型损伤,但差异无统计学意义(p = 0.600)。3例神经损伤均为横断,未恢复。5例血管损伤,无一例需要血运重建术。一个Bado I需要切开复位桡肱脱位。Bado II的畸形愈合和不愈合显著(p = 0.031)。结论在高能量人群中,bado I型最为常见。在相关神经或血管损伤的发生率方面,不同类型的Bado无显著差异。Bado II的骨不连/骨不连和桡骨头骨折明显更多,Bado III的开放性损伤比例更高。无患者出现筋膜间室综合征。12例患者有神经或血管损伤,32%为开放性骨折,6例不愈合,强调这不是良性损伤。
{"title":"Monteggia fractures and the Bado CLASSIFICATION: AN urban trauma center experience","authors":"Olivia Jagiella-Lodise ,&nbsp;Anna Meyer,&nbsp;Nicholas Cantu ,&nbsp;Adam Boissonneault,&nbsp;Thomas Large","doi":"10.1016/j.jcot.2025.103244","DOIUrl":"10.1016/j.jcot.2025.103244","url":null,"abstract":"<div><h3>Background</h3><div>There are conflicting reports regarding the incidence of Monteggia fractures by Bado type and their associated risks of nerve and vascular injury and other complications.</div></div><div><h3>Methods</h3><div>A registry was queried at a level I trauma center for Monteggia fracture codes. A retrospective chart and radiographic review were then conducted to correctly identify Monteggia fractures. The primary outcome was incidence by Bado type with secondary outcomes being associated injuries.</div></div><div><h3>Results</h3><div>69 patients sustained Bado I (42), Bado II (15), Bado III (8), and Bado IV (4) injuries. 83 % had a high-energy mechanism. 7 % had vascular injuries, 32 % were open, 13 % had a radial head fracture, 10 % had neurological deficits, 0 % had compartment syndrome, 1 % required open reduction of the radiocapitellar joint, 1 % developed malunion, and 9 % developed nonunion. 61 % were Bado I injuries. However, it was more common for Bado III fractures to be open (p = 0.018), and for Bado II fractures to involve radial head fractures (p = 0.008). Neurologic deficits were seen in Bado I, II, and IV injuries with 5/7 of these injuries in Bado I patients, although not significant (p = 0.600). Three nerve injuries were transections without recovery. Five vascular injuries were seen, none required revascularization. One Bado I required open reduction of the radiocapitellar dislocation. Malunion and nonunion were significant for Bado II (p = 0.031).</div></div><div><h3>Conclusion</h3><div>Bado I are the most common type in this mostly high-energy cohort. There were no significant differences in the incidence of associated neurologic or vascular injuries between Bado types. There were significantly more nonunion/malunion and radial head fractures in Bado II and greater percentage of open injuries in Bado III. No patients developed compartment syndrome. Twelve patients had nerve or vascular injuries, 32 % were open fractures, and 6 had nonunions, underscoring that this is not a benign injury.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"71 ","pages":"Article 103244"},"PeriodicalIF":0.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Clinical Orthopaedics and Trauma
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