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Safety and efficacy of autologous adipose-derived stem cells for knee osteoarthritis in the elderly population: A systematic review 自体脂肪干细胞治疗老年人膝关节骨关节炎的安全性和有效性:系统综述
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102804
Biagio Zampogna , Francesco Rosario Parisi , Augusto Ferrini , Andrea Zampoli , Giuseppe Francesco Papalia , Saseendar Shanmugasundaram , Rocco Papalia

Introduction

Osteoarthritis (OA) is a progressive joint disease, and over 240 million people suffer from symptomatic OA, primarily in the knee, and mainly affects the elderly population over 65. A combination of different risk factors leads to biological changes in the microenvironments of the joints, causing cartilage overload and chondrocyte aging. Adipose-derived MSCs (ADSCs) are demonstrated to improve joint environments with an effective therapy for Knee OA. This review focused on patients over 65 years old to evaluate the effectiveness of ADSC therapies in treating KOA in elderly patients and demonstrate that complications are not higher in this cohort of patients.

Materials and methods

We conducted a bibliography search through the PubMed, Scopus, and Cochrane databases for English-language and human clinical trials published until Feb 7, 2024. We extracted the following study characteristics: Authors, year of publication, type of study, number of patients, number of knees, sex, Kellgren-Lawrence classification, culture ADSC, Number of cells injected, mean follow-up, adverse events, significant complications, and clinical outcomes data were extracted recorded and analyzed.

Results

According to inclusion criteria, seven clinical trials on autologous adipose-derived stem cells were considered. Four studies analyzed stem cells as a stromal vascular fraction (SVF), two as ADSC cultured, and 1 study investigated the MAT procedure. All studies reported improved clinical outcomes using autologous adipose-derived stem cells, on 339 knees. Post-treatment increased KOOS, WOMAC, IKS, VAS, and Lysholm knee scores were highlighted. All studies showed an improvement in all outcomes scores, and regarding complications, only 44 knees underwent adverse events, but no significant complications were found in all the studies reported.

Conclusions

The current systematic review demonstrated that using autologous adipose-derived stem cells improved clinical outcomes and is effective and safe in elderly patients. Additionally, this study will encourage orthopedic surgeons not to consider surgery as the only solution in elderly patients who are refractory to treatment and do not show end-stage knee osteoarthritis.

Level of evidence

Level IV, systematic review of level IV studies.
导言骨关节炎(OA)是一种进行性关节疾病,超过 2.4 亿人患有无症状的骨关节炎,主要发生在膝关节,主要影响 65 岁以上的老年人群。不同风险因素的综合作用导致关节微环境发生生物变化,造成软骨超负荷和软骨细胞老化。脂肪来源间充质干细胞(ADSCs)被证明能改善关节环境,是治疗膝关节OA的有效疗法。本综述重点关注 65 岁以上的患者,以评估 ADSC 疗法治疗老年患者 KOA 的有效性,并证明该类患者的并发症并不高。材料与方法我们通过 PubMed、Scopus 和 Cochrane 数据库对 2024 年 2 月 7 日之前发表的英语人类临床试验进行了文献检索。我们提取了以下研究特征:作者、发表年份、研究类型、患者人数、膝关节数量、性别、Kellgren-Lawrence分类、培养ADSC、注射细胞数量、平均随访时间、不良事件、重大并发症和临床结果数据均被提取记录并进行分析。四项研究分析了作为基质血管成分(SVF)的干细胞,两项研究分析了培养的ADSC,一项研究调查了MAT程序。所有研究均报告称,使用自体脂肪衍生干细胞可改善339个膝关节的临床疗效。研究强调了治疗后KOOS、WOMAC、IKS、VAS和Lysholm膝关节评分的提高。在并发症方面,只有44个膝关节发生了不良事件,但在所有报告的研究中均未发现明显的并发症。结论目前的系统综述表明,使用自体脂肪衍生干细胞可改善老年患者的临床疗效,且有效、安全。此外,这项研究将鼓励骨科医生不要将手术作为治疗难治且未显示出终末期膝骨关节炎的老年患者的唯一解决方案。
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引用次数: 0
New evidence on patella resurfacing in modern total knee arthroplasty for all inflammatory arthritis in a mixed Asian population 现代全膝关节置换术治疗亚洲混血儿所有炎症性关节炎的髌骨复位新证据
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102798
Sherlyn Yen Yu Tham , Wu Chean Lee , Zavier Yongxuan Lim , Remesh Kunnasegaran

Background

Traditional teaching advocates for routine patella resurfacing (PR) during total knee arthroplasty (TKA) in patients with inflammatory arthritis. However, evidence on this topic remains limited in the Asian population. This study aims to evaluate the postoperative outcomes and complication of patella resurfacing (PR) during primary total knee arthroplasty (TKA) in Asian patients with inflammatory arthritis.

Methods

A retrospective analysis was conducted using registry data from our institution. Patients with inflammatory arthritis who underwent primary TKA from August 2017 to December 2021 were included in the study. Patients were divided into two groups - patella resurfaced (PR, n = 25) and non-resurfaced patella (PNR, n = 31) groups. Demographics, operative data, patient reported outcome measures, and complications were compared.

Results

Preoperative range of motion (ROM) (PR:95.3 ± 23.6° vs PNR:105 ± 19.5°, p = 0.106), Knee Society Scoring System Knee score (KS-KS) (PR:44.6 ± 17.4 vs PNR:49.3 ± 17.7, p = 0.331) and Knee Society Function Score (KS-FS) (PR:40.9 ± 27.3 vs PNR:47.7 ± 27.0, p = 0.325) and Oxford Knee Score (OKS) (PR:25.0 ± 7.8 vs PNR:23.3 ± 10.3, p = 0.525) were similar in both groups. Outcomes between PR and PNR groups at the one-year mark in terms of ROM (PR:112.7 ± 18.1 vs PNR:114.6 ± 16.5, p = 0.455), OKS (PR:41.5 ± 3.9 vs PNR:41 ± 4.7, p = 0.954), KS-KS (PR:84.5 ± 13.2 vs PNR:89.2 ± 9.3, p = 0.095) and KS-FS (PR:73.6 ± 18.3 vs PNR:78.7 ± 19.3, p = 0.173) were also similar. Intraoperative complication (PR:0/25 vs PNR: 3/31 (9.6 %), p = 0.245) and re-operation rates (PR: 1/25 (4 %) vs PNR: 1/31 (3.2 %), p = 0.877) were also similar in both groups.

Conclusion

This study conducted on a mixed Asian population with inflammatory arthritis demonstrated that the one-year postoperative ROM and functional outcomes, complication, and re-operation rates between PR and PNR groups were similar. Hence, routine patella resurfacing on all Asian patients with inflammatory arthritis undergoing TKA may not be necessary.
背景传统教学主张炎症性关节炎患者在进行全膝关节置换术(TKA)时常规进行髌骨复位(PR)。然而,在亚洲人群中,这方面的证据仍然有限。本研究旨在评估亚洲炎症性关节炎患者在初级全膝关节置换术(TKA)中进行髌骨翻修(PR)的术后效果和并发症。研究纳入了2017年8月至2021年12月期间接受初级TKA手术的炎症性关节炎患者。患者分为两组--髌骨复位组(PR,n = 25)和非髌骨复位组(PNR,n = 31)。结果术前活动范围(ROM)(PR:95.3 ± 23.6° vs PNR:105 ± 19.5°,P = 0.106)、膝关节协会评分系统膝关节评分(KS-KS)(PR:44.6 ± 17.4 vs PNR:49.3 ± 17.7,p = 0.331)、膝关节社会功能评分(KS-FS)(PR:40.9 ± 27.3 vs PNR:47.7 ± 27.0,p = 0.325)和牛津膝关节评分(OKS)(PR:25.0 ± 7.8 vs PNR:23.3 ± 10.3,p = 0.525)在两组中相似。PR 组和 PNR 组在一年后的 ROM(PR:112.7 ± 18.1 vs PNR:114.6 ± 16.5,p = 0.455)、OKS(PR:41.5 ± 3.9 vs PNR:41 ± 4.7,p = 0.954)、KS-KS(PR:84.5 ± 13.2 vs PNR:89.2 ± 9.3,p = 0.095)和 KS-FS(PR:73.6 ± 18.3 vs PNR:78.7 ± 19.3,p = 0.173)也相似。两组的术中并发症(PR:0/25 vs PNR:3/31 (9.6%),p = 0.245)和再次手术率(PR:1/25 (4 %) vs PNR:1/31 (3.2%),p = 0.877)也相似。因此,对所有接受 TKA 的亚洲炎症性关节炎患者进行常规髌骨复位可能并无必要。
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引用次数: 0
Rehabilitation from delayed bilateral complete quadriceps tendon repairs with knee extension assist braces: A case report 使用膝关节伸展辅助支架进行延迟性双侧股四头肌肌腱完全修复术后康复:病例报告
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102789
Benjamin Hewins, Sara Sparavalo, Ivan Wong
Simultaneous bilateral quadriceps tears are rare with fewer than 150 cases reported in the literature and typically occur in male patients greater than 40 years of age. If left untreated or with delayed clinical intervention, these injuries often lead to chronic disability including pain and reduced ambulation. Typical treatments include surgical repair with considerable post-operative rehabilitation and a guarded prognosis. However, given the scarcity of these cases, a consensus on a standard course of treatment remains unclear and ultimately at the discretion of the clinician.
A 67-year-old male presented 6-months after complete, retracted tears of bilateral quadriceps tendons after a fall onto both knees in flexion. Treatment included: immediate bilateral quadriceps tendon repairs, immobilization, physiotherapy, and the daily use of novel tri-compartment offloader knee braces providing knee-extension assist. To our knowledge, this is the first report of a full return to independent ambulation following a delayed diagnosis and surgical intervention of complete bilateral quadriceps tendon tears.
同时发生的双侧股四头肌撕裂非常罕见,文献报道的病例不到 150 例,通常发生在 40 岁以上的男性患者身上。如果不及时治疗或延误临床干预,这些损伤通常会导致慢性残疾,包括疼痛和行动不便。典型的治疗方法包括手术修复,术后需要大量的康复治疗,预后较差。一名 67 岁的男性在双膝屈曲摔倒后,双侧股四头肌肌腱完全撕裂并回缩,6 个月后就诊。治疗包括:立即进行双侧股四头肌肌腱修复、固定、理疗,以及每天使用新型三腔卸力膝关节支架提供膝关节伸展辅助。据我们所知,这是第一份关于双侧股四头肌肌腱完全撕裂延迟诊断和手术干预后完全恢复独立行走的报告。
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引用次数: 0
Factors influencing surgical treatment of De Quervain's tendinopathy: A retrospective cross-sectional observational study 影响德-夸尔曼肌腱病手术治疗的因素:回顾性横断面观察研究
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102790
Arjuna Thakker , Nicholas Johnson , Joseph Dias

Background

The literature surrounding how different patient, sociodemographic, and anatomical factors influence surgical treatment of De Quervain's tendinopathy (DQT) is limited.

Purpose

We hypothesised that different patient, anatomical, or sociodemographic factors influence the management of DQT with regard to non-operative vs. surgical management.

Methods

This retrospective cross-sectional study reviewed 155 cases of patients with DQT seen over a 10 year period. Patient-specific factors included age, gender, hand affected, dominant hand, steroid injection given and mean number of injections. Sociodemographic factors included ethnicity, employment, and deprivation, were measured using deprivation quintiles through The Index of Multiple Deprivation. Anatomical factors included the presence of subcompartmentalization, number of APL and EPB tendon slips, tendon thickening, exudative tenosynovitis, hypervascularization, and the presence of a sheath ganglion Patients were categorized into either non-operative or surgical cohort. Bivariate analysis was used to compare factors between the cohorts, and significant factors (p < 0.05) were included in the logistic regression model, used to predict factors influencing surgical management.

Results

Bivariate analysis detected a significant difference in the mean number of steroids given between the non-operative and surgical cohort (p = 0.001) patient factors. For sociodemographic factors, a significant difference was found between deprivation quintiles (p = 0.02). From the anatomical factors, the surgical cohort had more patients with multiple APL tendon slips (p = 0.02) and the presence of a tendon ganglion sheath ganglion (p = 0.02). For patient and sociodemographic factors, logistic regression identified that the number of steroids (per patient) and being in deprivation quintile 4 were associated with surgical treatment. For anatomical factors, multiple APL tendon slips and the presence of a tendon sheath ganglion were associated with the surgical treatment.

Conclusion

This study suggests that several factors are associated with the need for surgical treatment of DQT, including the number of steroid injections received, social deprivation, and anatomical factors, such as the presence of multiple tendon slips and a tendon sheath ganglion. Our findings add to the growing body of literature exploring factors that may influence treatment pathways for patients with DQT.
背景有关不同患者、社会人口和解剖学因素如何影响德-夸尔曼氏肌腱病(DQT)手术治疗的文献十分有限。目的我们假设,不同患者、解剖学或社会人口因素会影响德-夸尔曼氏肌腱病的非手术治疗与手术治疗。患者特异性因素包括年龄、性别、患手、主导手、类固醇注射量和平均注射次数。社会人口学因素包括种族、就业和贫困程度,这些因素通过 "多重贫困指数"(The Index of Multiple Deprivation)中的贫困五分位数来衡量。解剖学因素包括是否存在关节间隙下化、APL和EPB肌腱滑脱的数量、肌腱增厚、渗出性腱鞘炎、血管过多以及是否存在鞘神经节。采用双变量分析比较两组患者之间的因素,并将重要因素(p <0.05)纳入逻辑回归模型,用于预测影响手术治疗的因素。结果双变量分析发现,非手术组和手术组患者服用类固醇的平均次数存在显著差异(p = 0.001)。在社会人口学因素方面,贫困五分位数之间存在显著差异(p = 0.02)。从解剖学因素来看,手术队列中有更多患者患有多发性 APL 肌腱滑脱(p = 0.02)和存在腱鞘节(p = 0.02)。就患者和社会人口学因素而言,逻辑回归发现,类固醇的数量(每名患者)和处于贫困的五分位数4与手术治疗有关。结论本研究表明,多种因素与 DQT 的手术治疗需求相关,包括接受类固醇注射的次数、社会贫困程度以及解剖因素(如存在多处肌腱滑脱和腱鞘节)。我们的研究结果为越来越多探讨可能影响 DQT 患者治疗途径的因素的文献增添了新的内容。
{"title":"Factors influencing surgical treatment of De Quervain's tendinopathy: A retrospective cross-sectional observational study","authors":"Arjuna Thakker ,&nbsp;Nicholas Johnson ,&nbsp;Joseph Dias","doi":"10.1016/j.jcot.2024.102790","DOIUrl":"10.1016/j.jcot.2024.102790","url":null,"abstract":"<div><h3>Background</h3><div>The literature surrounding how different patient, sociodemographic, and anatomical factors influence surgical treatment of De Quervain's tendinopathy (DQT) is limited.</div></div><div><h3>Purpose</h3><div>We hypothesised that different patient, anatomical, or sociodemographic factors influence the management of DQT with regard to non-operative vs. surgical management.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study reviewed 155 cases of patients with DQT seen over a 10 year period. Patient-specific factors included age, gender, hand affected, dominant hand, steroid injection given and mean number of injections. Sociodemographic factors included ethnicity, employment, and deprivation, were measured using deprivation quintiles through The Index of Multiple Deprivation. Anatomical factors included the presence of subcompartmentalization, number of APL and EPB tendon slips, tendon thickening, exudative tenosynovitis, hypervascularization, and the presence of a sheath ganglion Patients were categorized into either non-operative or surgical cohort. Bivariate analysis was used to compare factors between the cohorts, and significant factors (p &lt; 0.05) were included in the logistic regression model, used to predict factors influencing surgical management.</div></div><div><h3>Results</h3><div>Bivariate analysis detected a significant difference in the mean number of steroids given between the non-operative and surgical cohort (p = 0.001) patient factors. For sociodemographic factors, a significant difference was found between deprivation quintiles (p = 0.02). From the anatomical factors, the surgical cohort had more patients with multiple APL tendon slips (p = 0.02) and the presence of a tendon ganglion sheath ganglion (p = 0.02). For patient and sociodemographic factors, logistic regression identified that the number of steroids (per patient) and being in deprivation quintile 4 were associated with surgical treatment. For anatomical factors, multiple APL tendon slips and the presence of a tendon sheath ganglion were associated with the surgical treatment.</div></div><div><h3>Conclusion</h3><div>This study suggests that several factors are associated with the need for surgical treatment of DQT, including the number of steroid injections received, social deprivation, and anatomical factors, such as the presence of multiple tendon slips and a tendon sheath ganglion. Our findings add to the growing body of literature exploring factors that may influence treatment pathways for patients with DQT.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"58 ","pages":"Article 102790"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucor mycosis of tibia: A case report of An unsolved entity 胫骨粘菌病:一个尚未解决的实体病例报告
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102793
Lavindra Tomar, Gaurav Govil
Mucormycosis of tibia is a highly aggressive fungal infection. It is an uncommon affection especially in immunocompromised host who have more propensity for such affections.
The nonhealing ulcer of the left leg in an immunocompromised host status of a 45-year-old male presented with a radiological lytic lesion of the distal lower fourth of tibia. The initial biopsy confirmed tubercular affection which responded to antitubercular medications to allow radiological healing. However, the repeat biopsy showed Mucormycosis which remained recalcitrant to antifungal medications with unresponsive wound healing and persisting suppuration. The case presented unique scenario of superadded fungal infection in a healing tubercular osteomyelitis tibia with alcoholic liver disease compromised host immunity.
The fungal infection of tibia remains an unsolved entity with poor clinical and functional outcomes. An early detection, high degree of suspicion with an adequate dosage of antifungal medications may allow resolution of the dreaded infection though an effective treatment remains an unsolved entity.
胫骨黏菌病是一种侵袭性极强的真菌感染。胫骨黏菌病是一种侵袭性极强的真菌感染,并不常见,尤其是在免疫力低下的宿主中,他们更容易患上这种疾病。一名 45 岁男性的左腿溃疡不愈合,免疫力低下的宿主出现了胫骨远端下四分之三处的放射性溶解性病变。初次活检证实为结核性病变,服用抗结核药物后放射学病灶愈合。然而,再次活检显示为粘孢子菌病,抗真菌药物仍然无效,伤口愈合无反应,持续化脓。胫骨真菌感染仍是一个尚未解决的问题,其临床和功能预后较差。早期发现、高度怀疑并使用足量的抗真菌药物可解决这一可怕的感染问题,但有效的治疗方法仍是一个未解之谜。
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引用次数: 0
Diagnostics and surgical treatment of ruptured Baker's cysts: A prospective study 贝克氏囊肿破裂的诊断和手术治疗:前瞻性研究
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102792
Murodjon E. Irismetov , Kudratbek K. Tursunov , Kobiljon T. Khudayberdiev , Markhabo A. Tursunova , Yulia Roitblat

Aims

We assessed diagnostic and arthroscopic surgery challenges the ruptured Baker's cysts (RBC) cases may present compared to intact Baker's cyst cases (IBC). The main question to explore was: Is RBC arthroscopic surgery more complex than IBS surgery? The null hypothesis was that RBC cases might present additional, and specific challenges for a surgeon and the arthroscopic procedure may be more complicated.

Methods

The prospective cohort study analyzed 100 operated patients (43 % female; mean age 61 ± 9.5 years) (2005–2022; follow-up to August 2023) diagnosed with RBC. The comparison group consisted of 100 operated patients (48 % female; mean age 57 ± 12.5 years) with IBC. We compared diagnostic challenges, surgical approaches, functional outcomes, the rates of postsurgical complications and recurrence, durations of surgery and immobilization, and the time to recovery.

Results

Among statistically significant results, RBCs were more frequently detected during the differential diagnosis with thrombophlebitis (28 vs. 17, p = 0.04) and by 99m-Tc-MDP radiography (30 vs. 10, p = 0.03). They frequently involved a three-port arthroscopic approach (89 vs. 71, p = 0.04), the cyst wall preservation (p = 0.03), and had the eight-day shorter time to recovery (p = 0.05). Other above-mentioned variables were similar in both groups of patients.

Conclusion

RBCs do not present an additional challenge for a surgeon if an arthroscopic technique is used, but the diagnostic process may be challenging. Most RBCs require a three-port arthroscopic approach and permit cyst wall preservation.
目的我们评估了与完整的贝克氏囊肿病例(IBC)相比,破裂的贝克氏囊肿(RBC)病例在诊断和关节镜手术方面可能遇到的挑战。要探讨的主要问题是RBC 关节镜手术是否比 IBS 手术更复杂?方法该前瞻性队列研究分析了 100 名被诊断为 RBC 的手术患者(43% 为女性;平均年龄为 61 ± 9.5 岁)(2005-2022;随访至 2023 年 8 月)。对比组包括 100 名 IBC 手术患者(48% 为女性;平均年龄为 57 ± 12.5 岁)。我们对诊断难题、手术方法、功能结果、术后并发症和复发率、手术和固定时间以及康复时间进行了比较。结果在统计学上有显著意义的是,在与血栓性静脉炎进行鉴别诊断时(28 对 17,P = 0.04)和通过 99m-Tc-MDP 放射摄影检查(30 对 10,P = 0.03)更经常发现 RBC。他们经常采用三孔关节镜方法(89 对 71,p = 0.04),保留囊壁(p = 0.03),康复时间缩短了 8 天(p = 0.05)。结论如果采用关节镜技术,RBC 不会给外科医生带来额外的挑战,但诊断过程可能具有挑战性。大多数 RBC 需要采用三孔关节镜方法,并允许保留囊壁。
{"title":"Diagnostics and surgical treatment of ruptured Baker's cysts: A prospective study","authors":"Murodjon E. Irismetov ,&nbsp;Kudratbek K. Tursunov ,&nbsp;Kobiljon T. Khudayberdiev ,&nbsp;Markhabo A. Tursunova ,&nbsp;Yulia Roitblat","doi":"10.1016/j.jcot.2024.102792","DOIUrl":"10.1016/j.jcot.2024.102792","url":null,"abstract":"<div><h3>Aims</h3><div>We assessed diagnostic and arthroscopic surgery challenges the ruptured Baker's cysts (RBC) cases may present compared to intact Baker's cyst cases (IBC). The main question to explore was: Is RBC arthroscopic surgery more complex than IBS surgery? The null hypothesis was that RBC cases might present additional, and specific challenges for a surgeon and the arthroscopic procedure may be more complicated.</div></div><div><h3>Methods</h3><div>The prospective cohort study analyzed 100 operated patients (43 % female; mean age 61 ± 9.5 years) (2005–2022; follow-up to August 2023) diagnosed with RBC. The comparison group consisted of 100 operated patients (48 % female; mean age 57 ± 12.5 years) with IBC. We compared diagnostic challenges, surgical approaches, functional outcomes, the rates of postsurgical complications and recurrence, durations of surgery and immobilization, and the time to recovery.</div></div><div><h3>Results</h3><div>Among statistically significant results, RBCs were more frequently detected during the differential diagnosis with thrombophlebitis (28 vs. 17, p = 0.04) and by 99m-Tc-MDP radiography (30 vs. 10, p = 0.03). They frequently involved a three-port arthroscopic approach (89 vs. 71, p = 0.04), the cyst wall preservation (p = 0.03), and had the eight-day shorter time to recovery (p = 0.05). Other above-mentioned variables were similar in both groups of patients.</div></div><div><h3>Conclusion</h3><div>RBCs do not present an additional challenge for a surgeon if an arthroscopic technique is used, but the diagnostic process may be challenging. Most RBCs require a three-port arthroscopic approach and permit cyst wall preservation.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"58 ","pages":"Article 102792"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common elbow injuries in children 儿童常见的肘部损伤
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102554
Gaurav Gupta , Sudhanshu Bansal , Chinmay Sangole
Elbow injuries are one of the commonest paediatric musculoskeletal injuries. Their spectrum varies from pulled elbow to elbow dislocation. Supracondylar fractures are the most common type of paediatric elbow fractures accounting for 65–75 % of all paediatric elbow injuries. Other common paediatric elbow injuries include Lateral condyle fractures, Medial epicondyle fractures, Radial neck fractures, olecranon fractures, TRASH injuries and Elbow dislocations. Osteochondral fractures in kids can be missed due to their benign appearance or invisibility on x rays. TRASH stands for “The Radiological Appearance Seems Harmless”. In contrast to the full form, the abbreviation TRASH tells the harmful consequences of missing these injuries. This article will discuss the salient points regarding common elbow injuries, their diagnosis and best treatment practices. It will help the caregivers to be more prepared to deal with these situations and thus avoiding complications and getting better outcomes.
肘部损伤是最常见的儿科肌肉骨骼损伤之一。其范围从肘关节牵拉到肘关节脱位不等。髁上骨折是最常见的儿科肘部骨折类型,占所有儿科肘部损伤的 65-75%。其他常见的儿科肘部损伤包括外侧髁骨折、内侧上髁骨折、桡骨颈骨折、肩胛骨骨折、TRASH损伤和肘关节脱位。儿童骨软骨骨折可能因其良性外观或在X光片上不明显而被漏诊。TRASH是 "The Radiological Appearance Seems Harmless "的缩写。与全称相比,缩写TRASH告诉人们遗漏这些损伤的危害后果。本文将讨论有关常见肘部损伤、诊断和最佳治疗方法的要点。它将帮助护理人员在处理这些情况时做好更充分的准备,从而避免并发症,获得更好的治疗效果。
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引用次数: 0
Combating antimicrobial resistance in osteoarticular infections: Current strategies and future directions 对抗骨关节感染中的抗菌药耐药性:当前战略和未来方向
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102791
Madhan Jeyaraman , Tarun Jayakumar , Naveen Jeyaraman , Arulkumar Nallakumarasamy , Swaminathan Ramasubramanian , Sathish Muthu , Vijay Kumar Jain
The emergence of antimicrobial resistance (AMR) has profoundly impacted the management of osteoarticular infections (OAIs), presenting significant challenges for healthcare systems worldwide. This review provides a comprehensive overview of the current landscape of AMR in OAIs, emphasizing the necessity for assertive and innovative strategies to combat this escalating health threat. It discusses the evolution of resistance among key pathogens, including ESKAPEE organisms, and the implications for treatment protocols and healthcare outcomes. The importance of antibiotic stewardship programs (ASPs) is highlighted as a core strategy to optimize antibiotic use and mitigate the development of resistance. Additionally, the review explores the potential of pharmacological approaches, including novel antibiotic regimens and combination therapies, alongside surgical interventions and alternative therapies such as bacteriophage-based treatments and probiotics, in managing these complex infections. The role of rapid diagnostic methods in improving treatment accuracy and the critical need for global surveillance to track AMR trends are also examined. By integrating insights from recent literature and expert recommendations, this review underscores the multifaceted approach required to address the challenge of AMR in OAIs effectively. It calls for a concerted effort among clinicians, researchers, and policymakers to foster innovation in treatment strategies, enhance diagnostic capabilities, and implement robust stewardship and surveillance programs. The goal is to adapt to the evolving landscape of OAIs and ensure optimal patient care in the face of rising AMR.
抗菌药耐药性(AMR)的出现对骨关节感染(OAIs)的管理产生了深远影响,给全球医疗保健系统带来了重大挑战。本综述全面概述了当前 OAIs 中的 AMR 状况,强调必须采取果断而创新的策略来应对这一不断升级的健康威胁。它讨论了包括 ESKAPEE 微生物在内的主要病原体耐药性的演变,以及对治疗方案和医疗效果的影响。抗生素监管计划 (ASP) 作为优化抗生素使用和减轻耐药性发展的核心战略,其重要性得到了强调。此外,该综述还探讨了药物治疗方法的潜力,包括新型抗生素治疗方案和联合疗法,以及外科干预和替代疗法,如基于噬菌体的治疗和益生菌,以管理这些复杂的感染。此外,还探讨了快速诊断方法在提高治疗准确性方面的作用,以及全球监测以跟踪 AMR 趋势的迫切需要。通过整合最新文献中的见解和专家建议,本综述强调了有效应对非传染性感染中的 AMR 挑战所需的多方面方法。它呼吁临床医生、研究人员和决策者共同努力,促进治疗策略的创新,提高诊断能力,并实施强有力的监管和监测计划。目标是适应 OAIs 不断变化的形势,确保在 AMR 不断增加的情况下为患者提供最佳护理。
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引用次数: 0
Designing orthopaedic seat cushion made of rattan using quality function deployment approach 采用质量功能部署法设计藤制矫形坐垫
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102771
Lina Gozali , Ambrosius Milano Lo'o Ukeng Watun , Lamto Widodo , Syuhaida Ismail , Abdoulmohammad Gholamzadeh Chofreh , Dyah Erni Herwindiati , Ariawan Gunadi , Feybi Ariani Goni , Sani Susanto , Wan Hee Cheng
Using ergonomic orthopaedic chairs can address spinal issues, particularly HNP, due to their flexible and elastic properties. By achieving optimal ergonomic design, various positive aspects can be achieved, such as increasing work quality productivity and reducing the cost of injuries or accidents. This research demonstrates diverse product design approaches to enhance posture health ergonomics, address specific musculoskeletal disorder issues, and consider local needs and available materials. Rattan is a tropical vine widely used in the furniture industry and predominantly found in wooded areas such as Indonesia. This research combines market research, morphology, ergonomic study, concept selection, QFD, HoQ, stiffness test, and prototype review. The QFD method was chosen in this study due to its excellence in connecting consumer desires with the product development process. Data of respondents consist of 51 % of respondents were male, 49 % were female, 88 % were aged between 18 and 34 years old, and 10 % were aged between 35 and 54 years old. The approach of 6 stages of product design as the primary framework for developing our product such as: planning, concept development (concept screening, product morphology, concept selection), system-level design, detailed design, testing, refinement and launching. Based on the calculations using the HOQ, it is identified that the primary focus in designing the rattan-based orthopaedic seating, lies in the orthopaedic design that provides maximum comfort for the spine. The comparison results indicate that the stiffness level of rattan weaving is nearly like latex, with a similarity percentage of 89 %. Data analysis using the QFD method indicates that the primary priority aspect is the orthopaedic design, followed by the selection of quality materials, cost-effectiveness, versatility, and appealing design aspects. Rattan's superior air circulation provides comfort by preventing excessive heat accumulation, excellence in strength and durability, ensuring ease of lightweight modelling, and providing more sustainable material.
由于人体工学矫形椅具有柔韧性和弹性,因此可以解决脊柱问题,特别是 HNP。通过实现最佳人体工程学设计,可以达到各种积极的效果,如提高工作质量和生产率,降低受伤或事故的成本。这项研究展示了各种产品设计方法,以提高姿势健康人体工程学,解决特定的肌肉骨骼疾病问题,并考虑当地需求和可用材料。藤是一种广泛应用于家具行业的热带藤本植物,主要分布在印度尼西亚等林区。本研究结合了市场调研、形态学、人体工程学研究、概念选择、QFD、HoQ、硬度测试和原型审查。本研究之所以选择 QFD 方法,是因为该方法在将消费者需求与产品开发过程联系起来方面表现出色。受访者数据包括:51% 的受访者为男性,49% 为女性,88% 的受访者年龄在 18 至 34 岁之间,10% 的受访者年龄在 35 至 54 岁之间。产品设计的 6 个阶段是我们开发产品的主要框架,如规划、概念开发(概念筛选、产品形态、概念选择)、系统级设计、详细设计、测试、完善和发布。根据使用 HOQ 进行的计算,可以确定藤制矫形座椅设计的首要重点在于为脊柱提供最大舒适度的矫形设计。比较结果表明,藤编织物的硬度水平与乳胶接近,相似度为 89%。使用 QFD 方法进行的数据分析表明,首要的优先方面是矫形设计,其次是优质材料的选择、成本效益、多功能性和吸引人的设计方面。藤条具有优越的空气流通性,可防止热量过度积聚,提供舒适感,具有卓越的强度和耐用性,确保易于轻量级建模,并提供更具可持续性的材料。
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引用次数: 0
Outcomes and complications of hip arthroscopy for femoroacetabular impingement syndrome: A narrative review 髋关节镜治疗股骨髋臼撞击综合征的疗效和并发症:叙述性综述
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102797
Cara Mohammed , Ronny Kong , Venkataramana Kuruba , Vikramaditya Rai , Shahzad Waqas Munazzam
Hip arthroscopy has emerged as the primary surgical intervention for Femoroacetabular Impingement Syndrome (FAIS), a common cause of hip pain in young adults, particularly athletes. This narrative review examines the long-term outcomes, complications, and debates surrounding arthroscopic management of FAIS. Key findings include sustained improvements in patient-reported outcomes, return to sport, and functional recovery, particularly in younger patients and those with cam-type FAIS. However, some patients may eventually require total hip arthroplasty (THA), highlighting the variability in long-term durability. Complications, though infrequent, remain a significant concern, with the most common being transient neuropathy due to prolonged traction, heterotopic ossification, and iatrogenic cartilage damage. Recent studies emphasize the importance of patient selection, with younger patients, those with capsular closure, and those without pre-existing osteoarthritis showing superior outcomes. Additionally, sex-based differences suggest females may experience higher complication rates, though they often report better functional improvements post-surgery. Areas of ongoing debate include the role of labral debridement versus repair, the optimal management of mixed-type FAIS, and the potential benefits of adjunctive procedures such as ligamentum teres debridement. Future research should focus on refining surgical techniques and identifying patient-specific factors to further optimize outcomes. Despite its complexities, hip arthroscopy remains an effective treatment for FAIS, though individualized treatment plans are crucial to addressing the unique needs of each patient. By synthesizing current evidence, this review aims to guide clinicians in optimizing FAIS management and identifying areas for future research.
髋关节镜已成为治疗股骨髋臼撞击综合征(FAIS)的主要手术干预方法,而股骨髋臼撞击综合征是导致青壮年尤其是运动员髋关节疼痛的常见原因。这篇叙述性综述探讨了关节镜治疗股骨髋臼撞击综合征的长期效果、并发症和相关争论。主要发现包括患者报告的疗效、运动恢复和功能恢复方面的持续改善,尤其是年轻患者和凸轮型 FAIS 患者。然而,有些患者最终可能需要进行全髋关节置换术(THA),这就凸显了长期耐久性的差异性。并发症虽然并不常见,但仍是一个值得关注的问题,最常见的并发症是长期牵引导致的短暂神经病变、异位骨化和软骨先天性损伤。最近的研究强调了患者选择的重要性,年轻患者、关节囊闭合的患者和无原有骨关节炎的患者疗效更佳。此外,性别差异表明女性可能会经历更高的并发症发生率,尽管她们通常报告术后功能改善得更好。目前仍在争论的问题包括:唇囊清创与修复的作用、混合型FAIS的最佳治疗方法以及韧带清创等辅助手术的潜在益处。未来的研究重点应放在完善手术技术和确定患者的特异性因素上,以进一步优化治疗效果。尽管髋关节镜手术很复杂,但它仍然是 FAIS 的有效治疗方法,不过个性化治疗方案对于满足每位患者的独特需求至关重要。本综述通过综合现有证据,旨在指导临床医生优化 FAIS 管理,并确定未来研究的领域。
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引用次数: 0
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Journal of Clinical Orthopaedics and Trauma
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