Pub Date : 2023-04-01DOI: 10.17843/rpmesp.2023.402.12998
Luciana Blanco-Villafuerte, Stella M Hartinger
{"title":"Impact of climate change on the health of peruvians: challenges and strategies for a comprehensive response.","authors":"Luciana Blanco-Villafuerte, Stella M Hartinger","doi":"10.17843/rpmesp.2023.402.12998","DOIUrl":"10.17843/rpmesp.2023.402.12998","url":null,"abstract":"","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":" ","pages":"130-131"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46885191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.17843/rpmesp.2023.402.12519
Boris Itkin, Samanta Straminsky, Hernán Cáceres, Mariana Onassis, Agustín Emilio García, Laura Avanzi, Lucia Kaminszczik, Richard Serna Sejas, Mara Rapaccioli, Gustavo Billordo, Damián Lavaccara, Julián Lanzavecchia, Luz Gibbons, Eugenia Settecase, Ariel Bardach
Objectives.: Motivation for the study. The impact of the COVID-19 pandemic on the risk of death in cancer patients on chemotherapy and immunotherapy is controversial. Published studies mainly compared patients on anti-cancer therapy to those off treatment or COVID-19 positive cancer patients to COVID-19 negative ones. Few studies were conducted in developing countries. Main findings. Mortality didn't increase in unvaccinated outpatients on active intravenous oncology treatment during the COVID-19 pandemic. Implications. This is the first propensity score-matched cohort study evaluating the impact of the COVID-19 pandemic on the population of unvaccinated oncology patients receiving intravenous anticancer therapy. . To compare all-cause mortality of unvaccinated oncology patients who received chemotherapy or immunotherapy during the pandemic with those treated before the pandemic.
Materials and methods.: We conducted a cohort study in four tertiary hospitals in Argentina. Outpatients with a solid neoplasm of any stage under-going cytotoxic or intravenous immunotherapy were eligible. The pandemic cohort was enrolled during the initial phase of the outbreak and compared with a pre-pandemic cohort using propensity score matching (PSM). Subjects were matched for age, sex, health insurance, risk factors for severe COVID-19 complications, performance status, cancer type and treatment, line of treatment, and body mass index. All-cause mortality was estimated for both cohorts after 6 months of follow-up.
Results.: A total of 169 patients were recruited between April and August 2020 for the pandemic cohort and 377 for the pre-pandemic cohort in the same months of 2019; 168 patients were matched. After PSM, all-cause mortality was 17.9% in the pandemic cohort and 18.5% in the pre-pandemic cohort; the Relative Risk was 0.97 (95 % confidence interval: 0.61-1.52; p=0.888). In the pandemic cohort, 30/168 patients died, but none from COVID-19.
Conclusions.: Our findings show that the mortality rate of unvaccinated ambulatory patients on active intravenous oncology treatment during the COVID-19 pandemic did not increase.
{"title":"Comparison of mortality in patients on chemotherapy or immunotherapy during and before COVID-19 pandemic. Multicenter matched cohort study in Argentina.","authors":"Boris Itkin, Samanta Straminsky, Hernán Cáceres, Mariana Onassis, Agustín Emilio García, Laura Avanzi, Lucia Kaminszczik, Richard Serna Sejas, Mara Rapaccioli, Gustavo Billordo, Damián Lavaccara, Julián Lanzavecchia, Luz Gibbons, Eugenia Settecase, Ariel Bardach","doi":"10.17843/rpmesp.2023.402.12519","DOIUrl":"10.17843/rpmesp.2023.402.12519","url":null,"abstract":"<p><strong>Objectives.: </strong>Motivation for the study. The impact of the COVID-19 pandemic on the risk of death in cancer patients on chemotherapy and immunotherapy is controversial. Published studies mainly compared patients on anti-cancer therapy to those off treatment or COVID-19 positive cancer patients to COVID-19 negative ones. Few studies were conducted in developing countries. Main findings. Mortality didn't increase in unvaccinated outpatients on active intravenous oncology treatment during the COVID-19 pandemic. Implications. This is the first propensity score-matched cohort study evaluating the impact of the COVID-19 pandemic on the population of unvaccinated oncology patients receiving intravenous anticancer therapy. . To compare all-cause mortality of unvaccinated oncology patients who received chemotherapy or immunotherapy during the pandemic with those treated before the pandemic.</p><p><strong>Materials and methods.: </strong>We conducted a cohort study in four tertiary hospitals in Argentina. Outpatients with a solid neoplasm of any stage under-going cytotoxic or intravenous immunotherapy were eligible. The pandemic cohort was enrolled during the initial phase of the outbreak and compared with a pre-pandemic cohort using propensity score matching (PSM). Subjects were matched for age, sex, health insurance, risk factors for severe COVID-19 complications, performance status, cancer type and treatment, line of treatment, and body mass index. All-cause mortality was estimated for both cohorts after 6 months of follow-up.</p><p><strong>Results.: </strong>A total of 169 patients were recruited between April and August 2020 for the pandemic cohort and 377 for the pre-pandemic cohort in the same months of 2019; 168 patients were matched. After PSM, all-cause mortality was 17.9% in the pandemic cohort and 18.5% in the pre-pandemic cohort; the Relative Risk was 0.97 (95 % confidence interval: 0.61-1.52; p=0.888). In the pandemic cohort, 30/168 patients died, but none from COVID-19.</p><p><strong>Conclusions.: </strong>Our findings show that the mortality rate of unvaccinated ambulatory patients on active intravenous oncology treatment during the COVID-19 pandemic did not increase.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"1 1","pages":"161-169"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41928697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.17843/rpmesp.2023.402.12472
Isidro Antitupa, Nury Jakeline Vargas-Mayuri, Jhon Vicent Mayo, Luis Arturo Estares-Porras, William Marcelino Quispe Paredes, Elizabeth Luz Sánchez, Gilmer Solis-Sánchez
Objectives.: Motivation for the study. To understand the characteristics and distribution of the main parasitic zoonoses in Peru and to generate data for decision making in surveillance, prevention and control. Main findings. These parasitic zoonoses are distributed in areas of extreme poverty in the central and southern highlands of Peru. Fascioliasis seropositivity was found to be higher than for echinococcosis and cysticercosis. In addition, sociodemographic characteristics and lifestyle habits influence the transmission of these zoonoses. Implications. An active search for these zoonoses should be carried out in other risk areas with similar epidemiological characteristics to determine the prevalence of each of these zoonoses and implement multisectoral prevention and control programs. . To determine seropositivity to anti-IgG antibodies against Echinococcus granulosus, Fasciola hepatica and Taenia solium cysticercus infection and to describe the characteristics of the infected patients in 13 regions of the Peruvian highlands between 2016 and 2019.
Materials and methods.: Cross-sectional, observational study, in which we analyzed 7811 epidemiological records of laboratory-based surveillance of parasitic zoonoses from 2016 to 2019. Diagnosis was established by detecting IgG type anti-E. granulosus, F. hepatica and T. solium cysticercus antibodies using native antigens by enzyme-linked immunosorbent assay (ELISA) and Immunoblot. We evaluated the difference in the frequency of the cases according to identified characteristics using Pearson's chi-square test and Fisher's exact test.
Results.: Seropositivity was 7.9% for fascioliasis, 4.9% for cystic echinococcosis, and 2.3% for T. solium cysticercus. These rates were higher in Cerro de Pasco for cystic echinococcosis (24.5%), in Ayacucho for T. solium cysticercus (4.5%) and in Puno for fascioliasis (40.6%). Regarding the sociodemographic characteristics, we found a statistically significant difference in the frequency of cases for all zoonoses according to age group, occupation, and region of residence. We also found a difference with the consumption of vegetables in emollients, and between clinical-epidemiological characteristics and having a family history of parasitic zoonoses.
Conclusions.: From the 7811 samples, we found that these parasitic zoonoses are distributed in 13 regions of the Peruvian highlands, and represent a major health problem, with frequencies that change according to different characteristics.
目的:确定2016年至2019年秘鲁山区颗粒棘球绦虫、肝片吸虫、猪带绦虫囊尾蚴的血清阳性率和与寄生虫性人畜共患病相关的特征。材料和方法:分析了2016-2019年期间国家卫生研究所在秘鲁山区13个地区开展的人畜共患病流行病学监测活动中评估的7811份报告。每一份报告都包括一份流行病学数据表,其中载有社会人口信息、习俗和活动特征、生活方式和流行病学信息。通过酶联免疫吸附试验(ELISA)和Western blotting,使用天然抗原,通过存在抗Solium颗粒E、肝F和囊尾蚴的IgG抗体来获得诊断。与这些人畜共患病存在相关的特征是通过皮尔逊卡方检验进行的。结果:包虫病血清阳性率为7.9%,包虫病为4.9%,猪囊尾蚴病为2.3%;这些频率在Cerro de Pasco的包虫病(24.5%)、Ayacucho的囊尾蚴病(4.5%)和Puno的筋膜病(40.6%)中最高。在社会人口学特征中,根据年龄组、职业和居住地区,所有人畜共患病在生活方式与食用润肤剂中的蔬菜有关,在流行病学特征与体重减轻有关方面,都有统计学意义的联系。结论:这些人畜共患病的发现频率及其分布是这些疾病是一个重要健康问题的指标,具有相关的共同特征。
{"title":"Serological surveillance of parasitic zoonoses in 13 highlands regions of Peru: Period 2016-2019.","authors":"Isidro Antitupa, Nury Jakeline Vargas-Mayuri, Jhon Vicent Mayo, Luis Arturo Estares-Porras, William Marcelino Quispe Paredes, Elizabeth Luz Sánchez, Gilmer Solis-Sánchez","doi":"10.17843/rpmesp.2023.402.12472","DOIUrl":"10.17843/rpmesp.2023.402.12472","url":null,"abstract":"<p><strong>Objectives.: </strong>Motivation for the study. To understand the characteristics and distribution of the main parasitic zoonoses in Peru and to generate data for decision making in surveillance, prevention and control. Main findings. These parasitic zoonoses are distributed in areas of extreme poverty in the central and southern highlands of Peru. Fascioliasis seropositivity was found to be higher than for echinococcosis and cysticercosis. In addition, sociodemographic characteristics and lifestyle habits influence the transmission of these zoonoses. Implications. An active search for these zoonoses should be carried out in other risk areas with similar epidemiological characteristics to determine the prevalence of each of these zoonoses and implement multisectoral prevention and control programs. . To determine seropositivity to anti-IgG antibodies against Echinococcus granulosus, Fasciola hepatica and Taenia solium cysticercus infection and to describe the characteristics of the infected patients in 13 regions of the Peruvian highlands between 2016 and 2019.</p><p><strong>Materials and methods.: </strong>Cross-sectional, observational study, in which we analyzed 7811 epidemiological records of laboratory-based surveillance of parasitic zoonoses from 2016 to 2019. Diagnosis was established by detecting IgG type anti-E. granulosus, F. hepatica and T. solium cysticercus antibodies using native antigens by enzyme-linked immunosorbent assay (ELISA) and Immunoblot. We evaluated the difference in the frequency of the cases according to identified characteristics using Pearson's chi-square test and Fisher's exact test.</p><p><strong>Results.: </strong>Seropositivity was 7.9% for fascioliasis, 4.9% for cystic echinococcosis, and 2.3% for T. solium cysticercus. These rates were higher in Cerro de Pasco for cystic echinococcosis (24.5%), in Ayacucho for T. solium cysticercus (4.5%) and in Puno for fascioliasis (40.6%). Regarding the sociodemographic characteristics, we found a statistically significant difference in the frequency of cases for all zoonoses according to age group, occupation, and region of residence. We also found a difference with the consumption of vegetables in emollients, and between clinical-epidemiological characteristics and having a family history of parasitic zoonoses.</p><p><strong>Conclusions.: </strong>From the 7811 samples, we found that these parasitic zoonoses are distributed in 13 regions of the Peruvian highlands, and represent a major health problem, with frequencies that change according to different characteristics.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":" ","pages":"189-199"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43236438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.17843/rpmesp.2023.402.12593
Carlos H Contreras-Pizarro, Gloria Chumpitaz-Anchiraico, Rosario Ticona Sanjínez, Carlos Peña-Diaz
Objectives.: Acquired hemophilia A is a rare bleeding disorder worldwide, characterized by the presence of inhibitory autoantibodies directed against a coagulation factor, most often factor VIII. There are several possible causes, and it can occur during the postpartum period. We present the case of a 34-year-old female patient with back pain, hematuria and a right gluteal hematoma, with no previous history of bleeding. She was transferred to the emergency department due to the extension of the hemorrhagic manifestations. Diagnosis was confirmed with the coagulation profile, mixing test and the assessment of factor VIII inhibitor tier. The case highlights the importance of considering this condition in a postpartum patient with persistent postoperative bleeding, extensive hematoma and no history of previous bleeding.
{"title":"Postpartum-acquired hemophilia A: case report.","authors":"Carlos H Contreras-Pizarro, Gloria Chumpitaz-Anchiraico, Rosario Ticona Sanjínez, Carlos Peña-Diaz","doi":"10.17843/rpmesp.2023.402.12593","DOIUrl":"10.17843/rpmesp.2023.402.12593","url":null,"abstract":"<p><strong>Objectives.: </strong>Acquired hemophilia A is a rare bleeding disorder worldwide, characterized by the presence of inhibitory autoantibodies directed against a coagulation factor, most often factor VIII. There are several possible causes, and it can occur during the postpartum period. We present the case of a 34-year-old female patient with back pain, hematuria and a right gluteal hematoma, with no previous history of bleeding. She was transferred to the emergency department due to the extension of the hemorrhagic manifestations. Diagnosis was confirmed with the coagulation profile, mixing test and the assessment of factor VIII inhibitor tier. The case highlights the importance of considering this condition in a postpartum patient with persistent postoperative bleeding, extensive hematoma and no history of previous bleeding.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":" ","pages":"242-246"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43506591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.17843/rpmesp.2023.402.12409
Giancarlo Alvarado-Gamarra, Vanessa Zarate-Campos, Jimena A Saavedra Díaz, Renato M Sánchez Julca, Andrea Tahua Vega, Aida Borcic, Alvaro Taype-Rondan, Luis Miguel Franchi Prato, Claudio F Lanata, Jesús Dominguez-Rojas, Raquel Garcés-Ghilardi, Matilde Estupiñan-Vigil
Objectives.: Motivation for the study. There are few reports on the clinical experience of the population infected with the omicron variant of COVID-19 in Latin America, particularly in pediatric population. Main findings. There was a rapid increase in the number of hospitalizations compared to previous waves, mainly due to respiratory conditions; most patients progressed favorably. Antibiotics and corticosteroids were the most used drugs. Implications. Studying the characteristics of children hospitalized during the third wave of COVID-19 in Peru may increase the knowledge of how the omicron variant affects this population group, which will allow comparisons with possible new waves or diseases.
{"title":"Characteristics of pediatric patients hospitalized with COVID-19 during the third wave (omicron variant) at a referral hospital in Peru.","authors":"Giancarlo Alvarado-Gamarra, Vanessa Zarate-Campos, Jimena A Saavedra Díaz, Renato M Sánchez Julca, Andrea Tahua Vega, Aida Borcic, Alvaro Taype-Rondan, Luis Miguel Franchi Prato, Claudio F Lanata, Jesús Dominguez-Rojas, Raquel Garcés-Ghilardi, Matilde Estupiñan-Vigil","doi":"10.17843/rpmesp.2023.402.12409","DOIUrl":"10.17843/rpmesp.2023.402.12409","url":null,"abstract":"<p><strong>Objectives.: </strong>Motivation for the study. There are few reports on the clinical experience of the population infected with the omicron variant of COVID-19 in Latin America, particularly in pediatric population. Main findings. There was a rapid increase in the number of hospitalizations compared to previous waves, mainly due to respiratory conditions; most patients progressed favorably. Antibiotics and corticosteroids were the most used drugs. Implications. Studying the characteristics of children hospitalized during the third wave of COVID-19 in Peru may increase the knowledge of how the omicron variant affects this population group, which will allow comparisons with possible new waves or diseases.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":" ","pages":"200-206"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48916464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17843/rpmesp.2023.404.13261
Percy Asmat, Manuel Hidalgo, Cynthia Ramos, Pedro Lezama-Asencio, Víctor Fernández-Gómez
{"title":"Cyclone \"Yaku\" and Leptospira serovars in La Libertad, Peru.","authors":"Percy Asmat, Manuel Hidalgo, Cynthia Ramos, Pedro Lezama-Asencio, Víctor Fernández-Gómez","doi":"10.17843/rpmesp.2023.404.13261","DOIUrl":"10.17843/rpmesp.2023.404.13261","url":null,"abstract":"","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"495-497"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We studied the prevalence of infection by trypanosomatid parasites in Didelphis marsupialis and its relationship with morphological/age aspects in a rural area of El Carmen de Bolivar, Colombia. Five visits were made to the Vereda El Alférez; each of which lasted three consecutive nights. During these visits, Tomahawk® traps were installed in the peridomestic and wild ecotopes of the Vereda El Alférez. Body measurements, sex and age were determined from the collected animals. Blood was extracted by cardiopuncture, after sedation, in order to obtain total deoxyribonucleic acid (DNA) and amplify the conserved region of the kinetoplast minicircle DNA (kDNA) of parasitic trypanosomatids. The association between morphological parameters of didelphids and their frequency of infection by parasitic trypanosomatids was determined by binomial regression. Thirty D. marsupialis specimens (60.0% females and 40.0% males/66.7% adults and 33.3% juveniles) were collected. Molecular diagnosis revealed a frequency of trypanosomatid parasite infection of 46.7%. Stage (p=0.024) was a determinant for infection. We discuss the role of D. marsupialis as a potential reservoir of parasitic trypanosomatids in the Vereda El Alférez.
我们在哥伦比亚 El Carmen de Bolivar 的一个农村地区研究了大羚羊锥体虫寄生虫的感染率及其与形态/年龄的关系。我们对 Vereda El Alférez 进行了五次访问,每次访问连续三个晚上。访问期间,在 Vereda El Alférez 的近郊和野生生态区安装了 Tomahawk® 诱捕器。对采集到的动物进行了身体测量、性别和年龄测定。为了获得总脱氧核糖核酸(DNA)并扩增寄生锥虫的动粒体小圆DNA(kDNA)保守区,在镇静后通过心脏穿刺提取血液。通过二项式回归法确定了双翅目蚜虫的形态参数与寄生锥虫感染频率之间的关系。共收集到 30 份马氏囊蝶标本(雌性占 60.0%,雄性占 40.0%/成虫占 66.7%,幼虫占 33.3%)。分子诊断显示,锥虫寄生虫感染率为 46.7%。阶段(p=0.024)是感染的决定因素。我们讨论了 D. marsupialis 作为 Vereda El Alférez 的潜在锥虫寄生库的作用。
{"title":"Molecular detection of the natural infection by trypanosomatid parasites in Didelphis marsupialis from a rural area in northern Colombia.","authors":"Marlon M Ardila, Yoselin Villadiego, Leidi Herrera, Wendy Zabala-Monterroza, Alveiro Pérez-Doria","doi":"10.17843/rpmesp.2023.401.11573","DOIUrl":"10.17843/rpmesp.2023.401.11573","url":null,"abstract":"<p><p>We studied the prevalence of infection by trypanosomatid parasites in Didelphis marsupialis and its relationship with morphological/age aspects in a rural area of El Carmen de Bolivar, Colombia. Five visits were made to the Vereda El Alférez; each of which lasted three consecutive nights. During these visits, Tomahawk® traps were installed in the peridomestic and wild ecotopes of the Vereda El Alférez. Body measurements, sex and age were determined from the collected animals. Blood was extracted by cardiopuncture, after sedation, in order to obtain total deoxyribonucleic acid (DNA) and amplify the conserved region of the kinetoplast minicircle DNA (kDNA) of parasitic trypanosomatids. The association between morphological parameters of didelphids and their frequency of infection by parasitic trypanosomatids was determined by binomial regression. Thirty D. marsupialis specimens (60.0% females and 40.0% males/66.7% adults and 33.3% juveniles) were collected. Molecular diagnosis revealed a frequency of trypanosomatid parasite infection of 46.7%. Stage (p=0.024) was a determinant for infection. We discuss the role of D. marsupialis as a potential reservoir of parasitic trypanosomatids in the Vereda El Alférez.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-06-23DOI: 10.17843/rpmesp.2023.401.12169
Enrique Zumaeta-Saavedra, Christian Chiara-Chilet, Julio Maquera-Afaray, Medalit Luna-Vilchez
Recurrent respiratory papillomatosis is a neoplastic disease caused by the human papillomavirus and characterized by the growth of exophytic proliferative lesions affecting the mucosa of the respiratory tract. This condition has a bimodal age distribution; the juvenile form affects those under 20 years of age, is more aggressive and presents multiple papillomatous lesions and high frequency of recurrence, compared to the adult form. Pulmonary involvement is rare and challenging to treat. We present the case of a 13-year-old male with a history of laryngeal papillomatosis since the age of two years. The patient showed respiratory distress and multiple stenosing nodules in the larynx and trachea, as well as several pulmonary cysts identified on chest CT. The patient underwent excision of the papillomatous lesions and tracheostomy. Then, the patient received a single dose of intravenous bevacizumab 400 mg and respiratory therapies with favorable evolution, without recurrences during follow-up.
{"title":"Recurrent laryngeal papillomatosis with pulmonary involvement: case report.","authors":"Enrique Zumaeta-Saavedra, Christian Chiara-Chilet, Julio Maquera-Afaray, Medalit Luna-Vilchez","doi":"10.17843/rpmesp.2023.401.12169","DOIUrl":"10.17843/rpmesp.2023.401.12169","url":null,"abstract":"<p><p>Recurrent respiratory papillomatosis is a neoplastic disease caused by the human papillomavirus and characterized by the growth of exophytic proliferative lesions affecting the mucosa of the respiratory tract. This condition has a bimodal age distribution; the juvenile form affects those under 20 years of age, is more aggressive and presents multiple papillomatous lesions and high frequency of recurrence, compared to the adult form. Pulmonary involvement is rare and challenging to treat. We present the case of a 13-year-old male with a history of laryngeal papillomatosis since the age of two years. The patient showed respiratory distress and multiple stenosing nodules in the larynx and trachea, as well as several pulmonary cysts identified on chest CT. The patient underwent excision of the papillomatous lesions and tracheostomy. Then, the patient received a single dose of intravenous bevacizumab 400 mg and respiratory therapies with favorable evolution, without recurrences during follow-up.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 1","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9748148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17843/rpmesp.2023.404.12724
Aracely Laque-Ale, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Luis Alvarado, José Alonso Cáceres Del Águila
Objective.: To determine the diagnostic performance of blood culture positivity times for distinguishing true bacteremia from contaminants in the automated "BACT/ALERT®" system.
Materials and methods.: A cross-sectional, diagnostic test-type study was conducted from a database of blood culture samples processed between January 2016 and August 2021. All blood culture samples from patients with suspected bacteremia were included; blood culture samples were entered into the "BACT/ALERT®" system to differentiate true bacteremia from contaminants.
Results.: We obtained 33,951 blood cultures samples, of which 3875 were positive. Of the total number of positive blood cultures, 75.2% (n=2913) were true bacteremia and 24.8% (n=962) were contaminants. The median time to positivity in blood cultures with true bacteremia was significantly shorter (16.3 hours; IQR: 11.2 - 24.9) than the median time to positivity of blood cultures with contaminants (22.5 hours; IQR: 18.4 - 31.8; p<0.001). The positivity time showed the capacity to differentiate true bacteremia from contaminants, with an AUC-ROC of 0.73 (95%CI: 0.71 - 0.75), with 85% and 63% sensitivity and specificity respectively for the diagnosis of contaminants when the positivity time exceeds 16.5 hours. The use of antibiotics prior to sampling delayed the time to positivity, while having fever before sampling shortened the time to positivity.
Conclusions.: Our results show good diagnostic performance of blood culture positivity times to differentiate true bacteremia from contaminants using the "BACT/ALERT®" system when the positivity time was longer than 16.5 hours.
{"title":"Diagnostic performance of the time to positivity of blood cultures to distinguish true bacteremia from contaminants based on an automated system.","authors":"Aracely Laque-Ale, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Luis Alvarado, José Alonso Cáceres Del Águila","doi":"10.17843/rpmesp.2023.404.12724","DOIUrl":"10.17843/rpmesp.2023.404.12724","url":null,"abstract":"<p><strong>Objective.: </strong>To determine the diagnostic performance of blood culture positivity times for distinguishing true bacteremia from contaminants in the automated \"BACT/ALERT®\" system.</p><p><strong>Materials and methods.: </strong>A cross-sectional, diagnostic test-type study was conducted from a database of blood culture samples processed between January 2016 and August 2021. All blood culture samples from patients with suspected bacteremia were included; blood culture samples were entered into the \"BACT/ALERT®\" system to differentiate true bacteremia from contaminants.</p><p><strong>Results.: </strong>We obtained 33,951 blood cultures samples, of which 3875 were positive. Of the total number of positive blood cultures, 75.2% (n=2913) were true bacteremia and 24.8% (n=962) were contaminants. The median time to positivity in blood cultures with true bacteremia was significantly shorter (16.3 hours; IQR: 11.2 - 24.9) than the median time to positivity of blood cultures with contaminants (22.5 hours; IQR: 18.4 - 31.8; p<0.001). The positivity time showed the capacity to differentiate true bacteremia from contaminants, with an AUC-ROC of 0.73 (95%CI: 0.71 - 0.75), with 85% and 63% sensitivity and specificity respectively for the diagnosis of contaminants when the positivity time exceeds 16.5 hours. The use of antibiotics prior to sampling delayed the time to positivity, while having fever before sampling shortened the time to positivity.</p><p><strong>Conclusions.: </strong>Our results show good diagnostic performance of blood culture positivity times to differentiate true bacteremia from contaminants using the \"BACT/ALERT®\" system when the positivity time was longer than 16.5 hours.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"451-458"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.17843/rpmesp.2023.404.12973
Mirko Lázaro-Serrano, César Domínguez-Curi
This article aims to describe the design and validation process of food guideline messages written in the braille reading and writing system for people with visual impairment. The process involved the following stages: i) design and elaboration of the material containing the food guideline messages, as well as its adaptation to the format; ii) technical validation with representatives of the National Council for the Integration of Persons with Disabilities (CONADIS); and iii) operational validation through focus groups with children, adolescents and adults with visual disabilities who can read braille. The participants agreed on the legibility, clarity and comprehension of the messages and approved the format of the material. Finally, it should be noted that the participation of key informants and people with visual impairment in all stages was important for the development of an informative material with healthy eating messages in braille.
{"title":"Adaptation of food guideline messages for the visually impaired in Lima, Peru: a validation experience.","authors":"Mirko Lázaro-Serrano, César Domínguez-Curi","doi":"10.17843/rpmesp.2023.404.12973","DOIUrl":"10.17843/rpmesp.2023.404.12973","url":null,"abstract":"<p><p>This article aims to describe the design and validation process of food guideline messages written in the braille reading and writing system for people with visual impairment. The process involved the following stages: i) design and elaboration of the material containing the food guideline messages, as well as its adaptation to the format; ii) technical validation with representatives of the National Council for the Integration of Persons with Disabilities (CONADIS); and iii) operational validation through focus groups with children, adolescents and adults with visual disabilities who can read braille. The participants agreed on the legibility, clarity and comprehension of the messages and approved the format of the material. Finally, it should be noted that the participation of key informants and people with visual impairment in all stages was important for the development of an informative material with healthy eating messages in braille.</p>","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"40 4","pages":"485-489"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}