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Stenotrophomonas maltophilia Pseudobacteraemia in a Pediatric Hospital Associated with Contaminated Citrated Tubes: Importance of Appropriate Blood Collection 儿科医院与污染的柠檬酸管相关的嗜麦芽窄养单胞菌假菌血症:适当采血的重要性
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229606
T. Erat, Aysun Yahşi, Tuğçe Tural Kara, H. Özdemir, A. Aysev, E. Çiftçi, E. Ince
Stenotrophomonas maltophilia pseudobacteraemia in a pediatric hospital associated with contaminated citrated tubes: Importance of appropriate blood collection
儿科医院与污染的柠檬酸管相关的嗜麦芽窄养单胞菌假菌血症:适当采血的重要性
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引用次数: 0
Evaluation of Mothers‘ Opinions on Routine Childhood Vaccinations 母亲对儿童常规疫苗接种意见的评价
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229605
Nazife Akman, Ayşegül Yıldız
Objective: Childhood vaccinations have been a milestone in the control of infectious diseases. However, even in countries that offer both free and equal access to vaccines, cases of vaccine hesitancy have increased from year to year. Parents are the decision-makers in childhood immunizations. The aim of the study was to determine the attitudes of parents about childhood vaccinations and to define the factors affecting these attitudes. Material and Methods: This is a descriptive study. The universe of the research consisted of mothers living in Nevşehir province. The Snowball sampling method was used to determine the participants. The snowball sampling method was used to determine the participants. Data collection forms (Google Form) prepared online were collected between 19.06.2021 and 20.11.2021 with 347 mothers who have children between the ages of 0-2 who agreed to participate in the study. Results: 58.5% (n= 203) of the participants in the study were between the ages of 18-30, 39.5% (n= 137) were university graduates, 59.7% (n= 207) were not working, 51.0% (n= 203) were unemployed (n= 177) had two children, and 30.7% (n= 197) of their children were in the 7-11 month age group. The mean total score of the mothers from the anti-vac- cination scale was found to be 50.9 ± 9.17. In the scores obtained from the sub-dimensions of the scale, the highest score was obtained from the “anti-vaccine” sub-dimension with 20.1 ± 5.01. Conclusion: As a result of study, it was determined that the parents had moderate anti-vaccination. Providing parents with basic information about vaccines and vaccine preventable diseases can help reduce opposi- tion to mandatory vaccination by reinforcing the safety and importance of routine childhood vaccinations.
目的:儿童疫苗接种已成为控制传染病的一个里程碑。然而,即使在提供免费和平等获得疫苗的国家,疫苗犹豫的病例也逐年增加。父母是儿童免疫接种的决策者。这项研究的目的是确定父母对儿童接种疫苗的态度,并确定影响这些态度的因素。材料与方法:本研究为描述性研究。这项研究的对象是居住在内华达州的母亲们。采用滚雪球抽样法确定研究对象。采用滚雪球抽样法确定参与者。在2021年6月19日至2021年11月20日期间收集在线准备的数据收集表(b谷歌表),347名同意参与研究的0-2岁孩子的母亲。结果:58.5% (n= 203)的被试年龄在18-30岁之间,39.5% (n= 137)的被试为大学毕业生,59.7% (n= 207)的被试没有工作,51.0% (n= 203)的被试没有工作,51.0% (n= 177)的被试有两个孩子,30.7% (n= 197)的被试的孩子年龄在7-11个月。母亲抗接种量表的平均总分为50.9±9.17分。量表子维度得分中,“抗疫苗”子维度得分最高,为20.1±5.01。结论:本研究确定患儿家长抗接种程度适中。向父母提供有关疫苗和疫苗可预防疾病的基本信息,可以通过加强儿童常规疫苗接种的安全性和重要性,帮助减少对强制性疫苗接种的反对。
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引用次数: 0
Çocuklarda COVID-19 ile İlişkili Multisistem Enflamatuvar Sendromunda Tanı Esnasında ve Tedavi Sonrasında Lenfosit Alt Gruplarının Değerlendirildiği Vaka Serisi
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229623
Şefika İlknur Kökçü Karadağ, Emine Hafize Erdeniz, Esra Özkan, Alişan Yıldıran
Objective: In this case series, we aimed to examine the changes in lymphocyte subgroups in children diagnosed with the multisystem inflammatory syndrome (MIS-C) during the acute phase and in the first month after treatment. Material and Methods: Ethics committee approval was received for the study from the Ethics Committee of Ondokuz Mayıs University patient data were analyzed from medical records in an electronic database. Initial immunological evaluations of our first five patients diagnosed with MIS-C were made, steroid and IVIG treatments were given to the patients, and lymphocyte subgroups were evaluated for the second time in the first month for control purposes. Results: In MIS-C cases, it was observed that lymphopenia was severe in the acute period, CD3 T cells decreased, the ratio of 2:1 between cytotoxic T cells and helper T cells was impaired, B cells increased proportionally, and NK cells were normal or decreased. When we evaluated MIS-C cases with the control lymphocyte subgroup in the first month, it was observed that lymphopenia improved and CD3 T cells increased proportionally, and active T cells decreased to normal values in the first month after treatment. On the other hand, while naive B cells decreased, non-switching and switching B cells increased and NK cells decreased. Conclusion: While COVID-19 is an acute infection, MIS-C is associated with cytokine storm induced by the acute infection. Immunologic assessment of MIS-C cases is considered important since the condition causes immune dysregulation in the host immune system. Lymphopenia, increased B cell count, reversal of the CD4/CD8 ratio, and increased active T cell count may be beneficial in the early diagnosis of MIS-C. Since it is thought that the cytokine storm causes complications in MIS-C, immediate administration of IVIG treatment is considered essential. Although it was demonstrated that the disease manifests with marked cellular changes, there is still a need for further studies.
目的:在本病例系列中,我们旨在研究诊断为多系统炎症综合征(MIS-C)的儿童在急性期和治疗后第一个月淋巴细胞亚群的变化。材料和方法:Ondokuz Mayıs大学伦理委员会批准了这项研究,并从电子数据库的病历中分析了患者数据。我们对前5名确诊为misc的患者进行了初步免疫学评估,对患者进行了类固醇和IVIG治疗,并在第一个月进行了第二次淋巴细胞亚群评估作为对照。结果:misc患者急性期淋巴细胞严重减少,CD3 T细胞减少,细胞毒性T细胞与辅助性T细胞的比例为2:1,B细胞比例增加,NK细胞正常或减少。当我们在第一个月用对照淋巴细胞亚组评估MIS-C病例时,我们观察到在治疗后的第一个月淋巴细胞减少改善,CD3 T细胞比例增加,活性T细胞下降到正常值。另一方面,初始B细胞减少,非开关和开关B细胞增加,NK细胞减少。结论:虽然COVID-19是急性感染,但MIS-C与急性感染诱导的细胞因子风暴有关。MIS-C病例的免疫学评估被认为是重要的,因为这种情况会导致宿主免疫系统的免疫失调。淋巴细胞减少、B细胞计数增加、CD4/CD8比值逆转和活性T细胞计数增加可能有助于MIS-C的早期诊断。由于细胞因子风暴被认为会引起MIS-C的并发症,因此立即给予IVIG治疗被认为是必要的。虽然已经证明该病表现为明显的细胞变化,但仍需要进一步的研究。
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引用次数: 0
Bağışıklanmamış İki Kardeşte Farklı Tüberküloz Klinikleri: Kaviter Akciğer Tüberkülozu ve Tüberküloz Plörezisi
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229626
Zeynep Kemer Aktaş, Tuğçe Tural Kara
Tuberculosis is a health problem that preserves its importance in devel-oping countries and populations with low socioeconomic means. The treatment process is long-term, laborious, costly and has high morbidity and mortality with many complications. The most important step to get rid against this disease is to prevent contamination. For this purpose, routine vaccination and chemoprophylaxis of the contacts are of great importance. In this case report, while examining different tuberculosis presentations in the pediatric population, we emphasized the importance of vaccination and screening the households that the index pa-tient is in contact with, the treatment of patients, and the importance of chemoprophylaxis in contacts
结核病是一个健康问题,在发展中国家和社会经济手段较低的人口中仍然很重要。治疗过程长期、费力、昂贵,发病率和死亡率高,并伴有许多并发症。根除这种疾病最重要的一步是防止污染。为此目的,接触者的常规疫苗接种和化学预防非常重要。在本病例报告中,在检查儿科人群中不同的结核病表现时,我们强调了接种疫苗和筛查指数患者接触过的家庭、患者的治疗以及接触者化学预防的重要性
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引用次数: 0
Üç Aydan Küçük Akut Otitis Medialı İnfantlarda Spontan Timpanik Membran Perforasyonu
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229624
Sevgi Yaşar Durmuş, Gonul Tanir, S. Mülazımoğlu, A. Kaman, Türkan Aydın Teke, Rumeysa Yalçınkaya, Fatma Nur Öz
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引用次数: 0
High Serum Transaminase Due to COVID-19 Infection COVID-19感染所致血清转氨酶升高
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229611
Aylin Kayalı Akyol, Özlem Mustafaoğlu, A. Güney, Latife Güder, Ömer Güneş, Belgin Gülhan, Saliha Kanık Yüksek, Aysun Yahşi, Aslınur Özkaya Parlakay, G. Bayhan
The liver can be damaged due to the virus's direct cytotoxic effect, immune-mediated damage, medication side effects, stasis due to myocardial damage, hypoxia, and ischemic damage due to hypoperfusion (6). The laboratory results were as follows: hemoglobin 14.3 g/dL, leukocytes 6.2 109/L, platelets 175 109/L (200-445 109), CRP 0.005 g/L (0-0.005), procalcitonin 0.04 pg/L, aspartate aminotransferase (AST) 393 U/L (0-46), alanine aminotransferase (ALT) 726 U/L (0-32), total bilirubin 0.5 mg/dL, direct bilirubin 0.2 mg/dL, lactate dehydrogenase (LDH) 548 U/L, gamma glutamyl transferase (GGT) 35 U/L. The biopsy, however, showed no virus particles. Since the patient had no known underlying disease, pathological findings in the liver were thought to be related to SARS-CoV-2 infection or the drugs used (11). According to reports, an increase in liver enzymes has no prognostic significance.
肝脏可因病毒的直接细胞毒作用、免疫介导的损伤、药物副作用、心肌损伤引起的瘀滞、缺氧和低灌注引起的缺血损伤而受损(6)。实验室结果如下:血红蛋白14.3 g/dL,白细胞6.2 109/L,血小板175 109/L (200 ~ 445 109), CRP 0.005 g/L(0 ~ 0.005),降钙素原0.04 pg/L,天冬氨酸转氨酶(AST) 393 U/L(0 ~ 46),丙氨酸转氨酶(ALT) 726 U/L(0 ~ 32),总胆红素0.5 mg/dL,直接胆红素0.2 mg/dL,乳酸脱氢酶(LDH) 548 U/L,谷氨酰转移酶(GGT) 35 U/L。然而,活检显示没有病毒颗粒。由于患者没有已知的基础疾病,肝脏病理结果被认为与SARS-CoV-2感染或使用的药物有关(11)。据报道,肝酶升高无预后意义。
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引用次数: 0
Case Series Evaluating Lymphocyte Subgroups at Diagnosis and After Treatment in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children 评估儿童COVID-19相关多系统炎症综合征诊断和治疗后淋巴细胞亚群的病例系列
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229607
Şefika İlknur Kökçü Karadağ, E. Erdeniz, E. Özkan, A. Yıldıran
Lymphopenia, Increased B cell count, reversal of the CD4/CD8 ratio, and Increased active T cell count may be beneficial In the early diagnosis of MIS-C. Since It Is thought that the cytokine storm causes complications In MIS-C, Immediate administration of IVIG treatment Is considered essential. The disease was considered a new multisystem inflammatory syndrome, and with the increase in awareness, it has been reported more frequently in children (MIS-C) in Europe and the United States (2,3). Since the disease is thought to cause complications by leading to cytokine storms, immediate administration of intravenous immunoglobulin (IVIG) treatment is deemed important, and it is also essential to emphasize that IVIG treatment leads to marked cellular changes. Case 2 A nine-year-old male patient presented with fever, abdominal pain, headache, and diarrhea that had been present for five days, followed by a rash, conjunctivitis, and cervical lymphadenopathy. [...]the patient was considered to have atypical Kawasaki disease. According to a review, the most common signs and symptoms reported during MIS-C consisted of abdominal pain (61.9%), vomiting (61.8%), skin rash (55.3%), diarrhea (53.2%), hypotension (49.5%), and conjunctivitis (48.4%), and particularly gastrointestinal (90.9%), cardiovascular (86.5%), or dermatological or mucocutaneous (70.9%) involvement (2).
淋巴细胞减少、B细胞计数增加、CD4/CD8比值逆转和活性T细胞计数增加可能有助于MIS-C的早期诊断。由于细胞因子风暴被认为会引起MIS-C的并发症,因此立即给予IVIG治疗被认为是必要的。该疾病被认为是一种新的多系统炎症综合征,随着认识的提高,在欧洲和美国,它在儿童(misc)中的报道频率更高(2,3)。由于该疾病被认为通过导致细胞因子风暴而引起并发症,因此立即给予静脉注射免疫球蛋白(IVIG)治疗被认为是重要的,并且必须强调IVIG治疗可导致显着的细胞变化。病例2:一名9岁男性患者,表现为发热、腹痛、头痛和腹泻,持续5天,随后出现皮疹、结膜炎和颈部淋巴结病。[…该患者被认为患有不典型川崎病。根据一项综述,MIS-C期间最常见的体征和症状包括腹痛(61.9%)、呕吐(61.8%)、皮疹(55.3%)、腹泻(53.2%)、低血压(49.5%)和结膜炎(48.4%),特别是胃肠道(90.9%)、心血管(86.5%)、皮肤或粘膜(70.9%)受累(2)。
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引用次数: 0
Local abscess due to BCGitis BCGitis引起的局部脓肿
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229615
E. Çiftçi, Hatice Belkıs İnceli, H. Özdemir, Şule Haskoloğlu, F. Doğu
An eight-month-old girl was brought in because of increasing swelling in the area where the BCG vaccine was given. It was learned that the BCG vaccine was administered at the age of two months. Over time, there was swelling in the vaccination area and gradually increased. There was no consanguinity be-tween mother and father. A sibling of the mother was lost at the age of one, for unknown reasons. The patient’s body tem-perature was normal. On examination, redness and fluctuating swelling with a diameter of about 3 cm was observed in the left deltoid region, where BCG vaccination was administered. Other physical examination findings of the patient were normal. The abscess drained spontaneously shortly after examination. Mycobacterium tuberculosis complex PCR was positive in the drainage material. The strain evaluated to be Mycobacterium bovis from the BCG vaccine was susceptible to isoniazid and rifampin. Lymphocyte subgroups, lymphocyte activation response, burst test and IL-12rβ1 expression were normal in the child with low serum IgG and IgM levels in immunologi-cal tests. Genetic study was planned in terms of other immu-nodeficiencies that predispose to mycobacterial diseases. The patient was started on isoniazid and rifampin treatment. The lesion of the patient, whose treatment was
一名8个月大的女婴因接种卡介苗的部位肿胀加剧而入院。据了解,卡介苗是在两个月大的时候接种的。随着时间的推移,接种区域出现肿胀并逐渐增大。母亲和父亲之间没有血缘关系。母亲的一个兄弟姐妹在一岁时失去了,原因不明。病人体温正常。检查时,在接种卡介苗的左三角肌区观察到直径约3cm的红肿和波动肿胀。其他体格检查结果正常。检查后不久脓肿就自发地流脓了。引流液中结核分枝杆菌复合体PCR阳性。从卡介苗中分离出的牛分枝杆菌对异烟肼和利福平敏感。免疫检查血清IgG、IgM水平低的患儿淋巴细胞亚群、淋巴细胞活化反应、爆发试验及IL-12rβ1表达均正常。基因研究计划针对其他易患分枝杆菌疾病的免疫缺陷。患者开始使用异烟肼和利福平治疗。病人的病变,其治疗方法是
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引用次数: 0
Annelerin Rutin Çocukluk Çağı Aşılarına İlişkin Görüşlerinin Değerlendirilmesi
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229621
Nazife Akman, Ayşegül Yıldız
Objective: Childhood vaccinations have been a milestone in the control of infectious diseases. However, even in countries that offer both free and equal access to vaccines, cases of vaccine hesitancy have increased from year to year. Parents are the decision-makers in childhood immunizations. The aim of the study was to determine the attitudes of parents about childhood vaccinations and to define the factors affecting these attitudes. Material and Methods: This is a descriptive study. The universe of the research consisted of mothers living in Nevşehir province. The Snowball sampling method was used to determine the participants. The snowball sampling method was used to determine the participants. Data col-lection forms (Google Form) prepared online were collected between 19.06.2021 and 20.11.2021 with 347 mothers who have children between the ages of 0-2 who agreed to participate in the study. Results: 58.5% (n= 203) of the participants in the study were between the ages of 18-30, 39.5% (n= 137) were university graduates, 59.7% (n= 207) were not working, 51.0% (n= 203) were unemployed (n= 177) had two children, and 30.7% (n= 197) of their children were in the 7-11 month age group. The mean total score of the mothers from the anti-vac- cination scale was found to be 50.9 ± 9.17. In the scores obtained from the sub-dimensions of the scale, the highest score was obtained from the “anti-vaccine” sub-dimension with 20.1 ± 5.01. Conclusion: As a result of study, it was determined that the parents had moderate anti-vaccination. Providing parents with basic information about vaccines and vaccine preventable diseases can help reduce oppo- sition to mandatory vaccination by reinforcing the safety and importance of routine childhood vaccinations.
目的:儿童疫苗接种已成为控制传染病的一个里程碑。然而,即使在提供免费和平等获得疫苗的国家,疫苗犹豫的病例也逐年增加。父母是儿童免疫接种的决策者。这项研究的目的是确定父母对儿童接种疫苗的态度,并确定影响这些态度的因素。材料与方法:本研究为描述性研究。这项研究的对象是居住在内华达州的母亲们。采用滚雪球抽样法确定研究对象。采用滚雪球抽样法确定参与者。在2021年6月19日至2021年11月20日期间收集了在线准备的数据收集表(Google Form), 347名同意参与研究的0-2岁儿童的母亲。结果:58.5% (n= 203)的被试年龄在18-30岁之间,39.5% (n= 137)的被试为大学毕业生,59.7% (n= 207)的被试没有工作,51.0% (n= 203)的被试没有工作,51.0% (n= 177)的被试有两个孩子,30.7% (n= 197)的被试的孩子年龄在7-11个月。母亲抗接种量表的平均总分为50.9±9.17分。量表子维度得分中,“抗疫苗”子维度得分最高,为20.1±5.01。结论:本研究确定患儿家长抗接种程度适中。向父母提供有关疫苗和疫苗可预防疾病的基本信息,可以通过加强儿童常规疫苗接种的安全性和重要性,帮助减少对强制性疫苗接种的反对。
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引用次数: 0
Spontaneous Tympanic Membrane Perforation in Infants Aged <3 Months with Acute Otitis Media 3个月以下急性中耳炎婴儿自发性鼓膜穿孔
IF 0.1 Q4 PEDIATRICS Pub Date : 2022-12-14 DOI: 10.5578/ced.20229608
Sevgi Yaşar Durmuş, G. Tanır, Selçuk Mülazımoğlu, A. Kaman, Türkan Aydın Teke, R. Yalçınkaya, F. Öz
. Spontaneous tympanic membrane perforation in infants aged <3 months with acute otitis media
。3个月以下急性中耳炎婴儿自发性鼓膜穿孔
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引用次数: 0
期刊
Journal of Pediatric Infection
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