Pub Date : 2025-02-18DOI: 10.1016/S2352-4642(25)00032-X
The Lancet Child & Adolescent Health Editors
{"title":"Thank you to The Lancet Child & Adolescent Health's statistical and peer reviewers in 2024","authors":"The Lancet Child & Adolescent Health Editors","doi":"10.1016/S2352-4642(25)00032-X","DOIUrl":"10.1016/S2352-4642(25)00032-X","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages e4-e6"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/S2352-4642(25)00034-3
Tanvi Hirekodi, Rebeccah Slater
{"title":"Children need space and support to talk about their pain","authors":"Tanvi Hirekodi, Rebeccah Slater","doi":"10.1016/S2352-4642(25)00034-3","DOIUrl":"10.1016/S2352-4642(25)00034-3","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 160-161"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/S2352-4642(25)00031-8
Allison Landman , Josefine Gibson , Amy L Slogrove
{"title":"Thank you to our peer reviewers and contributors in 2024","authors":"Allison Landman , Josefine Gibson , Amy L Slogrove","doi":"10.1016/S2352-4642(25)00031-8","DOIUrl":"10.1016/S2352-4642(25)00031-8","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 156-157"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-18DOI: 10.1016/S2352-4642(25)00001-X
Anhar Ullah MSc , Raquel Granell PhD , Lesley Lowe PhD , Sara Fontanella PhD , Prof Hasan Arshad DM , Clare S Murray MD , Prof Steve Turner MD , Prof John W Holloway PhD , Prof Angela Simpson PhD , Prof Graham Roberts DM , Gang Wang MD , Prof Jadwiga A Wedzicha MD , Prof Rosa Faner PhD , Hans Jacob L Koefoed MD , Judith M Vonk PhD , Prof Alvar Agusti PhD , Prof Gerard H Koppelman PhD , Prof Erik Melén MD , Prof Adnan Custovic PhD , CADSET Clinical Research Collaboration of the European Respiratory Society
<div><h3>Background</h3><div>Lung function during childhood is an important predictor of subsequent health and disease. Understanding patterns of lung function and development of airflow limitation through childhood is necessary to inform lung function trajectories in relation to health and chronic airway disease. We aimed to derive trajectories of airflow limitation from childhood (age 5–8 years) into early adulthood (age 20–26 years) using repeated spirometry data from birth cohorts.</div></div><div><h3>Methods</h3><div>In this study, we drew forced expiratory volume in 1 s (FEV<sub>1</sub>) and forced vital capacity (FVC) data from six population-based birth cohorts: the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC), Isle of Wight cohort (IOW), Manchester Asthma and Allergy Study (MAAS), and Aberdeen Study of Eczema and Asthma (SEATON) as well as the Swedish Child (<em>Barn</em>), Allergy, Milieu, Stockholm, Epidemiological survey (BAMSE) and the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. For the discovery analysis, we pooled data from ALSPAC, IOW, MAAS, and BAMSE with spirometry data recorded at middle childhood (age 8–10 years), adolescence (age 15–18 years), and early adulthood (age 20–26 years). For the replication analysis, we pooled middle childhood and adolescence spirometry data from PIAMA and SEATON. We used latent class trajectory modelling to derive trajectory classes based on joint modelling of FEV<sub>1</sub> and FEV<sub>1</sub>/FVC ratio regression residuals ascertained from all age groups. The final model was selected using the lowest Bayesian information criterion. Participants were assigned to the trajectory with the highest posterior probability. Weighted random-effect multinomial logistic regression models were used to investigate factors associated with joining each trajectory, the results of which are reported as relative risk ratios (RRRs) with 95% CIs.</div></div><div><h3>Findings</h3><div>The discovery population included 8114 participants: 4710 from ALSPAC, 808 from IOW, 586 from MAAS, and 2010 from BAMSE and was modelled into one of four lung function trajectories that showed normal airflow (6555 [80·8%] of 8114 people), persistent airflow obstruction (1280 [15·8%]), worsening airflow obstruction (161 [2·0%]), and improved airflow obstruction (118 [1·5%]). Both improvement in and worsening airflow obstruction by early adulthood were seen from all initial severity levels. Whereas improvement in airflow obstruction was more prominent between middle childhood and adolescence (57·8%) than between adolescence and early adulthood (13·4%), worsening airflow obstruction was more prominent between adolescence and early adulthood (61·5%) than between middle childhood and adolescence (32·6%). Among current wheezers, higher BMI was associated with a lower relative risk of joining the trajectory with improvement in airflow obstruction (RRR 0·69 [95% CI 0·49–0·95]), whereas among n
{"title":"Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts","authors":"Anhar Ullah MSc , Raquel Granell PhD , Lesley Lowe PhD , Sara Fontanella PhD , Prof Hasan Arshad DM , Clare S Murray MD , Prof Steve Turner MD , Prof John W Holloway PhD , Prof Angela Simpson PhD , Prof Graham Roberts DM , Gang Wang MD , Prof Jadwiga A Wedzicha MD , Prof Rosa Faner PhD , Hans Jacob L Koefoed MD , Judith M Vonk PhD , Prof Alvar Agusti PhD , Prof Gerard H Koppelman PhD , Prof Erik Melén MD , Prof Adnan Custovic PhD , CADSET Clinical Research Collaboration of the European Respiratory Society","doi":"10.1016/S2352-4642(25)00001-X","DOIUrl":"10.1016/S2352-4642(25)00001-X","url":null,"abstract":"<div><h3>Background</h3><div>Lung function during childhood is an important predictor of subsequent health and disease. Understanding patterns of lung function and development of airflow limitation through childhood is necessary to inform lung function trajectories in relation to health and chronic airway disease. We aimed to derive trajectories of airflow limitation from childhood (age 5–8 years) into early adulthood (age 20–26 years) using repeated spirometry data from birth cohorts.</div></div><div><h3>Methods</h3><div>In this study, we drew forced expiratory volume in 1 s (FEV<sub>1</sub>) and forced vital capacity (FVC) data from six population-based birth cohorts: the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC), Isle of Wight cohort (IOW), Manchester Asthma and Allergy Study (MAAS), and Aberdeen Study of Eczema and Asthma (SEATON) as well as the Swedish Child (<em>Barn</em>), Allergy, Milieu, Stockholm, Epidemiological survey (BAMSE) and the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. For the discovery analysis, we pooled data from ALSPAC, IOW, MAAS, and BAMSE with spirometry data recorded at middle childhood (age 8–10 years), adolescence (age 15–18 years), and early adulthood (age 20–26 years). For the replication analysis, we pooled middle childhood and adolescence spirometry data from PIAMA and SEATON. We used latent class trajectory modelling to derive trajectory classes based on joint modelling of FEV<sub>1</sub> and FEV<sub>1</sub>/FVC ratio regression residuals ascertained from all age groups. The final model was selected using the lowest Bayesian information criterion. Participants were assigned to the trajectory with the highest posterior probability. Weighted random-effect multinomial logistic regression models were used to investigate factors associated with joining each trajectory, the results of which are reported as relative risk ratios (RRRs) with 95% CIs.</div></div><div><h3>Findings</h3><div>The discovery population included 8114 participants: 4710 from ALSPAC, 808 from IOW, 586 from MAAS, and 2010 from BAMSE and was modelled into one of four lung function trajectories that showed normal airflow (6555 [80·8%] of 8114 people), persistent airflow obstruction (1280 [15·8%]), worsening airflow obstruction (161 [2·0%]), and improved airflow obstruction (118 [1·5%]). Both improvement in and worsening airflow obstruction by early adulthood were seen from all initial severity levels. Whereas improvement in airflow obstruction was more prominent between middle childhood and adolescence (57·8%) than between adolescence and early adulthood (13·4%), worsening airflow obstruction was more prominent between adolescence and early adulthood (61·5%) than between middle childhood and adolescence (32·6%). Among current wheezers, higher BMI was associated with a lower relative risk of joining the trajectory with improvement in airflow obstruction (RRR 0·69 [95% CI 0·49–0·95]), whereas among n","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 172-183"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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