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Modification of PEEK for implants: Strategies to improve mechanical, antibacterial, and osteogenic properties 用于植入物的聚醚醚酮改性:改善机械、抗菌和成骨特性的策略
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-30 DOI: 10.1515/rams-2024-0025
Menghao Chen, Chengfeng Luo, Ying Yuan, Hao Zhou, Zhanglong Li, Qiang Wang, Baijuan Gong, Zhimin Li, Hongchen Sun
Poly-ether-ether-ketone (PEEK), a biomaterial renowned for its mechanical prowess and biocompatibility, is increasingly preferred for medical implants. Its natural bone-like mechanical property, ease of manipulation, and ability to mitigate stress shielding render it a standout replacement for titanium in dental implantology. Adding carbon fiber and graphene to PEEK can further enhance the mechanical properties of PEEK. However, the biological passivity of PEEK hampers its efficacy in bone repair, driving spurring research into surface modifications to enhance its bioactivity. Incorporating metal, inorganic, and organic antimicrobial agents is anticipated to bolster PEEK’s resistance to bacteria, thereby reducing the risk of acute postoperative infections and peri-implantitis. Apart from its antimicrobial activity, researchers have also investigated methods to enhance the osteogenic properties of PEEK. These approaches include surface modification and blending modification. Surface modification includes physical modification, chemical modification, and biologically active substance modification. These methods can further enhance the implant integration and durability, potentially improving patient outcomes. This overview examines PEEK’s processing techniques and highlights recent research achievements in improving its biomechanical, antibacterial, and osteogenic properties. Considering these strides, we argue that modified PEEK holds significant promise as a material for dental implants, charting an encouraging course for its clinical future.
聚醚醚酮(PEEK)是一种以机械性能和生物相容性著称的生物材料,越来越多地用于医疗植入物。聚醚醚酮(PEEK)具有天然仿骨的机械特性,易于操作,并能减轻应力屏蔽,因此在牙科植入物领域是钛的理想替代品。在 PEEK 中添加碳纤维和石墨烯可进一步提高 PEEK 的机械性能。然而,PEEK 的生物被动性阻碍了其在骨修复方面的功效,这也推动了对其进行表面改性以增强其生物活性的研究。加入金属、无机和有机抗菌剂有望增强 PEEK 对细菌的抵抗力,从而降低术后急性感染和种植体周围炎的风险。除了抗菌活性,研究人员还研究了增强 PEEK 成骨特性的方法。这些方法包括表面改性和混合改性。表面改性包括物理改性、化学改性和生物活性物质改性。这些方法可以进一步提高植入物的整合性和耐用性,从而改善患者的治疗效果。本概述探讨了 PEEK 的加工技术,并重点介绍了最近在改善其生物力学、抗菌和成骨特性方面取得的研究成果。考虑到这些进步,我们认为改性聚醚醚酮作为牙科植入物的材料前景广阔,其临床前景令人鼓舞。
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引用次数: 0
Development and characterization of a coaxial strain-sensing cable integrated steel strand for wide-range stress monitoring 用于大范围应力监测的集成钢绞线的同轴应变传感电缆的开发与表征
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-24 DOI: 10.1515/rams-2023-0165
Tong Jiao, Chuhong Pu, Qiang Xu, Minggao Tang, Xing Zhu, Chuankun Liu, Jiang Li
Monitoring the stress of steel strands, from initial tension to eventual failure, is paramount for assessing structural safety and understanding its failure mechanism. Current monitoring methods are restricted in measuring stress only until yielding because of their limited range. This study proposes a novel coaxial strain-sensing cable (CSSC) based intelligent steel strand (CSSC-ISS), which has both functions of force-bearing and self-sensing. First, the prototype design of CSSC-ISS and the sensing principle of CSSC are introduced. Then, a fabrication method of small-diameter CSSC is proposed, which is then encapsulated with glass fiber reinforced polymer (GFRP) material, forming a GFRP sensing rod (GFRP-SR). The next step involves replacing the strand’s central wire with the GFRP-SR, culminating in the creation of the CSSC-ISS. Finally, Laboratory tests show that the CSSC has excellent strain-sensing performance with a resolution of at least 100 µε and a measurement range of 150,000 µε. The GFRP-SR offers good sensing potential and comparable mechanical strength to standard GFRP rods. Notably, the CSSC-ISS could measure stress up to strand failure, retaining 87.9% tensile strength and 88.7% elastic modulus compared to standard steel strands. It is verified that the CSSC-ISS can consistently measure its stress condition throughout its life cycle without compromising its load-bearing potential.
监测钢绞线从初始拉伸到最终失效的应力,对于评估结构安全和了解其失效机理至关重要。目前的监测方法由于范围有限,只能测量屈服前的应力。本研究提出了一种新型的基于同轴应变传感电缆(CSSC)的智能钢绞线(CSSC-ISS),它具有受力和自感应两种功能。首先,介绍了 CSSC-ISS 的原型设计和 CSSC 的传感原理。然后,提出了一种小直径 CSSC 的制造方法,并用玻璃纤维增强聚合物(GFRP)材料将其封装,形成 GFRP 传感杆(GFRP-SR)。下一步是用 GFRP-SR 取代钢绞线的中心线,最终形成 CSSC-ISS。最后,实验室测试表明,CSSC 具有出色的应变传感性能,分辨率至少为 100 µε,测量范围为 150,000 µε。GFRP-SR 具有良好的传感潜力,机械强度与标准 GFRP 棒相当。值得注意的是,与标准钢绞线相比,CSSC-ISS 可以测量直至钢绞线断裂的应力,并保持 87.9% 的抗拉强度和 88.7% 的弹性模量。经过验证,CSSC-ISS 可以在整个生命周期内持续测量其应力状况,而不会影响其承载潜力。
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引用次数: 0
Foam concrete for lightweight construction applications: A comprehensive review of the research development and material characteristics 用于轻质建筑的泡沫混凝土:研究发展和材料特性的全面回顾
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-18 DOI: 10.1515/rams-2024-0022
Yajun Liu, Zhilong Zhao, Muhammad Nasir Amin, Bilal Ahmed, Kaffayatullah Khan, Siyab Ul Arifeen, Fadi Althoey
Foam concrete or foamcrete is a lightweight, porous material with a wide range of applications in the construction domain. This article focused on reviewing porosity, thermal conductivity, acoustic properties, compressive strength (f c′), elastic modulus (E), flexural strength (f y), stability, resistance to hostile environments, density, and fire resistance of foam concrete. A systematic literature analysis was conducted to identify relevant research trends on foam concrete. The challenges and limitations of foam concrete research were highlighted, including the lack of standardized testing methods and the need for more research on the long-term durability and structural performance of foam concrete. The analysis of the literature data revealed that there had been a growing interest in foamcrete research over the past decade. Foam concrete may be utilized in several construction applications due to its adaptability and wide range of uses. Its potential uses can be increased by developing new manufacturing methods and the inclusion of certain admixtures. The present research has the potential to be advantageous for scholars interested in collaborative advancement and the exchange of novel tactics and concepts, owing to the visual and statistical representation of the regions/countries and researchers that have contributed.
泡沫混凝土或泡沫混凝土是一种轻质多孔材料,在建筑领域有着广泛的应用。本文重点评述了泡沫混凝土的孔隙率、导热性、声学特性、抗压强度(f c′)、弹性模量(E)、抗弯强度(f y)、稳定性、耐恶劣环境性、密度和耐火性。对文献进行了系统分析,以确定泡沫混凝土的相关研究趋势。重点指出了泡沫混凝土研究面临的挑战和局限性,包括缺乏标准化测试方法,以及需要对泡沫混凝土的长期耐久性和结构性能开展更多研究。对文献数据的分析表明,在过去十年中,人们对泡沫混凝土研究的兴趣与日俱增。由于适应性强、用途广泛,泡沫混凝土可用于多种建筑应用。通过开发新的制造方法和加入某些外加剂,可以增加其潜在用途。由于对做出贡献的地区/国家和研究人员进行了直观的统计,本研究有可能对有志于共同进步和交流新策略和新概念的学者大有裨益。
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引用次数: 0
Melting phenomenon of thermally stratified MHD Powell–Eyring nanofluid with variable porosity past a stretching Riga plate 具有可变孔隙率的热分层 MHD Powell-Eyring 纳米流体在经过拉伸的里加板时的熔化现象
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-17 DOI: 10.1515/rams-2024-0020
Haider Raza, Sohail Farooq, Sobia Sattar, Sadique Rehman, Aamir Farooq, Muhammad Kamran, Mansoor Alshehri, Nehad Ali Shah
Recently, experts have become particularly interested in the treatment of disorders caused by magnesium shortage. Hypomagnesemia is produced by a magnesium deficit in the blood, which is an additional stimulation for different diseases such as vomiting, drowsiness, nausea, loss of appetite, and so on. To compensate for this shortage, magnesium is injected as a nanoparticle in the blood (base fluid). The properties of these magnesium nanoparticles specifically their size, dispersion, and surface characteristics are crucial for optimizing their bioavailability and therapeutic efficacy. Advanced material characterization techniques ensure the stability and enhanced performance of these nanoparticles in the physiological environment. Based on these applications, the current research aims to address magnesium deficiency via Powell–Eyring nanofluid flow distorted by the linearly stretchable sheet in the region of the stagnation point. Linear thermal stratification, viscous dissipation, and Joule heating are used to reveal the heat transport features. The magnetic field is applied to the nanofluid at an angle α to further control the fluid dynamics and nanoparticle behavior. Transformations are used to create a set of dimensionless governing equations. Comparative graphs are used to explain the physical behaviors of temperature and velocity fields, demonstrating how material properties impact fluid dynamics. The well-known convergence method (homotopy analysis method) is used to solve the model by comparing graphs.
最近,专家们对治疗镁缺乏引起的疾病特别感兴趣。低镁血症是由于血液中的镁不足而产生的,它是对不同疾病的额外刺激,如呕吐、嗜睡、恶心、食欲不振等。为了弥补这种不足,镁以纳米粒子的形式注入血液(基础液)中。这些镁纳米粒子的特性,特别是其尺寸、分散性和表面特性,对于优化其生物利用度和疗效至关重要。先进的材料表征技术可确保这些纳米粒子在生理环境中的稳定性和更佳性能。基于这些应用,目前的研究旨在通过在停滞点区域被线性可拉伸片材扭曲的 Powell-Eyring 纳米流体流动来解决镁缺乏问题。线性热分层、粘性耗散和焦耳加热用于揭示热传输特征。以 α 角向纳米流体施加磁场可进一步控制流体动力学和纳米粒子行为。利用变换建立一组无量纲控制方程。对比图用于解释温度场和速度场的物理行为,展示材料特性如何影响流体动力学。著名的收敛法(同调分析法)用于通过比较图形来求解模型。
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引用次数: 0
Compressive strength of waste-derived cementitious composites using machine learning 利用机器学习研究废物衍生水泥基复合材料的抗压强度
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-15 DOI: 10.1515/rams-2024-0008
Qiong Tian, Yijun Lu, Ji Zhou, Shutong Song, Liming Yang, Tao Cheng, Jiandong Huang
Marble cement (MC) is a new binding material for concrete, and the strength assessment of the resulting materials is the subject of this investigation. MC was tested in combination with rice husk ash (RHA) and fly ash (FA) to uncover its full potential. Machine learning (ML) algorithms can help with the formulation of better MC-based concrete. ML models that could predict the compressive strength (CS) of MC-based concrete that contained FA and RHA were built. Gene expression programming (GEP) and multi-expression programming (MEP) were used to build these models. Additionally, models were evaluated by calculating R 2 values, carrying out statistical tests, creating Taylor’s diagram, and comparing theoretical and experimental readings. When comparing the MEP and GEP models, MEP yielded a slightly better-fitted model and better prediction performance (R 2 = 0.96, mean absolute error = 0.646, root mean square error = 0.900, and Nash–Sutcliffe efficiency = 0.960). According to the sensitivity analysis, the prediction of CS was most affected by curing age and MC content, then by FA and RHA contents. Incorporating waste materials such as marble powder, RHA, and FA into building materials can help reduce environmental impacts and encourage sustainable development.
大理石水泥(MC)是一种用于混凝土的新型粘结材料,本研究的主题是对由此产生的材料进行强度评估。我们对大理石水泥与稻壳灰(RHA)和粉煤灰(FA)的组合进行了测试,以充分挖掘其潜力。机器学习(ML)算法有助于更好地配制基于 MC 的混凝土。建立的 ML 模型可以预测含有 FA 和 RHA 的 MC 混凝土的抗压强度(CS)。基因表达编程(GEP)和多重表达编程(MEP)被用于建立这些模型。此外,还通过计算 R 2 值、进行统计测试、绘制泰勒图以及比较理论和实验读数对模型进行了评估。在对 MEP 和 GEP 模型进行比较时,MEP 得出的模型拟合度稍高,预测性能更好(R 2 = 0.96,平均绝对误差 = 0.646,均方根误差 = 0.900,纳什-苏特克利夫效率 = 0.960)。根据敏感性分析,CS 的预测受固化龄期和 MC 含量的影响最大,其次是 FA 和 RHA 含量。将大理石粉、RHA 和 FA 等废弃材料纳入建筑材料有助于减少对环境的影响,促进可持续发展。
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引用次数: 0
Optimizing the performance of TPCB/SCA composite-modified asphalt using improved response surface methodology 利用改进的响应面方法优化 TPCB/SCA 复合改性沥青的性能
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-14 DOI: 10.1515/rams-2023-0182
Chuangmin Li, Shuaibing Yi, Qinhao Deng, Youwei Gan, Zhangyong Hu
A composite-modified asphalt was developed by incorporating tire pyrolytic carbon black (TPCB) with a silane coupling agent (SCA) to enhance its ductility and storage stability. The functional binding between asphalt and TPCB was improved by the addition of SCA. The gray correlation comprehensive evaluation method is incorporated into the response surface methodology (RSM), leading to an improved RSM. The improved RSM was employed to optimize the content of the modifier and the preparation process to enhance overall performance. A central composite design-based experiment was conducted to optimize the penetration, softening point, 10°C ductility, Brookfield rotational viscosity, and storage stability indicators of modified asphalt. The response surface of the gray comprehensive evaluation value of the evaluation indicators was calculated using the gray correlation analysis method, and a second-order regression model was established between independent variables such as TPCB, SCA content, and shear time factor and the gray comprehensive evaluation value. This model analyzed the impact of a single variable and variable interaction on the performance of the TPCB/SCA composite-modified asphalt. The optimized model results showed that the preparation parameters that optimize the expected comprehensive performance of the composite-modified asphalt are 9.2% TPCB content, 2.1% SCA content, and a shear time of 56.3 min. Finally, the TPCB/SCA composite-modified asphalt prepared with the improved RSM exhibited the highest gray comprehensive evaluation value and the best overall performance, indicating the feasibility of the optimized preparation parameters with the improved RSM.
通过在轮胎热解炭黑(TPCB)中加入硅烷偶联剂(SCA),开发了一种复合改性沥青,以增强其延展性和储存稳定性。添加 SCA 后,沥青与 TPCB 之间的功能性结合得到了改善。将灰色关联综合评价方法纳入响应面方法 (RSM),从而改进了 RSM。改进后的 RSM 用于优化改性剂的含量和制备工艺,以提高整体性能。通过基于中心复合设计的实验,对改性沥青的贯入度、软化点、10°C 延度、Brookfield 旋转粘度和储存稳定性指标进行了优化。采用灰色关联分析方法计算了各评价指标灰色综合评价值的响应面,建立了TPCB、SCA含量、剪切时间因子等自变量与灰色综合评价值之间的二阶回归模型。该模型分析了单一变量和变量交互作用对 TPCB/SCA 复合改性沥青性能的影响。优化模型结果表明,能优化复合改性沥青预期综合性能的制备参数为 TPCB 含量 9.2%、SCA 含量 2.1%、剪切时间 56.3 分钟。最后,采用改进的 RSM 制备的 TPCB/SCA 复合改性沥青的灰度综合评价值最高,综合性能最好,表明采用改进的 RSM 优化制备参数是可行的。
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引用次数: 0
Effect of basalt fiber length on the behavior of natural hydraulic lime-based mortars 玄武岩纤维长度对天然水工石灰砂浆性能的影响
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-13 DOI: 10.1515/rams-2023-0191
Alfonso Cobo Escamilla, Purificación Bautiste Villanueva, María Isabel Prieto Barrio, María de las Nieves González García, Analía Vázquez Bouzón
The number of studies aimed at the characterization of reinforced lime-based mortars for use in the rehabilitation of historic buildings is still very small. This fact contrasts with the growing interest of the industry in these products as substitutes for cement mortars, both for their constructive advantages (compatibility requirements) and their lower cost (economic and environmental). For this reason, this study investigates the effect of basalt fiber length on the physical, mechanical, and durability properties of reinforced natural hydraulic lime mortars and provides criteria for selecting optical blends to meet the various performance requirements for their use as building materials for traditional and contemporary structures. Specimens with 1% volume of basalt fibers and lengths of 6, 12, 18, and 24 mm have been tested. The results in fresh mortar show that increasing the fiber length decreases the consistency and bulk density, as well as increases the air content. Regarding the durability properties of hardened mortar, no direct relationship is observed between fiber length and the decrease in the water absorption coefficient of reinforced mortars. Nor is there a clear relationship between fiber length and the increase in Shore hardness and the decrease in adhesive strength in the reinforced mortars. On the contrary, for small lengths (up to 12 mm), there is a direct relationship between fiber length and the increase in other fundamental mechanical properties such as flexural and compressive strength. Based on the results obtained, a predictive model is proposed to determine the amplification factor of flexural and compressive strength as a function of fiber length.
针对用于修复历史建筑的强化石灰基灰泥的特性进行的研究数量仍然很少。与此形成鲜明对比的是,业界对这些产品作为水泥砂浆替代品的兴趣与日俱增,因为它们既有施工优势(兼容性要求),又有较低的成本(经济和环境)。因此,本研究调查了玄武岩纤维长度对增强型天然水硬性石灰砂浆的物理、机械和耐久性能的影响,并提供了选择光学混合物的标准,以满足将其用作传统和现代建筑材料的各种性能要求。我们对玄武岩纤维含量为 1%、长度为 6、12、18 和 24 毫米的试样进行了测试。新鲜砂浆的测试结果表明,纤维长度增加会降低稠度和体积密度,并增加空气含量。关于硬化砂浆的耐久性能,纤维长度与加固砂浆吸水系数的降低之间没有直接关系。纤维长度与增强砂浆肖氏硬度的增加和粘合强度的降低之间也没有明显的关系。相反,对于小长度纤维(不超过 12 毫米),纤维长度与其他基本机械性能(如抗弯强度和抗压强度)的增加有直接关系。根据所获得的结果,提出了一个预测模型,以确定抗折和抗压强度的放大系数与纤维长度的函数关系。
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引用次数: 0
Biomedical and therapeutic potential of marine-derived Pseudomonas sp. strain AHG22 exopolysaccharide: A novel bioactive microbial metabolite 海洋假单胞菌菌株 AHG22 外多糖的生物医学和治疗潜力:一种新型生物活性微生物代谢物
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-08 DOI: 10.1515/rams-2024-0016
Ghfren S. Aloraini, Mona Othman I. Albureikan, Aisha M. A. Shahlol, Taghreed Shamrani, Hussam Daghistani, Mohammad El-Nablaway, Nagwa A. Tharwat, Ahmed M. Elazzazy, Ahmed F. Basyony, Ahmed Ghareeb
Microbial exopolysaccharides (EPSs) are gaining interest as alternatives to chemical antioxidants and pharmaceuticals. This study mines the promising biomedical and antimicrobial potential of a marine bacterium, a prolific EPS producer, isolated from the Red Sea. Pseudomonas sp. strain AHG22 generated an EPS weighing 6.98 g·L−1, coded EPSF8, subjected to FT-IR and HPLC chemical analysis. EPSF8 was then investigated for antioxidant assessment by 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, ABTS˙ + , nitric oxide, total antioxidant capacity (TAC), and ferric reducing antioxidant power (FRAP). EPSF8 had an IC50 of 46.99 μg·mL−1 in the DPPH antioxidant assay and antioxidant capacities of 219.45 μg·mg−1 ascorbic acid equivalent (AAE) in the TAC assay and 54.15 μg·mg−1 AAE in the FRAP assay. The in vitro anti-inflammatory effect of EPSF8 was tested against 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymes and compared with the drugs ibuprofen and celecoxib used as controls. The IC50 values of 5-LOX, COX-2, ibuprofen, and celecoxib were found to be 14.82, 15.49, 1.5, and 0.28 μg·mL−1, respectively. Additionally, EPSF8 revealed antidiabetic activity toward α-amylase and α-glucosidase, and the IC50 values were 93.1 and 127.28 μg·mL−1, compared to those of acarbose (50.93 and 4.13 μg·mL−1, respectively). Anti-obesity activity of EPSF8 by lipase inhibition revealed IC50 = 56.12 μg·mL−1 compared to orlistat (IC50 = 20.08 μg·mL−1) as a control. EPSF8 displayed antibiofilm and bactericidal activity against Gram-positive (G +ve) and Gram-negative (G −ve) ATCC pathogenic bacterial strains. It had a minimum bactericidal concentration/minimum inhibitory concentration ratio ≤2, indicating a broad bactericidal spectrum. Furthermore, EPSF8 is evidenced to have a promising anti-butyrylcholinesterase activity for the control of Alzheimer’s disease. The findings of the present analysis suggest that the isolated Pseudomonas sp. strain AHG22 EPS can potentially be explored as a promising green therapeutic compound.
作为化学抗氧化剂和药物的替代品,微生物外多糖(EPSs)正受到越来越多的关注。本研究从红海中分离出一种海洋细菌,它是一种多产的 EPS 生产者,该细菌具有广阔的生物医学和抗菌潜力。假单胞菌菌株 AHG22 产生的 EPS 重达 6.98 g-L-1,编码为 EPSF8,并进行了傅立叶变换红外光谱和高效液相色谱化学分析。随后,通过 2,2-二苯基-1-苦基肼(DPPH)、H2O2、ABTS˙ +、一氧化氮、总抗氧化能力(TAC)和铁还原抗氧化能力(FRAP)对 EPSF8 进行了抗氧化评估研究。在 DPPH 抗氧化试验中,EPSF8 的 IC50 值为 46.99 μg-mL-1 ;在 TAC 试验中,其抗氧化能力为 219.45 μg-mg-1 抗坏血酸当量(AAE);在 FRAP 试验中,其抗氧化能力为 54.15 μg-mg-1 AAE。测试了 EPSF8 对 5-脂氧合酶(5-LOX)和环氧化酶-2(COX-2)酶的体外抗炎作用,并与用作对照的药物布洛芬和塞来昔布进行了比较。结果发现,5-LOX、COX-2、布洛芬和塞来昔布的 IC50 值分别为 14.82、15.49、1.5 和 0.28 μg-mL-1。此外,EPSF8 对α-淀粉酶和α-葡萄糖苷酶具有抗糖尿病活性,其 IC50 值分别为 93.1 和 127.28 μg-mL-1,而阿卡波糖的 IC50 值分别为 50.93 和 4.13 μg-mL-1。与对照组奥利司他(IC50 = 20.08 μg-mL-1)相比,EPSF8 通过抑制脂肪酶的抗肥胖活性的 IC50 = 56.12 μg-mL-1。EPSF8 对革兰氏阳性(G +ve)和革兰氏阴性(G -ve)ATCC 致病细菌菌株具有抗生物膜和杀菌活性。它的最低杀菌浓度/最低抑菌浓度比值≤2,表明它具有广泛的杀菌谱。此外,EPSF8 还被证明具有抗丁酰胆碱酯酶活性,有望用于控制阿尔茨海默氏症。本分析的结果表明,分离出的假单胞菌菌株 AHG22 EPS 有可能被开发成一种有前景的绿色治疗化合物。
{"title":"Biomedical and therapeutic potential of marine-derived Pseudomonas sp. strain AHG22 exopolysaccharide: A novel bioactive microbial metabolite","authors":"Ghfren S. Aloraini, Mona Othman I. Albureikan, Aisha M. A. Shahlol, Taghreed Shamrani, Hussam Daghistani, Mohammad El-Nablaway, Nagwa A. Tharwat, Ahmed M. Elazzazy, Ahmed F. Basyony, Ahmed Ghareeb","doi":"10.1515/rams-2024-0016","DOIUrl":"https://doi.org/10.1515/rams-2024-0016","url":null,"abstract":"Microbial exopolysaccharides (EPSs) are gaining interest as alternatives to chemical antioxidants and pharmaceuticals. This study mines the promising biomedical and antimicrobial potential of a marine bacterium, a prolific EPS producer, isolated from the Red Sea. <jats:italic>Pseudomonas</jats:italic> sp. strain AHG22 generated an EPS weighing 6.98 g·L<jats:sup>−1</jats:sup>, coded EPSF8, subjected to FT-IR and HPLC chemical analysis. EPSF8 was then investigated for antioxidant assessment by 2,2-diphenyl-1-picrylhydrazyl (DPPH), H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, ABTS˙<jats:sup> + </jats:sup>, nitric oxide, total antioxidant capacity (TAC), and ferric reducing antioxidant power (FRAP). EPSF8 had an IC<jats:sub>50</jats:sub> of 46.99 μg·mL<jats:sup>−1</jats:sup> in the DPPH antioxidant assay and antioxidant capacities of 219.45 μg·mg<jats:sup>−1</jats:sup> ascorbic acid equivalent (AAE) in the TAC assay and 54.15 μg·mg<jats:sup>−1</jats:sup> AAE in the FRAP assay. The <jats:italic>in vitro</jats:italic> anti-inflammatory effect of EPSF8 was tested against 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymes and compared with the drugs ibuprofen and celecoxib used as controls. The IC<jats:sub>50</jats:sub> values of 5-LOX, COX-2, ibuprofen, and celecoxib were found to be 14.82, 15.49, 1.5, and 0.28 μg·mL<jats:sup>−1</jats:sup>, respectively. Additionally, EPSF8 revealed antidiabetic activity toward α-amylase and α-glucosidase, and the IC<jats:sub>50</jats:sub> values were 93.1 and 127.28 μg·mL<jats:sup>−1</jats:sup>, compared to those of acarbose (50.93 and 4.13 μg·mL<jats:sup>−1</jats:sup>, respectively). Anti-obesity activity of EPSF8 by lipase inhibition revealed IC<jats:sub>50</jats:sub> = 56.12 μg·mL<jats:sup>−1</jats:sup> compared to orlistat (IC<jats:sub>50</jats:sub> = 20.08 μg·mL<jats:sup>−1</jats:sup>) as a control. EPSF8 displayed antibiofilm and bactericidal activity against Gram-positive (G +ve) and Gram-negative (G −ve) ATCC pathogenic bacterial strains. It had a minimum bactericidal concentration/minimum inhibitory concentration ratio ≤2, indicating a broad bactericidal spectrum. Furthermore, EPSF8 is evidenced to have a promising anti-butyrylcholinesterase activity for the control of Alzheimer’s disease. The findings of the present analysis suggest that the isolated <jats:italic>Pseudomonas</jats:italic> sp. strain AHG22 EPS can potentially be explored as a promising green therapeutic compound.","PeriodicalId":54484,"journal":{"name":"Reviews on Advanced Materials Science","volume":"86 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140926990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the anti-aging properties of asphalt modified with polyphosphoric acid and tire pyrolysis oil 研究聚磷酸和轮胎热解油改性沥青的抗老化性能
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-05-07 DOI: 10.1515/rams-2024-0017
Chuangmin Li, Lubiao Liu, Youwei Gan, Qinhao Deng, Shuaibing Yi
This research focuses on the aging resistance properties of asphalt, which are crucial for determining the lifespan of asphalt pavement. To combat aging, waste tire pyrolysis oil (TPO) is often added to asphalt, enhancing its resistance to aging but compromising high-temperature performance. This study offered a pioneering solution by integrating TPO with polyphosphoric acid (PPA) to address these issues. In this study, we conducted a series of tests to characterize the properties of PPA/TPO modified asphalt, including temperature sweep and bending beam rheometer tests. The results demonstrated that the presence of PPA in the PPA/TPO modified asphalt could improve its high-temperature performance while maintaining its low-temperature properties. Moreover, PPA in the PPA/TPO modified asphalt enhanced the modified asphalt’s resistance to fatigue and deformation during the aging process, while the presence of TPO effectively reduced the impact of thermo-oxidative aging on the modified asphalt during the aging process. Additionally, physicochemical interactions between the base asphalt and modifiers were observed before and after aging. In summary, this study had offered an innovative method to enhance the anti-aging properties of asphalt, and had provided more options for sustainable, environmentally friendly roads.
这项研究的重点是沥青的抗老化性能,这对决定沥青路面的使用寿命至关重要。为了解决老化问题,通常会在沥青中添加废轮胎热解油(TPO),从而增强沥青的抗老化性能,但会影响其高温性能。本研究开创性地将 TPO 与聚磷酸(PPA)结合在一起,从而解决了这些问题。在这项研究中,我们进行了一系列测试来表征 PPA/TPO 改性沥青的性能,包括温度扫描和弯曲梁流变仪测试。结果表明,PPA/TPO 改性沥青中 PPA 的存在可以改善其高温性能,同时保持其低温性能。此外,PPA/TPO 改性沥青中的 PPA 增强了改性沥青在老化过程中的抗疲劳和抗变形能力,而 TPO 的存在则有效降低了老化过程中热氧化老化对改性沥青的影响。此外,在老化前后还观察到了基质沥青和改性剂之间的物理化学相互作用。总之,这项研究提供了一种增强沥青抗老化性能的创新方法,为可持续发展的环保型道路提供了更多选择。
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引用次数: 0
Impact of carbon content on the phase structure and mechanical properties of TiBCN coatings via direct current magnetron sputtering 碳含量对直流磁控溅射 TiBCN 涂层相结构和机械性能的影响
IF 3.6 4区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-04-29 DOI: 10.1515/rams-2024-0013
Anand Vyas, Ahmed Aliyu, Gary Chi-Pong Tsui
In this study, unbalanced direct current magnetron sputtering was employed to develop TiBCN coatings on Si (100) wafers. The carbon (C) concentration was varied to manipulate the phase structure and mechanical properties of the coatings. The coatings were analyzed using Raman spectroscopy, scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and nanoindentation. The results revealed that the TiBCN-2 coating, with a C concentration of 4.4 at.%, exhibited optimal hardness and elastic modulus values of 33 and 291 GPa, respectively. On the other hand, as the C content increased from 4.4 to 24.4 at.%, the hardness and elastic modulus values of the coatings decreased to 21 and 225 GPa, respectively, due to the formation of boron nitride and carbon phases within the coating matrix. Therefore, the inclusion of an ideal C concentration can considerably improve the properties of TiBCN coatings, thus rendering the coating a desirable material for cutting tools.
本研究采用非平衡直流磁控溅射技术在硅(100)晶片上形成 TiBCN 涂层。通过改变碳(C)的浓度来调节涂层的相结构和机械性能。使用拉曼光谱、扫描电子显微镜、X 射线衍射、X 射线光电子能谱和纳米压痕法对涂层进行了分析。结果显示,C 浓度为 4.4 at.% 的 TiBCN-2 涂层的最佳硬度和弹性模量值分别为 33 和 291 GPa。另一方面,随着 C 含量从 4.4% 增加到 24.4%,涂层的硬度和弹性模量值分别下降到 21 和 225 GPa,原因是涂层基体中形成了氮化硼和碳相。因此,加入理想的碳浓度可以大大改善 TiBCN 涂层的性能,从而使涂层成为切削工具的理想材料。
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Reviews on Advanced Materials Science
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