Progress in Biophysics & Molecular Biology最新文献_第2页

In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments 细胞集体迁移的体外调控：理解物理和化学微环境的作用。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-11-28 DOI: 10.1016/j.pbiomolbio.2024.11.005

Chang-Xing Li, Zi-Xu Zhao, Dan-Bo Su, Da-Chuan Yin, Ya-Jing Ye

Collective cell migration is the primary mode of cellular movement during embryonic morphogenesis, tissue repair and regeneration, and cancer invasion. Distinct from single-cell migration, collective cell migration involves complex intercellular signaling cascades and force transmission. Consequently, cell collectives exhibit intricate and diverse migration patterns under the influence of the microenvironment in vivo. Investigating the patterns and mechanisms of collective cell migration within complex environmental factors in vitro is essential for elucidating collective cell migration in vivo. This review elucidates the influence of physical and chemical factors in vitro microenvironment on the migration patterns and efficiency of cell collectives, thereby enhancing our comprehension of the phenomenon. Furthermore, we concisely present the effects of characteristic properties of common biomaterials on collective cell migration during tissue repair and regeneration, as well as the features and applications of tumor models of different dimensions (2D substrate or 3D substrate) in vitro. Finally, we highlight the challenges facing the research of collective cell migration behaviors in vitro microenvironment and propose that modulating collective cell migration may represent a potential strategy to promote tissue repair and regeneration and to control tumor invasion and metastasis.

细胞集体迁移是胚胎形态发生、组织修复和再生以及癌症侵袭过程中细胞运动的主要方式。与单细胞迁移不同，细胞集体迁移涉及复杂的细胞间信号级联和力传递。因此，细胞群在体内微环境的影响下表现出复杂多样的迁移模式。研究复杂环境因素下体外细胞集体迁移的模式和机制对于阐明体内细胞集体迁移至关重要。本文综述了体外微环境中物理和化学因素对细胞群迁移模式和效率的影响，从而加深了我们对这一现象的理解。此外，我们简要介绍了常见生物材料的特征特性对组织修复和再生过程中细胞集体迁移的影响，以及不同维度（2D基质或3D基质）的体外肿瘤模型的特点和应用。最后，我们强调了体外微环境下细胞集体迁移行为研究面临的挑战，并提出调节细胞集体迁移可能是促进组织修复和再生以及控制肿瘤侵袭和转移的潜在策略。

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引用次数: 0

A review on salt-induced DNA compaction and charge inversion 盐诱导 DNA 压实和电荷反转综述

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-11-20 DOI: 10.1016/j.pbiomolbio.2024.11.003

Khadka B. Chhetri

This review delves into the reversible process of DNA compaction, vital for cellular functions like replication and transcription. The study highlights how various cations assist in the condensation of DNA chains, highlighting their specificity. The impact of the ionic environment on chromatin characteristics is discussed, emphasizing the roles of mono- and divalent cations in neutralizing DNA charge and promoting compaction. Trivalent ions induce significant compaction, while divalent ions also contribute, albeit less strongly. Charge inversion, facilitated by high concentrations of multivalent counterions, affects DNA condensation dynamics. Manipulating solution pH and dielectric constant can alter charge inversion bidirectionally. The hydrophobic effect driven by organic cations plays a crucial role in DNA compaction. The review underscores the implications of charge inversion, including macroscopic phase separation and DNA precipitation, driven by the binding of cationic micelles to DNA.

这篇综述深入探讨了对复制和转录等细胞功能至关重要的 DNA 可逆压缩过程。研究强调了各种阳离子如何协助 DNA 链的凝结，并突出了它们的特异性。研究讨论了离子环境对染色质特性的影响，强调了一价和二价阳离子在中和 DNA 电荷和促进压实方面的作用。三价离子诱导显著的压实作用，而二价离子也有作用，但不那么强烈。高浓度的多价反离子会促进电荷反转，从而影响 DNA 的凝聚动力学。调节溶液的 pH 值和介电常数可双向改变电荷反转。有机阳离子驱动的疏水效应在 DNA 凝聚过程中起着至关重要的作用。综述强调了电荷反转的影响，包括阳离子胶束与 DNA 结合所产生的宏观相分离和 DNA 沉淀。

引用次数: 0

Electrical impedance sensing in stem cell research: Insights, applications, and future directions 干细胞研究中的电阻抗传感：见解、应用和未来方向。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-11-16 DOI: 10.1016/j.pbiomolbio.2024.11.004

Hassan Moghtaderi , Saeed Mohahammadi , Golfam Sadeghian , Mahua Choudhury , Ahmed Al-Harrasi , Shaikh Mizanoor Rahman

The exceptional differentiation abilities of stem cells make them ideal candidates for cell replacement therapies. Considering their great potential, researchers should understand how stem cells interact with other cell types. The production of high-quality differentiated cells is crucial for favorable treatment and makes them an ideal choice for clinical applications. Label-free stem cell monitoring approaches are anticipated to be more effective in this context, as they ensure quality of differentiation while preserving the therapeutic potential. Electric cell-substrate impedance sensing (ECIS) is a nonintrusive technique that enables cell quantification through continuous monitoring of adherent cell behavior using electronic transcellular impedance measurements. This technique also facilitates the study of cell growth, motility, differentiation, drug effects, and cell barrier functions. Therefore, numerous studies have identified ECIS as an effective method for monitoring stem cell quality and differentiation. In this review, we discuss the current understanding of ECIS's achievements in examining cell behaviors and the potential applications of ECIS arrays in preclinical stem cell research. Moreover, we highlight our present knowledge concerning ECIS's contributions in examining cell behaviors and speculate about the future uses of ECIS arrays in preclinical stem cell research. This review also aims to stimulate research on electrochemical biosensors for future applications in regenerative medicine.

干细胞具有卓越的分化能力，是细胞替代疗法的理想候选者。考虑到干细胞的巨大潜力，研究人员应了解干细胞如何与其他类型的细胞相互作用。生产高质量的分化细胞对治疗效果至关重要，也是临床应用的理想选择。在这种情况下，无标签干细胞监测方法预计会更加有效，因为它们既能确保分化质量，又能保持治疗潜力。电细胞-基底阻抗传感（ECIS）是一种非侵入性技术，通过电子跨细胞阻抗测量连续监测粘附细胞的行为，实现细胞量化。这项技术还有助于研究细胞的生长、运动、分化、药物作用和细胞屏障功能。因此，许多研究已将ECIS确定为监测干细胞质量和分化的有效方法。在这篇综述中，我们将讨论目前对ECIS在检查细胞行为方面成就的理解，以及ECIS阵列在临床前干细胞研究中的潜在应用。此外，我们还强调了我们目前对ECIS在检查细胞行为方面所作贡献的了解，并推测了ECIS阵列在临床前干细胞研究中的未来用途。这篇综述还旨在促进电化学生物传感器在再生医学领域的未来应用研究。

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引用次数: 0

A physical perspective on lithium therapy 从物理角度看锂疗法

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-11-14 DOI: 10.1016/j.pbiomolbio.2024.11.002

Dana Kamp

Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They have recently gathered attention due to their potential preventive effect in viral infections. Though the therapeutic effect of lithium was documented by Cade in the late 1940s, its underlying mechanism of action is still disputed. Acute lithium exposure has an activating effect on excitable organic tissue and organisms, and is highly toxic. Lithium exposure is associated with a strong metabolic response in the organism, with large changes in phospholipid and cholesterol expression. Opposite to acute exposure, this metabolic response alleviates excessive cellular activity. The presence of lithium ions strongly affects lipid conformation and membrane phase unlike other alkali ions, with consequences for membrane permeability, buffer property and excitability. This review investigates how lithium ions affect lipid membrane composition and function, and how lithium response might in fact be the body’s attempt to counteract the physical presence of lithium ions at cell level. Ideas for further research in microbiology and drug development are discussed.

锂盐对神经系统疾病，如躁郁症和锂反应性头痛有很强的医疗作用（Pereira da Silva Neto 和 James Almeida，2010 年；Lindner 等人，2023 年；Silva-Néto 等人，2019 年）。最近，它们因其对病毒感染的潜在预防作用而备受关注（Ferensztajn-Rochowiak 和 Rybakowski，2023；Rybakowski，2022）。虽然锂的治疗效果在 20 世纪 40 年代末就由 Cade 记录在案，但其基本作用机制仍存在争议（Malhi 和 Outhred，2016 年）。急性锂暴露对可兴奋的有机组织和生物体有激活作用，毒性很强（Schou，1957 年；Butler-Munro 等人，2010 年；Izsak 等人，2021 年；Yip 和 Yeung，2007 年）。接触锂会对机体产生强烈的新陈代谢反应，磷脂和胆固醇的表达发生巨大变化（López-Corcuera 等人，1988 年；Pettegrew 等人，2001 年；Aliyazicioğlu 等人，2007 年）。与急性接触相反，这种新陈代谢反应会减轻细胞的过度活动（Mertens 等人，2015 年；Stern 等人，2018 年；Santos 等人，2021 年）。与其他碱离子不同，锂离子的存在会强烈影响脂质构象和膜相（Hauser 和 Shipley，1983 年），从而对膜的通透性、缓冲特性和兴奋性产生影响。这篇综述探讨了锂离子如何影响脂膜的组成和功能，以及锂反应实际上是人体如何试图在细胞水平抵消锂离子的物理存在。文章还讨论了在微生物学和药物开发方面开展进一步研究的思路。

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引用次数: 0

Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases 细胞间受体-配体结合动力学在疾病中的测量方法、影响因素和应用。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-11-02 DOI: 10.1016/j.pbiomolbio.2024.11.001

Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng

Receptor-ligand binding on contacting cells dictates the extent of transmembrane signaling through membrane receptors during cell communication, influencing both the physiological and pathological activities of cells. This process is integral to fundamental biological mechanisms including signal transduction, cancer metastasis, immune responses, and inflammatory cascades, all of which are profoundly influenced by the cell microenvironment. This article provides an overview of the kinetic theory of receptor-ligand binding and examines methods for measuring this interaction, along with their respective advantages and disadvantages. Furthermore, it comprehensively explores the factors that impact receptor-ligand binding, encompassing protein-membrane interactions, the bioelectric microenvironment, auxiliary factors, hydrogen bond strength, pH levels, cis and trans interactions between ligands and receptors. The application of receptor-ligand binding kinetics in various diseases such as immunity, cancer, and inflammation are also discussed. Additionally, the investigation into how functional substances alter receptor-ligand binding dynamics within specific cellular microenvironments presents a promising new approach to treating related diseases.

接触细胞的受体-配体结合决定了细胞交流过程中通过膜受体进行跨膜信号传导的程度，从而影响细胞的生理和病理活动。这一过程是信号转导、癌症转移、免疫反应和炎症级联等基本生物机制不可或缺的组成部分，而所有这些机制都受到细胞微环境的深刻影响。本文概述了受体与配体结合的动力学理论，研究了测量这种相互作用的方法及其各自的优缺点。此外，文章还全面探讨了影响受体-配体结合的因素，包括蛋白质-膜相互作用、生物电微环境、辅助因素、氢键强度、pH 值、配体与受体之间的顺式和反式相互作用。还讨论了受体-配体结合动力学在免疫、癌症和炎症等各种疾病中的应用。此外，研究功能性物质如何改变特定细胞微环境中受体与配体的结合动力学，为治疗相关疾病提供了一种前景广阔的新方法。

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引用次数: 0

m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies 骨肉瘤中的 m6A 甲基化调节因子和 ncRNA：潜在的治疗策略

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-10-25 DOI: 10.1016/j.pbiomolbio.2024.10.003

Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng

Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%–15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades. The most pervasive and abundant modification of internal transcripts in eukaryotic messenger RNAs (mRNAs) is N6-methyladenosine (m6A), and it is regulated by m6A methylation regulators. A number of recent studies have demonstrated that m6A modifications can regulate the biological activities of tumour cells and are intimately linked with cancer development, prognosis, drug resistance, and therapy. N6-methyladenosine modification of Non-coding RNA (ncRNA) has likewise shown a broad potential in gene regulation and tumor biology. Epigenetic changes induced by mRNAs and ncRNAs methylation are important for a better understanding of OS development and targeted drug development. Therefore, this paper summarises the biological functions of m6A-modified regulators in osteosarcoma and the role of mutual regulation between m6A and ncRNAs in osteosarcoma. Furthermore, the potential clinical applications of m6A modifications in OS are presented for consideration. It provides new directions for the future research and clinical treatment strategies of osteosarcoma.

骨肉瘤（Osteosarcoma，OS）是在儿童和青少年群体中观察到的主要骨癌形式。近 10%至 15%的患者在确诊时已出现转移，5 年生存率低于 20%。尽管众多研究人员付出了巨大努力，但在过去 30 年中，OS 患者的生存率几乎没有变化。真核生物信使 RNA（mRNA）内部转录本最普遍、最丰富的修饰是 N6-甲基腺苷（m6A），它受 m6A 甲基化调节因子的调控。最近的一些研究表明，m6A 修饰可调节肿瘤细胞的生物活性，并与癌症的发展、预后、耐药性和治疗密切相关。非编码 RNA（ncRNA）的 N6-甲基腺苷修饰同样显示出在基因调控和肿瘤生物学方面的广泛潜力。由 mRNA 和 ncRNA 甲基化诱导的表观遗传学变化对于更好地了解操作系统的发展和靶向药物的开发非常重要。因此，本文总结了 m6A 修饰调控因子在骨肉瘤中的生物学功能，以及 m6A 和 ncRNA 在骨肉瘤中的相互调控作用。此外，文章还提出了 m6A 修饰在 OS 中的潜在临床应用，以供思考。它为骨肉瘤的未来研究和临床治疗策略提供了新的方向。

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引用次数: 0

Nuclear membrane: A key potential therapeutic target for lipid metabolism 核膜：脂质代谢的一个关键潜在治疗靶点。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-10-19 DOI: 10.1016/j.pbiomolbio.2024.10.002

Min Zeng , Longgui Chen , YaZhu Wang

Lipid homeostasis plays a pivotal role in cellular growth, necessitating the engagement of numerous lipid metabolism genes and the cohesive functioning of organelles. While the nucleus is traditionally recognized for its genetic roles, emerging evidence highlights its significant contribution to lipid homeostasis maintenance. Certain nuclear membrane proteins or associated proteins have the capacity to directly catalyze lipid synthesis or modification processes. Mutations in the genes encoding these proteins can lead to disrupted lipid metabolism, contributing to a spectrum of metabolic disorders. This article provides a comprehensive reviews of the investigations exploring the interplay between nuclear membrane proteins and lipid metabolism. Additionally, it delves into the heterogeneity of the nuclear membrane, positioning it as a novel therapeutic target for managing metabolic disorders and mitigating adverse drug reactions.

脂质平衡在细胞生长中起着关键作用，需要众多脂质代谢基因的参与和细胞器的协同运作。虽然传统上认为细胞核具有遗传作用，但新出现的证据强调了它在维持脂质平衡方面的重要贡献。某些核膜蛋白或相关蛋白具有直接催化脂质合成或修饰过程的能力。编码这些蛋白的基因发生突变会导致脂质代谢紊乱，从而引发一系列代谢性疾病。本文全面回顾了探索核膜蛋白与脂质代谢之间相互作用的研究。此外，文章还深入探讨了核膜的异质性，将其定位为控制代谢紊乱和减轻药物不良反应的新型治疗靶点。

引用次数: 0

A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives 回顾骨重塑过程的现状和未来前景：生物学和数学视角。

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-10-17 DOI: 10.1016/j.pbiomolbio.2024.10.001

Mehran Bahrami , Hanieh Khonakdar , Armaghan Moghaddam , Saba Nemati Mahand , Poorya Esmaili Bambizi , Benjamin Kruppke , Hossein Ali Khonakdar

This review dives into the complex dynamics of bone remodeling, combining biological insights with mathematical perspectives to better understand this fundamental aspect of skeletal health. Bone, being a crucial part of our body, constantly renews itself, and with the growing number of individuals facing bone-related issues, research in this field is vital. In this review, we categorized and classified most common mathematical models used to simulate the mechanical behavior of bone under different loading and health conditions, shedding light on the evolving landscape of bone biology. While current models have effectively captured the essence of healthy bone remodeling, the ever-expanding knowledge in bone biology suggests an update in mathematical methods. Knowing the role of the skeleton in whole-body physiology, and looking at the recent discoveries about activities of bone cells emphasize the urgency of refining our mathematical descriptions of the bone remodeling process. The underexplored impact of bone diseases like osteoporosis, Paget's disease, or breast cancer on bone remodeling also points to the need for intensified research into diverse disease types and their unique effects on bone health. By reviewing a range of bone remodeling models, we show the necessity for tailor-made mathematical models to decipher their roots and enhance patient treatment strategies. Collaboration among scientists from various domains is pivotal to surmount these challenges, ensuring improved accuracy and applicability of mathematical models. Ultimately, this effort aims to deepen our understanding of bone remodeling processes and their broader implications for diverse health conditions.

这篇综述深入探讨了骨重塑的复杂动态，将生物学见解与数学视角相结合，以更好地理解骨骼健康的这一基本方面。骨骼是人体的重要组成部分，会不断自我更新，随着越来越多的人面临与骨骼相关的问题，这一领域的研究至关重要。在这篇综述中，我们对用于模拟不同负荷和健康状况下骨骼机械行为的最常见数学模型进行了分类和归纳，从而揭示了骨骼生物学不断发展的前景。虽然目前的模型已经有效地捕捉到了健康骨重塑的本质，但随着骨生物学知识的不断扩展，建议对数学方法进行更新。了解骨骼在全身生理学中的作用以及最近对骨细胞活动的发现，都强调了完善骨重塑过程数学描述的紧迫性。骨质疏松症、帕吉特氏病或乳腺癌等骨科疾病对骨重塑的影响尚未得到充分探讨，这也表明我们需要加强对不同疾病类型及其对骨骼健康的独特影响的研究。通过回顾一系列骨重塑模型，我们表明有必要建立量身定制的数学模型，以破解其根源并改进患者治疗策略。要克服这些挑战，确保提高数学模型的准确性和适用性，来自不同领域的科学家之间的合作至关重要。最终，这项工作旨在加深我们对骨重塑过程及其对各种健康状况的广泛影响的理解。

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引用次数: 0

Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease 将长非编码 RNA H19 作为肝病治疗策略的靶点

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-09-30 DOI: 10.1016/j.pbiomolbio.2024.09.005

Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan

The liver has the function of regulating metabolic equilibrium in the human body, and the majority of liver disorders are chronic conditions that can significantly impair health. Recent research has highlighted the critical role of long noncoding RNAs (lncRNAs) in liver disease pathogenesis. LncRNA H19, an endogenous noncoding single-stranded RNA, exerts its influence through epigenetic modifications and affects various biological processes. This review focuses on elucidating the key molecular mechanisms underlying the regulation of H19 during the progression and advancement of liver diseases, aiming to highlight H19 as a potential therapeutic target and provide profound insights into the molecular underpinnings of liver pathologies.

肝脏具有调节人体新陈代谢平衡的功能，而大多数肝脏疾病都是慢性病，会严重损害人体健康。最近的研究强调了长非编码 RNA（lncRNA）在肝病发病机制中的关键作用。LncRNA H19是一种内源性非编码单链RNA，通过表观遗传修饰发挥影响，并影响各种生物过程。本综述重点阐明肝脏疾病进展和恶化过程中 H19 调控的关键分子机制，旨在突出 H19 作为潜在治疗靶点的作用，并对肝脏病变的分子基础提供深刻的见解。

引用次数: 0

Research progress on the effects and mechanisms of magnetic field on neurodegenerative diseases 磁场对神经退行性疾病的影响和机制的研究进展

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology

Pub Date : 2024-09-12 DOI: 10.1016/j.pbiomolbio.2024.09.004

Shuxian Ding , Jinhua Li , Yanwen Fang , Xingjie Zhuo , Lili Gu , Xinyue Zhang , Yuanxiao Yang , Min Wei , Zhongcai Liao , Qin Li

With the progress of modern science and technology, magnetic therapy technology develops rapidly, and many types of magnetic therapy methods continue to emerge, making magnetic therapy one of the main techniques of physiotherapy. With the continuous development of magnetic field research and clinical applications, magnetic therapy, as a non-invasive brain stimulation therapy technology, has attracted much attention due to its potential in the treatment of motor dysfunction, cognitive impairment and speech disorders in patients with neurodegenerative diseases. However, the role of magnetic fields in the prognosis and treatment of neurodegenerative diseases and their mechanisms remain largely unexplored. In this paper, the therapeutic effect and neuroprotective mechanism of the magnetic field on neurodegenerative diseases are reviewed, and the new magnetic therapy techniques are also summarized. Although the neuroprotective mechanism of magnetic field cannot be fully elaborated, it is helpful to promote the application of magnetic field in neurodegenerative diseases and provide a new theoretical basis for the related magnetic field research in the later period.

随着现代科学技术的进步，磁疗技术发展迅速，多种磁疗方法不断涌现，磁疗已成为物理治疗的主要技术之一。随着磁场研究和临床应用的不断发展，磁疗作为一种非侵入性脑刺激治疗技术，因其在治疗神经退行性疾病患者运动功能障碍、认知障碍和语言障碍等方面的潜力而备受关注。然而，磁场在神经退行性疾病的预后和治疗中的作用及其机制在很大程度上仍未得到探索。本文综述了磁场对神经退行性疾病的治疗作用和神经保护机制，并总结了新的磁疗技术。虽然磁场的神经保护机制还不能完全阐述清楚，但有助于推动磁场在神经退行性疾病中的应用，为后期相关磁场研究提供新的理论依据。

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引用次数: 0