Postepy Dermatologii I Alergologii最新文献

Introduction: Skin type assessment is important because it is a guidance for specialists and consumers to select and recommend the most appropriate skin care products and protocols. One easy-to-administer instrument used for skin type classification is the Baumann Skin Type Questionnaire.

Aim: Translation and validation of the Polish version of the Baumann Skin Type Questionnaire (BSTQ) - pigmented or non-pigmented and wrinkled or tight skin.

Material and methods: Both forward and backward translation of the English version of the BSTQ was performed. The study was conducted on 103 individuals. The respondents completed the questionnaire twice, 1 day after the other. The subjects participated in practical classes of facial care cosmetology which allowed for conducting interviews and skin examinations by a cosmetology expert.

Results: The Polish version of the BSTQ demonstrated high test-retest reliability (reproducibility) in the dimension evaluating skin with or without hyperpigmentation as well as wrinkled or tight skin (ICC3 = 0.91; ICC3 = 0.97, respectively). Moreover, an excellent level of agreement between initial test and retest (pigmented vs. non-pigmented: AC1 = 1.00, 95% CI:1.00; wrinkled vs. tight: AC1 = 0.93, 95% CI:0.87-0.99). However, the Polish version of the BSTQ demonstrated a low internal consistency, corroborated by low Guttman's Lambda 6 reliability (pigmented vs. non-pigmented: α_raw = 0.55, α_std = 0.54, G6 = 0.63; retest: α_raw = 0.58, α_std = 0.54, G6 = 0.63; wrinkled vs. tight: α_raw = 0.33, α_std = 0.25, G6 = 0.47; retest: α_raw = 0.36, α_std = 0.33, G6 = 0.54).

Conclusions: The use of the BSTQ in assessing the skin for hyperpigmentation and age-related changes should be complemented by another diagnostic approach - clinical assessment before starting treatment or anti-aging interventions.

Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.

Introduction: Baumann Skin Type Questionnaire (BSTQ) is a widely used questionnaire, that was designed to determine baseline skin type in dermatology. The self-reported BSTQ, consisting of four parts: oily vs. dry skin, sensitive vs. resistant skin, pigmented vs. non-pigmented skin and wrinkled vs. tight skin, can provide significant guidance for consumers and professionals to select and recommend the most appropriate skin care products and skin care protocols.

Aim: Translation and validation of the Polish version of the Baumann Skin Type Questionnaire (BSTQ) - oily vs. dry skin and sensitive vs. resistant skin.

Material and methods: Both forward and backward translation of the English version of the BSTQ was performed. The study was conducted on 103 individuals. The respondents completed the questionnaire twice, 1 day after the other. Moreover, the subjects participated in practical classes of facial care cosmetology which allowed for conducting interviews and skin examinations by a cosmetology expert.

Results: The Polish version of the BSTQ demonstrated high test-retest reliability (reproducibility) in the dimension assessing oily or dry skin as well as sensitive or resistant skin (ICC3 = 0.91; ICC3 = 0.96, respectively) and good internal consistency, corroborated by Guttman's Lambda 6 reliability (oily vs. dry: α_raw = 0.75, α_std = 0.74, G6 = 0.79; retest: α_raw = 0.77, α_std = 0.77, G6 = 0.81; sensitive vs. resistant: α_raw = 0.72, α_std = 0.74, G6 = 0.81; retest: α_raw = 0.78, α_std = 0.79, G6 = 0.85).

Conclusions: The Polish version of the BSTQ (oily vs. dry skin and sensitive vs. resistant skin) showed high reliability, good internal consistency and high accuracy and consistency. It can be used for assessment of oily or dry skin and sensitive or resistant skin.

Relationships between inflammatory diseases and metabolic abnormalities are recently raising much scientific interest. Convincing evidence on the association between atopic dermatitis (AD) and constituents of metabolic syndrome (MS) has already been established. In this article we aim to summarize current data on the link between AD and non-alcoholic fatty liver disease (NAFLD), which is considered a hepatic manifestation of MS. By reviewing animal models, human studies and possible pathogenetic points of contiguity we want to present the current state of knowledge and goals for further investigations. To our best knowledge, this is the first review of this topic so far.

Introduction: An increasing incidence in human immunodeficiency virus (HIV) and syphilis coinfection has been observed in recent years.

Aim: The purpose of this study was to evaluate the prevalence and characteristics of HIV diagnosis among patients with syphilis hospitalized from 2015 to 2022 at the Department of Dermatology.

Material and methods: This is a single-centre retrospective cohort study regarding adult patients diagnosed with syphilis and HIV. Data were collected from patient medical records and subsequently analysed to identify patterns and associations among patients with coinfection.

Results: Among 511 patients hospitalized because of syphilis, 98 had concomitant HIV infection (96 males and 2 females). An increase in the number of HIV infections was observed in the group of syphilis-positive patients at a rate of 3.89% per year (Pearson p < 0.001, N = 8). The correlation in the total yearly number of syphilis and HIV positive cases (Pearson p < 0.001, N = 8) was noticed in 2015-2022. The most frequent comorbidities were hepatitis viruses (42.9%), gonorrhoea (16.3%) and depression (13.3%).

Conclusions: In our study we observed a considerable increase in the number of patients diagnosed with the coinfection of syphilis and HIV in the last few years. The above analysis underscores the ongoing public health challenges associated with these diseases.

Introduction: Platelet-rich fibrin is an autologous biomaterial that is rich in platelets and various growth factors, has good biocompatibility, and has significant application potential in tissue repair and regeneration.

Aim: To explore the effect of platelet-rich fibrin (PRF) on the repair and healing of chronic refractory wounds in rats by regulating the Wnt/β-catenin (β-catenin) signalling pathway.

Material and methods: Full-thickness skin defect open wounds were established on the backs of 50 male SD rats.

Results: In comparison with the normal control group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the model group were significantly reduced at each time point; serum TNF-α, IL-1β, IL-6 levels, and GSK-3β protein expression levels were significantly increased. The granulation tissue was severely damaged and infiltrated by a large number of inflammatory cells. The collagen fibres were loosely arranged and unevenly distributed. In comparison with the model group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the PRF group and positive control group at each time point were significantly increased.

Conclusions: PRF can promote the repair and healing of chronic refractory wounds in rats by inhibiting ulcer surface inflammation and promoting collagen fibre deposition and angiogenesis. Its mechanism of action may be concerned with the activation of the Wnt/β-catenin signalling pathway.

Introduction: Anaphylaxis is an acute, life-threatening condition representing a systemic hypersensitivity reaction, particularly triggered by food in young children. Its rising prevalence in the paediatric population has made it a critical topic in clinical practice, with epinephrine as the recommended treatment.

Aim: This study aimed to characterize severe allergic reactions in children aged 0-2 years, focusing on gender, age, allergens, symptoms, and treatments applied.

Material and methods: A retrospective study was conducted using the hospital database to review anaphylaxis cases in children under 2 years of age hospitalized in a paediatric allergy department.

Results: Between 2014 and 2023, 87 patients (54 boys; mean age: 12.3 months, median age: 10 months, range: 4-24 months) with anaphylaxis were admitted to our department, comprising approximately 1% of all annual paediatric hospitalizations. The average onset time for symptoms was 17 min. Cow's milk and hen's egg were the most frequent triggers. Mucocutaneous symptoms (urticaria, angioedema; 81 patients; 93.1%) often appeared with respiratory symptoms. Asthma and hen's egg protein allergy were identified as risk factors for more severe reactions. Grade 4 anaphylaxis was observed in 38 cases (approximately 43% of all cases), though only 8 patients (10.5% of patients who received medication administered by professional staff) received epinephrine. Glucocorticosteroids were the most common treatment administered by medical staff.

Conclusions: Anaphylaxis is a multifaceted, life-threatening condition in infants, with significant diagnostic challenges. Our findings confirm insufficient use of epinephrine in managing severe allergic reactions in this age group.

Introduction: There is great need to screen for HIV, HBV, HBC and syphilis co-infected cases in china because of high prevalance of this disease.

Aim: To uncover the risk factors and incidence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) among syphilis patients.

Material and methods: A total of 5,206 patients with syphilis were enrolled in this retrospective cohort study. The data of clinical and laboratory characteristics of the participants were collected. The correlations between the clinical characteristics and HBV, HCV and HIV co-infection with syphilis were analysed.

Results: The prevalence of HBV, HCV and HIV among syphilis patients in our study was 8.4%, 1.8%, and 10.1%, respectively. The median age was significantly lower in the HBV/syphilis co-infected group (47.5 with IQR 36-58 vs. 52 with IQR 36-61), the majority of co-infected individuals were male (251, 57.6% vs. 185, 42.4%). Multivariate logistic regression analysis showed that co-infected with patients co-infected with HCV and combined with gonococcal infection and herpes virus type II infection were independently associated with HBV co-infection in syphilis patients. Multivariate logistic regression analysis found that male gender, age below 30 years, age group of 31-44-years old, co-infection with HSV-2, never married and divorced, and having a RPR titre of ≥ 1 : 32 were independently associated with HIV co-infection.

Conclusions: HIV co-infection or homosexuality among syphilis patients had no significant impact on the prevalence of HBV or HCV in the study.

Introduction: Atopic dermatitis (AD) is a chronic, inflammatory skin disease with severe itching. Particular attention is dedicated to the coexistence of AD with diseases of the cardiovascular system. Since the earliest manifestation of cardiovascular disease is microvascular endothelium dysfunction, an attempt was made to assess the skin microcirculation.

Aim: The work aims to analyse the assessment of skin microcirculation in patients with atopic dermatitis based on changes of nicotinamide adenine dinucleotide (NADH) fluorescence from the epidermis of the forearm measured with the flow mediated skin fluorescence (FMSF) technique.

Material and methods: Thirteen patients with AD and eleven healthy individuals participated in the study. Changes in NADH fluorescence were measured by the FMSF technique on the forearm in response to blockage and release of blood flow. Results are presented as a maximum ischemic response (IR_max and IR_index,), hyperaemic response (HR_max and HR_index) or hypoxia sensitivity (HS).

Results: The analysed FMSF parameters: IR_max, IR_index, HR_max and HR_index, HS were not significantly lower in AD patients compared with the control group. There was no association between disease severity and NADH fluorescence.

Conclusions: The association of AD with cardiovascular disease is multifactorial. The basis of these connections is still being investigated. Microvascular endothelial dysfunction may be one but not the only mechanism responsible for the increased cardiovascular risk in patients with AD.