Introduction: It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process.
Aim: To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.
Material and methods: Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10-24 Gy, 5-8 Gy/time, once a week.
Results: According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%.
Conclusions: Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.
{"title":"B-ultrasound or CT-guided 3D-printing individualized non-coplanar template brachytherapy for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.","authors":"Pengbing Han, Fengju Li, Yanping Zhang, Liying Gao, Guiqiong Zhang, Qing Guo, Yuxia Zhu, Qun Su","doi":"10.5114/ada.2024.136252","DOIUrl":"10.5114/ada.2024.136252","url":null,"abstract":"<p><strong>Introduction: </strong>It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process.</p><p><strong>Aim: </strong>To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.</p><p><strong>Material and methods: </strong>Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10-24 Gy, 5-8 Gy/time, once a week.</p><p><strong>Results: </strong>According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%.</p><p><strong>Conclusions: </strong>Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2024-02-28DOI: 10.5114/ada.2023.135676
Agnieszka Kowalczyk, Aneta Krogulska
Introduction: Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy.
Aim: Evaluation of clinical relevance of cluster analysis in phenotyping AR based on an analysis of selected clinical and environmental factors.
Material and methods: The study sample was 80 children (7-17 y.o.) with AR, including 28 children with associated asthma. The effects of AR symptoms on the patients daily functioning, skin prick tests (Allergopharma), allergen-specific IgE for airborne allergens (Biocheck GmbH), total cholesterol, cholesterol high-density lipoprotein (HDL), cholesterol low-density lipoprotein (LDL), triglyceride levels in the blood (ARCHITECTcSystem), FeNO and nNO concentrations (HypAir FeNO Medisoft) and results of methacholine challenge test (Lungtest 1000Ispa) were analysed.
Results: Four clusters of patients with AR were extracted, differing in the incidence and severity of AR symptoms and the coincidence of asthma. Most of the children from cluster 1 (n = 24; 85.71%) and cluster 2 (n = 15; 78.95%) had persistent AR, while most of the children from cluster 3 (n = 11; 73.33%) and cluster 4 (n = 14; 77.78%) had intermittent AR. The co-occurrence of asthma was significantly higher in cluster 1 than in other clusters (p = 0.0002). Children in clusters 3 and 4 reported a lower impact of AR symptoms on daily functioning (p = 0.0153). Children in cluster 1 had significantly more often an abnormally high total cholesterol level (p = 0.033) and in cluster 4 significantly more often abnormally high triglyceride levels (p = 0.009) were observed. Patients in cluster 2 were significantly less likely to have abnormal high LDL levels (p = 0.015).
Conclusions: Children with AR from the Kuyavian-Pomeranian voivodeship differing in the course of AR, the frequency of coexistence of asthma, and occurrence of lipid parameter abnormalities.
{"title":"Clinical relevance of cluster analysis in phenotyping allergic rhinitis in the paediatric population of the Kuyavian-Pomeranian voivodeship, Poland.","authors":"Agnieszka Kowalczyk, Aneta Krogulska","doi":"10.5114/ada.2023.135676","DOIUrl":"10.5114/ada.2023.135676","url":null,"abstract":"<p><strong>Introduction: </strong>Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy.</p><p><strong>Aim: </strong>Evaluation of clinical relevance of cluster analysis in phenotyping AR based on an analysis of selected clinical and environmental factors.</p><p><strong>Material and methods: </strong>The study sample was 80 children (7-17 y.o.) with AR, including 28 children with associated asthma. The effects of AR symptoms on the patients daily functioning, skin prick tests (Allergopharma), allergen-specific IgE for airborne allergens (Biocheck GmbH), total cholesterol, cholesterol high-density lipoprotein (HDL), cholesterol low-density lipoprotein (LDL), triglyceride levels in the blood (ARCHITECTcSystem), FeNO and nNO concentrations (HypAir FeNO Medisoft) and results of methacholine challenge test (Lungtest 1000Ispa) were analysed.</p><p><strong>Results: </strong>Four clusters of patients with AR were extracted, differing in the incidence and severity of AR symptoms and the coincidence of asthma. Most of the children from cluster 1 (<i>n</i> = 24; 85.71%) and cluster 2 (<i>n</i> = 15; 78.95%) had persistent AR, while most of the children from cluster 3 (<i>n</i> = 11; 73.33%) and cluster 4 (<i>n</i> = 14; 77.78%) had intermittent AR. The co-occurrence of asthma was significantly higher in cluster 1 than in other clusters (<i>p</i> = 0.0002). Children in clusters 3 and 4 reported a lower impact of AR symptoms on daily functioning (<i>p</i> = 0.0153). Children in cluster 1 had significantly more often an abnormally high total cholesterol level (<i>p</i> = 0.033) and in cluster 4 significantly more often abnormally high triglyceride levels (<i>p</i> = 0.009) were observed. Patients in cluster 2 were significantly less likely to have abnormal high LDL levels (<i>p</i> = 0.015).</p><p><strong>Conclusions: </strong>Children with AR from the Kuyavian-Pomeranian voivodeship differing in the course of AR, the frequency of coexistence of asthma, and occurrence of lipid parameter abnormalities.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01Epub Date: 2024-02-28DOI: 10.5114/ada.2024.135917
Michał Niedźwiedź, Marcin Noweta, Joanna Narbutt, Witold Owczarek, Magdalena Ciążyńska, Agnieszka Czerwińska, Janusz Krzyścin, Aleksandra Lesiak, Małgorzata Skibińska
Introduction: It is well known that biological medications acting on selected elements of the immune response are highly effective in psoriasis treatment. It is a common perception that psoriasis is a seasonal disorder with improvement in warmer months, however it has not been unequivocally confirmed. It is not known whether the time of year of starting systematic therapy for psoriasis influences treatment outcomes.
Material and methods: Changes in psoriasis severity scores during treatment with biologics were investigated. The scores were recorded for 62 patients with moderate to severe psoriasis at the beginning, after 1, 4 and 7 months of the therapy. Patients were divided into two groups: those beginning the treatment in the cold period of the year (November-March) and in the warm period (May-September). The seasonal groups were also divided into subgroups according to the type of biologics used: interleukin inhibitors and tumor necrosis factor α (TNF-α) inhibitors. Results of the treatment were analysed using standard statistical tests of differences between samples.
Results: After 1 and 4 months of the therapy, better efficacy of interleukin inhibitors was found in patients starting treatment in summer. The course of psoriasis improvement in patients taking TNF-α inhibitors resulted in consistent improvement regardless of the season. The outcome of the treatment after 7 months was similar for both seasonal groups and types of biologics used.
Conclusions: Our understanding of the effectiveness of the treatments depending on the time of the year combined with the type of biologics used, may further improve results of the therapy.
{"title":"Does the effectiveness of biological medications in the treatment for psoriasis depend on the moment of starting therapy? A preliminary study.","authors":"Michał Niedźwiedź, Marcin Noweta, Joanna Narbutt, Witold Owczarek, Magdalena Ciążyńska, Agnieszka Czerwińska, Janusz Krzyścin, Aleksandra Lesiak, Małgorzata Skibińska","doi":"10.5114/ada.2024.135917","DOIUrl":"10.5114/ada.2024.135917","url":null,"abstract":"<p><strong>Introduction: </strong>It is well known that biological medications acting on selected elements of the immune response are highly effective in psoriasis treatment. It is a common perception that psoriasis is a seasonal disorder with improvement in warmer months, however it has not been unequivocally confirmed. It is not known whether the time of year of starting systematic therapy for psoriasis influences treatment outcomes.</p><p><strong>Material and methods: </strong>Changes in psoriasis severity scores during treatment with biologics were investigated. The scores were recorded for 62 patients with moderate to severe psoriasis at the beginning, after 1, 4 and 7 months of the therapy. Patients were divided into two groups: those beginning the treatment in the cold period of the year (November-March) and in the warm period (May-September). The seasonal groups were also divided into subgroups according to the type of biologics used: interleukin inhibitors and tumor necrosis factor α (TNF-α) inhibitors. Results of the treatment were analysed using standard statistical tests of differences between samples.</p><p><strong>Results: </strong>After 1 and 4 months of the therapy, better efficacy of interleukin inhibitors was found in patients starting treatment in summer. The course of psoriasis improvement in patients taking TNF-α inhibitors resulted in consistent improvement regardless of the season. The outcome of the treatment after 7 months was similar for both seasonal groups and types of biologics used.</p><p><strong>Conclusions: </strong>Our understanding of the effectiveness of the treatments depending on the time of the year combined with the type of biologics used, may further improve results of the therapy.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133817
Vanesa García-Paz, Carolina Gómez-Farińas, Soledad Sánchez-Sánchez, Andrea Otero-Alonso, Clara Carballas-Vázquez, Leticia Vila-Sexto
{"title":"Linear IgA dermatosis secondary to treatment with piperacillin-tazobactam in a nonagenarian patient.","authors":"Vanesa García-Paz, Carolina Gómez-Farińas, Soledad Sánchez-Sánchez, Andrea Otero-Alonso, Clara Carballas-Vázquez, Leticia Vila-Sexto","doi":"10.5114/ada.2023.133817","DOIUrl":"10.5114/ada.2023.133817","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133454
Maciej Kupczyk, Wojciech Barg, Grażyna Bochenek, Grzegorz Brożek, Piotr D Browiecki, Dorota Brzostek, Andrzej D Browski, Rafał Dobek, Radosław Gawlik, Aleksandra Kucharczyk, Izabela Kupryś-Lipińska, Agnieszka Mastalerz-Migas, Marek L Kowalski
Introduction: Despite being linked to unfavourable outcomes, short-acting β2-agonists (SABAs) are still overused by a substantial proportion of patients with asthma.
Aim: To analyse the prevalence and predictors of SABA overuse and exacerbations in patients with asthma in a nationwide database of prescription purchase records.
Material and methods: The prevalence of excessive SABA use (≥ 12 canisters) and overuse (≥ 3 canisters) was analysed among patients aged 18-64 years who purchased asthma medications in 2018. Predictors of excessive SABA use and SABA overuse were examined by quasi-Poisson regression. Negative binomial regression was used to study the association of excessive SABA use or overuse to the risk of asthma exacerbation defined as a prescription for oral corticosteroids.
Results: Of 91,763 patients with asthma, 42,189 (46%) were SABA users (mean age, 47 years; 58% female). Among them, 34% purchased ≥ 3 SABA canisters, and 6% purchased ≥ 12 canisters. The risk (risk ratio, 95% CI) of excessive SABA use was lower in patients with concomitant prescriptions for inhaled corticosteroids (0.41, 0.34-0.48) or inhaled corticosteroids and long-acting β2-agonists (0.52, 0.47-0.56), women (0.63, 0.58-0.68), and those in secondary care (0.60, 0.44-0.66); older age was associated with a higher risk of excessive SABA use (1.06, 1.03-1.10). Excessive SABA use was the strongest predictor of asthma exacerbations among all patients (3.24, 2.84-3.70) and in those with ≥ 1 exacerbation (1.60, 1.50-1.71).
Conclusions: Excessive SABA use is highly prevalent in asthma management, is associated with lack of prescriptions for inhaled corticosteroids, and substantially increases the exacerbation risk.
简介:尽管短效β2-激动剂(SABAs)与不利的治疗结果有关,但仍有相当一部分哮喘患者过度使用这种药物:尽管短效β2-激动剂(SABAs)与不利的治疗结果有关,但仍有相当一部分哮喘患者过度使用该药物。目的:在一个全国性处方购买记录数据库中,分析哮喘患者过度使用SABAs和病情恶化的发生率和预测因素:在2018年购买哮喘药物的18-64岁患者中,分析SABA过度使用(≥12罐)和过度使用(≥3罐)的患病率。通过准泊松回归研究了SABA过量使用和SABA过度使用的预测因素。负二项回归用于研究过量使用或过度使用SABA与哮喘加重风险(定义为口服皮质类固醇处方)之间的关联:在 91,763 名哮喘患者中,42,189 人(46%)使用 SABA(平均年龄 47 岁;58% 为女性)。其中,34%的患者购买了≥3罐SABA,6%的患者购买了≥12罐。在同时开具吸入皮质类固醇(0.41,0.34-0.48)或吸入皮质类固醇和长效β2-激动剂处方的患者中,过量使用 SABA 的风险(风险比,95% CI)较低(0.52,0.47-0.56)、女性(0.63,0.58-0.68)和接受二级护理者(0.60,0.44-0.66);年龄越大,过度使用SABA的风险越高(1.06,1.03-1.10)。在所有患者(3.24,2.84-3.70)和哮喘加重≥1次的患者(1.60,1.50-1.71)中,过量使用SABA是哮喘加重的最强预测因素:过量使用 SABA 在哮喘治疗中非常普遍,与缺乏吸入皮质类固醇处方有关,并大大增加了病情恶化的风险。
{"title":"Predictors of excessive short-acting β<sub>2</sub>-agonist use and asthma exacerbations: a retrospective analysis of a Polish prescription database.","authors":"Maciej Kupczyk, Wojciech Barg, Grażyna Bochenek, Grzegorz Brożek, Piotr D Browiecki, Dorota Brzostek, Andrzej D Browski, Rafał Dobek, Radosław Gawlik, Aleksandra Kucharczyk, Izabela Kupryś-Lipińska, Agnieszka Mastalerz-Migas, Marek L Kowalski","doi":"10.5114/ada.2023.133454","DOIUrl":"10.5114/ada.2023.133454","url":null,"abstract":"<p><strong>Introduction: </strong>Despite being linked to unfavourable outcomes, short-acting β<sub>2</sub>-agonists (SABAs) are still overused by a substantial proportion of patients with asthma.</p><p><strong>Aim: </strong>To analyse the prevalence and predictors of SABA overuse and exacerbations in patients with asthma in a nationwide database of prescription purchase records.</p><p><strong>Material and methods: </strong>The prevalence of excessive SABA use (≥ 12 canisters) and overuse (≥ 3 canisters) was analysed among patients aged 18-64 years who purchased asthma medications in 2018. Predictors of excessive SABA use and SABA overuse were examined by quasi-Poisson regression. Negative binomial regression was used to study the association of excessive SABA use or overuse to the risk of asthma exacerbation defined as a prescription for oral corticosteroids.</p><p><strong>Results: </strong>Of 91,763 patients with asthma, 42,189 (46%) were SABA users (mean age, 47 years; 58% female). Among them, 34% purchased ≥ 3 SABA canisters, and 6% purchased ≥ 12 canisters. The risk (risk ratio, 95% CI) of excessive SABA use was lower in patients with concomitant prescriptions for inhaled corticosteroids (0.41, 0.34-0.48) or inhaled corticosteroids and long-acting β<sub>2</sub>-agonists (0.52, 0.47-0.56), women (0.63, 0.58-0.68), and those in secondary care (0.60, 0.44-0.66); older age was associated with a higher risk of excessive SABA use (1.06, 1.03-1.10). Excessive SABA use was the strongest predictor of asthma exacerbations among all patients (3.24, 2.84-3.70) and in those with ≥ 1 exacerbation (1.60, 1.50-1.71).</p><p><strong>Conclusions: </strong>Excessive SABA use is highly prevalent in asthma management, is associated with lack of prescriptions for inhaled corticosteroids, and substantially increases the exacerbation risk.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133831
Maria Wawszczak, Marek Kulus, Joanna Peradzyńska
Introduction: Recent studies have indicated the significance of the peripheral airways in asthma control. Methods estimating airway resistance, air trapping, and ventilation inhomogeneity are useful for assessing this area of the lung and have proven utility in the evaluation of asthma; however, it is unclear which method is most effective at characterising uncontrolled asthma.
Aim: To evaluate the diagnostic accuracy of various peripheral airway function measurements in the assessment of asthma control in children.
Material and methods: Children with controlled (n = 35) and uncontrolled (n = 29) asthma performed a sequence of pulmonary function tests (i.e. spirometry, body plethysmography, oscillometry, nitrogen washout test, and exhaled nitric oxide). The diagnostic accuracy of each peripheral airway measure was evaluated by an area under the receiver operating characteristic curve (AUC).
Results: Most peripheral airway parameters were significantly increased in children with uncontrolled asthma compared with children with controlled asthma. The measures with the highest diagnostic accuracy for asthma control were lung clearance index (LCI) (AUC = 0.76), with high specificity (0.97) and modest sensitivity (0.46), acinar ventilation heterogeneity (Sacin) (AUC = 0.73), with high sensitivity (0.85) and modest specificity (0.54), and resonance frequency (Fres) (AUC= 0.74), with perfect specificity (1.0) but low sensitivity (0.38).
Conclusions: LCI, Sacin and Fres had the highest discriminative capacity for distinguishing children with controlled and uncontrolled asthma among all evaluated peripheral airways measures. Discrepancies in the performance (i.e. sensitivity and specificity) of each parameter suggest that a combination may be most effective in determining asthma control status.
{"title":"Diagnostic accuracy of peripheral lung function measurements in paediatric asthma control assessment: a pilot study.","authors":"Maria Wawszczak, Marek Kulus, Joanna Peradzyńska","doi":"10.5114/ada.2023.133831","DOIUrl":"10.5114/ada.2023.133831","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have indicated the significance of the peripheral airways in asthma control. Methods estimating airway resistance, air trapping, and ventilation inhomogeneity are useful for assessing this area of the lung and have proven utility in the evaluation of asthma; however, it is unclear which method is most effective at characterising uncontrolled asthma.</p><p><strong>Aim: </strong>To evaluate the diagnostic accuracy of various peripheral airway function measurements in the assessment of asthma control in children.</p><p><strong>Material and methods: </strong>Children with controlled (<i>n</i> = 35) and uncontrolled (<i>n</i> = 29) asthma performed a sequence of pulmonary function tests (i.e. spirometry, body plethysmography, oscillometry, nitrogen washout test, and exhaled nitric oxide). The diagnostic accuracy of each peripheral airway measure was evaluated by an area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Most peripheral airway parameters were significantly increased in children with uncontrolled asthma compared with children with controlled asthma. The measures with the highest diagnostic accuracy for asthma control were lung clearance index (LCI) (AUC = 0.76), with high specificity (0.97) and modest sensitivity (0.46), acinar ventilation heterogeneity (Sacin) (AUC = 0.73), with high sensitivity (0.85) and modest specificity (0.54), and resonance frequency (Fres) (AUC= 0.74), with perfect specificity (1.0) but low sensitivity (0.38).</p><p><strong>Conclusions: </strong>LCI, Sacin and Fres had the highest discriminative capacity for distinguishing children with controlled and uncontrolled asthma among all evaluated peripheral airways measures. Discrepancies in the performance (i.e. sensitivity and specificity) of each parameter suggest that a combination may be most effective in determining asthma control status.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133468
Bahar Öztelcan Gündüz, Hatice Ataş
Introduction: Acne vulgaris is a prevalent skin disorder influenced by a variety of factors, including a high body mass index (BMI) and obesity.
Aim: To investigate the association between BMI z-scores and acne severity in boys and girls aged 10-18 years.
Material and methods: A 72-patient prospective analysis was performed, in which patient weight, height, body mass index (BMI), body mass index z score (BMI z-score), percentiles, and demographic information were collected, and acne severity was categorized as mild or moderate/severe.
Results: The results indicated that patients with moderate/severe acne were significantly older and had higher weight, height, BMI, and BMI z-scores than those with mild acne (p < 0.01).
Conclusions: The findings suggest that higher BMI z-scores are linked to increased acne severity. These results emphasize the importance of addressing weight-related risk factors for the prevention and treatment of acne vulgaris. The early detection and management of weight-related conditions can play a crucial role in improving the overall well-being of individuals with acne, considering its negative impact on mental health and social functioning.
简介:寻常痤疮是一种常见的皮肤疾病,受多种因素影响,包括高体重指数(BMI)和肥胖:寻常痤疮是一种常见的皮肤疾病,受多种因素的影响,包括高体重指数(BMI)和肥胖:对72名患者进行了前瞻性分析,收集了患者的体重、身高、体重指数(BMI)、体重指数z分数(BMI z-score)、百分位数和人口统计学信息,并将痤疮严重程度分为轻度和中度/重度:结果表明,与轻度痤疮患者相比,中度/重度痤疮患者的年龄明显偏大,体重、身高、体重指数和体重指数 z 值均偏高(P < 0.01):研究结果表明,较高的体重指数 z 值与痤疮严重程度的增加有关。这些结果强调了解决与体重相关的风险因素对预防和治疗寻常痤疮的重要性。考虑到痤疮对心理健康和社会功能的负面影响,及早发现和控制与体重相关的病症对改善痤疮患者的整体福祉至关重要。
{"title":"Relationship between body mass index <i>z</i>-score and acne severity in adolescents: a prospective analysis.","authors":"Bahar Öztelcan Gündüz, Hatice Ataş","doi":"10.5114/ada.2023.133468","DOIUrl":"10.5114/ada.2023.133468","url":null,"abstract":"<p><strong>Introduction: </strong>Acne vulgaris is a prevalent skin disorder influenced by a variety of factors, including a high body mass index (BMI) and obesity.</p><p><strong>Aim: </strong>To investigate the association between BMI <i>z</i>-scores and acne severity in boys and girls aged 10-18 years.</p><p><strong>Material and methods: </strong>A 72-patient prospective analysis was performed, in which patient weight, height, body mass index (BMI), body mass index <i>z</i> score (BMI <i>z</i>-score), percentiles, and demographic information were collected, and acne severity was categorized as mild or moderate/severe.</p><p><strong>Results: </strong>The results indicated that patients with moderate/severe acne were significantly older and had higher weight, height, BMI, and BMI <i>z</i>-scores than those with mild acne (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The findings suggest that higher BMI <i>z</i>-scores are linked to increased acne severity. These results emphasize the importance of addressing weight-related risk factors for the prevention and treatment of acne vulgaris. The early detection and management of weight-related conditions can play a crucial role in improving the overall well-being of individuals with acne, considering its negative impact on mental health and social functioning.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.134192
Luiza Marek-Józefowicz, Marcin Jaracz, Alina Borkowska
[This retracts the article DOI: 10.5114/ada.2021.104289.].
[此文收回 DOI: 10.5114/ada.2021.104289.]。
{"title":"Retracted: Affective temperament, depressive symptoms and interleukins in patients with psoriasis.","authors":"Luiza Marek-Józefowicz, Marcin Jaracz, Alina Borkowska","doi":"10.5114/ada.2023.134192","DOIUrl":"https://doi.org/10.5114/ada.2023.134192","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.5114/ada.2021.104289.].</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133959
Linxi Zeng, Sen Feng, Lulu Yao, Bin Wang, Guoqiang Zhang
Introduction: Recent studies have confirmed the possibility of using upadacitinib for treating atopic dermatitis (AD). However, there is no meta-analysis to summarize and quantify the efficacy and safety of the drug, especially for adolescents with AD.
Aim: To evaluate the overall efficacy and safety of upadacitinib in adults and adolescents with AD.
Material and methods: We developed this systematic review and meta-analysis according to PRISMA guidelines. Risk-of-bias assessment tool, RoB2 (revised version 2019) was used for quality assessment.
Results: Four RCTs were enrolled in the analysis, 3 of which on both adults and adolescents, while the other on adults only. For either adults or adolescents, the group treated with upadacitinib all had better performance than controls: EASI-75 (adults): RR = 4.68, 95% CI: 4.09, 5.35; NRS4 (adults): RR = 4.07, 95% CI: 3.15, 5.25; EASI-75 (adolescents): RR = 4.16, 95% CI: 2.70, 6.42; NRS4 (adolescents): RR = 4.52, 95% CI: 2.49, 8.21. Furthermore, upadacitinib 30 mg was more effective than 15 mg. For serious AEs, upper respiratory tract infection and headache, there was no significant difference between the upadacitinib group and controls. However, the treatment of upadacitinib may increase the risk of nasopharyngitis, increase blood creatine phosphokinase and cause acne.
Conclusions: Upadacitinib seems to be a promising drug for AD. More long-term and larger-sized randomized clinical trials are required to further assess the safety and efficacy of upadacitinib for AD.
{"title":"Efficacy and safety of upadacitinib for the treatment of moderate-to-severe atopic dermatitis: a meta-analysis of randomized clinical trials.","authors":"Linxi Zeng, Sen Feng, Lulu Yao, Bin Wang, Guoqiang Zhang","doi":"10.5114/ada.2023.133959","DOIUrl":"10.5114/ada.2023.133959","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have confirmed the possibility of using upadacitinib for treating atopic dermatitis (AD). However, there is no meta-analysis to summarize and quantify the efficacy and safety of the drug, especially for adolescents with AD.</p><p><strong>Aim: </strong>To evaluate the overall efficacy and safety of upadacitinib in adults and adolescents with AD.</p><p><strong>Material and methods: </strong>We developed this systematic review and meta-analysis according to PRISMA guidelines. Risk-of-bias assessment tool, RoB2 (revised version 2019) was used for quality assessment.</p><p><strong>Results: </strong>Four RCTs were enrolled in the analysis, 3 of which on both adults and adolescents, while the other on adults only. For either adults or adolescents, the group treated with upadacitinib all had better performance than controls: EASI-75 (adults): RR = 4.68, 95% CI: 4.09, 5.35; NRS4 (adults): RR = 4.07, 95% CI: 3.15, 5.25; EASI-75 (adolescents): RR = 4.16, 95% CI: 2.70, 6.42; NRS4 (adolescents): RR = 4.52, 95% CI: 2.49, 8.21. Furthermore, upadacitinib 30 mg was more effective than 15 mg. For serious AEs, upper respiratory tract infection and headache, there was no significant difference between the upadacitinib group and controls. However, the treatment of upadacitinib may increase the risk of nasopharyngitis, increase blood creatine phosphokinase and cause acne.</p><p><strong>Conclusions: </strong>Upadacitinib seems to be a promising drug for AD. More long-term and larger-sized randomized clinical trials are required to further assess the safety and efficacy of upadacitinib for AD.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01Epub Date: 2024-01-08DOI: 10.5114/ada.2023.133588
Zoran Terzić, Marinko Paunovic, Ana Popovic, Filip Vukmirovic, Miloš Bojić
{"title":"Transformation of recurrent hidradenoma into a metastatic hidradenocarcinoma in a 31-year old female patient.","authors":"Zoran Terzić, Marinko Paunovic, Ana Popovic, Filip Vukmirovic, Miloš Bojić","doi":"10.5114/ada.2023.133588","DOIUrl":"10.5114/ada.2023.133588","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}