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[The molecular pathology breviary: read depth and coverage in NGS analysis]. [分子病理学简章：阅读NGS分析的深度和覆盖面]。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2021-10-13 DOI: 10.1007/s00292-021-01009-5
Ulrich Lehmann, Albrecht Stenzinger
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引用次数: 0
[Standardized structured reports for gastrointestinal tumors]. 【胃肠肿瘤标准化结构化报告】。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2021-10-05 DOI: 10.1007/s00292-021-00986-x
Ekkehard Hewer, Anna Rump, Rupert Langer

Synoptic reporting in pathology as opposed to traditional narrative reporting is defined by a laboratory value-like format and use of standardized checklists. It contributes to completeness and comprehensibility of pathology reports and ultimately patient care. As of today, two major institutions publish synoptic reporting templates, the College of American Pathologists (CAP) and the International Collaboration for Cancer Reporting (ICCR). Synoptic protocols are available for all major cancer types and provide not only a standardized terminology and a checklist for completeness of reports, but also facilitate uniform utilization of diagnostic criteria. Additionally, both CAP and ICCR protocols are accompanied by detailed and up-to-date reference lists and thereby represent a valuable source of information even when synoptic reporting is not used. The benefits and challenges of implementation of synoptic reporting are discussed, in particular with regard to reporting in German.

病理学的概要报告与传统的叙述性报告相反，是由类似实验室价值的格式和标准化清单的使用来定义的。它有助于病理报告的完整性和可理解性，并最终对患者进行护理。时至今日，美国病理学家学会(CAP)和国际癌症报告合作组织(ICCR)这两个主要机构发布了概要性报告模板。所有主要癌症类型均可使用概要性协议，不仅提供标准化术语和报告完整性清单，而且还有助于统一使用诊断标准。此外，CAP和ICCR协议都附有详细和最新的参考清单，因此即使在不使用概要报告的情况下，也代表了有价值的信息来源。讨论了实施概要报告的好处和挑战，特别是关于用德语报告。
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引用次数: 0
Erratum zu: Standardisierte strukturierte Befundberichte gastrointestinaler Tumoren. 导致了对肠胃手术的标准化组织结构图
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 DOI: 10.1007/s00292-021-01020-w
Ekkehard Hewer, Anna Rump, Rupert Langer
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引用次数: 0
Mitteilungen der Deutschen Gesellschaft für Pathologie. 德国病理学协会的信息
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 DOI: 10.1007/s00292-021-01050-4
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引用次数: 0
[Grading of tumor regression of gastrointestinal carcinomas after neoadjuvant therapy]. 【胃肠癌新辅助治疗后肿瘤消退的分级】。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2021-12-23 DOI: 10.1007/s00292-021-01041-5
Drolaiz Liu, Rupert Langer

Pre- or perioperative chemo- or radiochemotherapy and subsequent resection is the standard therapy for locally advanced esophageal, gastric, and rectal cancer. A tumor regression grading (TRG; also tumor regression grade) categorizes the extent of the regressive changes after a neoadjuvant treatment. There are several TRG systems for gastrointestinal carcinomas that relate either to the extent of the therapy-induced fibrosis in relation to the residual tumor or the estimated proportion of the residual tumor in the area of the former tumor area. An ideal TRG system shows significant interobserver agreement and offers relevant prognostic information - in most cases a complete or almost complete regression after neoadjuvant therapy is associated with an improved prognosis. In this review, the most commonly used TRG systems for gastrointestinal carcinomas are presented and discussed. In addition, current issues such as the standardization of TRG and the subject of regression in lymph node metastases in the context of a TRG system are discussed.

术前或围手术期化疗或放化疗及术后切除是局部晚期食管癌、胃癌和直肠癌的标准治疗方法。肿瘤消退分级(TRG;同时，肿瘤消退等级(tumor regression grade)对新辅助治疗后退行性改变的程度进行了分类。胃肠道癌有几种TRG系统，它们与治疗诱导的纤维化与残留肿瘤的程度或残留肿瘤在原肿瘤区域的估计比例有关。理想的TRG系统表现出显著的观察者间一致性，并提供相关的预后信息——在大多数情况下，新辅助治疗后完全或几乎完全消退与预后改善有关。在这篇综述中，介绍和讨论了胃肠道癌中最常用的TRG系统。此外，还讨论了当前的问题，如TRG的标准化和TRG系统背景下淋巴结转移的回归问题。
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引用次数: 0
[Pathology of hepatocellular carcinoma]. [肝细胞癌病理]。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2022-01-04 DOI: 10.1007/s00292-021-01038-0
Thomas Longerich, Peter Schirmacher

Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide and has a well-defined etiology. It develops in a stepwise process with morphologically defined precursor lesions. Typing of highly differentiated hepatocellular tumors is supported by immunohistological marker panel and the so-called matrix diagnosis. The recent World Health Organization (WHO) classification defined morpho-molecular HCC subtypes showing typical clinical and prognostic characteristics. If HCC subtyping is considered in future clinical studies of advanced HCC, this could help to introduce personalized HCC therapy. Currently, precision oncology is not available for HCC.

肝细胞癌(HCC)是全球癌症相关死亡的第三大原因，其病因明确。它的发展是一个循序渐进的过程，具有形态学上明确的前驱病变。高分化肝细胞肿瘤的分型是由免疫组织学标记板和所谓的基质诊断支持的。最近世界卫生组织(WHO)的分类定义了HCC的形态分子亚型，显示了典型的临床和预后特征。如果在未来晚期HCC的临床研究中考虑HCC亚型，这将有助于引入个性化的HCC治疗。目前，精确肿瘤学还不能用于HCC。
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引用次数: 1
[Two new sections: "Molecular Tumor Board" and "Picture of the Month"]. [新增两个板块:“分子肿瘤板”和“月度图片”]。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2022-01-25 DOI: 10.1007/s00292-021-01045-1
Wilfried Roth, Matthias Gaida
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引用次数: 0
Mitteilungen der IAP. 来自国际原子能机构的消息
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 DOI: 10.1007/s00292-021-01043-3
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引用次数: 0
[Spring symposium pathology of the gastrointestinal tract]. 【春季会饮胃肠道病理】。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 Epub Date: 2022-01-25 DOI: 10.1007/s00292-021-01048-y
Heike I Grabsch, Rupert Langer, Michael Vieth
{"title":"[Spring symposium pathology of the gastrointestinal tract].","authors":"Heike I Grabsch,&nbsp;Rupert Langer,&nbsp;Michael Vieth","doi":"10.1007/s00292-021-01048-y","DOIUrl":"https://doi.org/10.1007/s00292-021-01048-y","url":null,"abstract":"","PeriodicalId":54641,"journal":{"name":"Pathologe","volume":"43 1","pages":"5-7"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39963670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dank an die Gutachter*innen von Der Pathologe. 感谢Der Pathologe的专家们。
4区 医学 Q3 Medicine
Pathologe
Pub Date : 2022-02-01 DOI: 10.1007/s00292-021-01047-z
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引用次数: 0
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