Ocular Surface最新文献

英文中文

Ocular manifestations in Stevens‒Johnson syndrome/toxic epidermal necrolysis in cancer patients Stevens-Johnson综合征/肿瘤患者中毒性表皮坏死松解的眼部表现

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.010

Jin-Jhe Wang , Chun-Bing Chen , Eugene Yu-Chuan Kang , Wen-Hung Chung , John Wen-Cheng Chang , Kevin Sheng-Kai Ma , Yueh-Ju Tsai , Ming-Tse Kuo , Chi-Chin Sun , Hung-Chi Chen , Shin-Yi Chen , Kuo-Hsuan Hung , Hsin-Yuan Tan , Pier Luigi Surico , David Hui-Kang Ma

Purpose

To evaluate the characteristics, risk factors, and outcomes of ocular involvement in cancer patients with Stevens‒Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), focusing on the role of immune checkpoint inhibitors (ICIs).

Methods

This retrospective case‒control study was conducted at Chang Gung Memorial Hospital, Linkou, Taiwan, between 2004 and 2024. A total of 112 patients with confirmed SJS/TEN and concurrent malignancies were included. The primary outcomes were the prevalence and severity of acute and chronic ocular involvement, assessed using Sotozono's classification. Risk factors for ocular involvement were investigated through univariate and multivariate logistic regression.

Results

Of 112 patients, 46 (41.1 %) developed ocular complications. TEN (adjusted OR, 3.11; 95 % CI, 1.24–7.78; P = 0.02), systemic mucosal involvement (adjusted OR, 4.89; 95 % CI, 1.52–15.80; P = 0.01), and polypharmacy (adjusted OR, 3.52; 95 % CI, 1.36–9.11; P = 0.01) were significant risk factors for ocular involvement. ICI-related SJS/TEN exhibited longer latency (31.0 vs. 13.4 days; P < 0.001) and delayed healing (72.3 vs. 45.8 days; P = 0.002). Chronic ocular complications were more severe in surviving ICI-related patients, as indicated by significantly higher chronic Sotozono scores (7.5 vs. 3.7; P = 0.001), worse dry eye (Schirmer's test 1.8 vs. 3.4 mm; P = 0.01), and poorer visual recovery (0.11 vs. 0.43 logMAR; P = 0.001).

Conclusions

SJS/TEN in cancer patients, particularly those receiving ICIs, is associated with substantial ocular morbidity. The increasing prevalence of ICI-related SJS/TEN emphasizes the need for vigilant ophthalmologic intervention and long-term monitoring.

目的探讨Stevens-Johnson综合征/中毒性表皮坏死松解（SJS/TEN）患者眼部受损伤的特点、危险因素及预后，重点探讨免疫检查点抑制剂（ICIs）的作用。方法回顾性病例对照研究于2004 ~ 2024年在台湾省林口市长庚纪念医院进行。共纳入112例确诊为SJS/TEN并伴有恶性肿瘤的患者。主要结果是急性和慢性眼部受累的患病率和严重程度，使用Sotozono分类进行评估。通过单因素和多因素logistic回归研究眼部受累的危险因素。结果112例患者中有46例（41.1%）出现眼部并发症。TEN（校正OR， 3.11; 95% CI, 1.24-7.78; P = 0.02）、全身粘膜受累（校正OR， 4.89; 95% CI, 1.52-15.80; P = 0.01）和多药（校正OR， 3.52; 95% CI, 1.36-9.11; P = 0.01）是眼部受累的显著危险因素。ici相关的SJS/TEN表现出更长的潜伏期（31.0 vs. 13.4天；P < 0.001）和延迟的愈合（72.3 vs. 45.8天；P = 0.002）。存活的ici相关患者的慢性眼部并发症更为严重，慢性Sotozono评分显著较高（7.5比3.7,P = 0.001），干眼更严重（Schirmer's test 1.8比3.4 mm, P = 0.01），视力恢复较差（0.11比0.43 logMAR, P = 0.001）。结论ssjs /TEN在癌症患者，特别是接受ICIs的患者中，与大量眼部发病率相关。ici相关SJS/TEN患病率的增加强调了警惕的眼科干预和长期监测的必要性。

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引用次数: 0

Re: Reply to Prof. Jacqueline Tan's letter. Efficacy of eyelid warming devices as a first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33-46 眼睑温热装置作为睑板腺功能障碍第一步治疗的疗效：一项系统综述和meta分析。

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.04.002

Ballesteros-Sánchez Antonio, Carlos Rocha-de-Lossada, José-María Sánchez-González

引用次数: 0

Methodological considerations regarding "Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence" [Letter] 关于“眼部过敏局部治疗的疗效排序：现有证据的网络荟萃分析”的方法学考虑[Letter]

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.006

Dror Ben Ephraim Noyman , Michael Mimouni , Ben Klinghoffer

引用次数: 0

Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'” 对“对眼部过敏局部治疗的疗效排序的方法学考虑：对现有证据的网络荟萃分析”的回应

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.007

Luksanaporn Krungkraipetch , Taweelarp Tansavadi , Dechathorn Krungkraipetch

引用次数: 0

In memoriam: Professor Maurizio Rolando (1950–2025) 纪念:毛里齐奥·罗兰多教授(1950 - 2025)

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.003

Stefano Bonini

引用次数: 0

Clinical and genetic profiling of fibromyalgia-associated dry eye: A multifactorial approach 纤维肌痛相关干眼的临床和基因分析：一种多因素方法

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.012

Carlos Vergés , Ana Giménez-Capitán , Verónica Ribas , Elizabeth Martínez-Pérez , María José González , Francesc March de Ribot , Noelia Armiger-Borras , Andrea Caycedo , Cristina Rodríguez-Muñoz , Cayetano Alegre , Susana Muñoz , José Salgado-Borges , Clara Mayo-de-las-Casas

Background

Fibromyalgia syndrome (FM) is a chronic pain disorder affecting 3–6 % of the global population, often underdiagnosed and lacking specific diagnostic tests. Many patients also present with dry eye disease (DED), suggesting a possible link. This study explores the relationship between DED and FM-associated DED (FM-DED) by evaluating corneal nerve abnormalities using in vivo corneal confocal microscopy (IVCM), alongside gene expression and polymorphisms (COMT, MTHFR) related to inflammation.

Methods

The study included 113 participants: 81 patients (44 with DED, 37 with FM-DED) and 32 healthy controls (HC). Cell lines SK-OV-3, NCI-H1781, and NCI-H460 were included as controls. Clinical evaluations, IVCM, and genotyping of COMT Val158Met and MTHFR C677T from blood samples were conducted. Conjunctival gene expression was analyzed using an nCounter custom panel of 77 genes. Protein–Protein Interaction (PPI) network analysis identified key biological processes.

Results

FM-DED patients showed significantly reduced corneal nerve density and increased Langerhans cells and microneuromas, with strong correlation with pain ((|ρ| > 0.7). Significant differences were observed in OSDI, NITBUT, TMH, and meibomian gland atrophy, but not in osmolarity or Schirmer I test. The GA genotype of COMT Val158Met was more frequent in FM-DED (60 %) and associated with severe cases. The CT genotype of MTHFR C677T was linked to increased corneal damage. Gene expression analysis showed immune-related gene overexpression (MUC1, IFITM1, PSMB8), with FM-DED-specific upregulation of PIGR and CEACAM6. PPI analysis highlighted lipopolysaccharide-mediated signaling.

Conclusions

Genetic polymorphisms and immune dysregulation contribute to FM-DED pathophysiology, supporting the need for differentiated diagnosis and targeted therapies.

纤维肌痛综合征（FM）是一种慢性疼痛疾病，影响全球3 - 6%的人口，通常诊断不足，缺乏特定的诊断测试。许多患者还出现干眼症（DED），提示两者之间可能存在联系。本研究通过使用体内角膜共聚焦显微镜（IVCM）评估角膜神经异常，以及与炎症相关的基因表达和多态性（COMT， MTHFR），探讨了DED和fm相关性DED （FM-DED）之间的关系。方法纳入113例患者：81例（DED 44例，FM-DED 37例），32例健康对照（HC）。将SK-OV-3、NCI-H1781和NCI-H460细胞系作为对照。临床评估、IVCM和血液样本COMT Val158Met和MTHFR C677T基因分型。使用nCounter定制的77个基因面板分析结膜基因表达。蛋白质-蛋白质相互作用（PPI）网络分析确定了关键的生物过程。结果fm - ded患者角膜神经密度明显降低，朗格汉斯细胞和微神经瘤增加，与疼痛有很强的相关性(（|ρ| > 0.7）。在OSDI、NITBUT、TMH和睑板腺萎缩中观察到显著差异，但在渗透压和Schirmer I试验中没有观察到显著差异。COMT Val158Met的GA基因型在FM-DED中更为常见（60%），并与重症病例相关。MTHFR C677T的CT基因型与角膜损伤增加有关。基因表达分析显示免疫相关基因MUC1、IFITM1、PSMB8过表达，并伴有fm - ed特异性的PIGR和CEACAM6上调。PPI分析强调脂多糖介导的信号传导。结论遗传多态性和免疫失调参与了FM-DED的病理生理，支持了鉴别诊断和靶向治疗的必要性。

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引用次数: 0

Letter to the editor regarding “Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns" 致编辑关于“单纯角膜缘上皮移植与培养角膜缘上皮移植治疗眼部烧伤”的信。

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.07.006

Mehmet Gurdal , Ozlem Barut Selver

引用次数: 0

Eye pain and ocular surface characteristics in Postural Orthostatic Tachycardia Syndrome (POTS): The role of autonomic dysfunction 体位性心动过速综合征（POTS）的眼痛和眼表特征：自主神经功能障碍的作用

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.009

Sezen Karakus , Jane Jin Huang , Meltem Yashar , Meron Haile , Ugur Tunc , Claudia Viton , Stefan Cehan , Pranav Kotamraju , Cynthia Wang , Brittany L. Adler , Tae H. Chung

Purpose

Postural Orthostatic Tachycardia Syndrome (POTS), an autonomic nervous system dysfunction, is frequently associated with ocular symptoms including pain and dryness. This study aimed to characterize ocular surface findings in POTS patients to clarify whether these symptoms reflect classic dry eye disease or altered sensory processing related to autonomic dysfunction.

Methods

A retrospective observational study was conducted on patients with confirmed POTS who underwent standardized ocular surface evaluations at a tertiary academic center between 2019 and 2024. Demographics and medical history were extracted from records. Assessments included pain ratings (0–10 Likert scale), proparacaine response, Schirmer testing, ocular staining score (OSS), and in vivo confocal microscopy (IVCM) when available.

Results

Forty-three patients (39 females; mean age 45.1 ± 14.0 years) were included. Thirty-eight reported ocular pain and dryness. Among 21 patients with recorded pain scores, the median (IQR) was 5 (4), reduced to 4 (4.5) after proparacaine. Median Schirmer score was 5 mm (IQR 27), with 13 patients ≤5 mm. Median OSS was 0 (IQR 2), with only 4 patients showing OSS>1 with improved symptoms after proparacaine, suggesting neuropathic etiology in 34 patients. IVCM, available in six cases, revealed reduced nerve density and microneuromas. Migraine was the most common comorbidity (76.7 %) and was strongly associated with pain without staining (OR = 15.0; 95 % CI 2.65–85.0; p = 0.002).

Conclusions

POTS patients frequently report ocular pain and dryness, yet objective signs of dry eye are uncommon. These findings underscore the need for ocular surface staining to distinguish dry eye disease from neuropathic ocular pain, suggesting that altered corneal nerve function in autonomic dysfunction may drive symptoms.

目的体位性站立性心动过速综合征（POTS）是一种自主神经系统功能障碍，常伴有眼部症状，包括疼痛和干燥。本研究旨在描述POTS患者的眼表表现，以阐明这些症状是否反映了典型的干眼病或与自主神经功能障碍相关的感觉处理改变。方法对2019 - 2024年在某三级学术中心进行标准化眼表评估的确诊POTS患者进行回顾性观察研究。从记录中提取人口统计和病史。评估包括疼痛评分（0-10李克特量表）、丙帕卡因反应、Schirmer试验、眼染色评分（OSS）和体内共聚焦显微镜（IVCM）（如果有的话）。结果纳入43例患者，其中女性39例，平均年龄45.1±14.0岁。38人报告眼部疼痛和干涩。在21例有疼痛评分记录的患者中，中位数（IQR）为5(4)，经丙帕卡因后降至4（4.5）。中位Schirmer评分为5 mm (IQR 27)， 13例患者≤5 mm。中位OSS为0 (IQR 2)，只有4例患者出现OSS>；1例患者经丙帕卡因后症状改善，提示34例患者的病因为神经性病变。6例IVCM显示神经密度降低和微神经瘤。偏头痛是最常见的合并症（76.7%），与无染色疼痛密切相关（OR = 15.0; 95% CI 2.65-85.0; p = 0.002）。结论斑点患者常报告眼部疼痛和干涩，但干眼的客观体征并不常见。这些发现强调了通过眼表染色来区分干眼病和神经性眼痛的必要性，表明自主神经功能障碍导致的角膜神经功能改变可能驱动症状。

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引用次数: 0

Predictors of vision-related quality of life in patients treated for filamentous fungal keratitis 丝状真菌性角膜炎患者视力相关生活质量的预测因素。

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.09.001

N.V. Prajna , N. Radhakrishnan , Prajna Lalitha , Revathi Rajaraman , Sarah Abdelrahman , Benjamin F. Arnold , Thomas M. Lietman , Jennifer Rose-Nussbaumer , Alejandro Arboleda

Purpose

To identify clinical characteristics that predict vision-related quality of life (QoL) in patients with fungal keratitis three months after treatment.

Methods

Patients with fungal keratitis enrolled in the Cross-Linking Assisted Infection Reduction trial were treated with topical natamycin 5 % or amphotericin 0.15 %, with or without adjuvant corneal cross-linking (CXL). Demographic data, ulcer characteristics, clinical course, and responses to the Indian Visual Function Questionnaire (IND-VFQ) were collected at baseline and follow-up. Logistic regression models were used to assess factors associated with patient-reported vision-related QoL at three months. Analyses included the average IND-VFQ score as well as Rasch-derived subscale scores for vision-specific mobility, activity limitation, psychosocial impact, and visual symptoms.

Results

Of 111 participants enrolled, 86 had complete data at both timepoints. Multivariable models identified baseline IND-VFQ score, scar size, and presence of hypopyon as significant predictors of 3-month IND-VFQ scores. A 1-point change in best spectacle corrected visual acuity is correlated with a 13.4-point change in the opposite direction in average IND-VFQ (P=0.001). Patients with adverse events requiring surgery had lower 3-month IND-VFQ scores than those managed medically (P=0.001). Ulcer characteristics including location, depth, symptom duration, repeat culture positivity, organism type, and fungal genus were not associated with final IND-VFQ scores.

Conclusions

Vision-related QoL after fungal keratitis is significantly influenced by change in visual acuity, need for surgical intervention, and select baseline factors including scar size, initial IND-VFQ score, and presence of hypopyon. Vision-related QoL did not differ by antifungal treatment or adjuvant CXL use.

目的：确定预测真菌性角膜炎患者治疗后3个月视力相关生活质量（QoL）的临床特征。方法：参加交联辅助减少感染试验的真菌性角膜炎患者接受5%纳他霉素或0.15%两性霉素外用治疗，伴或不伴角膜交联（CXL）。在基线和随访时收集人口统计数据、溃疡特征、临床病程和对印度视觉功能问卷（IND-VFQ）的反应。使用逻辑回归模型评估与患者报告的三个月视力相关生活质量相关的因素。分析包括IND-VFQ的平均得分以及rasch衍生的视觉特异性活动能力、活动限制、社会心理影响和视觉症状的亚量表得分。结果：在111名参与者中，86名在两个时间点都有完整的数据。多变量模型确定基线IND-VFQ评分、疤痕大小和假说的存在是3个月IND-VFQ评分的重要预测因素。最佳眼镜矫正视力变化1点与平均IND-VFQ相反方向变化13.4点相关（P=0.001）。需要手术的不良事件患者的3个月IND-VFQ评分低于药物治疗的患者（P=0.001）。溃疡特征包括位置、深度、症状持续时间、重复培养阳性、生物体类型和真菌属与最终IND-VFQ评分无关。结论：真菌性角膜炎术后的视力相关生活质量受视力变化、手术干预需要、疤痕大小、初始IND-VFQ评分、是否存在垂体后叶等基线因素的影响。抗真菌治疗或辅助使用CXL对视力相关的生活质量没有影响。

{"title":"Predictors of vision-related quality of life in patients treated for filamentous fungal keratitis","authors":"N.V. Prajna , N. Radhakrishnan , Prajna Lalitha , Revathi Rajaraman , Sarah Abdelrahman , Benjamin F. Arnold , Thomas M. Lietman , Jennifer Rose-Nussbaumer , Alejandro Arboleda","doi":"10.1016/j.jtos.2025.09.001","DOIUrl":"10.1016/j.jtos.2025.09.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify clinical characteristics that predict vision-related quality of life (QoL) in patients with fungal keratitis three months after treatment.</div></div><div><h3>Methods</h3><div>Patients with fungal keratitis enrolled in the Cross-Linking Assisted Infection Reduction trial were treated with topical natamycin 5 % or amphotericin 0.15 %, with or without adjuvant corneal cross-linking (CXL). Demographic data, ulcer characteristics, clinical course, and responses to the Indian Visual Function Questionnaire (IND-VFQ) were collected at baseline and follow-up. Logistic regression models were used to assess factors associated with patient-reported vision-related QoL at three months. Analyses included the average IND-VFQ score as well as Rasch-derived subscale scores for vision-specific mobility, activity limitation, psychosocial impact, and visual symptoms.</div></div><div><h3>Results</h3><div>Of 111 participants enrolled, 86 had complete data at both timepoints. Multivariable models identified baseline IND-VFQ score, scar size, and presence of hypopyon as significant predictors of 3-month IND-VFQ scores. A 1-point change in best spectacle corrected visual acuity is correlated with a 13.4-point change in the opposite direction in average IND-VFQ (P=0.001). Patients with adverse events requiring surgery had lower 3-month IND-VFQ scores than those managed medically (P=0.001). Ulcer characteristics including location, depth, symptom duration, repeat culture positivity, organism type, and fungal genus were not associated with final IND-VFQ scores.</div></div><div><h3>Conclusions</h3><div>Vision-related QoL after fungal keratitis is significantly influenced by change in visual acuity, need for surgical intervention, and select baseline factors including scar size, initial IND-VFQ score, and presence of hypopyon. Vision-related QoL did not differ by antifungal treatment or adjuvant CXL use.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 319-323"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amniotic membrane transplantation techniques in acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review 羊膜移植技术治疗急性史蒂文斯-约翰逊综合征和中毒性表皮坏死松解：系统综述。

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 DOI: 10.1016/j.jtos.2025.10.002

Jai Paris , Carmelo Macri , Abdullah I. Almater , James Slattery , Dinesh Selva

Ocular involvement in Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TENS) is common and can result in severe acute inflammation and long-term complications. Early intervention with amniotic membrane transplantation (AMT) is essential to preserve long term ocular surface integrity and function. This review aimed to evaluate and compare the different surgical techniques to AMT in the acute phase of SJS/TENS, covering sutured, glued, and sutureless/glueless approaches. A systematic search of PubMed, MEDLINE, Embase, Scopus, Cochrane, Google Scholar, and reference lists identified 630 articles, with 27 studies meeting inclusion criteria. Sutured AMT remains the most commonly used method due to its ability to provide comprehensive ocular surface coverage, however is time-consuming and often requires general anaesthesia. Glued AMT, using fibrin or cyanoacrylate adhesive, offers a faster, less invasive alternative suitable for bedside application, though evidence in SJS/TENS is limited. Sutureless/glueless options such as the Prokera® enable rapid deployment and patient comfort but do not provide full ocular surface protection and should only be usedas adjuncts. Hybrid glued approaches with limited suturing may be appropriate for extensive coverage with bedside application. Overall, the choice of technique depends on the extent of ocular involvement, patient stability, and available resources. Further studies are needed to directly compare outcomes across different AMT approaches in acute ocular SJS/TENS.

史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解（TENS）的眼部受累是常见的，可导致严重的急性炎症和长期并发症。早期干预羊膜移植（AMT）是必要的，以保持长期的眼表完整性和功能。本综述旨在评估和比较SJS/TENS急性期AMT的不同手术技术，包括缝合、胶合和无缝合/无胶合入路。对PubMed， MEDLINE, Embase, Scopus, Cochrane，谷歌Scholar和参考文献列表进行系统搜索，确定了630篇文章，其中27篇研究符合纳入标准。缝合AMT仍然是最常用的方法，因为它能够提供全面的眼表覆盖，但是耗时且通常需要全身麻醉。使用纤维蛋白或氰基丙烯酸酯胶粘剂的胶合AMT提供了一种更快速、侵入性更小的替代方案，适用于床边应用，尽管在SJS/TENS中的证据有限。无缝合线/无胶水的选择，如Prokera®，可以快速部署和患者舒适，但不能提供完整的眼表保护，只能作为辅助工具使用。混合胶合方法与有限的缝合可能适用于广泛覆盖的床边应用。总的来说，技术的选择取决于眼部受累程度、患者的稳定性和可用的资源。需要进一步的研究来直接比较不同AMT入路治疗急性眼部SJS/TENS的结果。

{"title":"Amniotic membrane transplantation techniques in acute ocular Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review","authors":"Jai Paris , Carmelo Macri , Abdullah I. Almater , James Slattery , Dinesh Selva","doi":"10.1016/j.jtos.2025.10.002","DOIUrl":"10.1016/j.jtos.2025.10.002","url":null,"abstract":"<div><div>Ocular involvement in Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TENS) is common and can result in severe acute inflammation and long-term complications. Early intervention with amniotic membrane transplantation (AMT) is essential to preserve long term ocular surface integrity and function. This review aimed to evaluate and compare the different surgical techniques to AMT in the acute phase of SJS/TENS, covering sutured, glued, and sutureless/glueless approaches. A systematic search of PubMed, MEDLINE, Embase, Scopus, Cochrane, Google Scholar, and reference lists identified 630 articles, with 27 studies meeting inclusion criteria. Sutured AMT remains the most commonly used method due to its ability to provide comprehensive ocular surface coverage, however is time-consuming and often requires general anaesthesia. Glued AMT, using fibrin or cyanoacrylate adhesive, offers a faster, less invasive alternative suitable for bedside application, though evidence in SJS/TENS is limited. Sutureless/glueless options such as the Prokera® enable rapid deployment and patient comfort but do not provide full ocular surface protection and should only be usedas adjuncts. Hybrid glued approaches with limited suturing may be appropriate for extensive coverage with bedside application. Overall, the choice of technique depends on the extent of ocular involvement, patient stability, and available resources. Further studies are needed to directly compare outcomes across different AMT approaches in acute ocular SJS/TENS.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 337-358"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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