Journal of Research of the National Institute of Standards and Technology最新文献

Data for interpreting virus inactivation on N95 face filtering respirators (FFRs) by ultraviolet (UV) radiation are important in developing UV strategies for N95 FFR disinfection and reuse for any situation, whether it be everyday practices, contingency planning for expected shortages, or crisis planning for known shortages. Data regarding the integrity, form, fit, and function of N95 FFR materials following UV radiation exposure are equally important. This article provides these data for N95 FFRs following UV-C irradiation (200 nm to 280 nm) in a commercial UV-C enclosure. Viral inactivation was determined by examining the inactivation of OC43, a betacoronavirus, inoculated on N95 FFRs. Different metrological approaches were used to examine irradiated N95 FFRs to determine if there were any discernible physical differences between non-irradiated N95 FFRs and those irradiated using the UV-C enclosure. Material integrity was examined using high-resolution scanning electron microscopy. Form, fit, and function were examined using flow resistance, tensile strength, and particle filtration measurements. A separate examination of filter efficiency, fit, and strap tensile stress measurements was performed by the National Personal Protective Technology Laboratory. Data from these metrological examinations provide evidence that N95 FFR disinfection and reuse using the UV-C enclosure can be effective.

A first-principles-based model for predicting the effect of germicidal radiation interventions for air disinfection is presented. Calculation of the "capacity" of an intervention expressed in volumetric flow rate allows for a direct comparison against fresh-air dilution ventilation and filtration systems, which are quantified in terms of the clean air provided. A closed-form expression to predict the combined quantitative impact of spatial gradients and mixing currents on the efficiency with which an intervention is applied is introduced. If validated, this would allow for systems to be selected and sized based on simple metrics across a broad range of settings and applications. The expressions developed are compared against available experimental data sets, and future validation efforts are proposed. Additionally, a method to identify an optimal operating capacity for a given setting by comparing costs associated with disease transmission against the cost of capacity is derived using the Wells-Riley equation and presented as an appendix.

A method is described for inactivation of pathogens, especially airborne pathogens, using ultraviolet (UV) radiation emitted directly into occupied spaces and exposing occupants to a dose below the accepted actinic exposure limit (EL). This method is referred to as direct irradiation below exposure limits, or DIBEL. It is demonstrated herein that low-intensity UV radiation below exposure limits can achieve high levels of equivalent air changes per hour (ACH_eq) and can be an effective component of efforts to combat airborne pathogens such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). An ACH_eq of 4 h-¹ is presently achievable over a continuous 8 h period for the SARS-CoV-2 virus with UV-C light-emitting diodes (LEDs) having peak wavelength at 275 nm, and future improvements in LED technology and optics are anticipated to enable improvements up to 150 h-¹ in the coming decade. For example, the actinic EL is 60 J/m² at 254 nm, and human coronaviruses, including SARS-CoV-2, have a UV dose required for 90 % inactivation of about 5 J/m² at 254 nm. Irradiation by 254 nm UV-C at the EL is expected to provide 90 % inactivation of these organisms in air in about 40 min when the UV-C is delivered at a constant irradiance over 8 h, or in about 5 min if the UV-C is delivered at a constant irradiance over 1 h. Since the irradiation is continuous, the inactivation of initial contaminants accumulates to 99 % and then 99.9 %, and it also immediately begins inactivating any newly introduced (e.g., exhaled) pathogens at the same rate throughout the 8 h period. The efficacy for inactivating airborne pathogens with DIBEL may be expressed in terms of ACHeq, which may be compared with conventional ventilation-based methods for air disinfection. DIBEL may be applied in addition to other disinfection methods, such as upper room UV germicidal irradiation, and mechanical ventilation and filtration. The ACHeq of the separate methods is additive, providing enhanced cumulative disinfection rates. Conventional air disinfection technologies have typical ACH_eq values of about 1 h-¹ to 5 h-¹ and maximum practical values of about 20 h-¹. UV-C DIBEL currently provides ACH_eq values that are typically about 1 h-¹ to 10 h-¹, thus either complementing, or potentially substituting for, conventional technologies. UV-C DIBEL protocols are forecast herein to evolve to >100 ACH_eq in a few years, potentially surpassing conventional technologies. UV-A (315 nm to 400 nm) and/or UV-C (100 nm to 280 nm) DIBEL is also efficacious at inactivating pathogens on surfaces. The relatively simple installation, low acquisition and operating costs, and unobtrusive aesthetic of DIBEL using UV LEDs contribute value in a layered, multi-agent disinfection strategy.

Standard Reference Material (SRM) 2806: Medium Test Dust in Hydraulic Fluid represents a series of reference materials certified by the National Institute of Standards and Technology (NIST) used to calibrate liquid-borne optical (or automatic) particle counters applied in a wide range of industrial, aerospace, and military applications. The series, including SRM 2806b, and SRM 2806d, was manufactured for NIST by IFTS, Institut de la Filtration et des Techniques Séparatives International Filter Testing Services, in France. An important factor for the acceptance of the material for certification was the degree of bottle-to-bottle homogeneity, which was evaluated by both IFTS and NIST. A statistical graphics methodology was developed that provided immediate visual as well as quantitative statistical metrics with which to characterize the SRM. This NIST-developed approach was used in four studies to assess the homogeneity of the material during both its production stage and its finished bottled-product stage. IFTS performed measurements using an optical particle counter for on-line quality assurance and sampled 40 bottles of the finished 400 bottle series to determine homogeneity from the particle size distribution. NIST also determined the particle size distribution of the finished material and performed microscopy to look for possible contaminant material in the suspension. An accelerated aging experiment was conducted on both materials (2806b and 2806d) to verify their stability.

We present a new paradigm for the primary standardization of radionuclide activity per mass of solution (Bq/g). Two key enabling capabilities are 4π decay-energy spectrometry using chip-scale sub-Kelvin microcalorimeters and direct realization of mass by gravimetric inkjet dispensing using an electrostatic force balance. In contrast to traditional traceability, which typically relies on chemical separation of single-radionuclide samples, 4π integral counting, and additional spectrometry methods to verify purity, the system described here has both 4π counting efficiency and spectroscopic resolution sufficient to identify multiple radionuclides in the same sample at once. This enables primary standardization of activity concentrations of mixed-radionuclide samples. A major benefit of this capability, beyond metrology, is in assay of environmental and forensics samples, for which the quantification of multiplenuclide samples can be achieved where presently inhibited by interferences. This can be achieved without the need for chemical separations or efficiency tracers, thereby vastly reducing time, radioactive waste, and resulting measurement uncertainty.

Uniaxial tensile tests are routinely conducted to obtain stress-strain data for forming applications. It is important to understand the deformation behavior of test specimens at plastic strains, temperatures, and strain rates typically encountered in metal forming processes. In this study, the Johnson-Cook (J-C) flow stress model was used to describe the constitutive behavior of ASTM International (ASTM) A 1008 steel specimens during uniaxial tensile tests at three different average strain rates (10-⁵ s-¹, 10-³ s-¹, and 10-¹ s-¹). The digital image correlation (DIC) technique was used for displacement and strain measurement, and two-dimensional (2D) infrared (IR) imaging was employed for temperature measurement. Separate optimization studies involving relevant finite element (FE) modeling with appropriate measured data yielded optimum values of convective heat transfer coefficients, J-C parameters, and inelastic heat fraction variables. FE modeling employing these optimum parameter values was then used to study the mechanical behavior. While FE predictions matched measured strain localization and thermal field very well in the intermediate- and low-rate experiments, the high-rate test showed narrower strain localization and a sharper temperature peak in the experiment. Possible use of a higher steel thermal conductivity value and/or exclusion of material inhomogeneities may have resulted in discrepancies between computed and measured temperature and strain fields. The study shows that an optimized set of parameters obtained with a controlled test could be reasonably applied for other tests conducted at very different strain rates.

The tragedy of the radium poisoning of young women dial painters in the 1920s has been the subject of best-selling books, plays, and motion pictures. With knowledge about radium and its accurate measurements in the hands of a very few scientists, what responsibilities did they have to sound the alarm and mitigate the hazards to workers and the general public? This two-part analysis looks at the role of the staff of the U.S. Bureau of Standards (the National Bureau of Standards [NBS] after 1934) in developing measurements and standards for accurate determinations of radium-226 and radon-222 that ultimately led to national standards for exposure to radioactive substances. Part I looks at the efforts of Elizabeth Hughes, with guidance from her senior colleague at the NBS, to assist dial painters with obtaining redress for their injuries. Part II examines the role of NBS in establishing the national radiation protection standards that were promulgated by the U.S. Department of Commerce (DOC) and the National Council on Radiation Protection and Measurements (NCRP).

We simulated the effects of gimbal-alignment errors and rotational step-size errors on measurements of the sensitivity matrix and intrinsic properties of a triaxial accelerometer. We restricted the study to measurements carried out on a two-axis calibration system using a previously described measurement and analysis protocol. As well as imperfections in the calibration system, we simulated imperfect orthogonality of the accelerometer axes and non-identical sensitivity of the individual accelerometers in an otherwise perfect triaxial accelerometer, but we left characterization of other accelerometer imperfections such as non-linearity for future study. Within this framework, sensitivity-matrix errors are caused by imperfections in the construction and installation of the accelerometer calibration system, but not by the accelerometer imperfections included in the simulations. We use the results of this study to assign type B uncertainties to the components of the sensitivity matrix and related intrinsic properties due to imperfections in the measurement system. For calibrations using a reasonably well manufactured and installed multi-axis rotation stage such as that studied in this paper, we estimated upper bounds to the standard uncertainties of the order of 1×10-5, 2×10-5, 5×10-5, and 2×10-4 for the intrinsic sensitivities, diagonal elements of the sensitivity matrix, off-diagonal elements of the sensitivity matrix, and zero-acceleration offsets, relative to a sensitivity-matrix element of 1, respectively, and 5×10-3 degrees for the intrinsic angles.

The multi-source common-view disciplined clock (MSCVDC) is a recent NIST invention designed to support critical infrastructure timing systems that require a verifiably accurate and fail-safe clock. This paper introduces the MSCVDC, provides a technical description of how it works, and discusses its reliability, redundancy, security, and performance. It also discusses the possibility of a commercially available MSCVDC product.

The National Institute of Standards and Technology (NIST) developed an experimental technique to measure the dynamic flow stress of metals under rapid heating to study their time-dependent plastic response when heating times are short enough to interrupt or bypass thermally driven microstructural evolution. Such conditions may exist as chips are formed in the machining process. Measurements of American Iron and Steel Institute1045 steel behavior up to 1000 °C showed complex thermal softening due to dynamic strain aging effects and the diffusion-limited austenite transformation process beginning at the A1 temperature (712 °C). This paper proposes a constitutive model to capture the flow stress and hardening evolution of 1045 steel under rapidly heated conditions for simulating metal cutting. The model combines the Preston-TonksWallace plasticity model, which uses five parameters to capture complex rate- and temperature-sensitive strain hardening, with a dual-ratesensitivity model to capture the response of rapidly heated 1045 steel. Finally, a strain-rate-dependent Gaussian function is introduced to capture dynamic strain aging effects, which act over a narrow range of temperatures that change with strain rate. The proposed model is compared to existing plasticity models for 1045 steel over the range of data available and at a representative machining condition.