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Best Practices for Germicidal Ultraviolet-C Dose Measurement for N95 Respirator Decontamination. 用于 N95 呼吸器净化的紫外线-C 杀菌剂剂量测量最佳实践。
IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-10-20 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.020
Alisha Geldert, Halleh B Balch, Anjali Gopal, Alison Su, Samantha M Grist, Amy E Herr

Ultraviolet-C (UV-C) decontamination holds promise in combating the coronavirus disease 2019 pandemic, particularly with its potential to mitigate the N95 respirator shortage. Safe, effective, and reproducible decontamination depends critically on UV-C dose, yet dose is frequently measured and reported incorrectly, which results in misleading and potentially harmful protocols. Understanding best practices in UV-C dose measurement for N95 respirator decontamination is essential to the safety of medical professionals, researchers, and the public. Here, we outline the fundamental optical principles governing UV-C irradiation and detection, as well as the key metrics of UV-C wavelength and dose. In particular, we discuss the technical and regulatory distinctions between UV-C N95 respirator decontamination and other applications of germicidal UV-C, and we highlight the unique considerations required for UV-C N95 respirator decontamination. Together, this discussion will inform best practices for UV-C dose measurement for N95 respirator decontamination during crisis-capacity conditions.

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引用次数: 0
Effects of Ultraviolet-C Radiation Exposure on Aircraft Cabin Materials. 紫外线-C 辐射照射对飞机机舱材料的影响。
IF 1.5 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-08-20 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.019
Stephen F Yates, Giorgio Isella, Emir Rahislic, Spencer Barbour, Lillian Tiznado

Ultraviolet-C (UV-C) radiation exposure is an attractive option for rapid and consistent disinfection of interior surfaces in aircraft cabins. In this study, fabric and plastic materials commonly used in aircraft cabins were exposed to UV-C radiation to determine their sensitivity to cumulative damage from frequent application. No significant effect on flame retardancy occurred up to 269 J/cm2 dose, and no effect on tensile or tear strength occurred up to 191 J/cm2 . Changes in color or appearance can occur at lower doses. A limit of 40 J/cm2 is proposed to avoid perceptible changes in appearance.

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引用次数: 0
Estimation of the Ultraviolet-C Doses from Mercury Lamps and Light-Emitting Diodes Required to Disinfect Surfaces. 估算表面消毒所需的汞灯和发光二极管的紫外线-C 剂量。
IF 1.5 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-08-20 eCollection Date: 2021-01-01 DOI: 10.6028/jres.vol.126.025
Pablo Fredes, Ulrich Raff, Ernesto Gramsch, Marcelo Tarkowski

Disinfection of surfaces by ultraviolet-C (UV-C) radiation is gaining importance in diverse applications. However, there is generally no accepted computational procedure to determine the minimum irradiation times and UV-C doses required for reliable and secure disinfection of surfaces. UV-C dose distributions must be comparable for devices presently on the market and future ones, as well as for the diverse surfaces of objects to be disinfected. A mathematical model is presented to estimate irradiance distributions. To this end, the relevant parameters are defined. These parameters are the optical properties of the UV-C light sources, such as wavelength and emitted optical power, as well as electrical features, like radiant efficiency and consumed power. Furthermore, the characteristics and geometry of the irradiated surfaces as well as the positions of the irradiated surfaces in relation to the UV-C light sources are considered. Because mercury (Hg) lamps are competitive with UV-C light-emitting diodes, a comparative analysis between these two light sources based on the simulation results is also discussed.

利用紫外线-C(UV-C)辐射对物体表面进行消毒在各种应用中的重要性与日俱增。然而,目前还没有公认的计算程序来确定可靠、安全的表面消毒所需的最短照射时间和紫外线-C 剂量。紫外线-C 的剂量分布必须与目前市场上的设备和未来的设备以及待消毒物体的不同表面具有可比性。本文提出了一个估算辐照度分布的数学模型。为此,定义了相关参数。这些参数包括紫外线-C 光源的光学特性(如波长和发射光功率)以及电气特性(如辐射效率和消耗功率)。此外,还要考虑照射表面的特性和几何形状,以及照射表面与紫外线-C 光源的位置关系。由于汞灯(Hg)与紫外-C 发光二极管具有竞争性,因此还讨论了根据模拟结果对这两种光源进行比较分析的问题。
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引用次数: 0
Sensitivity of Bacteria, Protozoa, Viruses, and Other Microorganisms to Ultraviolet Radiation. 细菌、原生动物、病毒和其他微生物对紫外线辐射的敏感性。
IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-08-20 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.021
Mahsa Masjoudi, Madjid Mohseni, James R Bolton

Data concerning the sensitivity of various organisms to ultraviolet (UV) radiation exposure are very important in the design of UV disinfection equipment. This review analyzes fluence data from almost 250 studies and organizes the data into a set of recommended fluence values for specific log reductions and an appendix containing all the collected data. This article was sponsored by Dianne L. Poster, Material Measurement Laboratory, and C. Cameron Miller, Physical Measurement Laboratory, National Institute of Standards and Technology (NIST). It is published in collaboration with the International Ultraviolet Association as a complement to the NIST Workshop on Ultraviolet Disinfection Technologies, 14-15 January 2020, Gaithersburg, MD. The views expressed represent those of the authors and not necessarily those of NIST.

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引用次数: 0
SARS-CoV-2 Ultraviolet Radiation Dose-Response Behavior. SARS-CoV-2 紫外线辐射剂量反应行为。
IF 1.5 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-08-20 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.018
Ernest R Blatchley Iii, Brian Petri, Wenjun Sun

Ultraviolet (UV) radiation in the wavelength range 200 nm ≤ λ ≤ 320 nm, which includes both the UV-C and UV-B portions of the spectrum, is known to be effective for inactivation of a wide range of microbial pathogens, including viruses. Previous research has indicated UV-C radiation to be effective for inactivation of severe acute respiratory syndrome coronavirus (SARS-CoV), the virus that caused an outbreak of SARS in 2003. Given the structural similarities of SARS-CoV and SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), it is anticipated that UV radiation should be effective for inactivation of SARS-CoV-2 too. Recently published data support this assertion, but only for a narrow set of exposure and matrix conditions. Models based on genomic and other characteristics of viruses have been developed to provide predictions of viral inactivation responses to UV exposure at λ = 254 nm. The predictions of these models are consistent with reported measurements of viral inactivation, including for SARS-CoV-2. As such, current information indicates that UV-C irradiation should be effective for control of SARS-CoV-2, as well as for control of other coronaviruses; however, additional research is needed to quantify the effects of several important process variables, including the wavelength of radiation, the effects of relative humidity on airborne and surface-associated viruses, and the effects of the medium of exposure.

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引用次数: 0
Measurement Uncertainty of Surface Temperature Distributions for Laser Powder Bed Fusion Processes. 激光粉末床熔融过程表面温度分布的测量不确定性。
IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-08-10 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.013
David C Deisenroth, Sergey Mekhontsev, Brandon Lane, Leonard Hanssen, Ivan Zhirnov, Vladimir Khromchenko, Steven Grantham, Daniel Cardenas-Garcia, Alkan Donmez

This paper describes advances in measuring the characteristic spatial distribution of surface temperature and emissivity during laser-metal interaction under conditions relevant for laser powder bed fusion (LPBF) additive manufacturing processes. Detailed descriptions of the measurement process, results, and approaches to determining uncertainties are provided. Measurement uncertainties have complex dependencies on multiple process parameters, so the methodology is demonstrated on one set of process parameters and one material. Well-established literature values for high-purity nickel solidification temperature and emissivity at the solidification temperature were used to evaluate the predicted uncertainty of the measurements. The standard temperature measurement uncertainty is found to be approximately 0.9% of the absolute temperature (16 AC), and the standard relative emissivity measurement uncertainty is found to be approximately 8% at the solidification point of high-purity nickel, both of which are satisfactory. This paper also outlines several potential sources of test uncertainties, which may require additional experimental evaluation. The largest of these are the metal vapor and ejecta that are produced as process by-products, which can potentially affect the imaging quality, reflectometry results, and thermal signature of the process, while also affecting the process of laser power delivery. Furthermore, the current paper focuses strictly on the uncertainties of the emissivity and temperature measurement approach and therefore does not detail a variety of uncertainties associated with experimental controls that must be evaluated for future generation of reference data.

本文介绍了在激光粉末床熔融(LPBF)快速成型制造工艺的相关条件下,测量激光与金属相互作用过程中表面温度和发射率空间分布特征的进展。文中详细描述了测量过程、结果以及确定不确定性的方法。测量的不确定性与多个工艺参数有着复杂的关系,因此该方法只针对一组工艺参数和一种材料进行演示。高纯度镍凝固温度和凝固温度下发射率的既定文献值用于评估测量的预测不确定性。结果发现,标准温度测量不确定度约为绝对温度(16 AC)的 0.9%,而高纯度镍凝固点的标准相对发射率测量不确定度约为 8%,两者均令人满意。本文还概述了测试不确定性的几个潜在来源,这可能需要额外的实验评估。其中最大的不确定因素是作为工艺副产品产生的金属蒸气和喷出物,它们可能会影响成像质量、反射测量结果和工艺的热特征,同时也会影响激光功率传输过程。此外,本文严格侧重于发射率和温度测量方法的不确定性,因此没有详细介绍与实验控制相关的各种不确定性,这些不确定性必须在未来生成参考数据时进行评估。
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引用次数: 0
Optbayesexpt: Sequential Bayesian Experiment Design for Adaptive Measurements. Optbayesexpt:自适应测量的序列贝叶斯实验设计
IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2021-02-03 eCollection Date: 2021-01-01 DOI: 10.6028/jres.126.002
Robert D McMichael, Sean M Blakley, Sergey Dushenko
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引用次数: 0
Characterization of 3-Dimensional Printing and Casting Materials for use in Magnetic Resonance Imaging Phantoms at 3 T 用于3T磁共振成像显象的三维印刷和铸造材料的表征
IF 1.5 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2020-09-15 DOI: 10.6028/jres.125.028
B. Yunker, K. Stupic, J. Wagner, S. Huddle, R. Shandas, R. Weir, S. Russek, K. Keenan
Imaging phantoms are used to calibrate and validate the performance of magnetic resonance imaging (MRI) systems. Many new materials have been developed for additive manufacturing (three-dimensional [3D] printing) processes that may be useful in the direct printing or casting of dimensionally accurate, anatomically accurate, patient-specific, and/or biomimetic MRI phantoms. The T1, T2, and T2* spin relaxation times of polymer samples were tested to discover materials for use as tissue mimics and structures in MRI phantoms. This study included a cohort of polymer compounds that was tested in cured form. The cohort consisted of 101 standardized polymer samples fabricated from: two-part silicones and polyurethanes used in commercial casting processes; one-part optically cured polyurethanes used in 3D printing; and fused deposition thermoplastics used in 3D printing. The testing was performed at 3 T using inversion recovery, spin echo, and gradient echo sequences for T1, T2, and T2*, respectively. T1, T2, and T2* values were plotted with error bars to allow the reader to assess how well a polymer matches a tissue for a specific application. A correlation was performed between T1, T2, T2* values and material density, elongation, tensile strength, and hardness. Two silicones, SI_XP-643 and SI_P-45, may be usable mimics for reported liver values; one silicone, SI_XP-643, may be a useful mimic for muscle; one silicone, SI_XP-738, may be a useful mimic for white matter; and four silicones, SI_P-15, SI_GI-1000, SI_GI-1040, and SI_GI-1110, may be usable mimics for spinal cord. Elongation correlated to T2 (p = 0.0007), tensile strength correlated to T1 (p = 0.002), T2 (p = 0.0003), and T2* (p = 0.003). The 80 samples not providing measurable signal with T1, T2, T2* relaxation values too short to measure with the standard sequences, may be useful for MRI-invisible fixturing and medical devices at 3 T.
成像模型用于校准和验证磁共振成像(MRI)系统的性能。已经开发了许多用于增材制造(三维[3D]打印)工艺的新材料,这些材料可以用于直接打印或铸造尺寸准确、解剖准确、患者特异性和/或仿生MRI模型。测试聚合物样品的T1、T2和T2*自旋弛豫时间,以发现用作MRI模型中的组织模拟物和结构的材料。这项研究包括一组以固化形式测试的聚合物化合物。该队列由101个标准化聚合物样品组成,这些样品由商业铸造工艺中使用的两部分硅酮和聚氨酯制成;用于3D打印的一部分光学固化的聚氨酯;以及3D打印中使用的熔融沉积热塑性塑料。测试在3T下进行,分别使用T1、T2和T2*的反演恢复、自旋回波和梯度回波序列。用误差条绘制T1、T2和T2*值,以允许读者评估聚合物与特定应用的组织匹配程度。在T1、T2、T2*值与材料密度、伸长率、拉伸强度和硬度之间进行相关性。两种硅酮,SI_XP-643和SI_P-45,可以是报告的肝脏值的可用模拟物;一种硅树脂,SI_XP-643,可能是肌肉的有用模拟物;一种硅树脂,SI_XP-738,可能是白质的有用模拟物;以及四种硅酮,SI_P-15、SI_GI-1000、SI_GI-1040和SI_GI-1110,可以是用于脊髓的可用模拟物。伸长率与T2相关(p=0.0007),抗拉强度与T1相关(p=0.0002),T2(p=0.0003)和T2*(p=0.003。
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引用次数: 7
Construction of a Dual Protease Column, Subzero (-30 °C) Chromatography System and Multi-channel Precision Temperature Controller for Hydrogen-Deuterium Exchange Mass Spectrometry 双蛋白酶柱、亚零度(-30°C)色谱系统和多通道精密温度控制器的构建
IF 1.5 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2020-08-12 DOI: 10.6028/jres.125.025
J. W. Hudgens
This tutorial provides mechanical drawings, electrical schematics, parts lists, stereolithography (STL) files for producing three-dimensional (3D)-printed parts, initial graphics exchange specification (IGS) files for automated machining, and instructions necessary for construction of a dual protease column, subzero, liquid chromatography system for hydrogen-deuterium exchange mass spectrometry (HDX-MS). Electro-mechanical schematics for construction of two multi-zone temperature controllers that regulate to ±0.05 oC are also included in this tutorial.
本教程提供了用于生产三维(3D)打印零件的机械图纸、电气原理图、零件清单、立体光刻(STL)文件、用于自动加工的初始图形交换规范(IGS)文件,以及构建双蛋白酶柱subzero所需的说明,用于氢-氘交换质谱的液相色谱系统(HDX-MS)。本教程还包括两个可调节至±0.05℃的多区域温度控制器的机电原理图。
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引用次数: 4
Path-Integral Calculation of the Second Dielectric and Refractivity Virial Coefficients of Helium, Neon, and Argon. 氦、氖和氩的二次介电和折射率维里系数的路径积分计算
IF 1.3 4区 工程技术 Q3 INSTRUMENTS & INSTRUMENTATION Pub Date : 2020-08-06 eCollection Date: 2020-01-01 DOI: 10.6028/jres.125.022
Giovanni Garberoglio, Allan H Harvey

We present a method to calculate dielectric and refractivity virial coefficients using the path-integral Monte Carlo formulation of quantum statistical mechanics and validate it by comparing our results with equivalent calculations in the literature and with more traditional quantum calculations based on wavefunctions. We use state-of-the-art pair potentials and polarizabilities to calculate the second dielectric and refractivity virial coefficients of helium (both 3He and 4He), neon (both 20Ne and 22Ne), and argon. Our calculations extend to temperatures as low as 1 K for helium, 4 K for neon, and 50 K for argon. We estimate the contributions to the uncertainty of the calculated dielectric virial coefficients for helium and argon, finding that the uncertainty of the pair polarizability is by far the greatest contribution. Agreement with the limited experimental data available is generally good, but our results have smaller uncertainties, especially for helium. Our approach can be generalized in a straightforward manner to higher-order coefficients.

我们提出了一种使用量子统计力学的路径积分蒙特卡罗公式计算介电和折射率维里系数的方法,并通过将我们的结果与文献中的等效计算以及基于波函数的更传统的量子计算进行比较来验证它。我们使用最先进的对势和极化率来计算氦(3He和4He)、氖(20Ne和22Ne)和氩的第二介电和折射率维里系数。我们的计算扩展到氦低至1 K,氖低至4 K,氩低至50 K的温度。我们估计了氦和氩的介电维里系数计算不确定性的贡献,发现对极化率的不确定性是迄今为止最大的贡献。与有限的实验数据相一致通常是好的,但我们的结果具有较小的不确定性,尤其是对于氦。我们的方法可以直接推广到高阶系数。
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引用次数: 0
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Journal of Research of the National Institute of Standards and Technology
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