Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114440
Julia Katz, Sarayu Ratnam, Robert H Listernick, Reema L Habiby, David H Gutmann
This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.
{"title":"Precocious Puberty in Children with Neurofibromatosis Type 1.","authors":"Julia Katz, Sarayu Ratnam, Robert H Listernick, Reema L Habiby, David H Gutmann","doi":"10.1016/j.jpeds.2024.114440","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114440","url":null,"abstract":"<p><p>This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114440"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114434
Kek Khee Loo, Su-Jau Yang, Jerry C Cheng
Objective: To determine the accuracy of the Parent's Observation of Social Interactions (POSI) when deployed for universal autism screening within a large healthcare network.
Study design: Retrospective analysis of electronic health record (EHR) data from children screened for autism spectrum disorder (ASD) using POSI at 18- and 24- month pediatric well child care (WCC) visits across Southern California Permanente Medical Group facilities throughout the 2022 calendar year. Data on ASD diagnoses placed in the EHR problem list were analyzed one year later (until end of 2023) to calculate sensitivity, specificity, and positive/negative likelihood ratio (LR+ and LR-) values.
Results: At 18-month WCC, 8014 (26.4%) out of 30,375 children had elevated POSI scores of >3 (positive screen), and the sensitivity and specificity were 77.9% and 76.1% respectively. At 24-month WCC, 5988 children (21.4%) out of 27,975 had positive POSI screens, and the sensitivity and specificity were 76.5% and 81.4% respectively. Likelihood ratio for positive screen (LR+) was 3.3 at 18 months and 4.2 at 24 months. Likelihood ratio for negative screen (LR-) was 0.29 at both 18 and 24-month time points.
Conclusion: The POSI screen for ASD had adequate sensitivity and specificity (both >76%) when systematically deployed in a primary care setting at 18- and 24-month WCC visits. Children diagnosed with ASD were 3.3 and 4.2 times more likely to have screened positive at 18 and 24 months, compared with children who were not diagnosed with ASD. Conversely, children not diagnosed with ASD were 3.4 times more likely to have screened negative than children with ASD at 18 and 24 months.
{"title":"Autism Screening Using the Parent's Observation of Social Interactions in a Large Integrated Healthcare System.","authors":"Kek Khee Loo, Su-Jau Yang, Jerry C Cheng","doi":"10.1016/j.jpeds.2024.114434","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114434","url":null,"abstract":"<p><strong>Objective: </strong>To determine the accuracy of the Parent's Observation of Social Interactions (POSI) when deployed for universal autism screening within a large healthcare network.</p><p><strong>Study design: </strong>Retrospective analysis of electronic health record (EHR) data from children screened for autism spectrum disorder (ASD) using POSI at 18- and 24- month pediatric well child care (WCC) visits across Southern California Permanente Medical Group facilities throughout the 2022 calendar year. Data on ASD diagnoses placed in the EHR problem list were analyzed one year later (until end of 2023) to calculate sensitivity, specificity, and positive/negative likelihood ratio (LR+ and LR-) values.</p><p><strong>Results: </strong>At 18-month WCC, 8014 (26.4%) out of 30,375 children had elevated POSI scores of >3 (positive screen), and the sensitivity and specificity were 77.9% and 76.1% respectively. At 24-month WCC, 5988 children (21.4%) out of 27,975 had positive POSI screens, and the sensitivity and specificity were 76.5% and 81.4% respectively. Likelihood ratio for positive screen (LR+) was 3.3 at 18 months and 4.2 at 24 months. Likelihood ratio for negative screen (LR-) was 0.29 at both 18 and 24-month time points.</p><p><strong>Conclusion: </strong>The POSI screen for ASD had adequate sensitivity and specificity (both >76%) when systematically deployed in a primary care setting at 18- and 24-month WCC visits. Children diagnosed with ASD were 3.3 and 4.2 times more likely to have screened positive at 18 and 24 months, compared with children who were not diagnosed with ASD. Conversely, children not diagnosed with ASD were 3.4 times more likely to have screened negative than children with ASD at 18 and 24 months.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114434"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114406
Rebecca A Carson, John L Lyles
{"title":"Corrigendum to \"Cognitive Bias in an Infant with Constipation\" J Pediatrics 270 (2024): 113996.","authors":"Rebecca A Carson, John L Lyles","doi":"10.1016/j.jpeds.2024.114406","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114406","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114406"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114436
Joel Gupta, Cathryn Sibbald, Miriam Weinstein, Martin Pusic, Madeline Bell, Nikolas MacLellan, Robert Bobotsis, Rashie Brar, Kathy Boutis
Objectives: To examine pediatrician diagnostic skill development of dermatology image-based cases via a web-based tool and to determine case-level variables that were associated with diagnostic error.
Study design: This was a multi-center, prospective, cross-sectional study. A convenience sample of pediatric trainees and attendings were eligible for participation. Using a web-based tool, physicians practiced 334 pediatric dermatology image-based cases until they achieved a performance standard. Participants identified whether the case was concerning, the morphologic category, and the specific diagnosis. After every case, participants received corrective feedback and their progress towards the performance standard.
Results: Among 185 participants, there was a significant improvement in diagnostic performance in classifying concerning vs. non-concerning (+19.2% [95% CI 17.7, 20.6]), morphologic category (+17.9% [95% CI 16.5, 19.3]), and specific diagnosis (+25.2% [95% CI 23.4, 26.7]). The median number of cases required to achieve the performance standard was 142 (IQR 96, 209; min 58, max 330), with a median time to achievement of 57.3 minutes (IQR 38.7, 84.3). Based on 38,502 case interpretations, children with darker versus lighter skin color had a lower odds of correct identification of "concerning" (OR=0.87; 95% CI 0.83, 0.93), morphologic category (OR=0.91; 95% CI 0.85, 0.97), and specific disease (OR=0.96; 95% CI 0.90; 0.99). Fewer than 60% of participants correctly identified bullous variations of diseases, psoriasis, herpes infections, and non-specific viral infections.
Conclusions: The deliberate practice of dermatologic presentations in the context of an education intervention significantly and efficiently improved pediatrician diagnostic ability. The specific diagnostic challenges identified also provide opportunity for targeted learning opportunities in these areas.
研究目的:通过基于网络的工具研究儿科医生对皮肤科图像病例的诊断技能发展,并确定与诊断错误相关的病例水平变量:通过网络工具检查儿科医生对皮肤科图像病例的诊断技能发展情况,并确定与诊断错误相关的病例水平变量:这是一项多中心、前瞻性、横断面研究。研究设计:这是一项多中心前瞻性横断面研究,儿科实习生和主治医师均符合参与条件。医生使用网络工具练习 334 例儿科皮肤病图像病例,直到达到标准为止。参与者要确定病例是否令人担忧、形态学类别和具体诊断。每个病例结束后,参与者都会收到纠正反馈以及他们在达到绩效标准方面的进展情况:结果:在 185 名参与者中,在有关与非有关病例分类(+19.2% [95% CI 17.7, 20.6])、形态学类别(+17.9% [95% CI 16.5, 19.3])和具体诊断(+25.2% [95% CI 23.4, 26.7])方面的诊断成绩均有显著提高。达到绩效标准所需的病例数中位数为 142 例(IQR 96,209;最低 58,最高 330),达到标准所需的时间中位数为 57.3 分钟(IQR 38.7,84.3)。根据 38502 个病例的解释,肤色深的儿童与肤色浅的儿童相比,正确识别 "有关"(OR=0.87;95% CI 0.83,0.93)、形态类别(OR=0.91;95% CI 0.85,0.97)和特定疾病(OR=0.96;95% CI 0.90,0.99)的几率较低。只有不到 60% 的参与者能正确识别牛皮癣、银屑病、疱疹感染和非特异性病毒感染:结论:在教育干预中有意识地练习皮肤病的表现形式,能显著有效地提高儿科医生的诊断能力。所发现的特定诊断难题也为在这些领域开展有针对性的学习提供了机会。
{"title":"Rash Decisions: Improving Pediatrician Skills in Dermatologic Diagnosis.","authors":"Joel Gupta, Cathryn Sibbald, Miriam Weinstein, Martin Pusic, Madeline Bell, Nikolas MacLellan, Robert Bobotsis, Rashie Brar, Kathy Boutis","doi":"10.1016/j.jpeds.2024.114436","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114436","url":null,"abstract":"<p><strong>Objectives: </strong>To examine pediatrician diagnostic skill development of dermatology image-based cases via a web-based tool and to determine case-level variables that were associated with diagnostic error.</p><p><strong>Study design: </strong>This was a multi-center, prospective, cross-sectional study. A convenience sample of pediatric trainees and attendings were eligible for participation. Using a web-based tool, physicians practiced 334 pediatric dermatology image-based cases until they achieved a performance standard. Participants identified whether the case was concerning, the morphologic category, and the specific diagnosis. After every case, participants received corrective feedback and their progress towards the performance standard.</p><p><strong>Results: </strong>Among 185 participants, there was a significant improvement in diagnostic performance in classifying concerning vs. non-concerning (+19.2% [95% CI 17.7, 20.6]), morphologic category (+17.9% [95% CI 16.5, 19.3]), and specific diagnosis (+25.2% [95% CI 23.4, 26.7]). The median number of cases required to achieve the performance standard was 142 (IQR 96, 209; min 58, max 330), with a median time to achievement of 57.3 minutes (IQR 38.7, 84.3). Based on 38,502 case interpretations, children with darker versus lighter skin color had a lower odds of correct identification of \"concerning\" (OR=0.87; 95% CI 0.83, 0.93), morphologic category (OR=0.91; 95% CI 0.85, 0.97), and specific disease (OR=0.96; 95% CI 0.90; 0.99). Fewer than 60% of participants correctly identified bullous variations of diseases, psoriasis, herpes infections, and non-specific viral infections.</p><p><strong>Conclusions: </strong>The deliberate practice of dermatologic presentations in the context of an education intervention significantly and efficiently improved pediatrician diagnostic ability. The specific diagnostic challenges identified also provide opportunity for targeted learning opportunities in these areas.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114436"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114441
Côme Horvat, Lélia Duclaux-Loras, Antoine Ouziel, Marine Butin, Sandrine Couray-Targe, Anne-Florence Myard-Dury, Julie Haesebaert, Mona Massoud, Mehdi Benchaib, Anne Ploin, Yves Gillet, Bruno Lina, Jean-Sebastien Casalegno, Dominique Ploin
Objective: To use a pre-COVID-19 birth cohort database to describe the clinical heterogeneity of severe acute respiratory infections (SARI) cases of the past seasons as a basis to investigate further distribution of clinical phenotypes in the era of immunization for respiratory syncytial virus (RSV).
Study design: Infants with RSV-SARI were identified from a 2014 through 2019 birth cohort in a tertiary care center in Lyon, France, and their medical records extensively reviewed. Using the criteria of the World Health Organization severity definitions, we classified SARI as having nutritional (inability to feed), respiratory (SpO2<93%), or neurological (failure to respond, apneas) impairments.
Results: We described three phenotypes: nutritional impairment, respiratory impairment, and neurological (with respiratory and nutritional) impairment. Respiratory impairment could overlap with nutritional impairment, or not. There was a significant difference in age categories distribution regarding nutritional impairment (greater proportion in 1.5- to 3-month-old, p=0.01) and neurological impairment (greater proportion in <1.5-month-old, p=0.002).
Conclusions: The present study highlights the presence of three potentially overlapping phenotypes as a new way to consider and describe RSV disease. In order to adapt care and healthcare policies in the RSV-immunization era, it is necessary to investigate further and monitor the residual SARI burden of each phenotype.
{"title":"Heterogeneity of Clinical Phenotypes in Severe Acute Respiratory Infections due to Respiratory Syncytial Virus: A Need to Look Beyond Hospitalization.","authors":"Côme Horvat, Lélia Duclaux-Loras, Antoine Ouziel, Marine Butin, Sandrine Couray-Targe, Anne-Florence Myard-Dury, Julie Haesebaert, Mona Massoud, Mehdi Benchaib, Anne Ploin, Yves Gillet, Bruno Lina, Jean-Sebastien Casalegno, Dominique Ploin","doi":"10.1016/j.jpeds.2024.114441","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114441","url":null,"abstract":"<p><strong>Objective: </strong>To use a pre-COVID-19 birth cohort database to describe the clinical heterogeneity of severe acute respiratory infections (SARI) cases of the past seasons as a basis to investigate further distribution of clinical phenotypes in the era of immunization for respiratory syncytial virus (RSV).</p><p><strong>Study design: </strong>Infants with RSV-SARI were identified from a 2014 through 2019 birth cohort in a tertiary care center in Lyon, France, and their medical records extensively reviewed. Using the criteria of the World Health Organization severity definitions, we classified SARI as having nutritional (inability to feed), respiratory (SpO<sub>2</sub><93%), or neurological (failure to respond, apneas) impairments.</p><p><strong>Results: </strong>We described three phenotypes: nutritional impairment, respiratory impairment, and neurological (with respiratory and nutritional) impairment. Respiratory impairment could overlap with nutritional impairment, or not. There was a significant difference in age categories distribution regarding nutritional impairment (greater proportion in 1.5- to 3-month-old, p=0.01) and neurological impairment (greater proportion in <1.5-month-old, p=0.002).</p><p><strong>Conclusions: </strong>The present study highlights the presence of three potentially overlapping phenotypes as a new way to consider and describe RSV disease. In order to adapt care and healthcare policies in the RSV-immunization era, it is necessary to investigate further and monitor the residual SARI burden of each phenotype.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114441"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.jpeds.2024.114435
Keerthi Anpalagan, Peter Jacoby, Katherine Stannage, Helen Leonard, Katherine Langdon, Noula Gibson, Lakshmi Nagarajan, Kingsley Wong, Jenny Downs
Objectiv: To evaluate the associations between complex hip surgery and subsequent hospitalizations in children with intellectual disability, including a subset of children with cerebral palsy.
Study design: We: conducted a retrospective cohort study using linked administrative, health, and disability data from Western Australia. Children born between 1983 and 2009 who underwent complex hip surgery by end 2014 were included (intellectual disability, n=154; subset with cerebral palsy, n=91). A self-controlled case series analysis using Poisson regression was used to estimate the age-adjusted associations of complex hip surgery on all-cause hospitalizations and when the principal diagnosis was lower respiratory tract infection (LRTI) or epilepsy, for periods following the individual's first major hip surgery, compared with the year before surgery.
Results: Age adjusted incidence of all-cause hospitalizations decreased after surgery (year 1: incidence rate ratio [IRR] 0.87 [95% CI, 0.74-1.02]; year 6: IRR 0.57 [95% CI, 0.46-0.72]). The incidence of hospitalizations for LRTI increased (year 1: IRR,1.03 [95% CI, 0.72-1.51]; year 6: IRR 2.08 [95% CI, 1.18-3.68]). The incidence of hospitalizations for epilepsy decreased (year 1: IRR 0.93 [95% CI, 0.57, 1.54]; year>6: IRR 0.72 [95% CI, 0.34-1.55]) after surgery. A similar pattern was observed for the subset of children with or without cerebral palsy.
Conclusion: Complex hip surgeries are associated with fewer hospitalizations overall but not respiratory hospitalizations for children with intellectual disability. Fewer hospitalizations suggest benefits for better musculoskeletal alignment.
{"title":"Hospitalizations Following Complex Hip Surgery in Children with Intellectual Disability: A Self-Controlled Case Series Analysis.","authors":"Keerthi Anpalagan, Peter Jacoby, Katherine Stannage, Helen Leonard, Katherine Langdon, Noula Gibson, Lakshmi Nagarajan, Kingsley Wong, Jenny Downs","doi":"10.1016/j.jpeds.2024.114435","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114435","url":null,"abstract":"<p><strong>Objectiv: </strong>To evaluate the associations between complex hip surgery and subsequent hospitalizations in children with intellectual disability, including a subset of children with cerebral palsy.</p><p><strong>Study design: </strong>We: conducted a retrospective cohort study using linked administrative, health, and disability data from Western Australia. Children born between 1983 and 2009 who underwent complex hip surgery by end 2014 were included (intellectual disability, n=154; subset with cerebral palsy, n=91). A self-controlled case series analysis using Poisson regression was used to estimate the age-adjusted associations of complex hip surgery on all-cause hospitalizations and when the principal diagnosis was lower respiratory tract infection (LRTI) or epilepsy, for periods following the individual's first major hip surgery, compared with the year before surgery.</p><p><strong>Results: </strong>Age adjusted incidence of all-cause hospitalizations decreased after surgery (year 1: incidence rate ratio [IRR] 0.87 [95% CI, 0.74-1.02]; year 6: IRR 0.57 [95% CI, 0.46-0.72]). The incidence of hospitalizations for LRTI increased (year 1: IRR,1.03 [95% CI, 0.72-1.51]; year 6: IRR 2.08 [95% CI, 1.18-3.68]). The incidence of hospitalizations for epilepsy decreased (year 1: IRR 0.93 [95% CI, 0.57, 1.54]; year>6: IRR 0.72 [95% CI, 0.34-1.55]) after surgery. A similar pattern was observed for the subset of children with or without cerebral palsy.</p><p><strong>Conclusion: </strong>Complex hip surgeries are associated with fewer hospitalizations overall but not respiratory hospitalizations for children with intellectual disability. Fewer hospitalizations suggest benefits for better musculoskeletal alignment.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114435"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-11DOI: 10.1016/j.jpeds.2024.114433
Emily N Yeo, Nathan D Young, Joseph C Cleveland, Tamara D Simon, Douglas L Vanderbilt, Juan Espinoza, Christine B Mirzaian, Tanya L Alderete
Objective: To assess how medical complexity and neighborhood opportunity jointly affect cognitive, motor, and language Bayley's Scales of Infant Development. Secondary objectives involved identifying the factors contributing to developmental disparities across diverse racial and ethnic groups.
Study design: Electronic health records from a Southern California high-risk infant follow-up clinic were analyzed for 440 infants from 2014 through 2023 who had either had neonatal intensive care unit stays, prematurity, very low birthweight, or developmental delay risk. Medical complexity was categorized using the Pediatric Medical Complexity Algorithm (PMCA) into complex chronic (CC), noncomplex chronic (NCC), or non-chronic (NC). Neighborhood opportunity was assessed using the Child Opportunity Index 2.0 (COI). Developmental progress was tracked from ages 4 to 35.6 months.
Results: Of the cohort, 56% were male, and 67% were born prematurely, with 143 NC, 115 NCC, and 182 CC cases. Developmental scores showed a progressive decline with increased medical complexity. CC infants had lower cognitive (β= -15.20, p<0.001, 95% CI: -18.75, -11.7), motor (β= -20.50, p<0.001, 95% CI: -24.25, -16.8), and language scores (β=-11.88, p<0.001, 95% CI = -15.13 to -8.6) compared with NC infants. Lower COI was linked with decreased language scores (β= -0.07, p = 0.005, 95% CI: 0.01, 0.12) but not cognitive or motor scores.
Conclusions: In high-risk infants, the adverse effects of medical complexities on developmental outcomes exceeded those of prematurity and additionally varied according to child neighborhood opportunity.
{"title":"High-Risk Infant Developmental Outcome Is Associated with Medical Complexity and Neighborhood Opportunity.","authors":"Emily N Yeo, Nathan D Young, Joseph C Cleveland, Tamara D Simon, Douglas L Vanderbilt, Juan Espinoza, Christine B Mirzaian, Tanya L Alderete","doi":"10.1016/j.jpeds.2024.114433","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114433","url":null,"abstract":"<p><strong>Objective: </strong>To assess how medical complexity and neighborhood opportunity jointly affect cognitive, motor, and language Bayley's Scales of Infant Development. Secondary objectives involved identifying the factors contributing to developmental disparities across diverse racial and ethnic groups.</p><p><strong>Study design: </strong>Electronic health records from a Southern California high-risk infant follow-up clinic were analyzed for 440 infants from 2014 through 2023 who had either had neonatal intensive care unit stays, prematurity, very low birthweight, or developmental delay risk. Medical complexity was categorized using the Pediatric Medical Complexity Algorithm (PMCA) into complex chronic (CC), noncomplex chronic (NCC), or non-chronic (NC). Neighborhood opportunity was assessed using the Child Opportunity Index 2.0 (COI). Developmental progress was tracked from ages 4 to 35.6 months.</p><p><strong>Results: </strong>Of the cohort, 56% were male, and 67% were born prematurely, with 143 NC, 115 NCC, and 182 CC cases. Developmental scores showed a progressive decline with increased medical complexity. CC infants had lower cognitive (β= -15.20, p<0.001, 95% CI: -18.75, -11.7), motor (β= -20.50, p<0.001, 95% CI: -24.25, -16.8), and language scores (β=-11.88, p<0.001, 95% CI = -15.13 to -8.6) compared with NC infants. Lower COI was linked with decreased language scores (β= -0.07, p = 0.005, 95% CI: 0.01, 0.12) but not cognitive or motor scores.</p><p><strong>Conclusions: </strong>In high-risk infants, the adverse effects of medical complexities on developmental outcomes exceeded those of prematurity and additionally varied according to child neighborhood opportunity.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114433"},"PeriodicalIF":3.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-09DOI: 10.1016/j.jpeds.2024.114415
Marie-Coralie Cornet, Fernando F Gonzalez, Hannah C Glass, Tai-Wei Wu, Jessica L Wisnowski, Yi Li, Patrick Heagerty, Sandra E Juul, Yvonne W Wu
Objective: To determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE).
Study design: This cohort study included all infants with moderate to severe HIE treated with therapeutic hypothermia and enrolled on the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. Clinical chorioamnionitis (CC) was defined as a diagnosis made by a treating obstetrician and histologic chorioamnionitis (HC) was defined as placental inflammation observed on histology. We used proportional odds regression to determine the associations between CC, HC, and an ordinal 2-year neurodevelopmental outcome measure: no neurodevelopmental impairment (NDI), mild NDI, moderate NDI, severe NDI, or death.
Results: Of 500 infants, 65 (13%) were exposed to CC. Of 317 infants with placental data available, 125 (39%) were exposed to HC. Infants exposed to CC (odds ratio 0.57, 95% CI 0.34-0.95) and those exposed to HC (odds ratio 0.62, 95% CI 0.40-0.96) had a lower severity of primary outcome than unexposed infants. Infants exposed to chorioamnionitis also had lower frequencies of sentinel events (CC: P = .001; HC: P = .005), central pattern magnetic resonance imaging brain injury (CC: P = .02; HC: P = .02), and electroencephalogram background abnormalities (CC: P = .046; HC: P = .02), compared with unexposed infants.
Conclusions: Infants with HIE who were exposed to chorioamnionitis had lower severity of 2-year outcomes than unexposed infants. Our findings suggest that chorioamnionitis may lead to a lower severity of brain dysfunction than other pathophysiologic mechanisms of encephalopathy.
研究目的研究设计:这项队列研究纳入了所有接受治疗性低温治疗的中重度缺氧缺血性脑病婴儿,他们都参加了 "高剂量促红细胞生成素治疗窒息和脑病(HEAL)试验"。临床绒毛膜羊膜炎(CC)是指由主治产科医生做出的诊断,组织学绒毛膜羊膜炎(HC)是指在组织学上观察到的胎盘炎症。我们采用比例几率回归法确定CC、HC与2年神经发育结果(无神经发育障碍(NDI)、轻度NDI、中度NDI、重度NDI或死亡)之间的关系:在500名婴儿中,有65名(13%)接触过CC。在317名有胎盘数据的婴儿中,125名(39%)暴露于HC。与未暴露的婴儿相比,暴露于CC(OR 0.57,95% CI 0.34-0.95)和HC(OR 0.62,95% CI 0.40-0.96)的婴儿主要结果的严重程度较低。与未暴露的婴儿相比,暴露于绒毛膜羊膜炎的婴儿发生哨点事件(CC:P=0.001;HC:P=0.005)、中央模式磁共振成像脑损伤(CC:P=0.02;HC:P=0.02)和脑电图背景异常(CC:P=0.046;HC:P=0.02)的频率也较低:结论:与未暴露于绒毛膜羊膜炎的婴儿相比,暴露于绒毛膜羊膜炎的 HIE 婴儿 2 年后的严重程度较低。我们的研究结果表明,与脑病的其他病理生理机制相比,绒毛膜羊膜炎可能导致脑功能障碍的严重程度较低。
{"title":"Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.","authors":"Marie-Coralie Cornet, Fernando F Gonzalez, Hannah C Glass, Tai-Wei Wu, Jessica L Wisnowski, Yi Li, Patrick Heagerty, Sandra E Juul, Yvonne W Wu","doi":"10.1016/j.jpeds.2024.114415","DOIUrl":"10.1016/j.jpeds.2024.114415","url":null,"abstract":"<p><strong>Objective: </strong>To determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE).</p><p><strong>Study design: </strong>This cohort study included all infants with moderate to severe HIE treated with therapeutic hypothermia and enrolled on the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. Clinical chorioamnionitis (CC) was defined as a diagnosis made by a treating obstetrician and histologic chorioamnionitis (HC) was defined as placental inflammation observed on histology. We used proportional odds regression to determine the associations between CC, HC, and an ordinal 2-year neurodevelopmental outcome measure: no neurodevelopmental impairment (NDI), mild NDI, moderate NDI, severe NDI, or death.</p><p><strong>Results: </strong>Of 500 infants, 65 (13%) were exposed to CC. Of 317 infants with placental data available, 125 (39%) were exposed to HC. Infants exposed to CC (odds ratio 0.57, 95% CI 0.34-0.95) and those exposed to HC (odds ratio 0.62, 95% CI 0.40-0.96) had a lower severity of primary outcome than unexposed infants. Infants exposed to chorioamnionitis also had lower frequencies of sentinel events (CC: P = .001; HC: P = .005), central pattern magnetic resonance imaging brain injury (CC: P = .02; HC: P = .02), and electroencephalogram background abnormalities (CC: P = .046; HC: P = .02), compared with unexposed infants.</p><p><strong>Conclusions: </strong>Infants with HIE who were exposed to chorioamnionitis had lower severity of 2-year outcomes than unexposed infants. Our findings suggest that chorioamnionitis may lead to a lower severity of brain dysfunction than other pathophysiologic mechanisms of encephalopathy.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114415"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.jpeds.2024.114429
Mary Galemmo
{"title":"Gut Check: Addressing Gaps in Gut Microbiome Research for Infants with Congenital Heart Disease.","authors":"Mary Galemmo","doi":"10.1016/j.jpeds.2024.114429","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114429","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114429"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-05DOI: 10.1016/j.jpeds.2024.114430
Michael P Fundora, Christina Calamaro, Yuhua Wu, Ann-Marie Brown, Amelia St John, Rachael Keiffer, Yijin Xiang, Katie Liu, Scott Gillespie, Patricia Wei Denning, Kolby Sanders-Lewis, Brooke Seitter, Jinbing Bai
{"title":"Reply to Letter \"Gut Check: Addressing Gaps in Gut Microbiome Research for Infants with Congenital Heart Disease\".","authors":"Michael P Fundora, Christina Calamaro, Yuhua Wu, Ann-Marie Brown, Amelia St John, Rachael Keiffer, Yijin Xiang, Katie Liu, Scott Gillespie, Patricia Wei Denning, Kolby Sanders-Lewis, Brooke Seitter, Jinbing Bai","doi":"10.1016/j.jpeds.2024.114430","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114430","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114430"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}