ON THE INNER BACK COVER: The focal adhesion protein Hic-5 localizes to the distal ends of stress fiber-associated septin filaments. U2OS osteosarcoma cells were stained for Hic-5 (blue), Septin 7 (green), and F-actin (red).
Credit: Katia Brock (Department of Cell and Developmental Biology, State University of New York Upstate Medical University)
ON THE FRONT COVER: The focal adhesion protein Paxillin localizes to the distal ends of stress fiber-associated septin filaments. U2OS osteosarcoma cells were stained for Paxillin (blue), Septin 7 (green), and F-actin (red).
Credit: Katia Brock (Department of Cell and Developmental Biology, State University of New York Upstate Medical University)
ON THE INNER FRONT COVER: Endogenous tropomyosin Tpm4.2 tagged with APEX at its C-terminus is incorporated into actin filament bundles in homozygous mouse embryo fibroblasts. The endogenous Tpm4.2-APEX shown in red were visualised by an anti-Tpm4.2 antibody and actin filaments shown in green were visualised by phalloidin.
Credit: Jeff Hook (Cytoskeleton Therapeutics Research Unit, School of Biomedical Sciences, UNSW Sydney, Australia)
ON THE BACK COVER: DA-Raf inhibits ERK activation, resulting in the suppression of collective cell migration and invasion of KRASmutant cancer cells. In human pancreatic carcinoma MIA PaCa-2 cells, phospho-ERK1/2 (magenta) is suppressed by the expression of EGFP–DA-Raf (green). EGFP–DA-Raf is concentrated on the plasma membrane.
Credit: Aoi Matsuda and Takeshi Endo (Chiba University, Japan)
ON THE FRONT COVER: Myosin A staining in the earliest stages of muscle cytoskeletal organization in a comma-stage C. elegans embryos shows an anterior-posterior gradient in the organization of myosin A into a striated pattern.
Credit: Kar Men Lee and Hao Peng (Western Michigan University Department of Biological Sciences).
ON THE INNER FRONT COVER: A genetic mosaic C. elegans adult stained for myosin A and UNC-89 (vertebrate homolog is obscurin) in body-wall muscle shows disorganized UNC-89/obscurin in a muscle cell that does not express myosin A.
Credit: Sarah Almuhanna (Imam Abdulrahman Bin Faisal University College of Medicine).
ON THE BACK COVER: Immunofluorescence analysis of a histological section derived from a cutaneous squamous cell carcinoma specimen. S100A4 (green), primarily expressed by fibroblast cells, cytokeratin 14 (red), primarily expressed by basal epidermal cells, and DAPI (blue) to mark cell nuclei.
Credit: Alexandra Pittar, Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia.
ON THE INNER BACK COVER: Immunofluorescence analysis of a histological section derived from a cutaneous squamous cell carcinoma specimen. S100A4 (green), primarily expressed by fibroblast cells, cytokeratin 14 (red), primarily expressed by basal epidermal cells, and DAPI (blue) to mark cell nuclei.
Credit: Alexandra Pittar, Centre for Cancer Biology, an Alliance between SA Pathology and the University of South Australia, Adelaide, Australia.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：