ON THE BACK COVER: Spindle assembled around sperm chromosomes in Xenopus egg extracts in the presence of a mutant TPX2 protein (X. laevis) that enhances microtubule nucleation, leading to disruption of spindle poles and the formation of ectopic microtubule asters. Microtubules are labeled in red, DNA in blue, and TPX2 is green.
Credit: Guadalupe Sepulveda, Molecular and Cell Biology Department, University of California, Berkeley, USA.
ON THE FRONT COVER: Spindles assembled around sperm chromosomes in Xenopus egg extracts in the presence of a mutant TPX2 protein (X. tropicalis) that enhances microtubule nucleation, leading to disruption of spindle poles and the formation of ectopic microtubule asters. Microtubules are labeled in red, DNA in blue, and TPX2 is green.
Credit: Guadalupe Sepulveda, Molecular and Cell Biology Department, University of California, Berkeley, USA.
ON THE INNER BACK COVER: Confocal image of a mixed sample of C. elegans and S. pombe, mounted onto the same coverslip, in which endogenous myo1 genes have been replaced with functional fluorescent labelled full-length myosin-I fusions. While the nematode worm contains both Myo1d (red) and Myo1e (green), yeasts only express Myo1e (green). Nuclei (blue) are labelled with Hoescht stain in the worm and actin (red) labelled with LifeAct in the yeast.
Credit: Holly Brooker's work performed in Daniel Mulvihill's lab (School of Biosciences, University of Kent, Canterbury, Kent, UK.).
ON THE BACK COVER: Beta myosin II filaments in iPSC-cardiac myocytes in culture.
Credit: Dylan T. Burnette and James B. Hayes, Vanderbilt University, USA.
ON THE FRONT COVER: Confocal image of a mixed sample of C. elegans and S. pombe, mounted onto the same coverslip, in which endogenous myo1 genes have been replaced with functional fluorescent labelled full-length myosin-I fusions. While the nematode worm contains both Myo1d (red) and Myo1e (green), yeasts only express Myo1e (green). Nuclei (blue) are labelled with Hoescht stain in the worm.
Credit: Holly Brooker's work performed in Daniel Mulvihill's lab (School of Biosciences, University of Kent, Canterbury, Kent, UK.).
ON THE INNER FRONT COVER: Confocal slices of a C. elegans worm head, showing pharyngeal muscles stained to show actin filaments (cyan), and expressing mCherry-tagged tropomyosin isoform LEV-11E (magenta) and GFP-tagged formin FHOD-1 (yellow).
Credit: Michael Kimmich, Cell and Developmental Biology, SUNY Upstate Medical University.
ON THE BACK COVER: Purified tubulin (from Goat brain) visualized using Scanning electron microscope.
Credit: Nameeta Choudhary and Priyanka Singh (Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, Rajasthan, India).
ON THE FRONT COVER: MDA-MB-231 cells treated with Mps1 kinase inhibitor AZ3146 (5 μM) for 20 h were examined for primary cilia by staining with antibodies against axoneme marker acetylated tubulin (red), and ciliary membrane marker Arl13B (green). DNA is stained by Hoechst 33358 (blue).
Credit: Arpita Dutta and Shubhra Majumder (CellBio Lab, Institute of Health Sciences, Presidency University, Kolkata, India).
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