Patients with cleft lip and palate (CLP) exhibit complex maxillary morphology, including hypoplasia, making Le Fort I osteotomy challenging and prone to complications. The aim of this retrospective, comparative study was to improve the safety of Le Fort I osteotomy by analysing the maxillary structure of patients with CLP. Fifteen unilateral CLP cases with maxillary hypoplasia (six males, nine females) and 15 non-CLP cases undergoing mandibular setback for prognathism (four males, 11 females) were evaluated. Axial computed tomographic (CT) images at 2.5 and 5 mm above the nasal floor were analysed. Ten parameters were measured, focusing on the distances between key anatomical landmarks including lateral and medial pterygoid plates and posterior maxillary sinus wall to pterygoid fossa. In the CLP group, the distance between the lateral and medial pterygoid plates was 4.8 ± 1.2 mm (healthy side) and 5.4 ± 1.3 mm (afflicted side), compared with 6.4 ± 1.2 mm in the non-CLP group. The shortest distance between the posterior maxillary sinus wall and pterygoid fossa was 2.7 ± 1.1 mm (healthy side) and 2.9 ± 1.3 mm (afflicted side) in CLP group, significantly greater than 1.9 ± 0.3 mm in non-CLP group. These findings indicate a thicker pterygomaxillary junction in patients with CLP, which highlights key anatomical differences. Understanding these features may help reduce surgical complications during Le Fort I osteotomy in patients with CLP.
To determine the prevalence of preoperative frailty among oral cancer patients and identify its risk factors, a thorough review of observational studies published until 30 August 2025 was performed in various databases, including PubMed, Web of Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, and Wanfang. The primary outcome was the prevalence of preoperative frailty or associated factors. Risk of bias and methodological quality were independently evaluated by two authors using both the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) criteria. The meta-analysis included 18 articles. The results indicated that the prevalence of preoperative frailty in oral cancer patients was 42.2%. The risk factors included age, cognitive impairment, American Society of Anesthesiologists' (ASA) score of ≥3, more than five medications, Charlson comorbidity index (CCI) score of ≥2, and a low skeletal muscle index (SMI). Body mass index (BMI) was identified as a protective factor. The findings can enable healthcare providers to implement effective interventions to prevent, reverse, or delay the progression of frailty.

