Pub Date : 2025-01-01DOI: 10.1016/j.bbe.2025.01.001
Marta Mikuła-Zdańkowska , Dawid Borycki , Piotr Węgrzyn , Karolis Adomavičius , Egidijus Auksorius , Maciej Wojtkowski
We demonstrate an experimental Spatio-Temporal Optical Coherence Tomography (STOC-T) system featuring optimized illumination and an increased lateral resolution of approximately 3 µm. The integration of high-speed phase randomization with a numerical averaging process facilitates a noticeable improvement in the signal-to-noise ratio. The effectiveness of this enhancement is demonstrated through volumetric imaging of a scattering object, and it enables in vivo imaging of the human retina at the cellular level. Additionally, the experiment is supported by computational aberration-correction techniques to achieve high-resolution in vivo imaging of the human retina. The visualization of retinal cone mosaics, and ganglion cell somas was achieved through contrast enhancement during the averaging process.
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