Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.030233
ZIPENG LIN, CHUXI TANG, LE KANG, GUANXI LAI, SHIWEN LIU, YIXIANG WU, HUIQUN TIAN, SONG LIU
{"title":"Structure, function, and mechanism of the TNFAIP8 (TIPE) family of proteins in cancer and inflammation","authors":"ZIPENG LIN, CHUXI TANG, LE KANG, GUANXI LAI, SHIWEN LIU, YIXIANG WU, HUIQUN TIAN, SONG LIU","doi":"10.32604/biocell.2023.030233","DOIUrl":"https://doi.org/10.32604/biocell.2023.030233","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"272 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135557423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.028035
Haiying Chen, Yuqing Wu, Baojian Huang, Lei Han
{"title":"Recent progress in microbial cell surface display systems and their application on biosensors","authors":"Haiying Chen, Yuqing Wu, Baojian Huang, Lei Han","doi":"10.32604/biocell.2023.028035","DOIUrl":"https://doi.org/10.32604/biocell.2023.028035","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"74 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74566854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.028790
Xingbo Wu, Dan Pan, Shouyi Tang, Yingqiang Shen
{"title":"Targeting the “undruggable” cancer driver genes: Ras, myc, and tp53","authors":"Xingbo Wu, Dan Pan, Shouyi Tang, Yingqiang Shen","doi":"10.32604/biocell.2023.028790","DOIUrl":"https://doi.org/10.32604/biocell.2023.028790","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"32 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74991655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.025747
Meran Keshawa Ediriweera
{"title":"DNA polymerase θ (POLQ): A druggable DNA polymerase for homologous recombination-deficient cancer cells","authors":"Meran Keshawa Ediriweera","doi":"10.32604/biocell.2023.025747","DOIUrl":"https://doi.org/10.32604/biocell.2023.025747","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"73 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86401019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.026556
Zeinab M. Klaab, Aziza M Hassan, Jawaher J Albaqami, Faizah A. ALMALKI
{"title":"The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro","authors":"Zeinab M. Klaab, Aziza M Hassan, Jawaher J Albaqami, Faizah A. ALMALKI","doi":"10.32604/biocell.2023.026556","DOIUrl":"https://doi.org/10.32604/biocell.2023.026556","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"18 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85345776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.029624
Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava
Biological entities are involved in complicated and complex connections; hence, discovering biological information using network biology ideas is critical. In the past few years, network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex interactions. Biological network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis, prognosis, and treatment. The network of biological entities can help us predict drug targets for several diseases. The drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to the progression and development of the disease. The novel strategical approach of system biologyassisted pharmacology coupled with computer-aided drug discovery (CADD) can help drugs fight multifactorial diseases efficiently. In the present review, we have summarized the role and application of network biology for not only unfolding the mechanism of complex neurodevelopmental disorders but also identifying important drug targets for diseases like ADHD, Autism, Epilepsy, and Intellectual Disability. Systems biology has emerged as a promising approach to identifying drug targets and aiming for targeted drug discovery for the precise treatment of neurodevelopmental disorders.
{"title":"Network biology: A promising approach for drug target identification against neurodevelopmental disorders","authors":"Wayez Naqvi, Ananya Singh, Prekshi Garg, P. Srivastava","doi":"10.32604/biocell.2023.029624","DOIUrl":"https://doi.org/10.32604/biocell.2023.029624","url":null,"abstract":"Biological entities are involved in complicated and complex connections; hence, discovering biological information using network biology ideas is critical. In the past few years, network biology has emerged as an integrative and systems-level approach for understanding and interpreting these complex interactions. Biological network analysis is one method for reducing enormous data sets to clinically useful knowledge for disease diagnosis, prognosis, and treatment. The network of biological entities can help us predict drug targets for several diseases. The drug targets identified through the systems biology approach help in targeting the essential biological pathways that contribute to the progression and development of the disease. The novel strategical approach of system biologyassisted pharmacology coupled with computer-aided drug discovery (CADD) can help drugs fight multifactorial diseases efficiently. In the present review, we have summarized the role and application of network biology for not only unfolding the mechanism of complex neurodevelopmental disorders but also identifying important drug targets for diseases like ADHD, Autism, Epilepsy, and Intellectual Disability. Systems biology has emerged as a promising approach to identifying drug targets and aiming for targeted drug discovery for the precise treatment of neurodevelopmental disorders.","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"5 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75555611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.025365
Yongdae Yoon, Soonjae Hwang, Fatema Tuj Saima, Moon YOUNG KIM, Soon KOO BAIK, Young WOO EOM
{"title":"AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells","authors":"Yongdae Yoon, Soonjae Hwang, Fatema Tuj Saima, Moon YOUNG KIM, Soon KOO BAIK, Young WOO EOM","doi":"10.32604/biocell.2023.025365","DOIUrl":"https://doi.org/10.32604/biocell.2023.025365","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"62 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86735970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.027205
Yue Cao, Lin Hu, Yishu Tang
{"title":"Hepatitis B virus X protein-mediated upregulation of miR-221 activates the CXCL12-CXCR4 axis to promote NKT cells in HBV-related hepatocellular carcinoma","authors":"Yue Cao, Lin Hu, Yishu Tang","doi":"10.32604/biocell.2023.027205","DOIUrl":"https://doi.org/10.32604/biocell.2023.027205","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"6 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90899701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.32604/biocell.2023.028121
Giulia Chiabotto, S. Bruno
{"title":"Anti-fibrotic and anti-inflammatory effect of mesenchymal stromal cell-derived extracellular vesicles in chronic kidney disease","authors":"Giulia Chiabotto, S. Bruno","doi":"10.32604/biocell.2023.028121","DOIUrl":"https://doi.org/10.32604/biocell.2023.028121","url":null,"abstract":"","PeriodicalId":55384,"journal":{"name":"Biocell","volume":"2 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90270092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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