Renata M S Leal, Emmanuel J N L Silva, Maria C B P Campos, Clarissa T Rodrigues, Marco A H Duarte, Bruno C Cavenago
This study evaluated the shaping ability of HyFlex EDM and Rotate rotary systems in the preparation of S-Shaped mesial root canals of mandibular molars (n = 13). After root canal preparation with instruments HyFlex EDM and Rotate 0.25 and 0.40, the specimens were evaluated for root canal volume, volume increase, static voxels, accumulated hard tissue debris, centring ability and canal transportation. After 0.40 preparation, the Rotate group exhibited a greater increase in volume and less accumulated hard-tissue debris compared to the HyFlex group (p > 0.05). 0.40 preparation with Rotate instruments resulted in greater volume increases across all thirds and less debris in the apical third (p < 0.05). The Rotate group displayed greater transportation and lower centring ability in the apical third after 0.40 preparation (p < 0.05). HyFlex and Rotate demonstrated similar performance up to the 0.25 preparation, and while differences emerged after the 0.40 preparation, both systems provided safe preparation without procedural accidents.
{"title":"Shaping Ability of Rotary NiTi Systems in S-Shaped Root Canals of Mandibular Molars.","authors":"Renata M S Leal, Emmanuel J N L Silva, Maria C B P Campos, Clarissa T Rodrigues, Marco A H Duarte, Bruno C Cavenago","doi":"10.1111/aej.12920","DOIUrl":"https://doi.org/10.1111/aej.12920","url":null,"abstract":"<p><p>This study evaluated the shaping ability of HyFlex EDM and Rotate rotary systems in the preparation of S-Shaped mesial root canals of mandibular molars (n = 13). After root canal preparation with instruments HyFlex EDM and Rotate 0.25 and 0.40, the specimens were evaluated for root canal volume, volume increase, static voxels, accumulated hard tissue debris, centring ability and canal transportation. After 0.40 preparation, the Rotate group exhibited a greater increase in volume and less accumulated hard-tissue debris compared to the HyFlex group (p > 0.05). 0.40 preparation with Rotate instruments resulted in greater volume increases across all thirds and less debris in the apical third (p < 0.05). The Rotate group displayed greater transportation and lower centring ability in the apical third after 0.40 preparation (p < 0.05). HyFlex and Rotate demonstrated similar performance up to the 0.25 preparation, and while differences emerged after the 0.40 preparation, both systems provided safe preparation without procedural accidents.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giusy Rita Maria La Rosa, Matteo Peditto, Andrea Venticinque, Antonia Marcianò, Alberto Bianchi, Eugenio Pedullà
{"title":"Response to the Letter to the Editor: Critical Appraisal of Advancements in Guided Surgical Endodontics: A Scoping Review.","authors":"Giusy Rita Maria La Rosa, Matteo Peditto, Andrea Venticinque, Antonia Marcianò, Alberto Bianchi, Eugenio Pedullà","doi":"10.1111/aej.12925","DOIUrl":"https://doi.org/10.1111/aej.12925","url":null,"abstract":"","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present systematic review was to evaluate the efficacy of surgical techniques for the preservation of a tooth with VRF. We included case series presenting techniques for the treatment of VRFs. Both electronic sources (MEDLINE, EMBASE, Cochrane Central) and reference lists/table of contents of pertinent journals were screened. Eight articles (six studies) were included. Four of the studies bonded the fractured fragments with 4-META/MMA-TBB resin, one adopted MTA, and in one study the authors used resin-ionomer cement. There was significant heterogeneity in the results regarding teeth survival rate and it was not possible to perform a quantitative synthesis. Scientific evidence concerning the treatment of vertically fractured roots is sparse and of low quality. Consequently, it is not possible to draw conclusions regarding the efficacy of the reported techniques. More studies with higher scientific standards may add validity to the techniques described here. Trial Registration: CRD42024524356 in PROSPERO.
{"title":"The Efficacy of Surgical Techniques for the Management of Confirmed Vertical Root Fractures: A Systematic Review.","authors":"Stefano Corbella, Silvio Taschieri, Igor Tsesis, Tomer Goldberger, Luca Francetti, Eyal Rosen","doi":"10.1111/aej.12923","DOIUrl":"https://doi.org/10.1111/aej.12923","url":null,"abstract":"<p><p>The aim of the present systematic review was to evaluate the efficacy of surgical techniques for the preservation of a tooth with VRF. We included case series presenting techniques for the treatment of VRFs. Both electronic sources (MEDLINE, EMBASE, Cochrane Central) and reference lists/table of contents of pertinent journals were screened. Eight articles (six studies) were included. Four of the studies bonded the fractured fragments with 4-META/MMA-TBB resin, one adopted MTA, and in one study the authors used resin-ionomer cement. There was significant heterogeneity in the results regarding teeth survival rate and it was not possible to perform a quantitative synthesis. Scientific evidence concerning the treatment of vertically fractured roots is sparse and of low quality. Consequently, it is not possible to draw conclusions regarding the efficacy of the reported techniques. More studies with higher scientific standards may add validity to the techniques described here. Trial Registration: CRD42024524356 in PROSPERO.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study tested the impact of troughing on the detection rates of MB2 canals with and without calcifications. Traditional access cavities were prepared and the detection of MB2 canals was recorded in 200 maxillary molars selected based on micro-CT scans. In specimens, the MB2 orifice was not detected; troughing was performed. The number of negotiated MB2 with and without troughing was compared with micro-CT using McNemar's test. After traditional access cavity preparation without troughing, the operator detected MB2 in 142 specimens (82%). Troughing of the remaining specimens led to the further identification of 16 MB2 canals, increasing detection rate to 91%. Troughing significantly improved the detection rate of non-calcified MB2s (p < 0.05) but did not significantly impact the detection of calcified MB2 canals (p > 0.05). While troughing is highly effective in enhancing MB2 canal detection in non-calcified canals, it may be limited in cases where calcification is present.
{"title":"Effect of Troughing on the Identification of the Second Mesiobuccal Canals With and Without Calcifications in Maxillary First Molars.","authors":"İlker Dinçer Ertürk, Ali Keleş, Cangül Keskin","doi":"10.1111/aej.12922","DOIUrl":"https://doi.org/10.1111/aej.12922","url":null,"abstract":"<p><p>This study tested the impact of troughing on the detection rates of MB2 canals with and without calcifications. Traditional access cavities were prepared and the detection of MB2 canals was recorded in 200 maxillary molars selected based on micro-CT scans. In specimens, the MB2 orifice was not detected; troughing was performed. The number of negotiated MB2 with and without troughing was compared with micro-CT using McNemar's test. After traditional access cavity preparation without troughing, the operator detected MB2 in 142 specimens (82%). Troughing of the remaining specimens led to the further identification of 16 MB2 canals, increasing detection rate to 91%. Troughing significantly improved the detection rate of non-calcified MB2s (p < 0.05) but did not significantly impact the detection of calcified MB2 canals (p > 0.05). While troughing is highly effective in enhancing MB2 canal detection in non-calcified canals, it may be limited in cases where calcification is present.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Laura Schauenberg Machado, Patrícia Maria Poli Kopper, Maurício Denicol Anastacio, Marcus Vinícius Reis Só, Patrícia Weidlich, Roberta Kochenborger Scarparo
This study reports two cases of traumatised non-vital immature teeth (IT). Both underwent surgical and nonsurgical treatments after healing failure. In the first case, both maxillary central incisors underwent revascularization as the first treatment option. Failure was detected in tooth #8 after 15 months, while tooth #9 showed periapical healing and further root development. Apical microsurgery was performed because of persistent cystic fluid during nonsurgical retreatment. In the second case, there was recurrent endodontic treatment failure in tooth #9 after nonsurgical mineral trioxide aggregate (MTA) apical plug placement and apical surgery (AS). Endodontic resurgery comprised debridement, apical and lateral root surface planning and removal of remaining MTA from the bone lesion. For both cases, histopathological examination revealed the presence of inflammatory cysts. Periapical healing was observed 1 year after treatment. Apical surgery, and even resurgery, should be considered as alternatives to tooth extraction in growing patients with IT and recurrent healing failure.
{"title":"Apical Surgery and Resurgery After Recurrent Failure in Traumatised Immature Teeth: Reflections on Management Based on Two Case Reports.","authors":"Ana Laura Schauenberg Machado, Patrícia Maria Poli Kopper, Maurício Denicol Anastacio, Marcus Vinícius Reis Só, Patrícia Weidlich, Roberta Kochenborger Scarparo","doi":"10.1111/aej.12921","DOIUrl":"https://doi.org/10.1111/aej.12921","url":null,"abstract":"<p><p>This study reports two cases of traumatised non-vital immature teeth (IT). Both underwent surgical and nonsurgical treatments after healing failure. In the first case, both maxillary central incisors underwent revascularization as the first treatment option. Failure was detected in tooth #8 after 15 months, while tooth #9 showed periapical healing and further root development. Apical microsurgery was performed because of persistent cystic fluid during nonsurgical retreatment. In the second case, there was recurrent endodontic treatment failure in tooth #9 after nonsurgical mineral trioxide aggregate (MTA) apical plug placement and apical surgery (AS). Endodontic resurgery comprised debridement, apical and lateral root surface planning and removal of remaining MTA from the bone lesion. For both cases, histopathological examination revealed the presence of inflammatory cysts. Periapical healing was observed 1 year after treatment. Apical surgery, and even resurgery, should be considered as alternatives to tooth extraction in growing patients with IT and recurrent healing failure.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felipe Immich, Tina Rödig, Philipp Kanzow, Evandro Piva, Giampiero Rossi-Fedele
Sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and calcium hydroxide (Ca(OH)2) are used in root canal treatment. However, further research is needed to assess their effectiveness at time points not considered in previous guidelines. This review complements the systematic review by Rossi-Fedele and Rödig (2023) by considering time points excluded by the latter. A search was conducted in PubMed-MEDLINE, Scopus, EMBASE, Google Scholar, and repositories between March and May 2024. Four studies met the inclusion criteria, providing data from 212 teeth for irrigation and 108 for dressings. No significant differences in pain reduction within 7 days or radiographic reduction of apical lesion size were found between 2% chlorhexidine, 5.25% NaOCl, EDTA, and various NaOCl concentrations. Single and multiple visit protocols also showed no significant differences in postoperative pain. Two studies had a 'low risk' of bias and two 'some concerns'. Evidence suggests that Ca(OH)2 dressings may not offer additional benefits.
{"title":"Effectiveness of Root Canal Irrigation and Dressing for the Treatment of Asymptomatic Apical Periodontitis: A Systematic Review Assessing Complementary Timeframes.","authors":"Felipe Immich, Tina Rödig, Philipp Kanzow, Evandro Piva, Giampiero Rossi-Fedele","doi":"10.1111/aej.12918","DOIUrl":"https://doi.org/10.1111/aej.12918","url":null,"abstract":"<p><p>Sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and calcium hydroxide (Ca(OH)<sub>2</sub>) are used in root canal treatment. However, further research is needed to assess their effectiveness at time points not considered in previous guidelines. This review complements the systematic review by Rossi-Fedele and Rödig (2023) by considering time points excluded by the latter. A search was conducted in PubMed-MEDLINE, Scopus, EMBASE, Google Scholar, and repositories between March and May 2024. Four studies met the inclusion criteria, providing data from 212 teeth for irrigation and 108 for dressings. No significant differences in pain reduction within 7 days or radiographic reduction of apical lesion size were found between 2% chlorhexidine, 5.25% NaOCl, EDTA, and various NaOCl concentrations. Single and multiple visit protocols also showed no significant differences in postoperative pain. Two studies had a 'low risk' of bias and two 'some concerns'. Evidence suggests that Ca(OH)<sub>2</sub> dressings may not offer additional benefits.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiliang Yang, Lingyun Xia, Yongji Chen, Lei Jiang, Tianxia Zheng, Yuhong Bai
This study evaluated the cytotoxicity and biocompatibility of a new strontium silicate-based root canal sealer (C-Root SP), in comparison with those of iRoot SP and AH plus. The sealer extract was diluted to the concentrations of 100%, 75%, 50%, and 25%. L929 cells were cultured for 24 h, and the absorbance value was determined. Two-way analysis of variance (two-way ANOVA) and sealers were implanted in the tibia of Sprague-Dawley (SD) rats, At 2, 6, and 12 weeks, rats were euthanised. The tissue reaction was evaluated by HE staining. The least significant difference (LSD) t-test and Kruskal-Wallis test were used. The cytotoxicity of C-Root SP and iRoot SP was found to be less than that of AH plus. At 12 weeks, new bone formation was induced around C-Root SP and iRoot SP sealer, but minimal evidence of bone formation was found in AH plus. C-Root SP has low cytotoxicity and superior biocompatibility.
{"title":"Cytotoxicity and Bone Biocompatibility of the C-Root SP Experimental Root Canal Sealer.","authors":"Xiliang Yang, Lingyun Xia, Yongji Chen, Lei Jiang, Tianxia Zheng, Yuhong Bai","doi":"10.1111/aej.12916","DOIUrl":"https://doi.org/10.1111/aej.12916","url":null,"abstract":"<p><p>This study evaluated the cytotoxicity and biocompatibility of a new strontium silicate-based root canal sealer (C-Root SP), in comparison with those of iRoot SP and AH plus. The sealer extract was diluted to the concentrations of 100%, 75%, 50%, and 25%. L929 cells were cultured for 24 h, and the absorbance value was determined. Two-way analysis of variance (two-way ANOVA) and sealers were implanted in the tibia of Sprague-Dawley (SD) rats, At 2, 6, and 12 weeks, rats were euthanised. The tissue reaction was evaluated by HE staining. The least significant difference (LSD) t-test and Kruskal-Wallis test were used. The cytotoxicity of C-Root SP and iRoot SP was found to be less than that of AH plus. At 12 weeks, new bone formation was induced around C-Root SP and iRoot SP sealer, but minimal evidence of bone formation was found in AH plus. C-Root SP has low cytotoxicity and superior biocompatibility.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yudi Deng, Jinglan Zhang, Xinran Wang, Lei Yang, Qiang He, Dingming Huang, Xuelian Tan
The study aims to conduct a bibliometric analysis on root canal irrigation to elucidate the development of this domain and pose the future research trends. Of 6722 articles retrieved from Clarivate Analytics' Web of Science Core Collection and PubMed, 6650 publications were included for bibliometric analysis. Irrigation field had received emerging attention for the last half century, peaking at 399 in 2022. The United States was revealed as the most influential contributor, with Journal of Endodontics representing the most voluminous resource. Franklin R Tay was regarded as the most productive author, while Siqueira, Jose. F. was the most prominent. Both keywords cluster analysis and burst analysis revealed the main research branch fields were irrigation protocols. Within this branch, the discussion of irrigants (with a frequency of 1135) ranked first. This bibliometric study revealed the research hotspot of irrigants, while suggesting the future directions of irrigants' creations and micro-level mechanism elucidation.
本研究旨在对根管灌溉进行文献计量分析,以阐明该领域的发展,并提出未来的研究趋势。从Clarivate Analytics的Web Of Science Core Collection和PubMed检索的6722篇文章中,6650篇被纳入文献计量学分析。在过去的半个世纪里,灌溉领域受到了越来越多的关注,在2022年达到了399的峰值。美国被认为是最有影响力的贡献者,《牙髓学杂志》是最大量的资源。富兰克林R .泰被认为是最多产的作家,而西奎拉何塞。F.是最突出的。关键词聚类分析和突发分析均显示灌溉方案是其研究的主要分支领域。在这个分支中,关于灌溉的讨论(频率为1135次)排名第一。本文的文献计量学研究揭示了灌溉水的研究热点,同时提出了灌溉水创造的未来方向和微观层面机理的阐释。
{"title":"A bibliometric analysis of root canal irrigation: From laboratory to clinical practice.","authors":"Yudi Deng, Jinglan Zhang, Xinran Wang, Lei Yang, Qiang He, Dingming Huang, Xuelian Tan","doi":"10.1111/aej.12909","DOIUrl":"https://doi.org/10.1111/aej.12909","url":null,"abstract":"<p><p>The study aims to conduct a bibliometric analysis on root canal irrigation to elucidate the development of this domain and pose the future research trends. Of 6722 articles retrieved from Clarivate Analytics' Web of Science Core Collection and PubMed, 6650 publications were included for bibliometric analysis. Irrigation field had received emerging attention for the last half century, peaking at 399 in 2022. The United States was revealed as the most influential contributor, with Journal of Endodontics representing the most voluminous resource. Franklin R Tay was regarded as the most productive author, while Siqueira, Jose. F. was the most prominent. Both keywords cluster analysis and burst analysis revealed the main research branch fields were irrigation protocols. Within this branch, the discussion of irrigants (with a frequency of 1135) ranked first. This bibliometric study revealed the research hotspot of irrigants, while suggesting the future directions of irrigants' creations and micro-level mechanism elucidation.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudia García-Guerrero, Ana Priscila Rodas Serrano, Maria Carolina Leal Fernández, Sara Quijano-Guauque
This in-vitro study aimed to explore the potential of Diode Laser by quantifying the release of transforming growth factor-beta 1 (TGF-β1), platelet-derived growth factor (PDGF)-BB, and vascular endothelial growth factor (VEGF) from root dentin after ethylenediaminetetraacetic acid (EDTA) and diode laser. In 30 hemi-roots distributed into five groups: G1: Tris-buffered solution (TBS); G2: 17%EDTA; G3: 17% EDTA +650 nm Diode Laser; G4:17% EDTA +810 nm Diode Laser; and G5: 810 nm Diode Laser. The concentration of the three factors was quantified using a cytokine bead array. Statistical tests were performed to estimate intergroup differences (p ≤ 0.05). TGF-β1 and VEGF were solubilised in all test protocols. The ability of low-level power diode lasers to release proteins from the matrix is limited. Its effect on the release of VEGF and PDGF-BB does not make a difference. A synergy between EDTA and Diode Laser led to a greater proportion of TGF-β1 release.
{"title":"In vitro bioactive dentin protein release by diode laser conditioning.","authors":"Claudia García-Guerrero, Ana Priscila Rodas Serrano, Maria Carolina Leal Fernández, Sara Quijano-Guauque","doi":"10.1111/aej.12911","DOIUrl":"https://doi.org/10.1111/aej.12911","url":null,"abstract":"<p><p>This in-vitro study aimed to explore the potential of Diode Laser by quantifying the release of transforming growth factor-beta 1 (TGF-β1), platelet-derived growth factor (PDGF)-BB, and vascular endothelial growth factor (VEGF) from root dentin after ethylenediaminetetraacetic acid (EDTA) and diode laser. In 30 hemi-roots distributed into five groups: G1: Tris-buffered solution (TBS); G2: 17%EDTA; G3: 17% EDTA +650 nm Diode Laser; G4:17% EDTA +810 nm Diode Laser; and G5: 810 nm Diode Laser. The concentration of the three factors was quantified using a cytokine bead array. Statistical tests were performed to estimate intergroup differences (p ≤ 0.05). TGF-β1 and VEGF were solubilised in all test protocols. The ability of low-level power diode lasers to release proteins from the matrix is limited. Its effect on the release of VEGF and PDGF-BB does not make a difference. A synergy between EDTA and Diode Laser led to a greater proportion of TGF-β1 release.</p>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}