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Identification of oxidative stress biomarkers in apical periodontitis: A scoping review with bibliometric analysis 根尖牙周炎中氧化应激生物标志物的鉴定:范围综述与文献计量分析
IF 1.6 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-19 DOI: 10.1111/aej.12888
Nara Sarmento Macedo Signorelli, Sávio Gabriel Silva Rende, Eugenio Luigi Iorio, Danilo Cassiano Ferraz, Luiz Renato Paranhos, Camilla Christian Gomes Moura
Oxidative stress (OS) is a ubiquitous process for protecting against microorganisms' challenges. This review maps the most used methods for obtaining samples and analysing reactive oxygen species levels in apical periodontitis, following the PRISMA Extension for Scoping Reviews and is registered in Open Science Framework ([https://doi.org/10.17605/OSF.IO/D5U76]). A systematic search was conducted in electronic databases MEDLINE (PubMed), Embase, Scopus, Web of Science, LILACS, SciElo, OATD and DANS up to 17 July 2023. A total of 18 studies were included, with periapical tissue being the most common sample. Twenty-eight different oxidative stress markers were identified, with inducible nitric oxide synthase being the most prevalent. The use of diverse biomarkers for oxidative stress assessment lacks specificity in identifying particular OS species for evaluating apical periodontitis and potential systemic effects. Studies are necessary to compare results obtained from less invasive methods (such as saliva and crevicular fluid) with those from periapical lesion samples.
氧化应激(OS)是抵御微生物挑战的一个无处不在的过程。本综述按照《范围界定综述的 PRISMA 扩展》(PRISMA Extension for Scoping Reviews)的要求,介绍了牙根尖周炎中获取样本和分析活性氧水平的最常用方法,并在开放科学框架([https://doi.org/10.17605/OSF.IO/D5U76])中进行了注册。截至 2023 年 7 月 17 日,在 MEDLINE (PubMed)、Embase、Scopus、Web of Science、LILACS、SciElo、OATD 和 DANS 等电子数据库中进行了系统检索。共纳入 18 项研究,其中根尖周组织是最常见的样本。研究发现了 28 种不同的氧化应激标记物,其中以诱导型一氧化氮合酶最为普遍。使用不同的生物标记物评估氧化应激缺乏特异性,无法确定特定的 OS 种类来评估根尖牙周炎和潜在的全身影响。有必要进行研究,将侵入性较小的方法(如唾液和缝隙液)与根尖周病变样本的结果进行比较。
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引用次数: 0
Permanent tooth avulsions: A retrospective analysis of the demographics and aetiology of cases at a tertiary hospital in Sydney, Australia 恒牙脱落:对澳大利亚悉尼一家三级医院病例的人口统计学和病因学的回顾性分析
IF 1.6 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-19 DOI: 10.1111/aej.12891
Julia Bradshaw, Bill Kahler, Shanika Nanayakkara, Neeta Prabhu
This retrospective analysis reviewed the demographics of patients sustaining dental avulsion injuries at a tertiary dental hospital in Sydney, Australia. Data were extracted from dental records of patients who presented with avulsed permanent anterior teeth and were treated between 1 January 2001 and 30 June 2021. Demographic, clinical and radiographic data from 91 patients with 117 avulsed permanent anterior teeth were available for analysis. The median age of the patients was 12 years (IQR 9.0–17.0). Males accounted for 68.4% of avulsion injuries. Non-organised sports were the most common cause of injury (42.7%). Maxillary central incisors were the most frequently avulsed tooth (83.3%). Peak prevalence of injuries occurred on the weekend. The findings from this study may reflect regional factors such as climate and participation in sport. Anticipatory guidance should be provided to patients at elevated risk of dental avulsion.
这项回顾性分析回顾了澳大利亚悉尼一家三级牙科医院的牙齿撕脱伤患者的人口统计学特征。数据提取自2001年1月1日至2021年6月30日期间接受治疗的恒前牙脱落患者的牙科记录。共有 91 名患者的人口统计学、临床和放射学数据可供分析,这些患者共有 117 颗脱落的恒前牙。患者的中位年龄为 12 岁(IQR 9.0-17.0)。男性占撕脱伤的68.4%。非组织性运动是最常见的受伤原因(42.7%)。上颌中切牙是最常见的撕脱伤牙齿(83.3%)。受伤的高峰期出现在周末。这项研究的结果可能反映了气候和参与体育运动等地区因素。应为牙齿脱落风险较高的患者提供预期指导。
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引用次数: 0
Survival evaluation of surgical extrusion for the management of complicated crown‐root fractured maxillary incisors: A clinical study 手术挤压治疗复杂牙冠-牙根骨折上颌切牙的存活率评估:临床研究
IF 1.6 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-10 DOI: 10.1111/aej.12889
J. Jenisha, K. G. Geeth Deepika, I. Anand Sherwood, A. Azhagu Abirami
This study aimed to clinically evaluate the survivability of surgically extruded teeth, to assess the success rate and predictable factors pertaining to alterations in both hard and soft tissues adjacent to extruded teeth. A total of 46 complicated crown‐root fractured maxillary central and lateral incisors with >75% tooth structure loss relatively due to trauma were included. Preoperative clinical and radiographic variables were recorded. Single operator performed endodontic treatment before surgical extrusion. Patients were recalled for review at 6, 12, 18, 24 and 36 months. Survivability was assessed using Kaplan–Meier survival analysis. With a mean follow‐up of 2.8 years, survival rate was 95.7%. Mobility observed in only two cases. The crown‐root ratio was favourable (1:2) in all the cases except for five teeth. Only two teeth displayed non‐progressive root resorption. Survival of surgically extruded teeth relies on significant predictors like favourability of CRR and implementation of atraumatic extrusion.
本研究旨在临床评估手术挤压牙齿的存活率,评估成功率以及与挤压牙齿邻近软硬组织改变相关的可预测因素。本研究共纳入了46颗复杂的牙冠-牙根折断的上颌中切牙和侧切牙,其中75%的牙齿结构损失是由外伤造成的。记录术前临床和放射学变量。手术挤压前,由单一操作者进行牙髓治疗。分别在 6、12、18、24 和 36 个月时对患者进行复查。采用卡普兰-米尔生存分析法评估存活率。平均随访时间为 2.8 年,存活率为 95.7%。仅在两个病例中观察到移动性。除五颗牙齿外,其他所有病例的牙冠与牙根的比例都很理想(1:2)。只有两颗牙齿显示出非进行性牙根吸收。手术挤压牙齿的存活率取决于一些重要的预测因素,如 CRR 的良好性和非创伤性挤压的实施。
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引用次数: 0
Micro‐computed tomography evaluation of minimally invasive root canal preparation in 3D‐printed C‐shaped canal 微计算机断层扫描评估 3D 打印 C 型根管中的微创根管预备技术
IF 1.6 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-10 DOI: 10.1111/aej.12890
Nutcha Supavititpattana, Siriwan Suebnukarn, Panupat Phumpatrakom, Kamon Budsaba
This study aimed to evaluate and compare the shaping abilities and minimum dentin thickness of minimally invasive rotary instruments via micro‐computed tomography. Twelve 3D‐printed C‐shaped canal models from a mandibular molar were divided into two groups, and root canals were prepared with either XP‐endo Rise (XR) or TruNatomy (TN) systems. Pre‐ and post‐preparation evaluations included canal volume, prepared area and minimum dentin thickness. No significant differences were found in canal volume change (XR: 22.66 ± 4.28%, TN: 23.02 ± 5.10%), prepared canal area (XR: 31.86 ± 10.72%, TN: 30.26 ± 11.59%) and minimum dentin thickness (XR: 0.30 ± 0.05 mm, TN: 0.28 ± 0.05 mm) between groups (p > 0.05). The canal volume change in the middle third was significantly higher than that in the coronal and apical thirds (p < 0.05) in both groups. In conclusion, XR demonstrated comparable shaping abilities and minimum dentin thickness to TN in preparing 3D‐printed C‐shaped canals.
本研究旨在通过微型计算机断层扫描评估和比较微创旋转器械的塑形能力和最小牙本质厚度。研究人员将 12 个三维打印的下颌臼齿 C 型根管模型分成两组,分别使用 XP-endo Rise (XR) 或 TruNatomy (TN) 系统进行根管预备。预备前后的评估包括根管体积、预备面积和最小牙本质厚度。各组之间在牙管容积变化(XR:22.66 ± 4.28%,TN:23.02 ± 5.10%)、预备牙管面积(XR:31.86 ± 10.72%,TN:30.26 ± 11.59%)和最小牙本质厚度(XR:0.30 ± 0.05 mm,TN:0.28 ± 0.05 mm)方面无明显差异(p > 0.05)。在两组中,中间三分之一的牙槽骨体积变化明显高于冠状和根尖三分之一的牙槽骨体积变化(p < 0.05)。总之,在制备 3D 打印的 C 形牙冠时,XR 的塑形能力和最小牙本质厚度与 TN 相当。
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引用次数: 0
Sharing endodontic research on social media platforms: Is it effective? A 10-year timeline analysis. 在社交媒体平台上分享牙髓病学研究:有效吗?10 年时间轴分析。
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-05 DOI: 10.1111/aej.12887
Reham Hassan, Maha Nasr, Hams H Abdelrahman, Mohamed G Hassan

The purpose of this study was to analyse the social media activity related to endodontic research over the last 10-years. All research articles published in endodontic journals listed in Scopus (Sc) published in 2012 and 2018 were included in our study. The Altmetric Attention Score (AAS), Twitter, and Facebook mentions were obtained for each article. Citation counts were extracted using two citation metrics: Google Scholar (GS) and Sc. Correlations between the AAS, the number of social media mentions, and citations were analysed using Spearman's rank order correlation coefficient. A multivariable Poisson log-linear regression analysis shows that papers mentioned on social media gain about 35% more citations in GS and 31% more citations in Sc. The academic citations per article on GS and Sc were positively correlated with the AAS. Our data suggest an increasing positive correlation between social media mentions and article citations over the years.

本研究旨在分析过去 10 年中与牙髓病学研究相关的社交媒体活动。我们的研究纳入了 2012 年至 2018 年发表在 Scopus (Sc) 所列牙髓病学期刊上的所有研究文章。我们获得了每篇文章的 Altmetric Attention Score (AAS)、Twitter 和 Facebook 提及率。使用两种引文指标提取引文计数:谷歌学者(GS)和Sc.使用斯皮尔曼秩相关系数分析了AAS、社交媒体提及数和引用数之间的相关性。多变量泊松对数线性回归分析表明,在社交媒体上被提及的论文在GS上的引用次数比在Sc上的引用次数分别高出约35%和31%。每篇文章在 GS 和 Sc 上的学术引用与 AAS 呈正相关。我们的数据表明,社交媒体提及率与文章引用率之间的正相关性逐年增加。
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引用次数: 0
Successful retreatment of a maxillary central incisor with a wide-open apex using MTA to fill the entire canal: 24-year follow-up. 使用 MTA 填充整个牙道,成功再治疗了一颗牙尖宽大的上颌中切牙:24 年随访。
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-02 DOI: 10.1111/aej.12885
Juan Domingo Saavedra Felipe, Virginia Andrea Watson Molina, Anabell Bologna Escalona, Rafael Laplana Martínez, Aitzol Areso, Venkateshbabu Nagendrababu, Francesc Abella Sans

Managing teeth with open apices can be a challenging scenario for clinicians. This case report describes the 24-year follow-up of a maxillary central incisor that failed to develop after a traumatic injury resulting in a wide-open apex. A 10-year-old girl presented complaining of discomfort in her upper teeth. Tooth #9 had received a traumatic blow several years before and was discoloured with a resin composite restoration on the mesio-incisal edge. The tooth was painful to percussion and palpation. An inadequate root canal filling and incomplete root formation were observed on the initial periapical radiograph. Root canal retreatment was initiated, and the canal filled entirely with mineral trioxide aggregate (MTA) because of the extremely wide canal and open apex. The patient was asymptomatic at the 24-year follow-up with the cone beam computed tomography and periapical radiographs demonstrating the stability of the MTA.

对于临床医生来说,处理牙尖开放的牙齿是一种具有挑战性的情况。本病例报告描述了对一颗上颌中切牙 24 年的随访情况,这颗上颌中切牙在一次外伤后未能发育,导致牙尖开放过大。一名 10 岁女孩主诉上牙不适。她的 9 号牙齿在几年前受到过一次外伤,中切缘的树脂复合修复体已经变色。叩诊和触诊时牙齿疼痛。在最初的根尖周炎 X 光片上可以看到根管充填不充分,牙根形成不完整。由于根管极宽且根尖开放,因此开始了根管再治疗,并用三氧化物矿物质骨料(MTA)完全填充了根管。在 24 年的随访中,患者没有任何症状,锥形束计算机断层扫描和根尖周X光片显示 MTA 很稳定。
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引用次数: 0
Minimally invasive guided endodontic microsurgery with Zekrya bur: A 48-month follow-up case report. 使用 Zekrya bur 进行微创引导牙髓显微手术:48 个月的随访病例报告。
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-20 DOI: 10.1111/aej.12884
Lucas Moreira Maia, Gil Moreira Júnior, Nelson Renato França Alves Silva, Vinícius de Carvalho Machado, Larissa Fassarela Marquiore, Emmanuel João Nogueira Leal Silva, Antônio Paulino Ribeiro Sobrinho, Warley Luciano Fonseca Tavares

Endodontic microsurgery guided by navigation systems represents a precise and minimally invasive approach for retreatment of apical periodontitis following failed conventional endodontic therapy. Accurate localization and minimal access to the root apex are paramount for successful outcomes and preservation of anatomical structures. Workflow considerations, such as three-dimensional (3D) virtual planning and endodontic guidance represent new crucial aspects for addressing complex cases. This clinical case report presents the successful reintervention of a complex case using a Zekrya bur, operative microscopy, cone beam computed tomography and biocompatible materials. After a 48-month follow-up, complete healing of the treated area was observed. This minimally invasive technique, employing a simple instrument widely available globally, underscores the potential for efficient and predictable outcomes in complex endodontic microsurgical retreatment.

导航系统引导下的根管显微手术是一种精确、微创的方法,用于传统根管治疗失败后根尖牙周炎的再治疗。精确定位和尽量少地进入根尖是取得成功结果和保留解剖结构的关键。工作流程方面的考虑因素,如三维(3D)虚拟规划和牙髓引导,是解决复杂病例的新的关键环节。本临床病例报告介绍了使用 Zekrya 钻头、手术显微镜、锥形束计算机断层扫描和生物相容性材料对复杂病例进行再干预的成功案例。经过 48 个月的随访,观察到治疗区域完全愈合。这种微创技术采用了全球广泛使用的简单器械,强调了在复杂牙髓病显微外科再治疗中实现高效和可预测结果的潜力。
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引用次数: 0
Antibiofilm effect of different concentrations of silver nanoparticles combined with calcium hydroxide against Enterococcus faecalis biofilm: An ex vivo study. 不同浓度的纳米银颗粒与氢氧化钙结合对粪肠球菌生物膜的抗生物膜效应:一项体内外研究。
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-14 DOI: 10.1111/aej.12882
Sumaya Basudan, Alanoud Alqahtani, Fatemah Alrwais, Reem Almeaither, Sayed Auda, Hanan A Balto

This study aimed to evaluate the antibiofilm activity of different concentrations of silver nanoparticles (AgNPs) in combination with calcium hydroxide [Ca(OH)2] against Enterococcus faecalis biofilm. On an E. faecalis biofilm on dentin discs, the following medicaments were applied for 7 days (n = 13/group): 0.005% AgNPs+Ca(OH)2, 0.01% AgNPs+Ca(OH)2, 0.02% AgNPs + Ca(OH)2, Ca(OH)2 and saline/control. Specimens were stained with LIVE/DEAD® BacLight™ dye and analysed with confocal laser scanning microscopy. Proportion of dead bacteria was calculated and analysed. There was a significant reduction in E. faecalis biofilm in all medicament groups (43.5%, 49.1%, 69.1%, 48.7%) respectively, compared with control group (2.54%) (p < 0.001). The 0.02% AgNPs + Ca(OH)2 group demonstrated the most significantly superior antibiofilm effect, with no significant difference between remaining groups. In conclusion, combining 0.02% AgNPs enhanced the antibiofilm effect of Ca(OH)2 on E. faecalis biofilm compared with lower AgNPs concentrations.

本研究旨在评估不同浓度的银纳米粒子 (AgNPs) 与氢氧化钙 [Ca(OH)2] 结合使用对粪肠球菌生物膜的抗生物膜活性。在牙本质盘上的粪肠球菌生物膜上,使用以下药物 7 天(n = 13/组):0.005%AgNPs+Ca(OH)2、0.01%AgNPs+Ca(OH)2、0.02%AgNPs+Ca(OH)2、Ca(OH)2 和生理盐水/对照组。用 LIVE/DEAD® BacLight™ 染料对标本进行染色,并用激光共聚焦扫描显微镜进行分析。计算并分析死亡细菌的比例。与对照组(2.54%)相比,所有药物组(43.5%、49.1%、69.1%、48.7%)的粪大肠杆菌生物膜均有明显减少(p 2 组的抗生物膜效果最为显著,其余各组之间无明显差异)。总之,与较低浓度的 AgNPs 相比,添加 0.02% 的 AgNPs 增强了 Ca(OH)2 对粪大肠杆菌生物膜的抗生物膜作用。
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引用次数: 0
Reliability of sealer penetration measurement methods and assessment of dentine penetrability after endodontic retreatment: A correlation in vitro study. 牙髓再治疗后封闭剂渗透性测量方法和牙本质渗透性评估的可靠性:相关体外研究
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-05 DOI: 10.1111/aej.12881
Sukainah A Aldawood, Omar Omar, Dana Almohazey, Amre R Atmeh

This study evaluated the reliability of sealer penetration measurement methods used with confocal laser scanning microscopy in correlation with the percentage of residual root filling and examined the effect of residual root-filling material on dentine penetrability after retreatment. Extracted teeth were randomly divided into different groups according to the obturation sealer used (n = 6); BioRoot RCS; MTA Fillapex; Bio-C and AH Plus. Root-filling material was removed before the secondary chemo-mechanical preparation and obturation using fluorescein labelled AH Plus. Multiple micro-computed tomography scans were obtained followed by confocal laser scanning microscopy to measure the penetration of the labelled sealer into the dentinal tubules using four different methods. Measuring sealer penetration into radicular dentine using the penetration percentage method was found to be the most reliable. Dentine penetrability during retreatment did not seem to be affected by the type of residual root-filling material.

本研究评估了共聚焦激光扫描显微镜使用的封闭剂渗透性测量方法与残留根充百分比相关性的可靠性,并研究了残留根充材料对再治疗后牙本质渗透性的影响。拔牙后,根据所使用的钝化封闭剂(n = 6)、BioRoot RCS、MTA Fillapex、Bio-C 和 AH Plus,随机分为不同的组别。在使用荧光素标记的 AH Plus 进行二次化学机械预备和封闭之前,先去除根部填充材料。使用四种不同的方法测量标记的封闭剂渗入牙本质小管的情况,然后使用共聚焦激光扫描显微镜进行多次显微计算机断层扫描。结果发现,使用渗透百分比法测量封闭剂渗入根尖牙本质的情况最为可靠。再治疗过程中牙本质的渗透性似乎不受残留根充材料类型的影响。
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引用次数: 0
APEC News July 2024: Ongoing process for organisation of APEC2025 Dhaka 亚太经合组织新闻 2024 年 7 月:正在进行的APEC2025达卡会议组织进程
IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-21 DOI: 10.1111/aej.12879
Hyeon-Cheol Kim DDS, PhD
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引用次数: 0
期刊
Australian Endodontic Journal
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