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Aggressive Neoplasms That Mimic Chronic Endodontic Lesions: A Multi-Institutional Case Series 模拟慢性牙髓病变的侵袭性肿瘤:多机构病例系列。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-30 DOI: 10.1111/aej.12956
Natália Gonçalves Macedo, Fernanda Geraldo Pappen, Bernardo da Fonseca Orcina, Gustavo Mascarenhas, Jean Nunes dos Santos, Paulo Sérgio da Silva Santos, Carolina Clasen Vieira, Alexandre Simões Garcia, Alini Cardoso Soares, Lauren Frenzel Schuch, Ana Paula Neutzling Gomes, Ana Carolina Uchoa Vasconcelos

This study aimed to report sociodemographic, clinicopathologic and radiological features of 12 cases of aggressive neoplasms that were clinically diagnosed as chronic endodontic lesions. The series comprised seven females (58.33%) and five males (41.67%), with a mean age of 48.9 ± 19.19 years (range: 16–75 years). In six cases (50%), the posterior maxillary region was involved. Internal appearance was radiolucent density (n = 12/100%). Eleven cases (91.67%) exhibited well-defined borders, while one (8.33%) showed ill-defined borders. Histopathologic diagnoses included metastasis (n = 4/33.33%), squamous cell carcinoma (n = 3/25%), mucoepidermoid carcinoma (n = 2/16.68%), acinic cell carcinoma (n = 1/8.33%), Ewing's sarcoma (n = 1/8.33%) and Langerhans cell histiocytosis (n = 1/8.33%). Survival status was retrieved for three patients (25.00%), all of whom were alive at the time of reporting. This study identified seven distinct histological types of aggressive neoplasms that mimic chronic periapical lesions. Given that such lesions often lack clinical or radiological signs of aggressive behaviour, it is imperative that all excised tissue undergo histopathological examination.

本研究旨在报告12例临床诊断为慢性牙髓病变的侵袭性肿瘤的社会人口学、临床病理和放射学特征。其中女性7例(58.33%),男性5例(41.67%),平均年龄48.9±19.19岁(范围16 ~ 75岁)。6例(50%)上颌后区受累。内部表现为放射密度(n = 12/100%)。边界清晰11例(91.67%),边界不清1例(8.33%)。组织病理学诊断包括转移(n = 4/33.33%)、鳞状细胞癌(n = 3/25%)、黏液表皮样癌(n = 2/16.68%)、腺泡细胞癌(n = 1/8.33%)、尤文氏肉瘤(n = 1/8.33%)和朗格汉斯细胞组织细胞增多症(n = 1/8.33%)。检索了3例患者(25.00%)的生存状态,所有患者在报告时均存活。本研究确定了七种不同的组织学类型的侵袭性肿瘤,模拟慢性根尖周围病变。鉴于这种病变通常缺乏临床或放射学上的侵略性行为迹象,所有切除的组织都必须进行组织病理学检查。
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引用次数: 0
Artificial Intelligence for Root Canal Orifice Identification Using Dental Operating Microscope Images: A Preliminary Evaluation 人工智能在牙操作显微镜图像根管口识别中的应用:初步评价。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-30 DOI: 10.1111/aej.12955
E. Karataş, O. Ünal, Ö. Çelik, İ. Ş. Bayrakdar

To evaluate the diagnostic performance of artificial intelligence (AI) in detecting root canal orifices using images captured with a dental operating microscope (DOM). A total of 80 human maxillary first and second molars were included in the study. After preparing traditional access cavities, root canal orifices were identified under a dental operating microscope (DOM) at 21.25× magnification. Following orifice identification, video recordings were obtained using the DOM, from which a total of 1527 frames were randomly selected for analysis. The root canal orifices in these frames were manually labelled using CranioCatch labeling software (CranioCatch, Eskişehir, Turkey). In the binary classification task, the system correctly identified 502 out of 526 root canal orifices, yielding an accuracy of 91%. The YOLO-based CNN demonstrated high accuracy and sensitivity in detecting root canal orifices from DOM images.

目的:评价人工智能(AI)在牙科操作显微镜(DOM)图像检测根管口中的诊断性能。共有80颗人类上颌第一和第二磨牙被纳入研究。在制备传统通道腔后,在牙科操作显微镜(DOM)下,以21.25倍放大镜对根管孔进行识别。在孔口识别之后,使用DOM获得视频记录,从中随机抽取1527帧进行分析。使用CranioCatch标记软件(CranioCatch, eski ehir,土耳其)手动标记这些框架中的根管孔。在二元分类任务中,系统正确识别了526个根管孔中的502个,准确率为91%。基于yolo的CNN在DOM图像中检测根管孔具有较高的准确性和灵敏度。
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引用次数: 0
Intraosseous Adenoid Cystic Carcinoma Mimicking Endodontic Periapical Lesion Along With Orofacial Pain: A Case Report 骨内腺样囊性癌模拟牙髓尖周病变伴口面部疼痛1例报告。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-30 DOI: 10.1111/aej.12958
Ji Wook Jeong, Ida Ann Varghese, Yong Kyun Won, Nadarajah Vigneswaran, Timothy Kirkpatrick

A 57-year-old patient with temporomandibular disorder and toothache underwent root canal treatments on teeth 42–31 by an endodontist. Despite these treatments, the patient experienced persistent pain radiating to his ears and sought evaluation by another endodontist. No notable facial or intraoral swelling nor paresthesia was observed; however, he reported difficulty with swallowing and trismus. A large periapical radiolucent lesion was identified spanning from tooth 42 to 32, and root resorptions were observed at the apices of teeth 42, 41 and 31. The initial diagnoses for teeth 42, 41, and 31 were previously treated and symptomatic apical periodontitis. Root-end surgery with biopsy was performed. One month later, the biopsy results revealed the lesion to be a carcinoma. The patient was immediately referred to a cancer centre, where a definitive diagnosis of adenoid cystic carcinoma was made. A prompt biopsy is critical for the definitive diagnosis of malignancies for timely treatment.

一位57岁的颞下颌紊乱和牙痛患者在牙髓科接受了42-31牙的根管治疗。尽管进行了这些治疗,患者仍然感到持续的疼痛放射到他的耳朵,并寻求另一位牙髓专家的评估。未观察到明显的面部或口腔肿胀或感觉异常;然而,他报告吞咽困难和咬牙。在第42 ~ 32颗牙的根尖周围发现了一个大的放射状病变,并且在第42、41和31颗牙的根尖观察到根吸收。第42、41和31颗牙的初步诊断为先前治疗过的症状性根尖牙周炎。进行根端手术并活检。一个月后,活检结果显示病变为癌。患者被立即转到癌症中心,在那里确诊为腺样囊性癌。及时活检对于恶性肿瘤的明确诊断和及时治疗至关重要。
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引用次数: 0
Healing Outcomes of Through-And-Through Bone Defects in Periapical Surgery: A Systematic Review and Meta-Analysis 根尖周围手术中贯通性骨缺损的愈合效果:系统回顾和荟萃分析。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-27 DOI: 10.1111/aej.12951
Bibi Fatima, Farhan Raza Khan, Syeda Abeerah Tanveer

Through-and-through (TAT) cortical plate defects present a challenge in periapical surgery, influencing treatment outcomes. This study investigates whether guided regenerative procedures (GRPs) enhance cortical plate healing and overall success compared to non-GRP treatments in TAT lesions. A systematic search was conducted across PubMed, CINAHL Plus, Wiley Cochrane Library, and Dental and Oral Science. Studies assessing endodontically treated teeth with TAT lesions via Cone Beam Computed Tomography were included. The risk of bias was assessed using Cochrane Risk of Bias 2.0 tool and Newcastle-Ottawa Scale. Five studies met inclusion criteria, with four included in meta-analysis. No significant differences were observed in cortical plate healing (OR: 0.52, 95% CI: 0.12–2.39; p = 0.40) or treatment success (OR: 0.35, 95% CI: 0.09–1.39; p = 0.14) between GRPs and non-GRPs. Findings suggest that GRPs do not significantly improve healing in TAT lesions, highlighting the need for further studies with larger sample sizes.

透-透(TAT)皮质板缺损在根尖周围手术中是一个挑战,影响治疗结果。本研究探讨了与非grp治疗相比,引导再生手术(grp)是否能提高TAT病变的皮质板愈合和总体成功率。系统检索PubMed, CINAHL Plus, Wiley Cochrane Library和Dental and Oral Science。通过锥形束计算机断层扫描评估牙髓治疗后TAT病变的研究。采用Cochrane risk of bias 2.0工具和Newcastle-Ottawa量表评估偏倚风险。5项研究符合纳入标准,其中4项纳入meta分析。皮质板愈合无显著差异(OR: 0.52, 95% CI: 0.12-2.39;p = 0.40)或治疗成功(or: 0.35, 95% CI: 0.09-1.39;p = 0.14)。研究结果表明,grp不能显著改善TAT病变的愈合,因此需要进一步进行更大样本量的研究。
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引用次数: 0
Determination of Surface Characteristics, Solubility and Ion Release of a Calcium Silicate Root Canal Sealer 硅酸钙根管密封剂的表面特性、溶解度和离子释放的测定。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-27 DOI: 10.1111/aej.12950
Anastasios Katakidis, Alexandros K. Nikolaidis, Konstantinos Ioannidis, Elisabeth A. Koulaouzidou, Christos Gogos, Nikolaos Economides

This study investigated the solubility of AH Plus Bioceramic sealer (AHPB), the ion release, and the modification of surface characteristics compared to AH Plus (AHP). Solubility was examined according to ISO guidelines in deionised water and phosphate buffer saline (PBS) for 3 months. Surface characteristics and elemental analysis were conducted with scanning electron microscopy and energy-dispersive X-ray spectroscopy, while ion release was determined with ICP-OES. In PBS, solubility values were significantly lower than those recorded in deionised water for both materials (p < 0.05). Upon the AHPB sealer surface, crystalline structures developed that differed in composition, dependent on the immersion solution, whereas no crystal formations were observed on AHP. Calcium ion release of AHPB was significantly higher than AHP throughout the whole study period (p = 0.028). Immersion solution significantly affected solubility and superficial characteristics of materials, highlighting the need to modify experimental protocols to resemble clinical conditions.

本研究考察了AH Plus生物陶瓷封口剂(AHPB)的溶解度、离子释放以及与AH Plus (AHP)相比表面特性的改变。根据ISO指南在去离子水和磷酸盐缓冲盐水(PBS)中检测溶解度3个月。采用扫描电镜和能量色散x射线光谱对其进行了表面特征和元素分析,并用ICP-OES测定了离子释放。在PBS中,两种材料的溶解度值明显低于在去离子水中记录的溶解度值
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引用次数: 0
Manufacturing Order Matters? Exploring the Impact of Heat Treatment and Machining Sequences on the NiTi Instruments Properties 制造订单重要吗?探讨热处理和加工顺序对NiTi仪器性能的影响。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-26 DOI: 10.1111/aej.12953
Emmanuel J. N. L. Silva, Jorge N. R. Martins, Livia Neri Menezes de Oliveira, Mylena do Rosário do Pereira, Murilo Priori Alcalde, Victor T. L. Vieira, Francisco Manuel Braz Fernandes, Marco A. Versiani

This study assessed how manufacturing sequence affects the metallurgical and mechanical properties of two nickel-titanium instruments: Procodile Q (heat-treated before machining) and Procodile +HT (heat-treated after machining). Both instruments (n = 74 each, size 25/0.06) were analysed for design, NiTi composition, phase transformation temperatures and mechanical performance (cyclic fatigue at 20°C and 35°C, torsional fatigue, bending load, buckling strength, cutting ability, microhardness and roughness). The Student's t-test and Mann–Whitney test were used for statistical analysis (α = 5%). Results showed that both instruments had similar design and composition. Procodile Q had a slightly higher austenitic start temperature and superior cyclic fatigue resistance at 20°C and 35°C (p < 0.001), along with higher surface roughness (p = 0.041). Other mechanical properties showed no significant differences (p > 0.05). These findings suggest that the order of machining and heat treatment of Procodile instruments had minimal impact on overall performance, primarily affecting cyclic fatigue resistance and surface roughness.

本研究评估了两种镍钛仪器:procodiile Q(加工前热处理)和procodiile +HT(加工后热处理)的制造顺序对其冶金和力学性能的影响。分析了两种仪器(n = 74,尺寸25/0.06)的设计、NiTi成分、相变温度和机械性能(20°C和35°C的循环疲劳、扭转疲劳、弯曲载荷、屈曲强度、切削能力、显微硬度和粗糙度)。统计学分析采用Student’st检验和Mann-Whitney检验(α = 5%)。结果表明,两种仪器具有相似的设计和组成。procodiile Q在20°C和35°C时具有略高的奥氏体启动温度和较好的循环疲劳抗力(p < 0.05)。这些结果表明,加工顺序和热处理顺序对Procodile仪器的整体性能影响最小,主要影响循环疲劳抗力和表面粗糙度。
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引用次数: 0
Impact of Instrumentation Technique on Endodontic Treatment Quality in Curved Molars: A Retrospective Analysis 器械技术对弯曲磨牙根管治疗质量影响的回顾性分析。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-26 DOI: 10.1111/aej.12952
Carolina Clasen Vieira, Luciéli Andréia Zajkowski, Daniele Assumpção Prado, Fábio de Almeida Gomes, Patrícia Maria Poli Kopper, Katerine Jahnecke Pilownic, Daiana Elisabeth Böttcher, Tatiana Pereira Cenci, Erick Miranda Souza, Fernanda Geraldo Pappen

This cross-sectional study evaluated technical failures in root canal treatments (RCTs) of curved molars (> 10°) performed by undergraduate students and their association with instrumentation techniques. Evaluations included filling extension, density, taper and ledge/zip formation. Bivariate analysis (chi-square, 5% significance) calculated odds ratios (OR) and 95% confidence intervals (CI). Among 188 RCTs, manual instrumentation had higher risks of ledge/zip formation, inadequate density, taper and underfilling, while reciprocating techniques showed more overfilling. Root curvature did not influence failure rates. The study showed 100% power for detecting underfilling, inadequate density and taper; 97.98% for overfilling and 71.11% for ledge/zip formation. Instrumentation technique significantly impacted failure frequency, with manual techniques associated with more complications.

本横断面研究评估了本科生在弯曲磨牙(bbb10°)根管治疗中的技术失败及其与器械技术的关系。评价内容包括充填延伸、密度、锥度和边缘/压缩地层。双变量分析(卡方,5%显著性)计算优势比(OR)和95%置信区间(CI)。在188项随机对照试验中,手动仪器存在较高的隆起/凹陷形成、密度不足、锥形和欠填充风险,而往复仪器存在较多的过填充风险。根部曲率对故障率没有影响。研究表明,检测欠填、密度不足和锥度的能力为100%;过充填率为97.98%,岩脊/zip层为71.11%。仪器技术显著影响故障频率,手工技术与更多并发症相关。
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引用次数: 0
Content and Reliability Analysis of YouTube Videos Regarding Minimally Invasive Endodontics: A Cross-Sectional Analysis 关于微创牙髓学的YouTube视频内容和可靠性分析:一项横断面分析。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-24 DOI: 10.1111/aej.12954
Özge Kurt, Emine Şimşek

This study aims to evaluate the content and quality of videos related to minimally invasive endodontics available on the YouTube platform. Twenty videos were analysed using the video information and quality index for content quality, the Global Quality Scale for educational value, the Journal of the American Medical Association benchmark for source reliability and the adapted DISCERN tool, known as the reliability score, for overall information accuracy. Data were assessed using Kolmogorov–Smirnov, Mann–Whitney U and Spearman's correlation tests. The findings indicate that low-quality videos had higher view counts, while videos of moderate quality achieved higher Global Quality Scale, reliability score and video information and quality index scores. Additionally, statistically significant positive correlations were identified among these scores. In conclusion, most online content regarding minimally invasive endodontics presents limited accuracy and reliability, and professional consultation is recommended.

本研究旨在评估YouTube平台上与微创牙髓学相关的视频内容和质量。对20个视频进行了分析,使用视频信息和质量指数来衡量内容质量,使用全球质量量表来衡量教育价值,使用美国医学协会杂志的基准来衡量来源的可靠性,并使用适应性的DISCERN工具来衡量整体信息的准确性。采用Kolmogorov-Smirnov、Mann-Whitney U和Spearman相关检验对数据进行评估。研究结果表明,低质量视频的观看次数较高,而中等质量视频的全球质量量表、可靠性评分以及视频信息和质量指标得分较高。此外,这些分数之间存在统计学上显著的正相关。总之,大多数关于微创牙髓学的在线内容的准确性和可靠性有限,建议进行专业咨询。
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引用次数: 0
Antibacterial and Antibiofilm Efficacy of Green Synthesised Haloxylon Capped Silver Nanoparticles Against Enterococcus faecalis 绿色合成氟氧ylon包覆银纳米颗粒对粪肠球菌的抗菌和抗生物膜效果。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-22 DOI: 10.1111/aej.12948
Rawda O. Alsuwaidi, Priyadharshini Sekar, Abdelaziz Elgamouz, Shashikant P. Patole, Alaa Alatta, Anil Kishen, Venkateshbabu Nagendrababu

This study synthesised and characterised Haloxylon-capped silver nanoparticles (Haloxylon-AgNPs) and assessed their antibacterial and antibiofilm activity against Enterococcus faecalis. The study also examined Haloxylon-AgNPs' ability to target E. faecalis biofilms in root canals. Haloxylon salicornicum extract was used to synthesise silver nanoparticles. Physiochemical characterisation of Haloxylon-AgNPs was conducted. Antimicrobial and antibiofilm activity of Haloxylon-AgNPs was studied by agar diffusion method, minimum inhibitory concentration (MIC) determination, time-kill assay, confocal laser scanning microscopy (CLSM) and qPCR for virulence gene attenuation. One hundred and twenty extracted teeth were infected with E. faecalis and treated with either Haloxylon-AgNPs, chlorhexidine, calcium hydroxide or saline. The data were analysed using a one-way ANOVA and Tukey multiple comparison test to investigate the bacterial reduction between groups (p < 0.05, significant; p < 0.001, highly significant). A significant reduction in the thickness of biofilm and expression of cylA virulence gene of Haloxylon-AgNPs treated E. faecalis was observed. No difference was observed between Haloxylon-AgNPs, chlorhexidine and calcium hydroxide in the tooth model.

本研究合成并表征了Haloxylon-AgNPs纳米银微粒(Haloxylon-AgNPs),并评估了它们对粪肠球菌的抗菌和抗生物膜活性。该研究还检测了Haloxylon-AgNPs靶向根管中粪肠杆菌生物膜的能力。以盐角兰提取物为原料合成纳米银。对卤代酮agnps进行了理化表征。采用琼脂扩散法、最低抑菌浓度(MIC)测定、时间杀伤法、共聚焦激光扫描显微镜(CLSM)和毒力基因衰减qPCR等方法研究了Haloxylon-AgNPs的抑菌活性和抗生物膜活性。120颗拔除的牙齿感染粪肠杆菌,分别用Haloxylon-AgNPs、氯己定、氢氧化钙或生理盐水处理。采用单因素方差分析和Tukey多重比较检验对数据进行分析,以调查组间细菌减少的情况(p
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引用次数: 0
Comparative Evaluation of Removal of Gutta Percha and Bioceramic Sealer Using EdgeFile-XR and ProTaper Universal Retreatment Files: Micro-Computed Tomography Study EdgeFile-XR和ProTaper通用再处理文件去除杜仲胶和生物陶瓷密封剂的比较评价:微计算机断层扫描研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-05-22 DOI: 10.1111/aej.12949
Sindhuja Srirama, Sooriaprakas Chandrasekaran, Buvaneshwari Arul, Velmurugan Natanasabapathy

Aim of the study was to compare the removal of gutta-percha and bioceramic sealer using EdgeFile-XR (EF-XR) retreatment file system and PTU-RE files from mesial root from mandibular molars with mild to moderate curvature using Micro Computed Tomography (Micro-CT) imaging. EF-XR is a newly introduced retreatment file for removal of gutta-percha that has not been evaluated before. Sixteen anatomically matched mesial roots of mandibular molars with mild to moderate curvature were allotted into two groups (n = 8), ProTaper Universal Retreatment files (PTU-RE) and EF-XR. Root canal instrumentation and single cone obturation with BioRoot RCS sealer was performed. Following this, retreatment was done. Pre-and post-Micro-CT analysis was performed to determine the volume of remaining obturating material and root dentin removed and statistically analysed. Within the limitations of the present study, it can be concluded that PTU-RE retreatment files are better than EF-XR files for retrieval of gutta-percha and BioRoot RCS sealer.

本研究的目的是比较使用EdgeFile-XR (EF-XR)再治疗文件系统和PTU-RE文件从轻度至中度弯曲的下颌磨牙近中根使用微计算机断层扫描(Micro- ct)成像去除胶过胶和生物陶瓷封口剂的效果。EF-XR是一种新引入的用于去除杜仲胶的再处理文件,以前没有对其进行过评估。将16例解剖匹配的轻度至中度弯曲下颌磨牙近中根分为ProTaper通用再治疗锉组(PTU-RE)和EF-XR组(n = 8)。采用BioRoot RCS密封器进行根管预备和单锥体封闭。在此之后,进行再处理。进行micro - ct前后分析,以确定剩余封闭材料和根牙本质去除的体积,并进行统计学分析。在本研究的限制下,可以得出结论,PTU-RE再处理文件比EF-XR文件更适合于检索杜胶和BioRoot RCS密封剂。
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引用次数: 0
期刊
Australian Endodontic Journal
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