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Evaluation of Postoperative Pain Following Root Canal Treatment Performed With and Without a Dental Operating Microscope: A Randomised Clinical Trial 有和没有牙科手术显微镜的根管治疗术后疼痛的评估:一项随机临床试验。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-22 DOI: 10.1111/aej.70016
Vivek Hegde, Srilatha Shanmugasundaram, Hussain Abbas Mookhtiar, Khatija Iqbal Memon, Nishat Anjum Nagaonkar, Nandini Suresh, Velmurugan Natanasabapathy, Henry F. Duncan, Venkateshbabu Nagendrababu

The aim of this study was to compare postoperative pain levels in patients with necrotic teeth after non-surgical root canal treatment (NSRCT) using or not using a dental operating microscope (DOM). One hundred patients with pulp necrosis and symptomatic apical periodontitis were randomly assigned to two groups (n = 50): Group 1 (DOM) and Group 2 (no DOM). Postoperative pain was measured using the Numeric Rating Scale (NRS) at 6 h, 12 h, 1 day, 3 days, and 7 days. The pain intensity was determined by calculating the mean pain score at each interval and was statistically analysed. The results showed no significant difference in pain intensity between the two groups. However, gender and tooth type affected pain levels at 6 h, 12 h, and 1 day. In conclusion, using a DOM during NSRCT did not significantly reduce postoperative pain.

本研究的目的是比较使用或不使用牙科操作显微镜(DOM)进行非手术根管治疗(NSRCT)后坏死牙齿患者的术后疼痛水平。将100例牙髓坏死伴症状性根尖牙周炎患者随机分为两组(n = 50): 1组(DOM)和2组(无DOM)。术后疼痛在6小时、12小时、1天、3天和7天采用数字评定量表(NRS)进行测量。通过计算每个间隔的平均疼痛评分来确定疼痛强度,并进行统计学分析。结果显示,两组疼痛强度无显著差异。然而,性别和牙齿类型会影响6小时、12小时和1天的疼痛程度。总之,在NSRCT期间使用DOM并没有显著减轻术后疼痛。
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引用次数: 0
Assessment of the Accuracy of Modern Artificial Intelligence Chatbots in Responding to Endodontic Queries 现代人工智能聊天机器人回答牙髓问题的准确性评估。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-20 DOI: 10.1111/aej.70012
Melis Çakar, Ayşe Tuğba Eminsoy Avcı, Salih Düzgün, Tuğrul Aslan, Kübra Nur Hekimoğlu

This study aims to compare the accuracy of modern AI chatbots, including Gemini 1.5 Flash, Gemini 1.5 Pro, ChatGPT-3.5 and ChatGPT-4, in responding to endodontic questions and supporting clinicians. Forty yes/no questions covering 12 endodontic topics were formulated by three experts. Each question was presented to the AI models on the same day, with a new chat session initiated for each. The agreement between chatbot responses and expert consensus was assessed using Cohen's kappa test (p < 0.05). ChatGPT-3.5 demonstrated the highest accuracy (80%), followed by ChatGPT-4 (77.5%), Gemini 1.5 Pro (72.5%) and Gemini 1.5 Flash (60%). The agreement levels ranged from weak (ChatGPT models) to minimal (Gemini Flash). The findings indicate variability in chatbot performance, with ChatGPT models outperforming Gemini. However, reliance on AI-generated responses for clinical decision-making remains questionable. Future studies should incorporate more complex clinical scenarios and broader analytical approaches to enhance the assessment of AI chatbots in endodontics.

本研究旨在比较包括Gemini 1.5 Flash、Gemini 1.5 Pro、ChatGPT-3.5和ChatGPT-4在内的现代AI聊天机器人在回答牙髓问题和支持临床医生方面的准确性。由三位专家制定了涵盖12个牙髓主题的40个是/否问题。每个问题都在同一天提交给人工智能模型,并为每个问题启动一个新的聊天会话。聊天机器人的反应和专家共识之间的一致性使用科恩的卡帕测试进行评估
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引用次数: 0
In Vitro Assessment of the Effects of Endodontic Sealers on Cell Viability, Adhesion, and Migration 牙髓密封剂对细胞活力、粘附和迁移影响的体外评估。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-18 DOI: 10.1111/aej.70013
Anna Carolina Neves Leutz, Victor Augusto Benedicto dos Santos, Ana Cristina Padilha Janini, Amanda Nowicki de Salles, Brenda Paula Figueiredo de Almeida Gomes, Adriana de Jesus Soares, Talita Tartari, Marina Angélica Marciano

This study aimed to evaluate the in vitro cytocompatibility and bioactivity of the newly launched calcium silicate-based sealer BioRoot Flow, compared with other calcium silicate-based sealers (AH Plus Bioceramic Sealer and BioRoot RCS) and the epoxy resin-based AH Plus Jet. NIH/3 T3 fibroblasts were used to assess cell viability, adhesion, and migration. Material characterisation was performed using SEM, EDS, and XRD. BioRoot RCS exhibited the highest cell viability, while BioRoot Flow showed fewer adherent cells and reduced migration at 72 h. EDS revealed zirconium content in BioRoot Flow, and XRD confirmed calcite presence in all calcium silicate-based sealers. Variations in cell behaviour may be related to differences in chemical composition and surface properties, highlighting the need for further investigation.

本研究旨在评估新推出的硅酸钙基密封剂BioRoot Flow的体外细胞相容性和生物活性,并与其他硅酸钙基密封剂(AH Plus Bioceramic sealer和BioRoot RCS)和环氧树脂基AH Plus Jet进行比较。NIH/3 T3成纤维细胞用于评估细胞活力、粘附和迁移。采用SEM、EDS、XRD对材料进行了表征。在72 h时,BioRoot RCS的细胞活力最高,而BioRoot Flow的贴壁细胞较少,迁移量减少。EDS显示了BioRoot Flow中的锆含量,XRD证实了所有硅酸钙基密封剂中都存在方解石。细胞行为的变化可能与化学成分和表面性质的差异有关,这突出了进一步研究的必要性。
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引用次数: 0
Evaluation of the Retreatability and Different Supplementary Cleaning Techniques for Removing Bioceramic Sealers in Oval-Shaped Canals 生物陶瓷封闭物在椭圆管中去除的可退性及不同辅助清洁技术的评价。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-15 DOI: 10.1111/aej.70011
Fernando Peña-Bengoa, Jaime Abarca, Carolina Cáceres, Karin Steinfort, Sven Eric Niklander, Emmanuel João Nogueira Leal Silva

This study evaluated the retreatability of two bioceramic-based sealers in oval-shaped canals and the effectiveness of supplementary cleaning techniques for removing sealer remnants. Mandibular premolars were obturated with either NeoSEALER Flo or AH Plus Bioceramic. After obturation, specimens were retreated followed by supplementary cleaning with XP-Endo Finisher R, EasyClean, or passive ultrasonic irrigation. Sealer remnants were analysed using confocal laser scanning microscopy and scanning electron microscopy. AH Plus Bioceramic showed a significantly lower residual sealer percentage than NeoSEALER Flo in the coronal and middle thirds. XP-Endo Finisher R was more effective for NeoSEALER Flo in the apical third, while passive ultrasonic irrigation was superior for AH Plus Bioceramic in the coronal and middle thirds. Scanning electron microscopy revealed sealer remnants in all groups, with partial obstruction of dentinal tubules. Bioceramic sealers exhibit different retreatability, and supplementary cleaning protocols improved sealer removal, but none achieved complete canal wall cleanliness.

本研究评估了两种基于生物陶瓷的封闭剂在椭圆形管中的可退性,以及辅助清洁技术去除封闭剂残留物的有效性。下颌前磨牙用NeoSEALER floo或AH Plus生物陶瓷进行封闭。封闭后,退回标本,然后用XP-Endo Finisher R、EasyClean或被动超声冲洗进行补充清洁。采用激光共聚焦扫描显微镜和扫描电镜对封口剂残留物进行分析。AH Plus Bioceramic在冠状和中间三分之一处的残留封闭百分比明显低于NeoSEALER Flo。XP-Endo Finisher R对NeoSEALER Flo的根尖三分之一更有效,而被动超声冲洗对AH Plus Bioceramic的冠状和中三分之一更有效。扫描电镜显示,所有组均有牙本质小管部分阻塞。生物陶瓷密封剂表现出不同的可退性,补充清洁方案改善了密封剂的去除,但没有一种能达到完全的管壁清洁度。
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引用次数: 0
Investigation of an Injectable Concentrated Growth Factor Gel for Pulp Tissue Regeneration 可注射浓缩生长因子凝胶用于牙髓组织再生的研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-15 DOI: 10.1111/aej.70015
Minghao Wang, Qian Guo, Wanmin Zhao, Zihan Dai, Xiaoru Zhu, Xiaomiao Zhu, Zhihua Wang, Shengchao Wang, Paul Roy Cooper, Wenkai Jiang, Wenxi He

Cell homing and stem cell transplantation offers promising approaches for pulp regeneration. This study investigated the efficacy of an injectable concentrated growth factor gel for dental pulp regeneration in beagles. Six groups of beagle teeth were studied: Blank control group, CGF group, Collagen sponge group, CGF + Collagen sponge group, Dental pulp stem cells group, CGF + Dental pulp stem cells group. Specimens were examined by CBCT and histological analysis. No obvious change was identified in the periapical condition. Fewest inflammatory cells were found in the CGF + CS group. Odontoblast-like cells and dentin-like tissue were identified in the root canals of experimental groups, and the thickness of dentin-like tissue was positively correlated with the number of odontoblast-like cells. CD31-positive cells appeared in root canals containing pulp-like tissue. Injectable concentrated growth factor (CGF) can induce in situ pulp-dentin complex regeneration either on its own or in combination with collagen sponge and dental pulp stem cells.

细胞归巢和干细胞移植为牙髓再生提供了很有前途的方法。本研究探讨了一种可注射的浓缩生长因子凝胶用于小猎犬牙髓再生的效果。选择空白对照组、CGF组、海绵胶原组、CGF +海绵胶原组、牙髓干细胞组、CGF +牙髓干细胞组,共6组。标本行CBCT检查和组织学分析。根尖周围未见明显变化。CGF + CS组炎症细胞最少。实验组根管内均可见成牙本质样细胞和牙本质样组织,牙本质样组织的厚度与成牙本质样细胞的数量呈正相关。含有髓样组织的根管内出现cd31阳性细胞。注射用浓缩生长因子(CGF)可单独或与胶原海绵、牙髓干细胞联合诱导牙本质-牙本质复合体原位再生。
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引用次数: 0
Postoperative Pain Following Single-Visit Versus Two-Visit Endodontic Retreatment – A Comparison of Inter-Appointment and Post-Obturation Periods: Randomised Clinical Trial 单次与两次牙髓再治疗后的术后疼痛——预约期间和封闭后时间的比较:随机临床试验。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-13 DOI: 10.1111/aej.70004
Fulya Karaoğlan, Ayşenur Kiziltaş Gül, Mehmet Kemal Çalışkan

This study aimed to compare the incidence of postoperative pain after single-visit retreatment and two-visit retreatment, assessing pain both after the inter-appointment and post-obturation periods in teeth with asymptomatic periapical lesions. 100 single-rooted endodontically treated teeth were randomly assigned to single-visit or two-visit groups. Postoperative pain was assessed at 12, 24, 48 h and 7 days after obturation and the inter-appointment period. Data were analysed using the Chi-square, Fisher's Exact, McNemar and McNemar–Bowker tests. Postoperative pain after obturation was similar between the groups at 12, 24 h (p > 0.05), but higher at 48 h in single-visit (p < 0.05). No differences were observed between single-visit and inter-appointment periods (p > 0.05). Within the two-visit group, pain decreased in the post-obturation period compared to the inter-appointment period at 12, 24, 48 h (p < 0.05). These findings suggest that the pain experienced between appointments was greater than post-obturation and single-visit retreatment is clinically feasible in terms of postoperative pain.

本研究旨在比较无症状根尖周围病变的牙齿在一次再治疗和两次再治疗后的术后疼痛发生率,评估在预约期间和封闭后的疼痛。100颗单根根管治疗的牙齿随机分为单次或两次就诊组。术后疼痛分别于缝合后12、24、48小时和7天及预约间期进行评估。使用卡方检验、Fisher’s Exact检验、McNemar检验和McNemar- bowker检验对数据进行分析。术后12、24 h组间疼痛差异无统计学意义(p < 0.05), 48 h组间疼痛差异有统计学意义(p < 0.05)。在两次就诊组中,与预约期间的12、24、48小时相比,闭孔后疼痛减轻
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引用次数: 0
Guided Endodontics in Managing Root Canal Treatment for Anomalous Teeth—A Narrative Review 引导牙髓学在畸形牙根管治疗中的应用综述。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-12 DOI: 10.1111/aej.70007
Pouya Sabanik, Mohammad Samiei, Shiva Tavakkoli Avval, Bruno Cavalcanti

This review evaluates the effectiveness and clinical applicability of guided endodontics (GE) in managing dental anomalies, which present challenges for conventional endodontics. The primary objective is to assess how GE enhances treatment predictability and minimises errors in cases such as dens invaginatus (DI), dentinogenesis imperfecta (DGI), dentinal dysplasia (DD), dens evaginatus (DE) and dental fusion. A narrative review was conducted using a comprehensive search across PubMed/MEDLINE, Scopus, Web of Science, EMBASE and Cochrane Library databases for studies published 2015–2025. Nine studies met the inclusion criteria. GE was found to offer high success rates in the treatment of DI, DGI and DD. The integration of CBCT and 3D-printed guides allowed for minimally invasive access cavity preparation, reduced iatrogenic complications and improved precision. Despite these advantages, challenges include increased cost, being time-consuming and limitations in curved canals. Guided endodontics holds promise as a transformative technique in modern endodontic practice.

这篇综述评估了引导牙髓学(GE)在治疗牙畸形方面的有效性和临床适用性,这些牙畸形是传统牙髓学面临的挑战。主要目的是评估GE如何提高治疗的可预测性,并最大限度地减少诸如牙槽突(DI)、牙本质发育不全(DGI)、牙本质发育不良(DD)、牙槽突外翻(DE)和牙融合等病例的错误。使用PubMed/MEDLINE、Scopus、Web of Science、EMBASE和Cochrane Library数据库对2015-2025年发表的研究进行综合检索。9项研究符合纳入标准。GE在治疗DI、DGI和DD方面具有很高的成功率。CBCT和3d打印导具的结合可以实现微创通道腔准备,减少医源性并发症,提高精度。尽管有这些优势,但挑战包括成本增加、耗时和弯曲运河的局限性。引导牙髓治疗有望成为现代牙髓治疗实践中的一种变革性技术。
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引用次数: 0
Factors Influencing Technology Adoption Among Endodontists: A Questionnaire-Based Pilot Study 影响牙髓医生采用技术的因素:一项基于问卷的初步研究。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-12 DOI: 10.1111/aej.70005
Abhishek Parolia, David C. Johnsen, Fang Qian, Sara E. Miller, Fabricio B. Teixeira

This pilot study explores how Endodontists make decisions regarding the adoption of rapidly evolving technologies in clinical practice, an area with little existing literature. Graduates of an Advanced Endodontics Program were surveyed to assess the importance of 23 decision-making factors using a 5-point Likert scale. The survey was distributed via Qualtrics and remained open for 3 months, with reminders sent to participants. A total of 46 responses were received, yielding a 37% response rate. The most highly ranked factors influencing technology adoption were evidence (100%), safety/risk (97.8%), health benefits (91.3%), quality (89.1%) and post-implementation patient care quality improvement. In contrast, company representative input (15.8%), initial disruption (33.3%) and training duration (45.5%) were rated as least important. These findings provide valuable insight into the priorities of Endodontists, emphasising a strong commitment to patient-centered care and clinical rigour in technology adoption decisions.

这项初步研究探讨了牙髓医生如何在临床实践中采用快速发展的技术,这是一个现有文献很少的领域。对高级牙髓学课程的毕业生进行调查,使用5分李克特量表评估23个决策因素的重要性。该调查通过Qualtrics分发,开放时间为3个月,并向参与者发送提醒。共收到46份回应,回应率为37%。影响技术采用排名最高的因素是证据(100%)、安全/风险(97.8%)、健康益处(91.3%)、质量(89.1%)和实施后患者护理质量改善。相比之下,公司代表的投入(15.8%)、最初的干扰(33.3%)和培训时间(45.5%)被评为最不重要的。这些发现为牙髓医生的优先事项提供了有价值的见解,强调了对以患者为中心的护理和临床技术采用决策的严格承诺。
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引用次数: 0
Case Report of Maxillary Alveolar Rhabdomyosarcoma Misdiagnosed as Periapical Lesion: Clinicopathological Alerts and Life-Saving Lessons for Dentists. 上颌牙槽横纹肌肉瘤误诊为根尖周围病变1例:临床病理警示及牙医的救命经验。
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-11 DOI: 10.1111/aej.70009
Saliha Akçay Köprücü, Erdal Rahman Köprücü, Aysun Atasoy Sındıraç, Ümit Çobanoğlu

This report describes a rare case of alveolar rhabdomyosarcoma initially presenting with clinical features resembling an endodontic lesion. A 15-year-old male presented with progressive right maxillary swelling initially treated as a dental abscess. Radiographic examination revealed a poorly defined destructive lesion associated with the apices of teeth #14-18, exhibiting expansion and destruction of the maxillary sinus walls. Additional imaging demonstrated a contrast-enhancing soft tissue mass with extensive local invasion. Histopathological examination confirmed alveolar rhabdomyosarcoma that was positive for myogenin, myoD1, CD56 and desmin, with a Ki-67 proliferation index of 80%-90%. This case highlights that approximately 3% of non-endodontic periapical lesions are malignant, reinforcing the importance of thorough clinical, radiographic and histopathological examinations for lesions demonstrating atypical features. Dentists should maintain vigilance when evaluating periapical lesions, particularly those with atypical presentations or unresponsive to conventional therapy.

本报告描述一例罕见的肺泡横纹肌肉瘤,最初表现为类似牙髓病变的临床特征。一个15岁的男性提出了进行性上颌肿胀最初治疗作为牙脓肿。x线检查显示一界限不清的与牙尖相关的破坏性病变,显示上颌窦壁扩张和破坏。附加影像显示一个增强对比的软组织肿块,并伴有广泛的局部侵犯。组织病理学检查证实肺泡横纹肌肉瘤,肌原素、myoD1、CD56和desmin阳性,Ki-67增殖指数为80%-90%。本病例强调约3%的非根管性根尖周病变是恶性的,强调了对表现出非典型特征的病变进行彻底的临床、放射学和组织病理学检查的重要性。牙医在评估根尖周围病变时应保持警惕,特别是那些表现不典型或对常规治疗无反应的病变。
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引用次数: 0
Ex Vivo Evaluation of the Fit of Matched Gutta Percha Points in Human Root Canals Prepared With the Corresponding Nickel-Titanium Files 镍钛锉制备的人根管配点的离体评价
IF 1.5 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-08-08 DOI: 10.1111/aej.70000
Samuel Deng, Paul V. Abbott

The aim of this study was to evaluate the fit of matched gutta-percha (GP) points in tooth root canals after preparation with their corresponding rotary files. Single canal human tooth roots were matched according to root canal volume and eccentricity. Forty-five roots were divided into three experimental groups (n = 15) and sequentially prepared with either SybronEndo TF Adaptive SM2, ProTaper Next X2 or ProTaper Ultimate F2 files to working length. The corresponding GP points were placed into the prepared root canals without cement and scanned with micro-computed tomographic imaging. The unfilled volume and unfilled areas at 1, 3, 5 and 7 mm from working length were evaluated. Over one-third of the root canal space remained unfilled in all groups. There was no significant difference between unfilled areas measured at the different distances. Unprepared and unfilled spaces remained in root canals after preparation with rotary files when filled with the corresponding GP points.

本研究的目的是评估牙根管中匹配的杜胶(GP)点与相应的旋转锉预备后的配合度。根据根管体积和偏心率进行单管人牙根匹配。45根根分为3个实验组(n = 15),依次用SybronEndo TF Adaptive SM2、ProTaper Next X2或ProTaper Ultimate F2文件制备至工作长度。将相应的GP点置入预备好的根管中,不使用骨水泥,用微计算机断层成像扫描。评估距离工作长度1,3,5和7mm处的未填充体积和未填充区域。在所有组中,超过三分之一的根管空间未填充。在不同距离测量的未填充面积之间无显著差异。在用旋转锉预备并填充相应的GP点后,在根管中保留未准备和未填充的空隙。
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引用次数: 0
期刊
Australian Endodontic Journal
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