{"title":"Activity Detection and Inhibitor Development of GH92 Mannosidase Derived from Streptococcus pneumoniae","authors":"Ryosuke Koyama","doi":"10.4052/tigg.2336.6j","DOIUrl":"https://doi.org/10.4052/tigg.2336.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"101 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139236856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Application of Supramolecular Glycopolymer","authors":"Norihiko Sasaki","doi":"10.4052/tigg.2301.1e","DOIUrl":"https://doi.org/10.4052/tigg.2301.1e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"78 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139238058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Substrate Specificity of Chondroitinase ABC-I Based on Analyses of Biochemical Reactions and Crystal Structure","authors":"Ippei Watanabe, Akimasa Miyanaga","doi":"10.4052/tigg.2319.1j","DOIUrl":"https://doi.org/10.4052/tigg.2319.1j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"7 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139236789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"超分子グライコポリマーの合成と応用","authors":"Norihiko Sasaki","doi":"10.4052/tigg.2301.1j","DOIUrl":"https://doi.org/10.4052/tigg.2301.1j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"174 ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139236957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"呼吸上皮細胞へのB3GAT1導入による糖鎖発現変化がウィルス感染を防ぐ","authors":"Jyoji Morise","doi":"10.4052/tigg.2330.6j","DOIUrl":"https://doi.org/10.4052/tigg.2330.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"34 41","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alternation of Glycan Expression by Introducing B3GAT1 into the Respiratory Epithelium Restricts Viral Infections","authors":"Jyoji Morise","doi":"10.4052/tigg.2330.6e","DOIUrl":"https://doi.org/10.4052/tigg.2330.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"144 ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>N</i>-グリコシル化VHH抗体","authors":"Takahiko Matsushita","doi":"10.4052/tigg.2327.6j","DOIUrl":"https://doi.org/10.4052/tigg.2327.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a group of proteins anchored to glycolipid on the cell membrane and are ubiquitous in eukaryotes. The basic structure of the glycosylphosphatidylinositol (GPI) moiety comprises ethanolamine phosphate, three mannose residues, glucosamine and phosphatidylinositol (PI). This basic structure and the mechanism by which proteins are anchored to membranes via the structure are conserved among organisms. After the identification of paroxysmal nocturnal hemoglobinuria (PNH), diseases derived from GPI anchor deficiencies were discovered. To comprehend these diseases fully, a comprehensive understanding of GPI anchor biosynthesis, encompassing the intricate remodeling of glycans and lipids, becomes imperative. We used mutant strains of Saccharomyces cerevisiae in which the gene encoding the enzyme that catalyzes remodeling was knocked out and a model molecule for GPI-APs to observe the remodeling process. Herein, we introduce a method for analyzing and identifying glycan structures in GPI anchors using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS).
{"title":"Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry","authors":"Miyako Nakano","doi":"10.4052/tigg.2209.1e","DOIUrl":"https://doi.org/10.4052/tigg.2209.1e","url":null,"abstract":"Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a group of proteins anchored to glycolipid on the cell membrane and are ubiquitous in eukaryotes. The basic structure of the glycosylphosphatidylinositol (GPI) moiety comprises ethanolamine phosphate, three mannose residues, glucosamine and phosphatidylinositol (PI). This basic structure and the mechanism by which proteins are anchored to membranes via the structure are conserved among organisms. After the identification of paroxysmal nocturnal hemoglobinuria (PNH), diseases derived from GPI anchor deficiencies were discovered. To comprehend these diseases fully, a comprehensive understanding of GPI anchor biosynthesis, encompassing the intricate remodeling of glycans and lipids, becomes imperative. We used mutant strains of Saccharomyces cerevisiae in which the gene encoding the enzyme that catalyzes remodeling was knocked out and a model molecule for GPI-APs to observe the remodeling process. Herein, we introduce a method for analyzing and identifying glycan structures in GPI anchors using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS).","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>N</i>-glycosylated VHH Antibodies","authors":"Takahiko Matsushita","doi":"10.4052/tigg.2327.6e","DOIUrl":"https://doi.org/10.4052/tigg.2327.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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