{"title":"Target-Specific <i>O</i>-linked <i>N</i>-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of <i>O</i>-GlcNAcylation in <i>β</i>-catenin","authors":"Haruki Odaka","doi":"10.4052/tigg.2309.6e","DOIUrl":"https://doi.org/10.4052/tigg.2309.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Aspects of Cancer-associated Glycans in Gliomas","authors":"Yuki Ohkawa","doi":"10.4052/tigg.2306.2j","DOIUrl":"https://doi.org/10.4052/tigg.2306.2j","url":null,"abstract":"哺乳類細胞は多種多様な糖鎖を発現しており、その発現パターンは糖転移酵素やその基質、糖分解酵素などによって厳密に制御されている。しかし、病変部においてはしばしば、糖鎖発現制御機構に異常が生じ、正常ではみられない糖鎖が発現する。特にがんにおいては、それら糖鎖の異所的な発現が同定され、その幾つかはバイオマーカーとして利用される一方で、治療標的として研究されている。本稿では著者とその研究グループがこれまでに明らかにしてきたガングリオシドGD3およびヘパラン硫酸グリコサミノグリカンの、グリオーマにおける悪性形質増強に寄与する分子機能を紹介する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polysialic Acid/Polysialyltransferases and Psychiatric Disorders","authors":"Masaya Hane","doi":"10.4052/tigg.2313.2e","DOIUrl":"https://doi.org/10.4052/tigg.2313.2e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45320146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glycoengineering for the Production of Lysosomal Enzymes","authors":"Yu-He Tang, Ganglong Yang, Morihisa Fujita","doi":"10.4052/tigg.2204.1e","DOIUrl":"https://doi.org/10.4052/tigg.2204.1e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47530956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polysialic Acid/Polysialyltransferases and Psychiatric Disorders","authors":"Masaya Hane","doi":"10.4052/tigg.2313.2j","DOIUrl":"https://doi.org/10.4052/tigg.2313.2j","url":null,"abstract":"ポリシアル酸はシアル酸の直鎖状のホモポリマーであり、胎児脳では広く発現しているが、成体脳では神経可塑性の高い限られた領域にしか発現していない。従来、ポリシアル酸はその物理化学的性質から反接着分子と考えられていた。しかし、近年、脳の発達や高次脳機能にかかわる生理活性物質を細胞表面付近で直接結合させ、その作用を包括的に制御していることが明らかになった。また、死後脳の解析や大規模比較ゲノム解析により、ポリシアル酸やその生合成酵素であるST8SIA2と精神疾患との関連性が明らかにされてきている。本稿では、ST8SIA2に見出された様々な一塩基多型（SNPs）のポリシアル酸の生合成及び機能に与える影響について、培養細胞やマウスを用いた生化学的解析の結果を中心に紹介する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glycoengineering for the Production of Lysosomal Enzymes","authors":"Yu-He Tang, Ganglong Yang, Morihisa Fujita","doi":"10.4052/tigg.2204.1j","DOIUrl":"https://doi.org/10.4052/tigg.2204.1j","url":null,"abstract":"リソソームは細胞内外で不要となった核酸、タンパク質、脂質、糖質などの生体高分子の分解を行う細胞内小器官である。内部は酸性に保たれており、約60種類の多種多様な加水分解酵素が存在している。これらのリソソーム酵素をコードする遺伝子や酵素の細胞内輸送に関わるタンパク質をコードする遺伝子に欠損が生じると、基質である代謝物が細胞内に蓄積し、リソソーム蓄積症を発症する。現在、いくつかのリソソーム蓄積症の治療として、最も用いられているのが酵素補充療法である。これは、体外で生産された組換えリソソーム酵素を静脈内投与する方法である。リソソーム酵素の細胞内への取り込みには、マンノース-6-リン酸受容体やマンノース受容体が関与しており、組換えリソソーム酵素のN結合型糖鎖構造が取り込み効率に寄与している。本総説では、リソソーム蓄積症と酵素補充療法について概説し、組換えリソソーム酵素の糖鎖改変の現状について解説をする。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Aspects of Cancer-associated Glycans in Gliomas","authors":"Y. Ohkawa","doi":"10.4052/tigg.2306.2e","DOIUrl":"https://doi.org/10.4052/tigg.2306.2e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46406352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gangliosides are the components of lipid rafts involved in several biological events such as signal transduction. The synthesis of structurally well-defined gangliosides is necessary in order to elucidate the formation mechanisms and functions of lipid rafts at the molecular level. However, previous methods to achieve stereocontrol in glycosidic bond formation of sialic acid have shown that it is substrate-dependent. Therefore, the chemical synthesis of gangliosides and their glycans remains a challenging task in carbohydrate chemistry. This review presents the development of a 1,5-lactam synthetic strategy for gangliosides.
{"title":"Development of a Synthetic Strategy for Gangliosides Using the Unique Chemical Structure of Sialic Acid","authors":"Hide-Nori Tanaka","doi":"10.4052/tigg.2312.2e","DOIUrl":"https://doi.org/10.4052/tigg.2312.2e","url":null,"abstract":"Gangliosides are the components of lipid rafts involved in several biological events such as signal transduction. The synthesis of structurally well-defined gangliosides is necessary in order to elucidate the formation mechanisms and functions of lipid rafts at the molecular level. However, previous methods to achieve stereocontrol in glycosidic bond formation of sialic acid have shown that it is substrate-dependent. Therefore, the chemical synthesis of gangliosides and their glycans remains a challenging task in carbohydrate chemistry. This review presents the development of a 1,5-lactam synthetic strategy for gangliosides.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":"323 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134996415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Target-Specific O-linked N-acetylglucosamine Modification with a Dual-Specificity Aptamer Reveals Functions of O-GlcNAcylation in β-catenin","authors":"Haruki Odaka","doi":"10.4052/tigg.2309.6j","DOIUrl":"https://doi.org/10.4052/tigg.2309.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43631481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ステープルオリゴ糖の設計・合成・機能評価","authors":"Shinnosuke Wakamori","doi":"10.4052/tigg.2311.6j","DOIUrl":"https://doi.org/10.4052/tigg.2311.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47742301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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