Pub Date : 2022-07-04DOI: 10.1177/00211400221107418b
Alexander O’Hara
{"title":"Book Review: Maynooth College Reflects on Covid-19: New Realities in Uncertain Times","authors":"Alexander O’Hara","doi":"10.1177/00211400221107418b","DOIUrl":"https://doi.org/10.1177/00211400221107418b","url":null,"abstract":"","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"243 - 245"},"PeriodicalIF":0.3,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43213531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-04DOI: 10.1177/00211400221107418f
Aaron Pidel SJ
{"title":"Book Review: The Center is Jesus Christ Himself: Essays on Revelation, Salvation & Evangelization in Honor of Robert P. Imbelli","authors":"Aaron Pidel SJ","doi":"10.1177/00211400221107418f","DOIUrl":"https://doi.org/10.1177/00211400221107418f","url":null,"abstract":"","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"253 - 255"},"PeriodicalIF":0.3,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48399983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-04DOI: 10.1177/00211400221107418a
Liam Tracey OSM
{"title":"Book Review: Lively Oracles of God: Perspectives on the Bible and Liturgy","authors":"Liam Tracey OSM","doi":"10.1177/00211400221107418a","DOIUrl":"https://doi.org/10.1177/00211400221107418a","url":null,"abstract":"","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"240 - 243"},"PeriodicalIF":0.3,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46977504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.1177/00211400221098018
Zane E. Chu
Aquinas’s exposition of the twofold commandment of charity embeds a pedagogy for learning the imitation of Christ. This pedagogy may be gathered from his commentaries on the Gospels of Matthew and John, with refinements from the Summa theologiae. Christ commands love of God and neighbour and calls us to friendship that requires imitation of him. Aquinas depicts this imitation of Christ as a gratuitous, effective, and right love of neighbour which, I suggest, is grounded in, and develops his articulation of, love of neighbour as an expansion of love of self that is holy, just, and true. In this way, we learn to imitate Christ by following his commandment of charity, and we learn to follow the commandment of charity by imitating Christ. This interpenetrating pedagogy exemplifies and belongs essentially to Aquinas’s broader goal of promoting conformity to Christ through his practice of sacra doctrina or holy teaching.
{"title":"Reading the Love Commandments and Learning the Imitation of Christ in Aquinas","authors":"Zane E. Chu","doi":"10.1177/00211400221098018","DOIUrl":"https://doi.org/10.1177/00211400221098018","url":null,"abstract":"Aquinas’s exposition of the twofold commandment of charity embeds a pedagogy for learning the imitation of Christ. This pedagogy may be gathered from his commentaries on the Gospels of Matthew and John, with refinements from the Summa theologiae. Christ commands love of God and neighbour and calls us to friendship that requires imitation of him. Aquinas depicts this imitation of Christ as a gratuitous, effective, and right love of neighbour which, I suggest, is grounded in, and develops his articulation of, love of neighbour as an expansion of love of self that is holy, just, and true. In this way, we learn to imitate Christ by following his commandment of charity, and we learn to follow the commandment of charity by imitating Christ. This interpenetrating pedagogy exemplifies and belongs essentially to Aquinas’s broader goal of promoting conformity to Christ through his practice of sacra doctrina or holy teaching.","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"60 24","pages":"222 - 236"},"PeriodicalIF":0.3,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41308442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Radiation is currently used to be a mainstay of salvage therapy for nasopharyngeal carcinoma (NPC), however, development of radioresistance largely limits the radiation efficacy. Circular RNAs (circRNAs) have been shown to affect NPC progression, but its role in radioresistance remain unclear.
Methods: The circular structure of circFIP1L1(circ_0069740) was verified by RNA-sequencing, RT-PCR based on gDNA or cDNA, RNase R treatment, and actinomycin D treatment. Cellular localization of circFIP1L1 and miR-1253 was detected by nucleoplasmic separation and/or fluorescence in situ hybridization. Expression of non-coding RNAs and mRNAs was detected by qRT-PCR, protein expression was detected by Western blot. Functionally, EdU, CCK-8, and colony formation experiments were employed to assess cell proliferation, flow cytometry was adopted to estimate cell cycle and apoptosis. Xenograft tumor growth was performed to detect the role of circFIP1L1 in vivo. Mechanistically, we examined the interplay between miR-1253 and circFIP1L1 or EIF4A3 through dual-luciferase reporter assay. The potential regulatory impacts of EIF4A3 on circFIP1L1 or PTEN was examined by RNA immunoprecipitation and RNA pull-down assays.
Results: CircFIP1L1 overexpression and miR-1253 knockdown repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity. Mechanistically, circFIP1L1 was revealed to repress miR-1253 by binding to it, and EIF4A3 is a target gene of miR-1253. CircFIP1L1 regulated NPC proliferation, apoptosis, and radiosensitivity through miR-1253/EIF4A3. Moreover, we found that EIF4A3 bound to FIP1L1 mRNA transcript and induced circFIP1L1 formation, and thus stabilizing PTEN mRNA.
Conclusion: Our findings suggested that EIF4A3-induced circFIP1L1 repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity by miR-1253.
{"title":"EIF4A3-induced circFIP1L1 represses miR-1253 and promotes radiosensitivity of nasopharyngeal carcinoma.","authors":"Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang","doi":"10.1007/s00018-022-04350-x","DOIUrl":"10.1007/s00018-022-04350-x","url":null,"abstract":"<p><strong>Background: </strong>Radiation is currently used to be a mainstay of salvage therapy for nasopharyngeal carcinoma (NPC), however, development of radioresistance largely limits the radiation efficacy. Circular RNAs (circRNAs) have been shown to affect NPC progression, but its role in radioresistance remain unclear.</p><p><strong>Methods: </strong>The circular structure of circFIP1L1(circ_0069740) was verified by RNA-sequencing, RT-PCR based on gDNA or cDNA, RNase R treatment, and actinomycin D treatment. Cellular localization of circFIP1L1 and miR-1253 was detected by nucleoplasmic separation and/or fluorescence in situ hybridization. Expression of non-coding RNAs and mRNAs was detected by qRT-PCR, protein expression was detected by Western blot. Functionally, EdU, CCK-8, and colony formation experiments were employed to assess cell proliferation, flow cytometry was adopted to estimate cell cycle and apoptosis. Xenograft tumor growth was performed to detect the role of circFIP1L1 in vivo. Mechanistically, we examined the interplay between miR-1253 and circFIP1L1 or EIF4A3 through dual-luciferase reporter assay. The potential regulatory impacts of EIF4A3 on circFIP1L1 or PTEN was examined by RNA immunoprecipitation and RNA pull-down assays.</p><p><strong>Results: </strong>CircFIP1L1 overexpression and miR-1253 knockdown repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity. Mechanistically, circFIP1L1 was revealed to repress miR-1253 by binding to it, and EIF4A3 is a target gene of miR-1253. CircFIP1L1 regulated NPC proliferation, apoptosis, and radiosensitivity through miR-1253/EIF4A3. Moreover, we found that EIF4A3 bound to FIP1L1 mRNA transcript and induced circFIP1L1 formation, and thus stabilizing PTEN mRNA.</p><p><strong>Conclusion: </strong>Our findings suggested that EIF4A3-induced circFIP1L1 repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity by miR-1253.</p>","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"22 1","pages":"357"},"PeriodicalIF":8.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11072984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87494070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.1177/00211400221098013
John Stayne
The Congregation for the Doctrine of the Faith’s letter Iuvenescit Ecclesia represents a considerable, and largely unnoticed, development in the Catholic doctrine of the charisms. Despite being widely overlooked, this document contains a sophisticated, and quasi-systematic, theological presentation of the charismatic gifts. The present essay compares the teaching on the charisms in Iuvenescit Ecclesia with the earlier teaching in Lumen Gentium in three areas: (1) the wider theological grounding of the charisms; (2) the meaning of the term charism; (3) the value assigned to the charisms. Through this, the postconciliar developments in the area of the charisms are brought sharply into focus, demonstrating the significance of Iuvenescit Ecclesia for the future of Catholic ecclesiology.
{"title":"Post-Conciliar Developments in the Catholic Doctrine of Charisms: Lumen Gentium and Iuvenescit Ecclesia Compared","authors":"John Stayne","doi":"10.1177/00211400221098013","DOIUrl":"https://doi.org/10.1177/00211400221098013","url":null,"abstract":"The Congregation for the Doctrine of the Faith’s letter Iuvenescit Ecclesia represents a considerable, and largely unnoticed, development in the Catholic doctrine of the charisms. Despite being widely overlooked, this document contains a sophisticated, and quasi-systematic, theological presentation of the charismatic gifts. The present essay compares the teaching on the charisms in Iuvenescit Ecclesia with the earlier teaching in Lumen Gentium in three areas: (1) the wider theological grounding of the charisms; (2) the meaning of the term charism; (3) the value assigned to the charisms. Through this, the postconciliar developments in the area of the charisms are brought sharply into focus, demonstrating the significance of Iuvenescit Ecclesia for the future of Catholic ecclesiology.","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"192 - 211"},"PeriodicalIF":0.3,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45323006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.1177/00211400221098012
Nathan W. O’Halloran
In this article I bring an analysis of the boy possessed ‘from childhood’ in Mark 9:14–29 to bear on the contemporary situation of victims abused as children. I suggest that at least some of the discomfort we may feel in comparing an abused child to a possessed child in the Gospels stems from a residual feeling that demoniacs are guilty. But the Gospel witness is that possessed people are innocent and unwillingly ‘colonized.’ I then note the literary echoes between Mark 9:14–29 and Mark 14:32–42 which highlight Jesus’ identification with victims in Gethsemane. I conclude by suggesting that the possessed boy of Mark 9 is representative of innocent childhood victims in his unwilling bondage, and that Jesus’ salvific solidarity with him in Gethsemane offers to all victims of childhood abuse a healing space from which to identify with Christ on his healing journey toward resurrection.
{"title":"‘From Childhood’: A Markan Soteriology for Victims of Childhood Abuse","authors":"Nathan W. O’Halloran","doi":"10.1177/00211400221098012","DOIUrl":"https://doi.org/10.1177/00211400221098012","url":null,"abstract":"In this article I bring an analysis of the boy possessed ‘from childhood’ in Mark 9:14–29 to bear on the contemporary situation of victims abused as children. I suggest that at least some of the discomfort we may feel in comparing an abused child to a possessed child in the Gospels stems from a residual feeling that demoniacs are guilty. But the Gospel witness is that possessed people are innocent and unwillingly ‘colonized.’ I then note the literary echoes between Mark 9:14–29 and Mark 14:32–42 which highlight Jesus’ identification with victims in Gethsemane. I conclude by suggesting that the possessed boy of Mark 9 is representative of innocent childhood victims in his unwilling bondage, and that Jesus’ salvific solidarity with him in Gethsemane offers to all victims of childhood abuse a healing space from which to identify with Christ on his healing journey toward resurrection.","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"181 - 191"},"PeriodicalIF":0.3,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42261014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-03DOI: 10.1177/00211400221098017
G. O'collins
The article agrees that meaning-for-meaning rather than word-for-word sums up the primary scope of translation from biblical texts. Yet Greek and Hebrew words may enjoy the same or at least very similar meanings in different contexts; and the scriptural authors may intend intertextual links between their use of these words. In such cases differing translations can not only be unnecessary but may also lead readers to miss links intended by the authors. This case is established by examining the use of phaneroō (‘reveal,’ John) and diakoneō (‘serve,’ Mark).
{"title":"Variations in Bible Translations: Necessity or Impoverishment?","authors":"G. O'collins","doi":"10.1177/00211400221098017","DOIUrl":"https://doi.org/10.1177/00211400221098017","url":null,"abstract":"The article agrees that meaning-for-meaning rather than word-for-word sums up the primary scope of translation from biblical texts. Yet Greek and Hebrew words may enjoy the same or at least very similar meanings in different contexts; and the scriptural authors may intend intertextual links between their use of these words. In such cases differing translations can not only be unnecessary but may also lead readers to miss links intended by the authors. This case is established by examining the use of phaneroō (‘reveal,’ John) and diakoneō (‘serve,’ Mark).","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"212 - 221"},"PeriodicalIF":0.3,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49090636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-09DOI: 10.1177/00211400221085759
Tobias L. Winright
{"title":"Book Review: God and Guns: The Bible against American Gun Culture","authors":"Tobias L. Winright","doi":"10.1177/00211400221085759","DOIUrl":"https://doi.org/10.1177/00211400221085759","url":null,"abstract":"","PeriodicalId":55939,"journal":{"name":"Irish Theological Quarterly","volume":"87 1","pages":"164 - 168"},"PeriodicalIF":0.3,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46599402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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