Current Opinion in Behavioral Sciences最新文献

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A light at the end of the axon: genetically encoded fluorescent indicators shine light on the dopamine system 轴突末端的曙光：基因编码荧光指示器照亮多巴胺系统

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-11-16 DOI: 10.1016/j.cobeha.2024.101460

Zacharoula Kagiampaki , Xuehan Zhou , Paul J Lamothe-Molina , Tommaso Patriarchi

In this focused review, we center the attention on detection technologies used for monitoring dopamine (DA) release during animal behavior. We briefly examine the evolution of DA measurement techniques, from traditional methods like microdialysis and fast-scan cyclic voltammetry to cutting-edge genetically encoded fluorescent indicators (GEFIs). We then delve into how this latest generation technologies are contributing to unraveling some of the intricacies of the DA system, ranging from the spatial and molecular regulation of DA release, to the underlying rules governing its system-level functions. By showcasing recent exemplar works, we highlight how these modern tools provide new insights into the heterogeneity of DA signaling across different brain regions and help refining the theoretical framework of DA functions extending beyond the conventional reward prediction error model. Finally, we provide important methodological recommendations to be taken into consideration when employing DA GEFIs in neuroscience research.

在这篇重点综述中，我们将关注用于监测动物行为过程中多巴胺（DA）释放的检测技术。我们简要回顾了多巴胺测量技术的发展历程，从微量透析和快速扫描循环伏安法等传统方法到最先进的基因编码荧光指示剂（GEFIs）。然后，我们将深入探讨最新一代技术如何有助于揭示 DA 系统的一些错综复杂之处，包括 DA 释放的空间和分子调控，以及支配其系统级功能的基本规则。通过展示最新的示范性研究成果，我们强调了这些现代工具是如何为不同脑区DA信号的异质性提供新的见解，并帮助完善DA功能的理论框架，使其超越传统的奖赏预测误差模型。最后，我们提出了在神经科学研究中使用 DA GEFIs 时应考虑的重要方法学建议。

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引用次数: 0

Dopaminergic computations for perceptual decisions 感知决策的多巴胺能计算

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-11-15 DOI: 10.1016/j.cobeha.2024.101458

Samuel Liebana, Matthias Fritsche, Armin Lak

Studies linking the brain’s dopamine signals with learning and decision making have enjoyed enormous progress using predominantly value-based decision-making tasks. However, recent studies have demonstrated pervasive dopamine signaling also during perceptual decision making. These signals have been shown to depend on both feedback and perceptual parameters, such as perceptual decision confidence and sensory statistics. Here, we review recent studies investigating dopamine signals in simple and complex forms of perceptual decision tasks across species and dopaminergic circuits. We discuss how reinforcement learning (RL) models can account for key aspects of learning during perceptual decision making and its dopaminergic underpinnings, thus bridging the gap with the literature on dopamine in value-based decisions. Finally, we propose that RL may provide a promising framework to address current challenges in the dopamine literature, such as explaining the function of its heterogeneous responses and its role in learning from naive to expert.

将大脑多巴胺信号与学习和决策联系起来的研究取得了巨大进展，这些研究主要使用基于价值的决策任务。然而，最近的研究表明，多巴胺信号在感知决策过程中也普遍存在。这些信号被证明取决于反馈和知觉参数，如知觉决策信心和感觉统计。在此，我们回顾了最近在不同物种和多巴胺能回路的简单和复杂形式的知觉决策任务中调查多巴胺信号的研究。我们将讨论强化学习（RL）模型如何解释感知决策过程中学习的关键环节及其多巴胺能基础，从而缩小与基于价值决策的多巴胺研究之间的差距。最后，我们提出强化学习可以为解决目前多巴胺文献中的挑战提供一个有前景的框架，例如解释多巴胺异质反应的功能及其在从幼稚到专家的学习过程中的作用。

引用次数: 0

From sensory motor and perceptual development to primary consciousness in the fetus: converging neural, behavioral, and imaging correlates of cognition-mediated emergent transitions 胎儿从感觉运动和知觉发展到初级意识：认知介导的新兴过渡的神经、行为和成像相关性汇聚

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-10-24 DOI: 10.1016/j.cobeha.2024.101455

Gerry Leisman , Rahela Alfasi , Amedeo D’Angiulli

We reviewed current evidence from experimental, clinical, and animal research about the level and content of cognition and consciousness in the fetus from convergent observations of behavior and measurable neurobiological changes, including neuroimaging findings. Between the second and the third trimesters, there are compelling observations that the fetus is capable of basic cognitive and behavioral processes that can scaffold the emergence of primary consciousness, mediated and governed by the connectivities between brainstem, thalamic, cortical subplate circuitry, and the maturing cortex. This work integrates the most recent transdisciplinary body of evidence demonstrating that the building of functional connectivities and integration of complex brain functions typically associated with minimal human consciousness start early in utero and suggesting that consciousness is not an all-or-none process but rather a continuum of increasingly complex and emergent interactions within multiple neural networks.

我们通过对行为和可测量的神经生物学变化（包括神经影像学发现）的综合观察，回顾了实验、临床和动物研究中有关胎儿认知和意识的水平和内容的现有证据。有令人信服的观察结果表明，胎儿在妊娠第二至三个月期间能够进行基本的认知和行为过程，这些过程能够为初级意识的出现提供支架，并由脑干、丘脑、皮质亚板回路和成熟皮质之间的联系所介导和支配。这项研究整合了最新的跨学科证据，证明功能连接性的建立和复杂大脑功能的整合通常与人类最低限度的意识有关，并表明意识不是一个全有或全无的过程，而是一个在多个神经网络中日益复杂和新兴的相互作用的连续体。

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引用次数: 0

Nonsynaptic encoding of behavior by neuropeptides 神经肽对行为的非突触编码

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-10-23 DOI: 10.1016/j.cobeha.2024.101456

Gáspár Jékely , Rafael Yuste

A basic tenet of neuroscience is that animal behavior is generated by neural circuits that operate through synaptic transmission. On top of this synaptic ‘chassis’ of nervous systems, neuropeptides and hormones have traditionally been considered as slow neuromodulatory signals that fine-tune synaptic circuits. However, neuropeptides can generate many behaviors, including quite complex ones, from cnidarians to humans. Moreover, neuropeptide actions span larger temporal scales than fast synaptic transmission and are thus better matched to behavioral time courses than synaptic circuits. Furthermore, in some metazoans, the effects of neuropeptides are independent of synaptic connectivity, and in many species, the systemic application of neuropeptides can trigger selective behaviors. Based on this, we argue that nonsynaptic neuropeptide signaling via chemical networks — forming a ‘chemical’ connectome — represents the ancestral mechanism to encode behavioral sequences, whereas synaptic networks co-evolved as a specialization complementing chemical networks in the control of behaviors and computational functions.

神经科学的一个基本原理是，动物行为是由神经回路通过突触传递产生的。在神经系统的突触 "底盘 "之上，神经肽和激素历来被认为是微调突触回路的缓慢神经调节信号。然而，神经肽可以产生许多行为，包括相当复杂的行为，从刺胞动物到人类都是如此。此外，与快速突触传递相比，神经肽作用的时间跨度更大，因此比突触回路更符合行为时间进程。此外，在某些后生动物中，神经肽的作用与突触连接无关，而且在许多物种中，神经肽的系统应用可以触发选择性行为。基于这一点，我们认为，通过化学网络发出非突触神经肽信号--形成 "化学 "连接组--代表了编码行为序列的祖先机制，而突触网络则是作为化学网络在控制行为和计算功能方面的补充而共同进化的一种专业化机制。

引用次数: 0

Diversity of REM sleep 快速动眼期睡眠的多样性

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-10-16 DOI: 10.1016/j.cobeha.2024.101457

Sho T Yamaguchi , Zhiwen Zhou , Hiroaki Norimoto

Recently, progress has been made in understanding sleep and wakefulness regulation at the molecular and neurocircuitry levels. Research on the evolution of sleep has also advanced remarkably across a wide range of animal species, from invertebrates to vertebrates. Pioneering studies on electroencephalography and other physiological features of sleep have raised the concept of two-stage sleep, categorizing sleep in some animals into two stages: slow-wave sleep (SWS) and rapid eye movement sleep (REMS). Currently, it is widely accepted that SWS and REMS occur in mammals and birds. Although these sleep stages have been observed in a wide range of animals, debates continue regarding their roles and evolutionary origins. This review discusses the diversity of REMS by evaluating their reported similarities and differences across various species.

最近，人们在分子和神经回路层面对睡眠和觉醒调控的理解取得了进展。从无脊椎动物到脊椎动物等各种动物物种，对睡眠进化的研究也取得了显著进展。对脑电图和其他睡眠生理特征的开创性研究提出了两阶段睡眠的概念，将某些动物的睡眠分为两个阶段：慢波睡眠（SWS）和快速眼动睡眠（REMS）。目前，人们普遍认为哺乳动物和鸟类都存在慢波睡眠和快速眼动睡眠。虽然这些睡眠阶段已在多种动物身上观察到，但关于它们的作用和进化起源的争论仍在继续。这篇综述通过评估不同物种中REMS的相似性和差异性，讨论了REMS的多样性。

引用次数: 0

Stress-free indulgence: indulge adaptively to promote goal pursuit and well-being 无压力放纵：适应性放纵，促进目标追求和身心健康

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-10-16 DOI: 10.1016/j.cobeha.2024.101454

Shuna S Khoo , Lile Jia , Junhua Dang , Ying Li

People pursue long-term goals amidst abundant hedonic options made available by modern society’s technological and productivity advancements. Curiously, individuals often find their enjoyment in leisure and pleasure contaminated by stressful cognitive and affective reactions. We argue that the stunted experience of indulgence is an overlooked source of self-control problems and diminished well-being. We review the social cognitive process related to this notion of stressful indulgence and propose that an adaptive incorporation of indulgence into long-term pursuits, choosing the right type of indulgence, and mindful savoring can reduce the consternation and stress associated with hedonic activities. When done right, indulgence can be adaptive and stress free, facilitates goal pursuit, and promotes psychological resilience and well-being. Theoretical and practical implications are discussed.

现代社会的技术和生产力进步为人们提供了丰富的享乐选择，人们在其中追求长期目标。奇怪的是，人们在享受休闲和愉悦的同时，却常常发现自己的认知和情感反应受到了压力的影响。我们认为，放纵体验的缺失是自我控制问题和幸福感降低的一个被忽视的根源。我们回顾了与这种有压力的放纵概念相关的社会认知过程，并提出将放纵适应性地融入长期追求、选择正确的放纵类型以及用心品味可以减少与享乐活动相关的焦虑和压力。如果方法得当，放纵可以是适应性的、无压力的，有利于追求目标，并促进心理复原力和幸福感。本文讨论了其理论和实践意义。

引用次数: 0

Resources, costs and long-term value: an integrative perspective on serotonin and meta-decision making 资源、成本和长期价值：血清素和元决策的综合视角

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-10-04 DOI: 10.1016/j.cobeha.2024.101453

Renée S Koolschijn , Bertalan Polner , Julie M Hoomans , Roshan Cools , Eliana Vassena , Hanneke EM den Ouden

Serotonin has been associated with a wide range of neural computations and behaviours, yet an overarching function of this neurotransmitter has been hard to pinpoint. Here, we combine recent theories and findings on serotonin and propose a framework where serotonin integrates information on resource availability and state value to represent a cost–benefit trade-off at the neural level. Critically, this framework supports meta-decision making, that is, the flexible allocation of resources to decision-making. We highlight a computational and neural implementation of this framework, and through this novel, lens interpret empirical findings in the domains of controllability and persistence.

血清素与广泛的神经计算和行为有关，但这种神经递质的总体功能一直难以确定。在这里，我们结合了有关血清素的最新理论和发现，提出了一个框架，即血清素整合了资源可用性和状态价值的信息，在神经水平上代表了一种成本效益权衡。至关重要的是，这一框架支持元决策，即为决策灵活分配资源。我们重点介绍了这一框架的计算和神经实现，并通过这一新颖的视角解释了可控性和持久性领域的经验发现。

引用次数: 0

Artificial intelligence in mental health: innovations brought by artificial intelligence techniques in stress detection and interventions of building resilience 人工智能在心理健康中的应用：人工智能技术在压力检测和复原力建设干预方面带来的创新

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-09-25 DOI: 10.1016/j.cobeha.2024.101452

Feng Liu , Qianqian Ju , Qijian Zheng , Yujia Peng

The last few decades have witnessed a revolution in the field of mental health, brought about by state-of-the-art techniques of artificial intelligence (AI). Here, we review the evidence for the systematic application of AI for the detection and intervention of stress-related mental health problems. We first explore the potential application of AI in stress detection and screening through advanced computational techniques of machine learning algorithms that analyze biomarkers of stress and anxiety. Building on the accurate detection of mental health problems, we further review the evidence for AI-based stress interventions and propose the promising prospect of applying decoded neurofeedback as a personalized resilience-building intervention. Together, the current review assesses the effectiveness and major challenges of AI technologies in real-world applications and demonstrates the transforming impact of AI on the field of mental health.

在过去的几十年里，人工智能（AI）的先进技术为心理健康领域带来了一场革命。在此，我们回顾了系统应用人工智能检测和干预压力相关心理健康问题的证据。我们首先通过分析压力和焦虑生物标志物的机器学习算法的先进计算技术，探讨了人工智能在压力检测和筛查方面的潜在应用。在准确检测心理健康问题的基础上，我们进一步回顾了基于人工智能的压力干预措施的证据，并提出了应用解码神经反馈作为个性化复原力建设干预措施的美好前景。综上所述，本综述评估了人工智能技术在现实世界应用中的有效性和主要挑战，并展示了人工智能对心理健康领域的变革性影响。

引用次数: 0

“But why?” Dopamine and causal learning "但是为什么呢？"多巴胺与因果学习

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-09-19 DOI: 10.1016/j.cobeha.2024.101443

Vijay MK Namboodiri

The computational and algorithmic role of striatal dopamine signaling has been one of the most investigated topics in systems neuroscience. Though there have been many hypotheses of dopamine function over the years, the reward prediction error (RPE) hypothesis has remained the most popular for decades. Despite substantial evidence consistent with this hypothesis, considerable recent evidence is also inconsistent with it. Accordingly, multiple alternate hypotheses of dopamine function have been recently proposed. Here, I review one such alternative from my lab stating that dopamine is a teaching signal for causal learning. I show that there are fundamental similarities between this and other recent hypotheses, and that this hypothesis is consistent with the core results supporting RPE coding. Therefore, RPE should be considered a provisional hypothesis of dopamine function requiring further evaluation, with a critical need for openly examining a host of recent experimental results inconsistent with the hypothesis.

纹状体多巴胺信号的计算和算法作用一直是系统神经科学研究最多的课题之一。尽管多年来对多巴胺功能提出了许多假说，但奖赏预测错误（RPE）假说几十年来一直是最流行的假说。尽管有大量证据与这一假说相符，但最近也有大量证据与之不符。因此，最近提出了多种多巴胺功能的替代假说。在此，我回顾了我的实验室提出的一种替代方案，即多巴胺是因果学习的教学信号。我的研究表明，这一假说与最近提出的其他假说有基本的相似之处，而且这一假说与支持 RPE 编码的核心结果是一致的。因此，RPE 应被视为多巴胺功能的一个临时假说，需要进一步评估，而且迫切需要公开研究与该假说不一致的一系列最新实验结果。

引用次数: 0

Stress-induced modulation of maternal behavior and mesolimbic dopamine function 压力对母性行为和间叶多巴胺功能的调节

IF 4.9 2区心理学 Q1 BEHAVIORAL SCIENCES

Current Opinion in Behavioral Sciences

Pub Date : 2024-09-18 DOI: 10.1016/j.cobeha.2024.101445

Millie Rincón-Cortés

In humans, maternal stress exposure is associated with compromised quality of mother–infant interactions and increased risk for affective disorders that impair maternal care. These effects have been recapitulated in rodent studies employing postpartum stressors. Here, I provide a brief overview of recent studies showing stress-induced alterations in maternal behaviors in both humans and rodents. In addition, I review current literature indicating a role for mesolimbic dopamine function in maternal sensitivity and goal-directed responses and discuss its disruption by stress exposure.

在人类中，孕产妇面临的压力与母婴互动质量下降和情感障碍风险增加有关，而情感障碍会损害孕产妇护理。利用产后应激源进行的啮齿动物研究也再现了这些影响。在此，我将简要概述最近的一些研究，这些研究显示压力会导致人类和啮齿动物的母性行为发生改变。此外，我还回顾了目前的文献，这些文献表明间叶多巴胺功能在母性敏感性和目标定向反应中的作用，并讨论了压力暴露对其的干扰。

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