Geriatric Nursing最新文献

{"title":"Media exposure and the trajectory of depression in older adults: An analysis based on latent variable growth models","authors":"Maomin Jiang PhD , Lin Liu MM , Xincheng Huang PhD , Yisong Yao MSc , Jialiang Feng MB , Zengming Ma PhD","doi":"10.1016/j.gerinurse.2026.103916","DOIUrl":"10.1016/j.gerinurse.2026.103916","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to understand the developmental trajectory of media exposure and depression in the older adults Chinese population and explore the associated influencing factors. This research seeks to establish a scientific basis for preventing and treating depression in older adults.</div></div><div><h3>Methods</h3><div>Data were sourced from the Chinese Longitudinal Aging Social Survey (CLASS) database. We selected survey data from 2016, 2018, and 2020, focusing on participants who fully completed the depression status panel and three interviews, totaling 5,496 older adults. First, demographic variables were analyzed for descriptive statistics using SPSS 27.0, and Pearson correlation analyses of media exposure, marital status, and depression were conducted at the three time points. Second, using unconditional least squares, we estimated parameters for potential change trajectories in media exposure, marital status, and depression status among older adults, excluding covariates. Finally, latent variable growth models were constructed using Mplus 8.0 to test the developmental trajectories of media exposure and depression status among older adults, and we reported cross-sectional and prospective cross-lag correlations and ran baseline-adjusted two-wave lagged regressions in both directions as sensitivity analyses.</div></div><div><h3>Results</h3><div>The unconditional least squares analysis revealed significant differences in initial media exposure (Ψ<sub>1</sub> = 3.655) and its growth rate (Ψ<sub>2</sub> = 1.504, <em>p</em> < 0.001), initial marital status (Ψ<sub>1</sub> = 0.123) and its growth rate (Ψ<sub>2</sub> = 0.009, <em>p</em> < 0.001), as well as in initial depression levels (Ψ<sub>1</sub> = 4.852) and their growth rate (Ψ<sub>2</sub> = 2.655, <em>p</em> < 0.001) among older adults. The latent variable growth model indicated a negative correlation between the intercept and slope of depression (<em>β</em> = -0.227, <em>p</em> < 0.001) and media exposure (<em>β</em> = -0.423, <em>p</em> < 0.001) in older adults. Regarding demographic characteristics, age, residence, and marital status significantly influenced the initial level of depression (<em>p</em> < 0.001), while gender, age, education, and residence significantly affected the slope of depression levels (<em>p</em> < 0.05). Additionally, the regression analysis showed that the intercept of media exposure significantly influenced the depression intercept in older adults (<em>β</em> = -0.373, <em>p</em> < 0.001), and the slope of media exposure significantly affected the slope of depression (<em>β</em> = -0.319, <em>p</em> < 0.001). Cross-lag zero-order correlations were small and mixed, baseline-adjusted two-wave lagged tests yielded similarly small effects in both directions, consistent with the parallel-process growth findings.</div></div><div><h3>Conclusions</h3><div>Over time, media exposure in the older adults gradually decre","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103916"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health belief and self-management behaviors in patients with stroke: The mediating role of time perspective","authors":"Xin-Yu Ma BSc ,&nbsp;Heng-Yu Liu MSc ,&nbsp;Yi-Dong Wang PhD ,&nbsp;Yue Guo BSc ,&nbsp;Yan Chen BSc ,&nbsp;Li-Hong Wan PhD","doi":"10.1016/j.gerinurse.2026.103843","DOIUrl":"10.1016/j.gerinurse.2026.103843","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate the mediating role of time perspective in the relationship between health belief and self-management behaviors in patients with stroke.</div></div><div><h3>Methods</h3><div>A cross-sectional survey involving 250 stroke patients was conducted at a hospital in Guangzhou, China, from July 2022 to July 2023. Participants' self-management behaviors, health belief, and time perspective were assessed using validated questionnaires. Multiple linear regression analysis was employed to identify factors influencing self-management behaviors. Mediation analysis was performed using the PROCESS macro in SPSS.</div></div><div><h3>Results</h3><div>Correlation analysis indicated significant positive associations among health belief, time perspective, and self-management behaviors. The multiple linear regression model explained 51.5 % of the variance in self-management behaviors among stroke patients. Time perspective partially mediated the relationship between health belief and self-management behaviors, accounting for 37.14 % of the total effect.</div></div><div><h3>Conclusion</h3><div>Based on the General Conceptual Model of Time Perspective, this study provides empirical evidence that time perspective partially mediates the link between health belief and self-management behaviors in stroke patients. Healthcare providers should therefore encourage positive health belief and reframe patients' time perspective to enhance self-management behaviors.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103843"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between family support and life satisfaction in hypertensive patients: the multiple mediating roles of self-esteem and self-care","authors":"Han Wu MSc ,&nbsp;Haijun Zhang MSc ,&nbsp;Congzhi Wang MSc ,&nbsp;Tian Pan MSc ,&nbsp;Yue Zhao MSc ,&nbsp;Xiang Chen MSc ,&nbsp;Lin Zhang PhD","doi":"10.1016/j.gerinurse.2026.103799","DOIUrl":"10.1016/j.gerinurse.2026.103799","url":null,"abstract":"<div><h3>Background</h3><div>Family support is related to the life satisfaction of hypertensive patients, but the mechanism is unclear. This study aimed to explore the influencing mechanism and analyze the multiple mediating roles of self-esteem and self-care.</div></div><div><h3>Methods</h3><div>From June to November 2022, in the First Affiliated Hospital of Wannan Medical College, patients with essential hypertension were surveyed using multiple scales, and the data were analyzed with SPSS 26.0 and PROCESS 4.1 macros.</div></div><div><h3>Results</h3><div>Family support directly affected the life satisfaction of patients (β = 0.068), and also indirectly affected it through three pathways: self-esteem, self-care, and the combination of both. The overall mediating effect was 48.48%.</div></div><div><h3>Conclusions</h3><div>Self-esteem and self-care act as mediators. Medical staff should encourage family members to support patients and improve patients' self-esteem and self-care abilities to enhance their life satisfaction.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103799"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social participation and health status trajectories in older adults: A 19-year yamanashi healthy life expectancy cohort study (Y-HALE)","authors":"Takeru Oka MS ,&nbsp;Tadao Ooka MD, PhD ,&nbsp;Hiroshi Yokomichi MD, PhD ,&nbsp;Zentaro Yamagata MD, PhD","doi":"10.1016/j.gerinurse.2026.103875","DOIUrl":"10.1016/j.gerinurse.2026.103875","url":null,"abstract":"<div><h3>Objective</h3><div>Population aging highlights the importance of understanding social factors that promote healthy aging. We aimed to identify health status trajectories among older adults in Japan and determine social participation associated with each trajectory cluster.</div></div><div><h3>Methods</h3><div>Data from 497 older adults from Yamanashi Prefecture, Japan, were used to identify their health status trajectories based on caregiving levels defined by the Japan’s national care insurance system. We determined social participants associated with each trajectory cluster.</div></div><div><h3>Results</h3><div>Men aged 65–74 who worked and participated in “Mujin” were more likely to belong to beneficial health clusters. For men aged ≥75, frequent interactions with friends and neighbors and participation in vertical community groups were positively associated with these clusters. Among women, active participation in horizontal groups was positively linked to beneficial health clusters across both age groups.</div></div><div><h3>Conclusion</h3><div>Tailored approaches to promoting social activity participation are needed, considering differences by sex and age group.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103875"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Counting teeth, countering frailty: A systematic review and meta-analysis","authors":"Sarah Paul MDS ,&nbsp;Neha Chauhan MDS ,&nbsp;Harsh Priya MDS ,&nbsp;Ritu Duggal MDS ,&nbsp;Bharathi M. Purohit MDS ,&nbsp;Sasidharan Sivakumar MDS","doi":"10.1016/j.gerinurse.2026.103864","DOIUrl":"10.1016/j.gerinurse.2026.103864","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between the number of remaining teeth and frail and pre-frail status in the older adults.</div></div><div><h3>Background</h3><div>Frailty and the number of remaining teeth are significant concerns in aging populations. However, evidence from various studies exploring this association is limited.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search of databases (PUBMED, MEDLINE, EMBASE, SCOPUS, Web of Science and LILACS) for relevant literature up to May 2024 using a predefined search strategy. Various study designs were considered for inclusion, following the PRISMA guidelines. The risk of bias for the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). A total of 18,472 participants aged 60 years and above from eleven studies demonstrating an association of frailty and pre-frailty with the number of remaining teeth were included in the systematic review. The random-effects model was used to obtain the pooled odds ratio (OR). Individuals with fewer than 20 teeth had 3.6 times higher odds of developing frailty compared to those with 20 or more teeth (OR 3.60, 95% CI: 2.93–4.42; <em>p</em> = 0.0001). Both pre-frailty and frailty were significantly affected by the number of remaining teeth, highlighting the broader impact of dental health on overall frailty status.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis underscores the significant association between the number of remaining teeth and both frailty and pre-frailty in older adult populations. Maintaining dental health may help prevent or delay the onset of frailty, improving the quality of life in aging individuals.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103864"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia, cognitive function, amd dysphagia-related quality of life among oral cancer patients: A cross-sectional survey","authors":"Miao He MSN ,&nbsp;Chunjie Li PhD ,&nbsp;Lan Xiao BSN ,&nbsp;Tingting Liu BSN ,&nbsp;Juan Wang BSN ,&nbsp;Xie Yu BSN ,&nbsp;Zijian Guo MDS ,&nbsp;Yan Sun BSN","doi":"10.1016/j.gerinurse.2026.103895","DOIUrl":"10.1016/j.gerinurse.2026.103895","url":null,"abstract":"<div><h3>Purpose</h3><div>The relationship between dysphagia, cognitive function and dysphagia-related quality of life (QoL) was unclear. The aim of this study was to investigate the prevalence of dysphagia, cognitive function, and dysphagia-related QoL in oral cancer patients and their potential relationships.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted at a tertiary teaching dental hospital in Southwest China, during May 2022 and June 2024. Data were collected using demographic and clinical information questionnaire, the Eating Assessment Tool-10 (EAT-10), the Montreal Cognitive Assessment (MoCA), and the M.D. Anderson Dysphagia Inventory (MDADI). Descriptive statistics, bivariate correlations, and multiple linear regressions were used to explore relationships of the variables and identify factors associated with dysphagia-related QoL.</div></div><div><h3>Results</h3><div>A total of 193 oral cancer patients were included. Dysphagia was reported in 32.1% of participants. Around 75% of the participants exhibited at least mild cognitive impairment. The mean dysphagia-related QoL score was moderate (78.64 ± 12.77). Cognitive function, including Abstraction and Delayed Recall were negatively correlated with dysphagia-related QoL (<em>r</em> = -0.179 ∼ -0.229, <em>P</em> &lt;.01; <em>r</em> = -0.159 ∼ -0.168, <em>P</em> &lt;.05), whereas Orientation showed a positive correlation (<em>r</em> = 0.141 ∼ 177, <em>P</em> &lt;.05). Multiple regression analysis revealed that tumor site at Lips, higher education level, lower EAT-10 scores, and specific MoCA domains (Language, Abstraction, Orientation, and Delayed Recall) explained 55% of the variance of dysphagia-related QoL in oral cancer patients.</div></div><div><h3>Conclusions</h3><div>The study findings highlight that to enhance dysphagia-related QoL in oral cancer patients, integrated interventions addressing both cognitive function and dysphagia rehabilitation modality are needed.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103895"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nutritional screening instruments and their relationship with length of hospital stay of older adult in-patients: model adjusted for the type of disease","authors":"Vânia Aparecida Leandro-Merhi PhD ,&nbsp;Adeline Mariano Silva de Resende MSc ,&nbsp;Larissa Silveira Stopiglia BSc ,&nbsp;Lucas Rosasco Mazzini MD (Scientific Initiation Scholarship Fapesp) ,&nbsp;José Luis Braga de Aquino PhD","doi":"10.1016/j.gerinurse.2026.103814","DOIUrl":"10.1016/j.gerinurse.2026.103814","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the length of hospital stay (LHS) in connection with nutritional screening instruments (NSI) in hospitalized elderly patients (HEP).</div></div><div><h3>Method</h3><div>This was a cross-sectional and retrospective study with 565 HEP. NSI such as the Nutritional Risk Screening (NRS), the Subjective Global Assessment (SGA) and the Mini Nutritional Assessment (MNA) as well as the LHS were investigated. Data were analyzed using the Kolmogorov-Smirnov, Mann-Whitney, Chi-square tests and the Poisson regression model.</div></div><div><h3>Results</h3><div>Through the multiple Poisson model adjusted for the disease, the variables that together explained the LHS were the classification of malnutrition and nutritional risk according to the SGA (estimated parameter = 0.123348, standard error = 0.033580, <em>p</em> = 0.0002); NRS (estimated parameter = 0.339066, standard error = 0.032706, <em>p</em> &lt; 0.0001) and MNA (estimated parameter = 0.180824, standard error<em>=0.051674, p</em> <em>=</em> <em>0.0005).</em></div></div><div><h3>Conclusion</h3><div>After adjusting for disease type, the NRS, SGA and MNA were predictors of LHS of HEP. The integrated use of these assessment tools can enhance the decision-making process in nutritional care and hospital assistance, leading to improved clinical outcomes.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103814"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of physical activity with depression and suicidal ideation in people with osteoarthritis experiencing moderate to severe pain: A multinational study","authors":"Joaquín Salazar-Méndez MSc ,&nbsp;Rodrigo Núñez-Cortés PhD ,&nbsp;Lars Louis Andersen PhD ,&nbsp;Rubén López-Bueno PhD ,&nbsp;Luis Suso-Martí PhD ,&nbsp;Carlos Cruz-Montecinos PhD ,&nbsp;Laura López-Bueno PhD ,&nbsp;Joaquín Calatayud PhD","doi":"10.1016/j.gerinurse.2026.103908","DOIUrl":"10.1016/j.gerinurse.2026.103908","url":null,"abstract":"<div><h3>Introduction</h3><div>Previous single-center studies highlighted the association between physical activity and depression in people with osteoarthritis (OA). However, large-scale multinational studies are needed to provide robust evidence. The aim was to determine the association of physical activity with depression and suicidal thoughts in a multinational sample of people with OA with moderate and severe pain.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis based on the 9th wave of SHARE, a representative survey in 27 European countries and Israel. Self-reported physical activity (frequency and intensity) was the independent variable. Depression (≥4 points) and suicidal thoughts (yes/no) from the 12-item EURO-D scale were the outcomes. We conducted multivariable logistic regression, controlling for age, sex, geographic region, education, smoking, alcohol consumption, fruit and vegetable consumption, number of comorbidities, body mass index, and verbal fluency.</div></div><div><h3>Results</h3><div>A total of 7785 participants were included (mean age 72.0 ± 9.5 years). Respondents who engaged in moderate physical activity more than once a week were less likely to be depressed (OR=0.51; 95%CI = 0.45–0.59) and less likely to have suicidal thoughts (OR=0.56; 95%CI = 0.47–0.68) compared to those who hardly ever or never engaged in physical activity. Similarly, responders who engaged in vigorous physical activity were less likely to be depressed (OR=0.69; 95%CI=0.61–0.79) and less likely to have suicidal thoughts (OR=0.67; 95%CI=0.54–0.83).</div></div><div><h3>Conclusions</h3><div>This study shows that engaging in moderate to vigorous physical activity more than once a week may help reduce high rates of depression and suicidal thoughts in people with osteoarthritis with moderate to severe pain.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103908"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors influencing reversible cognitive frailty among older adults in elderly care facilities in Northeast China: A cross-sectional survey","authors":"Yi Zhao MSc,&nbsp;Jianwen Lu MSc,&nbsp;Jiajun Sai MSc,&nbsp;Yaqi Wang MSc,&nbsp;Ruiyang Guo MSc,&nbsp;Xinyi Meng MSc","doi":"10.1016/j.gerinurse.2026.103822","DOIUrl":"10.1016/j.gerinurse.2026.103822","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the prevalence and factors influencing reversible cognitive frailty among older adults in elderly care facilities in Northeast China.</div></div><div><h3>Method</h3><div>A cross-sectional survey was conducted on 204 older adults in one of three elderly care facilities in Dalian, China. Data were collected using the Sociodemographic Characteristics Questionnaire, FRAIL scale, Rapid Cognitive Screening Scale (RCS), Subjective Cognitive Decline (SCD) rating entries, streamlined version of the Centre for Streamlined Depression Scale (CES-D-R), shortened version of the Self-perceived Aging Scale (B-APQ), and Barthel Index (BI). SPSS 26.0 and R Studio 4.4.1 software was utilized for univariate and binary logistic regression analyses.</div></div><div><h3>Result</h3><div>The results showed that the prevalence of reversible cognitive frailty was 28.4 %. In binary logistic regression analysis, different ages, physical exercise, sleep quality, number of chronic diseases, self-perceived aging, and BI were the significant influencing factors of reversible cognitive frailty among older adults in elderly care facilities.</div></div><div><h3>Conclusion</h3><div>Institutional workers should assess older people's ability to perform daily living tasks and their mental health, strengthen chronic disease management, and formulate a personalized exercise program to delay or reverse the onset of reversible cognitive frailty.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103822"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between hepatitis C virus infection and cognitive decline in seniors: further evidence from Taiwan","authors":"Fu-Hsiung Su MD, PhD ,&nbsp;Yi-Chien Lai BSc ,&nbsp;Tiffany Luke BSc ,&nbsp;Ming-Zhen Yu MPH ,&nbsp;Moreen Maliko PhD ,&nbsp;Ming-Jang Su MD, PhD ,&nbsp;Chia-Ling Wu MD ,&nbsp;Chih-Ching Yeh PhD","doi":"10.1016/j.gerinurse.2026.103811","DOIUrl":"10.1016/j.gerinurse.2026.103811","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the association between hepatitis C virus (HCV) infection and cognitive impairment among seniors in Taiwan, building on our previous findings from a cross-sectional study.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Taiwan Biobank.</div></div><div><h3>Participants</h3><div>326 participants with positive serum anti-HCV and a control group of 8753 with negative HCV free of cognitive impairment were assessed by the Mini-Mental State Examination at baseline.</div></div><div><h3>Measurements</h3><div>The association between HCV infection and cognitive impairment was evaluated using Cox proportional hazard models. The analysis was adjusted for age, sex, education, BMI, hypertension, cirrhosis, depression, estimated glomerular filtration rate, <em>APOE</em> genotype, and recruitment periods.</div></div><div><h3>Results</h3><div>Anti-HCV positive patients showed a significantly higher incidence of cognitive impairment compared to anti-HCV negative individuals (14.28 vs. 7.21 per 1000 person-years, <em>P</em> = 0.004). After adjusting for covariates, HCV infection was significantly associated with an increased risk of developing cognitive impairment (adjusted HR [aHR]: 1.80, 95% confidence interval [CI]: 1.12–2.90). Subgroup analyses for individuals diagnosed prior to the public direct-acting antivirals reimbursement in 2017 and with high antibody titres (sample/cutoff ratio ≥ 5), the elevated risk of cognitive impairment remained statistically significant, with aHRs of 1.69 (95% CI: 1.04–2.75) and 1.81 (95% CI: 1.11–2.96) respectively. Additionally, HCV patients carrying the <em>APOE</em> ɛ4 allele had a marginally higher risk (aHR: 2.60, 95% CI: 0.96–7.08, <em>P</em> = 0.06).</div></div><div><h3>Conclusions</h3><div>In Taiwan, our findings strengthen evidence that individuals above the age of 60 with HCV infections are at a greater risk of developing cognitive impairment than their counterparts, who were HCV negative.</div></div>","PeriodicalId":56258,"journal":{"name":"Geriatric Nursing","volume":"69 ","pages":"Article 103811"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}