Background: The systemic and psychosocial associations of temporomandibular disorders (TMD) in youth are poorly defined. This study assessed distribution of TMD-related symptoms by age and sex and examined associations with comorbidities in children and adolescents from multiple academic centers.
Methods: Data from BigMouth repository (01/2014-05/2025) included 5-to-17-year-old children and adolescents with completed TMD-related intake items. Painful TMD was defined as self-reported pain upon chewing/talking/jaw use. Symptom distribution was compared by age and sex; associations with comorbidities were assessed using chi-square and multivariable logistic regression.
Results: Among 13,678 children and adolescents (12.9±3.5 years, 53.1% female), common symptoms included grinding (13.1%), headaches (11.3%), and temporomandibular joint noises (8.2%). Adolescents (10-17 years) more frequently reported painful TMD (4.2% vs. 2.7%, p<.001) and self-reported joint sounds (16.7% vs. 12.02%, p<.001) compared to 5-to-9-years-old children. Females reported more painful TMD than males (58.5% vs. 52.8%, p=.012). Painful TMD co-occurred with higher prevalence of headaches (29.9% vs. 12.5%), sleep apnea (10.1% vs. 4.3%), depression (39.4% vs. 12.4%) and anxiety (39.7% vs. 23.5%, all p's<0.001) than with non-painful TMD. Youth with higher psychological comorbidity had higher odds of painful TMD (p<.001, OR=2.37, 95%CI 1.76, 3.19).
Conclusions: TMD symptoms increase during adolescence. Painful TMD is associated with somatic and psychological comorbidities, highlighting need for early identification and targeted intervention.
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