Cranio-The Journal of Craniomandibular & Sleep Practice最新文献

Objective: To investigate the relationship between T102C (rs6313) polymorphism in the 5-hydroxytryptamine receptor-2A (5HTR2A) gene and temporomandibular disorder (TMD) and anxiety.

Methods: This observational case-control study included 80 patients and 70 healthy controls. TMD was diagnosed using the criteria for TMD (DC/TMD). Anxiety was assessed with the Beck anxiety scale. A genotyping study of HTRR2A T102C (rs6313) gene polymorphism was performed from genomic DNA isolated from blood.

Results: The TMD group had higher anxiety scores than the control group (p < .05). The TMD group was similar to the control group regarding genotype and allele frequencies. However, the polymorphic CC genotype was more common in those with high anxiety (p < .05).

Conclusion: There was no clear evidence of an association between TMD and the T102C polymorphism in HTR2A and TMD. However, anxiety is closely related to the T102C polymorphism in HTR2A.

Objective: The aim of this study was to investigate the effects of exercise and mandibular advancement device (MAD) on severity of Obstructive sleep apnea syndrome (OSAS) with mandibular retrognathia.

Methods: Patients were randomly allocated into either exercise group or MAD group. All patients underwent blood tests, polysomnography studies and questionnaires studies at enrollment and at the 12-week's follow-up.

Results: Our study showed MAD was superior to exercise in improving polysomnographic outcomes and Snore Scale (SS) score. No significant difference was observed between the two treatments in terms of Epworth Sleepiness Scale (ESS) score. Moreover, in the exercise group, improvements were also observed in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C).

Conclusion: MAD was more effective than exercise in improving sleep efficiency. Exercise can improve daytime sleepiness and lipid metabolism, independent of the effects on BMI.Trial registration ChiCTR2000034188.

Objective: The objective of this study was to investigate whether trigeminal somatosensory function and mechanosensitivity differ between groups with craniofacial neuropathic pain (CNP), non-neuropathic craniofacial pain (NNP), and healthy controls (HC).

Methods: Thirty-three participants were categorized into these groups, matched for age and sex. The study evaluated pain intensity, the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), and various trigeminal somatosensory tests, including vibration, pressure pain, thermal detection, cold pain, and neurodynamic tests of the trigeminal nerve.

Results: Cold pain thresholds differed significantly among the three groups CNP, NNP, and HC (p = .047). No difference was found in vibration detection, pressure pain threshold, and thermal detection. Trigeminal nerve mechanosensitivity was significantly different among the three groups (p = .03), particularly between groups CNP and HC (p = .01).

Conclusion: Differences in aspects of trigeminal somatosensory function, including cold pain and trigeminal mechanosensitivity, exist between subjects with chronic craniofacial pain and HC. This implies that a clinical classification system for neuromusculoskeletal rehabilitation could be valuable in evaluating patients.

Objective: We reviewed the efficacy of dextrose prolotherapy versus placebo and other active interventions, like autologous blood injection (ABI) and botulinum toxin (BTX), in improving the outcomes of temporomandibular joint (TMJ) hypermobility.

Methods: We searched PubMed, the Cochrane CENTRAL library, Embase, Scopus, and Web of Science databases to identify randomized controlled trials (RCTs) . Maximal mouth opening (MMO), pain, and frequency of dislocations were analyzed.

Results: Eight RCTs were included. In comparison with placebo, dextrose prolotherapy was associated with significantly reduced pain and MMO. Comparison of dextrose with ABI revealed no significant difference in MMO. Qualitative analysis showed no significant difference in outcomes in patients who received dextrose prolotherapy and BTX.

Conclusions: Low-quality evidence suggests that dextrose prolotherapy may reduce MMO and improve pain scores compared to placebo in patients with TMJ hypermobility. Low-quality evidence also suggests that there may be minimal difference in outcomes between dextrose vs ABI and BTX.

Objective: This study aimed to investigate the potential genetic link between sleep traits and periodontitis.

Methods: A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies data on chronotype, daytime sleepiness, daytime napping frequency, insomnia, sleep duration, snoring, and the apnea-hypopnea index (AHI), along with a separate dataset on periodontitis.

Results: Chronotype (OR = 0.929, 95% CI = 0.788-1.095), daytime sleepiness (OR = 0.492, 95% CI = 0.186-1.306), daytime napping frequency (OR = 1.178, 95% CI = 0.745-1.863), sleep duration (OR = 0.868, 95% CI = 0.644-1.169), AHI (OR = 1.124, 95% CI = 0.980-1.289), insomnia (OR = 0.832, 95% CI = 0.440-1.573), and snoring (OR = 0.641, 95% CI = 0.198-2.075) had no effect on periodontitis. Similarly, periodontitis demonstrated no significant effect on sleep traits.

Conclusions: There is no evidence of a bidirectional genetic relationship between sleep traits and the risk of periodontitis.

Objective: Anxiety tends to increase muscle tension and painful symptoms; however, its symptoms can be associated with temporomandibular dysfunction (TMD). Therefore, it is crucial for professionals to identify the presence of both comorbidities and determine whether they are related. This study aims to systematically evaluate the literature and answer the question: "Is there an association between anxiety and TMD in adults?"

Methods: The study followed the PRISMA protocol and was registered in PROSPERO. The custom search was performed in PubMed, Embase, Scopus, and Lilacs databases, as inclusion criteria observational studies that evaluated the association between anxiety and TMD in adults.

Results: A total of 1640 articles were found. After removing duplicates, 988 were evaluated by title and abstract. Of these, 28 were selected for reading in full, of which 13 were included in the present review.

Conclusion: The association of anxiety with TMD is positive, except for the minority indicating a low relationship between the disorders, which is explained by neuroscience.

Objective: Videos containing exercises for masticatory muscles to enhance esthetic appearance are published on social media platforms. The aim of the study was to find out the nature of the exercises and whether they could have an impact on the health of the masticatory muscles.

Method: For the netnography, social media videos of jaw area exercises were collected as material and reviewed. The literature review investigated the effect of voluntary masticatory muscle exercises.

Results: 71 videos were collected, with none referring to scientific evidence. Muscle exercises found by netnography were isometric exercise of the masseter muscles. The scoping review revealed isometric exercise of the masticatory muscles can cause symptoms in the masticatory system in temporomandibular disorder patients.

Conclusion: Non-professional masticatory muscle exercises should be considered in the etiology of muscle-related TMD. Dental professionals should to explore social media platforms to be aware of content about dental issues.

Objective: To evaluate the effect of conservative therapeutic interventions in adult patients with temporomandibular disorders (TMD) and associated otologic symptoms.

Methods: An electronic search across six databases and grey literature was conducted. Studies were assessed for risk of bias, a random-effects meta-analysis, and the certainty of the evidence was evaluated using the GRADE tool.

Results: Eighteen studies were included in the final synthesis. Otologic symptoms significantly decreased following intervention compared to baseline [OR = 0.09; 95% CI = 0.04 - 0.23, I² = 56%], reflecting an approximately 11-fold reduction in symptom likelihood of otologic symptoms after conservative treatment. Of the studies, eight had a low risk of bias, five had moderate, and four had high risk, with evidence certainty rated as very low.

Conclusion: Conservative therapeutic interventions for TMD appear to reduce otologic symptoms. However, the certainty of the current evidence is limited, warranting further research to establish more definitive conclusions..

Objective: To investigate the effect of parathormone and thyroid hormones, along with their associated biochemical factors in individuals with and without symptoms indicative of temporomandibular disorder (TMDs) admitted to the internal medicine department.

Methods: The study involved 416 participants with symptoms indicative of TMDs and 415 controls. Serum concentrations of anti-thyroid peroxidase antibody (Anti-TPO Ab), free triiodothyronine, free thyroxine, thyroid-stimulating hormone, parathyroid hormone, calcium, sodium, potassium, magnesium, phosphorus, vitamin D, vitamin B12, folate, creatine kinase, haemoglobin, ferritin, C-reactive protein and sedimentation rate were analysed.

Results: The serum level of anti-TPO Ab was found to be elevated in participants with symptoms indicative of TMDs in comparison to controls (p < .001). However, no significant differences were observed in the other parameters assessed between the two groups (p > .05).

Conclusion: Serum concentrations of parathormone and thyroid hormones associated biochemical factors are not affected in participants with symptoms indicative of TMDs except Anti-TPO Ab.

Objective: The study aimed to determine the associations between several important and potentially modifiable health variables and TMD signs and symptoms.

Methods: A total of 209 adult dental patients from two clinics completed surveys on demographics, self-reported awake and sleep bruxism, TMD signs and symptoms, stress, depression, chronic pain, and sleep quality. Correlations and regression analyses were used to identify associations between these health variables and TMD symptoms.

Results: Awake bruxism was significantly associated with chronic pain intensity, jaw pain, clenching pain, and headaches. Stress and depression correlated with chronic pain intensity and clenching pain. No correlation was found between BMI and TMD symptoms. In multivariate analysis, both awake and sleep bruxism were associated with TMD symptoms, while sleep quality was related to pain on chewing and depression was associated with chronic pain intensity.

Conclusions: Identifying these associations can guide clinicians in assessing, educating and managing TMD-related issues by addressing bruxism, sleep quality, and depressive symptoms.