Pub Date : 2017-05-15DOI: 10.4236/OJBIPHY.2017.73011
P. O. Adueming, M. J. Eghan, B. Anderson, S. Kyei, Jerry Opoku-Ansah, C. Amuah, S. S. Sackey, P. Buah-Bassuah
Cataracts are the leading cause of blindness worldwide. Current methods for discriminating cataractous lenses from healthy lenses of Sprague-Dawley rats during preclinical studies are based on either histopathological or clinical assessments which are weakened by subjectivity. In this work, both cataractous and healthy lens tissues of Sprague-Dawley rats were studied using multispectral imaging technique in combination with multivariate analysis. Multispectral images were captured in transmission, reflection and scattering modes. In all, five spectral bands were found to be markers for discriminating cataractous lenses from healthy lenses; 470 nm and 625 nm discriminated in reflection mode whereas 435 nm, 590 nm and 700 nm discriminated in transmission mode. With Fisher’s Linear discriminant analysis, the midpoints for classifying cataractous from healthy lenses were found to be 14.718 × 10−14 and 3.2374 × 10−14 for the two spectra bands in the reflection mode and the three spectral bands in the transmission mode respectively. Images in scattering mode did not show significant discrimination. These spectral bands in reflection and transmission modes may offer potential diagnostic markers for discriminating cataractous lenses from healthy lenses thereby promising multispectral imaging applications for characterizing cataractous and healthy lenses.
{"title":"Multispectral Imaging in Combination with Multivariate Analysis Discriminates Selenite Induced Cataractous Lenses from Healthy Lenses of Sprague-Dawley Rats","authors":"P. O. Adueming, M. J. Eghan, B. Anderson, S. Kyei, Jerry Opoku-Ansah, C. Amuah, S. S. Sackey, P. Buah-Bassuah","doi":"10.4236/OJBIPHY.2017.73011","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.73011","url":null,"abstract":"Cataracts are the leading cause of blindness worldwide. Current methods for discriminating cataractous lenses from healthy lenses of Sprague-Dawley rats during preclinical studies are based on either histopathological or clinical assessments which are weakened by subjectivity. In this work, both cataractous and healthy lens tissues of Sprague-Dawley rats were studied using multispectral imaging technique in combination with multivariate analysis. Multispectral images were captured in transmission, reflection and scattering modes. In all, five spectral bands were found to be markers for discriminating cataractous lenses from healthy lenses; 470 nm and 625 nm discriminated in reflection mode whereas 435 nm, 590 nm and 700 nm discriminated in transmission mode. With Fisher’s Linear discriminant analysis, the midpoints for classifying cataractous from healthy lenses were found to be 14.718 × 10−14 and 3.2374 × 10−14 for the two spectra bands in the reflection mode and the three spectral bands in the transmission mode respectively. Images in scattering mode did not show significant discrimination. These spectral bands in reflection and transmission modes may offer potential diagnostic markers for discriminating cataractous lenses from healthy lenses thereby promising multispectral imaging applications for characterizing cataractous and healthy lenses.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42222763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-29DOI: 10.4236/OJBIPHY.2017.72005
Konin E. Jean Michel, Yale Pavel, Megnassan Eugene, M. A. Kouacou, J. Zoueu
In recent years, extensive research has been carried out on red blood cells in order to investigate their mechanical properties. The interest in these studies has been possible thanks to the technological innovations made in the field of micro or nano manipulation of biological and non-biological particles without physical contact. In the present project, we have developed a new approach to study the deformation of red blood cells moving against a trapped microbead by applying a sinusoidal voltage (DC offset 3.5 Vpp) to the stage at 0.4 Hz frequencies. The oscillating movement imposed on the stage highlights the indentation test and the tensile test known for the study of mechanical behavior of materials. The mechanical properties found are: the modulus of elasticity (Young Modulus), the shear modulus, the coefficient of hardening and erythrocyte resistance coefficient. The axial shear modulus 25.00 ± 1.5 μN/m and the transversal shear modulus 15.7 ± 4.63 μN/m were compared to those in the literature. These values were respectively determined by Hooke’s law and the Hertz model.
{"title":"Dynamics Study of the Deformation of Red Blood Cell by Optical Tweezers","authors":"Konin E. Jean Michel, Yale Pavel, Megnassan Eugene, M. A. Kouacou, J. Zoueu","doi":"10.4236/OJBIPHY.2017.72005","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.72005","url":null,"abstract":"In recent years, extensive research has been carried out on red blood cells in order to investigate their mechanical properties. The interest in these studies has been possible thanks to the technological innovations made in the field of micro or nano manipulation of biological and non-biological particles without physical contact. In the present project, we have developed a new approach to study the deformation of red blood cells moving against a trapped microbead by applying a sinusoidal voltage (DC offset 3.5 Vpp) to the stage at 0.4 Hz frequencies. The oscillating movement imposed on the stage highlights the indentation test and the tensile test known for the study of mechanical behavior of materials. The mechanical properties found are: the modulus of elasticity (Young Modulus), the shear modulus, the coefficient of hardening and erythrocyte resistance coefficient. The axial shear modulus 25.00 ± 1.5 μN/m and the transversal shear modulus 15.7 ± 4.63 μN/m were compared to those in the literature. These values were respectively determined by Hooke’s law and the Hertz model.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44935684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4236/OJBIPHY.2017.71002
M. Omer, Abdulrahman A. Alsayyari, J. Tamboul, R. B. Ali, A. A. Ahmed, A. Abukonna
The aim of this study was to study the technical factors affecting the reading of TLD (LiF:Mg:Ti) for radiation dosimetry. The method adapted was an exposure of LiF:Mg:Ti crystal with γ-ray with the following filters (Hp 0.07 and Hp 10), before and after usage of filter Hp (0.07), annealing, cooling by nitrogen flux and crystal morphology by scanning electron microscope. The collected data analyzed by EXCELL software showed that: TLD average count/second (C/s) with filter Hp (10) was greater than that obtained with filter Hp (0.07) with an amount of 1191 c/s (19%). Also the analysis showed that: the average C/s without filter Hp (0.07) was greater than that with filter by an amount of 994.5 C/s (16.4%), and there was proportional linear relationship; as the applied dose increased the TLD C/s increased significantly (R2 = 0.9) based on the equations: y = 885.1x ? 286.5 and y = 860.5x + 856.8 for filtered and without filtered beam respectively, where x refers to applied dose in mGy and y refers to C/s. Also the average C/s without nitrogen flux (cooling) was greater than with nitrogen count with an amount of 52.4 C/s (11%). The annealing (without filter) causes a reduction in dose by 82.2 μGy (19.2%), and in case of annealing with filter, the dose reduced by 66.7 μGy (21.9%) relative to annealing without filter. The morphology of TLD crystal shown by scanning electron microscope SEM was a darkening surface after irradiation.
{"title":"Studying of Common Factors Affecting Reading of Lithium Fluoride Thermo-Luminescence Dosimeter Crystal","authors":"M. Omer, Abdulrahman A. Alsayyari, J. Tamboul, R. B. Ali, A. A. Ahmed, A. Abukonna","doi":"10.4236/OJBIPHY.2017.71002","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.71002","url":null,"abstract":"The aim of this study was to study the technical factors affecting the reading of TLD (LiF:Mg:Ti) for radiation dosimetry. The method adapted was an exposure of LiF:Mg:Ti crystal with γ-ray with the following filters (Hp 0.07 and Hp 10), before and after usage of filter Hp (0.07), annealing, cooling by nitrogen flux and crystal morphology by scanning electron microscope. The collected data analyzed by EXCELL software showed that: TLD average count/second (C/s) with filter Hp (10) was greater than that obtained with filter Hp (0.07) with an amount of 1191 c/s (19%). Also the analysis showed that: the average C/s without filter Hp (0.07) was greater than that with filter by an amount of 994.5 C/s (16.4%), and there was proportional linear relationship; as the applied dose increased the TLD C/s increased significantly (R2 = 0.9) based on the equations: y = 885.1x ? 286.5 and y = 860.5x + 856.8 for filtered and without filtered beam respectively, where x refers to applied dose in mGy and y refers to C/s. Also the average C/s without nitrogen flux (cooling) was greater than with nitrogen count with an amount of 52.4 C/s (11%). The annealing (without filter) causes a reduction in dose by 82.2 μGy (19.2%), and in case of annealing with filter, the dose reduced by 66.7 μGy (21.9%) relative to annealing without filter. The morphology of TLD crystal shown by scanning electron microscope SEM was a darkening surface after irradiation.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4236/OJBIPHY.2017.71003
E. Escultura
As an application of the grand unified theory (GUT) to medicine, this paper introduces two natural nanomaterials—the gene and electromagnetic wave. They are involved in the proposed treatment of genetic and infectious diseases. It introduces the superstring as the fundamental building block of matter and the basic constituent of dark matter, one of the two fundamental states of matter. It also introduces the primum, unit of visible or ordinary matter, the other fundamental state of matter. They are convertible to each other by the action of basic cosmic or electromagnetic waves. Eleven biological laws define biology as a biological and physical theory. The gene is the primitive ingredient of living things and, therefore, the beginning of biological life and the virus the simplest living thing. Treatment ranges from genetic modification and alteration to remove undesirable symptom through genetic sterilization to stop the spread of the disease and outright destruction of the disease. Genetic sterilization and outright destruction apply also to infectious diseases. The paper concludes with a blueprint for research and development of appropriate technologies for the treatment.
{"title":"The Gene as Natural Nanomaterial for Treatment of Diseases","authors":"E. Escultura","doi":"10.4236/OJBIPHY.2017.71003","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.71003","url":null,"abstract":"As an application of the grand unified theory (GUT) to medicine, this paper introduces two natural nanomaterials—the gene and electromagnetic wave. They are involved in the proposed treatment of genetic and infectious diseases. It introduces the superstring as the fundamental building block of matter and the basic constituent of dark matter, one of the two fundamental states of matter. It also introduces the primum, unit of visible or ordinary matter, the other fundamental state of matter. They are convertible to each other by the action of basic cosmic or electromagnetic waves. Eleven biological laws define biology as a biological and physical theory. The gene is the primitive ingredient of living things and, therefore, the beginning of biological life and the virus the simplest living thing. Treatment ranges from genetic modification and alteration to remove undesirable symptom through genetic sterilization to stop the spread of the disease and outright destruction of the disease. Genetic sterilization and outright destruction apply also to infectious diseases. The paper concludes with a blueprint for research and development of appropriate technologies for the treatment.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4236/OJBIPHY.2017.71001
Nicolas Rouleau, J. N. Costa, M. Persinger
The signal processing function of human cerebral cortical tissues is determined by the regional cytoarchitectures distributed throughout the brain. Based upon this assumption, we pursued the hypothesis that residual microstructure within the primary and associative visual cortices of a fixed, post-mortem whole human brain would process electrical signals differentially. To this end, we designed and engineered a very simple brain-photocell interface. Photostimuli, presented as either periodic flashes or as dynamic visual images, were transduced by photocells attached to the optic nerve of a post-mortem human brain specimen. The novel approach revealed that microvolt fluctuations within the primary and associative visual cortices could be discriminated. Simple light-dark discrimination was noted for the primary visual area (BA17) whereas within the right occipito-parietal cortices of the dorsal visual stream (BA19, BA7), spectral power of microvolt fluctuations could discriminate moving visual stimuli from those which were non-moving. Discriminant analysis classified movement represented within the right parietal lobe with 80% success. Together, the results suggest that artificially generated electrical signals are processed differentially by alternative cortical regions in the post-mortem brain.
{"title":"Evaluating the Signal Processing Capacities of Post-Mortem Cerebral Cortical Tissue by Artificial Phototransduction of Dynamic Visual Stimuli","authors":"Nicolas Rouleau, J. N. Costa, M. Persinger","doi":"10.4236/OJBIPHY.2017.71001","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.71001","url":null,"abstract":"The signal processing function of human cerebral cortical tissues is determined by the regional cytoarchitectures distributed throughout the brain. Based upon this assumption, we pursued the hypothesis that residual microstructure within the primary and associative visual cortices of a fixed, post-mortem whole human brain would process electrical signals differentially. To this end, we designed and engineered a very simple brain-photocell interface. Photostimuli, presented as either periodic flashes or as dynamic visual images, were transduced by photocells attached to the optic nerve of a post-mortem human brain specimen. The novel approach revealed that microvolt fluctuations within the primary and associative visual cortices could be discriminated. Simple light-dark discrimination was noted for the primary visual area (BA17) whereas within the right occipito-parietal cortices of the dorsal visual stream (BA19, BA7), spectral power of microvolt fluctuations could discriminate moving visual stimuli from those which were non-moving. Discriminant analysis classified movement represented within the right parietal lobe with 80% success. Together, the results suggest that artificially generated electrical signals are processed differentially by alternative cortical regions in the post-mortem brain.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4236/OJBIPHY.2017.71004
Neville Y. Forlemu, P. Watkins, Joseph Sloop
The parasite Plasmodium falciparum is responsible for the major world scourge malaria, a disease that affects 3.3 billion people worldwide. The development of new drugs is critical because of the diminished effectiveness of current antimalarial agents mainly due to parasitic resistance, side effects and cost. Molecular docking was used to explore structural motifs responsible for the interactions between triose phosphate isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and aldolase (ALD) from human and Plasmodium cells with 8 novel sufonylamide derivatives. All the ligands modeled, interact with all three enzymes in the micromolar range. The top ligand (sulfaE) shows a 70-fold increase in selective binding to pfTPI compared to hTPI (dissociation constant-KI of 7.83 μM and 0.177 μM for hTPI and pfTPI respectively), on par with antimalarial drug chloroquine.ALD and GAPDH form complexes with similar binding sites, comprising amino acids of similar chemical properties and polarities. Human TPI and pfTPI bind sulfonamide derivatives using two distinct binding sites and residues. Key residues at the dimer interface of pfTPI (VAL44, SER45, TYR48, GLN64, ASN65, VAL78) form a tight pocket with favorable polar contacts. The affinity with TPI is the most specific, stable, and selective suggesting pfTPI is a candidate for development of antimalarial drugs.
{"title":"Molecular Docking of Selective Binding Affinity of Sulfonamide Derivatives as Potential Antimalarial Agents Targeting the Glycolytic Enzymes: GAPDH, Aldolase and TPI","authors":"Neville Y. Forlemu, P. Watkins, Joseph Sloop","doi":"10.4236/OJBIPHY.2017.71004","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2017.71004","url":null,"abstract":"The parasite Plasmodium falciparum is responsible for the major world scourge malaria, a disease that affects 3.3 billion people worldwide. The development of new drugs is critical because of the diminished effectiveness of current antimalarial agents mainly due to parasitic resistance, side effects and cost. Molecular docking was used to explore structural motifs responsible for the interactions between triose phosphate isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and aldolase (ALD) from human and Plasmodium cells with 8 novel sufonylamide derivatives. All the ligands modeled, interact with all three enzymes in the micromolar range. The top ligand (sulfaE) shows a 70-fold increase in selective binding to pfTPI compared to hTPI (dissociation constant-KI of 7.83 μM and 0.177 μM for hTPI and pfTPI respectively), on par with antimalarial drug chloroquine.ALD and GAPDH form complexes with similar binding sites, comprising amino acids of similar chemical properties and polarities. Human TPI and pfTPI bind sulfonamide derivatives using two distinct binding sites and residues. Key residues at the dimer interface of pfTPI (VAL44, SER45, TYR48, GLN64, ASN65, VAL78) form a tight pocket with favorable polar contacts. The affinity with TPI is the most specific, stable, and selective suggesting pfTPI is a candidate for development of antimalarial drugs.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-30DOI: 10.4236/OJBIPHY.2016.64010
S. Jastaniah
The objective of the present study was to access to imaging material density close to or identical density imaging of bone and soft tissue, from raw materials of nature to be used in different model applications and to provide comprehensive evaluation of the imaging system and techniques under realistic conditions in radiology departments for educational purposes. The palm tree of abundance in Saudi Arabia was chosen to study the date’s seeds and palm leaves in terms of photographic density. The results achieved were referring to the lack of imaging density of dates seeds and palm leaves compared to bone density. Thus, it was necessary to use two additional materials: Salt and eggshells in order to find the highest density and graphic approach to bone density. The present preliminary study indicated that the permanent and stable model can be achieved by palm leaves, salt & eggshell powder with imaging material density close to the imaging density of the bone and soft tissue for achieving more clinical skills and medical education.
{"title":"Novel Mixture of Materials Produces Bone- and Soft Tissue-Like Imaging Density","authors":"S. Jastaniah","doi":"10.4236/OJBIPHY.2016.64010","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2016.64010","url":null,"abstract":"The objective of the present study was to access to imaging material density close to or identical density imaging of bone and soft tissue, from raw materials of nature to be used in different model applications and to provide comprehensive evaluation of the imaging system and techniques under realistic conditions in radiology departments for educational purposes. The palm tree of abundance in Saudi Arabia was chosen to study the date’s seeds and palm leaves in terms of photographic density. The results achieved were referring to the lack of imaging density of dates seeds and palm leaves compared to bone density. Thus, it was necessary to use two additional materials: Salt and eggshells in order to find the highest density and graphic approach to bone density. The present preliminary study indicated that the permanent and stable model can be achieved by palm leaves, salt & eggshell powder with imaging material density close to the imaging density of the bone and soft tissue for achieving more clinical skills and medical education.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-30DOI: 10.4236/OJBIPHY.2016.64011
V. M. F. Lima, W. Hanke
In this paper we make the assertion that the key to understand the emergent properties of excitable tissue (brain and heart) lies in the application of irreversible thermodynamics. We support this assertion by pointing out where symmetry break, phase transitions both in structure of membranes as well as in the dynamic of interactions between membranes occur in excitable tissue and how they create emergent low dimensional electrochemical patterns. These patterns are expressed as physiological or physiopathological concomitants of the organ or organism behavior. We propose that a set of beliefs about the nature of biological membranes and their interactions are hampering progress in the physiology of excitable tissue. We will argue that while there is no direct evidence to justify the belief that quantum mechanics has anything to do with macroscopic patterns expressed in excitable tissue, there is plenty of evidence in favor of irreversible thermodynamics. Some key predictions have been fulfilled long time ago and they have been ignored by the mainstream literature. Dissipative structures and phase transitions appear to be a better conceptual context to discuss biological self-organization. The central role of time as a global coupling agent is emphasized in the interpretation of the presented results.
{"title":"Macroscopic Self-Organized Electrochemical Patterns in Excitable Tissue and Irreversible Thermodynamics","authors":"V. M. F. Lima, W. Hanke","doi":"10.4236/OJBIPHY.2016.64011","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2016.64011","url":null,"abstract":"In this paper we make the assertion that the key to understand the emergent properties of excitable tissue (brain and heart) lies in the application of irreversible thermodynamics. We support this assertion by pointing out where symmetry break, phase transitions both in structure of membranes as well as in the dynamic of interactions between membranes occur in excitable tissue and how they create emergent low dimensional electrochemical patterns. These patterns are expressed as physiological or physiopathological concomitants of the organ or organism behavior. We propose that a set of beliefs about the nature of biological membranes and their interactions are hampering progress in the physiology of excitable tissue. We will argue that while there is no direct evidence to justify the belief that quantum mechanics has anything to do with macroscopic patterns expressed in excitable tissue, there is plenty of evidence in favor of irreversible thermodynamics. Some key predictions have been fulfilled long time ago and they have been ignored by the mainstream literature. Dissipative structures and phase transitions appear to be a better conceptual context to discuss biological self-organization. The central role of time as a global coupling agent is emphasized in the interpretation of the presented results.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-30DOI: 10.4236/OJBIPHY.2016.64009
Honghui Li, Junhua Hou
Effects of entropy and free radical in life system are elucidated. The results indicate that living organism can maintain normal activities only if a suitable free radicals inside living organism can be guaranteed. Excessive free radical should be eliminated to reduce entropy in living organism. Some ways provided to eliminate excessive free radical, reduce entropy and keep health.
{"title":"Entropy, Free Radical and Life System","authors":"Honghui Li, Junhua Hou","doi":"10.4236/OJBIPHY.2016.64009","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2016.64009","url":null,"abstract":"Effects of entropy and free radical in life system are elucidated. The results indicate that living organism can maintain normal activities only if a suitable free radicals inside living organism can be guaranteed. Excessive free radical should be eliminated to reduce entropy in living organism. Some ways provided to eliminate excessive free radical, reduce entropy and keep health.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-30DOI: 10.4236/OJBIPHY.2016.64012
K. Iguchi
The purpose of this paper is to introduce to you, the Western people, nowadays a “widely unknown” Japanese thermodynamicist by the name of Motoyosi Sugita and his study on the thermodynamics of transient phenomena and his theory of life. This is because although he was one of the top theoretical physicists in Japan before, during and after WWII and after WWII he promoted the establishment of the biophysical society of Japan as one of the founding members, he himself and his studies themselves have seemed to be totally forgotten nowadays in spite that his study was absolutely important for the study of life. Therefore, in this paper I would like to present what kind of person he was and what he studied in physics as a review on the physics work of Motoyosi Sugita for the first time. I will follow his past studies to introduce his ideas in theoretical physics as well as in biophysics as follows: He proposed the bright ideas such as the quasi-static change in the broad sense, the virtual heat, and the field of chemical potential etc. in order to establish his own theory of thermodynamics of transient phenomena, as the generalization of the Onsager-Prigogine’s theory of the irreversible processes. By the concept of the field of chemical potential that acquired the nonlinear transport, he was seemingly successful to exceed and go beyond the scope of Onsager and Prigogine. Once he established his thermodynamics, he explored the existence of the 4th law of thermodynamics for the foundation of theory of life. He applied it to broad categories of transient phenomena including life and life being such as the theory of metabolism. He regarded the 4th law of thermodynamics as the maximum principle in transient phenomena. He tried to prove it all life long. Since I have recently found that his maximum principle can be included in more general maximum principle, which was known as the Pontryagin’s maximum principle in the theory of optimal control, I would like to explain such theories produced by Motoyosi Sugita as detailed as possible. And also I have put short history of Motoyosi Sugita’s personal life in order for you to know him well. I hope that this article helps you to know this wonderful man and understand what he did in the past, which was totally forgotten in the world and even in Japan.
{"title":"Motoyosi Sugita—A “Widely Unknown” Japanese Thermodynamicist Who Explored the 4th Law of Thermodynamics for Creation of the Theory of Life","authors":"K. Iguchi","doi":"10.4236/OJBIPHY.2016.64012","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2016.64012","url":null,"abstract":"The purpose of this paper is to introduce to you, the Western people, nowadays a “widely unknown” Japanese thermodynamicist by the name of Motoyosi Sugita and his study on the thermodynamics of transient phenomena and his theory of life. This is because although he was one of the top theoretical physicists in Japan before, during and after WWII and after WWII he promoted the establishment of the biophysical society of Japan as one of the founding members, he himself and his studies themselves have seemed to be totally forgotten nowadays in spite that his study was absolutely important for the study of life. Therefore, in this paper I would like to present what kind of person he was and what he studied in physics as a review on the physics work of Motoyosi Sugita for the first time. I will follow his past studies to introduce his ideas in theoretical physics as well as in biophysics as follows: He proposed the bright ideas such as the quasi-static change in the broad sense, the virtual heat, and the field of chemical potential etc. in order to establish his own theory of thermodynamics of transient phenomena, as the generalization of the Onsager-Prigogine’s theory of the irreversible processes. By the concept of the field of chemical potential that acquired the nonlinear transport, he was seemingly successful to exceed and go beyond the scope of Onsager and Prigogine. Once he established his thermodynamics, he explored the existence of the 4th law of thermodynamics for the foundation of theory of life. He applied it to broad categories of transient phenomena including life and life being such as the theory of metabolism. He regarded the 4th law of thermodynamics as the maximum principle in transient phenomena. He tried to prove it all life long. Since I have recently found that his maximum principle can be included in more general maximum principle, which was known as the Pontryagin’s maximum principle in the theory of optimal control, I would like to explain such theories produced by Motoyosi Sugita as detailed as possible. And also I have put short history of Motoyosi Sugita’s personal life in order for you to know him well. I hope that this article helps you to know this wonderful man and understand what he did in the past, which was totally forgotten in the world and even in Japan.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：