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A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19 应对COVID-19复杂挑战的生物电磁方案
Pub Date : 2021-01-01 DOI: 10.4236/ojbiphy.2021.111001
A. Szász
The COVID-19 pandemic has experienced unprecedented limitations and extraordinary scientific efforts to address this exceptional situation. Despite blanket closures that have resulted in significant financial constraints and losses around the world, research has an “unlimited” budget, with an exceptional concentration of medical and scientific care on a single topic: understanding the mechanisms for overcoming the disease. A large number of clinical trials have been launched with different drugs that have been behind different concepts and solutions. I would like to focus on the complexity aspect of COVID-19. Living systems are organized in a complex way, which implies dynamic stochastic phenomena, and deterministic reductionism can mislead research. When research focuses on individual molecules or pathways as products, it is distracted from the processes in which these products operate, thus neglecting the complex interactions between regulations and feedback controls. Common problems in product-oriented research are articulated as “double-edged swords”, “Janus behavior”, “two-sided action”, with a simple question: “friend or foe?” I focus on the missing complexity. I propose a bioelectromagnetic process that can maintain a complex approach, affecting processes rather than products. This hypothetical proposal is not a comprehensive solution. Complexity itself limits the overall effects of causing “miracles”. Well-designed electromagnetic effects can support current efforts and, in combination with intensively developed pharmaceuticals, bring us closer to a pharmaceutical solution against COVID-19.
COVID-19大流行经历了前所未有的限制和非凡的科学努力,以应对这一特殊情况。尽管全面关闭在世界各地造成了严重的财政限制和损失,但研究拥有“无限”的预算,将医疗和科学护理特别集中在一个主题上:了解克服这种疾病的机制。大量的临床试验已经启动,不同的药物背后有不同的概念和解决方案。我想重点谈谈2019冠状病毒病的复杂性。生命系统以复杂的方式组织,这意味着动态随机现象,确定性还原论可能会误导研究。当研究集中于单个分子或作为产物的途径时,它就会从这些产物运作的过程中分散注意力,从而忽略了调控和反馈控制之间复杂的相互作用。以产品为导向的研究中常见的问题被表述为“双刃剑”、“两面性行为”、“双面行动”,用一个简单的问题:“是敌是友?”我关注的是缺失的复杂性。我提出了一种生物电磁过程,它可以维持一种复杂的方法,影响过程而不是产品。这个假设的建议并不是一个全面的解决方案。复杂性本身限制了创造“奇迹”的整体效果。精心设计的电磁效应可以支持当前的努力,并与密集开发的药物相结合,使我们更接近针对COVID-19的药物解决方案。
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引用次数: 1
Bio-Electromagnetics without Fields: The Effect of the Vector Potential 无场生物电磁学:矢量电位的影响
Pub Date : 2021-01-01 DOI: 10.4236/OJBIPHY.2021.112007
A. Szász
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引用次数: 0
The Mystery on the Physical Conditions for Life 生命的物理条件之谜
Pub Date : 2021-01-01 DOI: 10.4236/ojbiphy.2021.114015
K. Wong, W. Chow
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引用次数: 0
Cancer Uses the Common Morphogenesis Source of the Host 癌症利用宿主的共同形态发生源
Pub Date : 2020-09-29 DOI: 10.4236/OJBIPHY.2020.104013
A. N. Shoutko
Trophic properties of hematopoietic stem cells can influence the malignant growth alternatively to immune control. The annual growth of the body mass by age in adult populations of welfare countries used as the most common criterion of metabolic and proliferative tissue activity, and these data compared with death’ rate for malignant and somatic diseases in different age-groups of the same countries. The rate of physiologic involution of different cell populations in the lymphoid lineage by age also involved in correlations between the above parameters. A decrease in death rate for cancer and increase it’s for non-malignant diseases found in 60+ populations, which have the lowest physiological temp of renewal of lymphocytes number and mass of the body. The lack of both the thymus gland volume and proliferative activity of naive lymphocytes reduces physiological body mass renewal as well as the cancer death rate but enhances somatic death rate, opposing to anticancer immunity at large. A protumor character of the lymphopoietic system’s relation with malignancy seems more realistic than defending one.
造血干细胞的营养特性可以影响恶性生长,而不是免疫控制。福利国家成年人口按年龄划分的体重年增长率被用作代谢和增殖组织活动的最常见标准,这些数据与同一国家不同年龄组恶性和躯体疾病的死亡率进行了比较。淋巴谱系中不同细胞群随年龄的生理退化率也与上述参数之间的相关性有关。癌症死亡率下降,60多个人群中发现的非恶性疾病死亡率上升,这些人群的淋巴细胞数量和质量更新的生理温度最低。缺乏原始淋巴细胞的胸腺体积和增殖活性降低了生理体重更新以及癌症死亡率,但提高了体细胞死亡率,这与抗癌免疫相反。淋巴生成系统与恶性肿瘤的关系的预防特征似乎比防御更现实。
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引用次数: 0
The Growth of Healthy and Cancerous Tissues 健康和癌变组织的生长
Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103010
G. Szigeti, A. M. Szász, A. Szász
The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth model fine-tuned by various connections of the cells (junctions and adherent connections), intended to direct material and energy transports between them. This secondary control of cell metabolism decreases primary metabolic transport through the free surfaces of the cells. The cellular network is formed by triggering the endogenous electric fields, which are dominantly governed by cell membrane potential. Proliferation exhibits a different electric pattern due to the low cell-membrane potential and resulting negativity relative to its environment. This potential change characterizes cells in normal proliferation and a cluster of cells (a tumor) in the case of cancerous development. This latter has certain similarities to the leakage transport of liquid in porous media, substituting the pressure with endogenous tumor potential. The average survival of a tumor depends on the kind of available metabolic transport and the fractal dimensions of the newly built angiogenic network.
组织的结构是以自相似的方式形成的,在其传输网络中形成分形结构。该结构表现出异速生长和所谓的缩放行为。这是一个基本的生长模型,通过细胞的各种连接(连接和粘附连接)进行微调,旨在引导细胞之间的物质和能量传输。这种对细胞代谢的次级控制减少了通过细胞自由表面的初级代谢转运。细胞网络是通过触发内源性电场而形成的,内源性电场主要由细胞膜电位控制。由于细胞膜电位低以及由此产生的相对于环境的负性,增殖表现出不同的电模式。这种潜在的变化是正常增殖中的细胞和癌症发展中的细胞簇(肿瘤)的特征。后者与液体在多孔介质中的泄漏传输有一定的相似性,用内源性肿瘤潜能代替压力。肿瘤的平均存活率取决于可用的代谢转运类型和新建血管生成网络的分形维数。
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引用次数: 4
Mechanics of Twisted DNA Molecule Adsorbed on a Biological Membrane 扭曲DNA分子在生物膜上的吸附力学
Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103011
R. E. Kinani, H. Kaidi, Noureddine Barka
DNA is the carrier of all cellular genetic information and increasingly used in nanotechnology. The study of DNA molecule achieved in vitro while submitting the DNA to all chemicals agent capabilities to destabilize links hydrogen, such as pH, temperature. In fact, the DNA enveloped in the membrane cellular, so it is legitimate to study the influence of membrane undulations. In this work, we try to show that the fluctuations of the membrane can be considerate as a physics agent is also capable to destabilize links hydrogen. In this investigation, we assume that each pair base formed an angle an with the membrane’s surface. We have proposed a theoretical model, and we have established a relationship between the angle formed by the pair base θeq and an angle formed by the membrane and each pair base. We assume that DNA and biomembrane interact via a realistic potential of Morse type. To this end, use is made of a generalized model that extends that introduced by M. Peyrard and A. R. Bishop in the past modified by M. Zoli. This generalized model is based on the resolution of a Schrodinger-like equation. The exact resolution gives the expression of the ground state, and the associated eigenvalue (energy) that equals the free energy, in the thermodynamic limit. First, we compute the denaturation temperature of DNA strands critical temperature. Second, we deduce all critical properties that mainly depend on the parameters of the model, and we quantify the effects of the membrane undulations. These undulations renormalize all physical quantities, such as harmonic stacking, melting temperature, eigenfunctions, eigenvalues and regular part of specific heat.
DNA是所有细胞遗传信息的载体,越来越多地用于纳米技术。DNA分子的研究是在体外完成的,同时将DNA提交给所有化学试剂,如pH值、温度等,以破坏氢链的稳定性。事实上,DNA包裹在细胞膜中,因此研究细胞膜波动的影响是合理的。在这项工作中,我们试图表明膜的波动可以被认为是一种物理剂,也能够破坏氢链的稳定。在这项研究中,我们假设每对碱基与膜表面形成一个角。我们提出了一个理论模型,并建立了由一对碱基θeq形成的角与膜与每一对碱基形成的角之间的关系。我们假设DNA和生物膜通过莫尔斯型的现实电位相互作用。为此,使用了一个广义模型,该模型扩展了过去由M. Peyrard和a . R. Bishop引入的模型,并由M. Zoli修改。这个广义模型是基于类薛定谔方程的解析。精确的分辨率给出了基态的表达式,以及在热力学极限下等于自由能的相关特征值(能量)。首先,我们计算了DNA链的临界变性温度。其次,我们推导了主要依赖于模型参数的所有关键特性,并量化了膜波动的影响。这些波动使所有物理量重新规范化,如谐波叠加、熔化温度、特征函数、特征值和比热的规则部分。
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引用次数: 0
Biological Stress as a Principle of Nature: A Review of Literature 生物应激作为自然规律:文献综述
Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103012
C. Cortez, Dílson Silva
This review paper attempts to approximate the concept of biological stress to the stress concept in Physics using the phenomenological view of physics to discuss the source of generator forces of biological stress state. Based on the literature, parallels are drawn between the two concepts and a discussion on the steady state in open systems and homeostatic state in biological systems is developed. Using the concepts of thermodynamic entropy and informational entropy, and comparing stress in living systems and nonliving, we attempt to build a basis for a view of stress as a principle of nature linked to the adaptability property of matter, opposing entropy. It is known that the increasing number of microstates possible in a complex system increases the entropy. In that way, entropy is related to the amount of additional information needed to specify the exact physical state of a system, given its macroscopic specification. By controlling the metabolic processes (catabolism-anabolism) to decrease the entropy, stress reduces the number of possible states for which the living system could evolve, avoiding the loss of “life information”, preserving its characteristics and preventing its extinction. The loss of function of a species within an ecosystem or of cells within an organ can be showing that the limits of the stress principle were “transgressed”. That is, the intensity and/or duration of stress exceeded the capacity of living organism to process of information extracted from stressor and reprogram its physiological mechanisms, activating its adaptability process, while its internal balance is preserved.
本文试图用物理学现象学的观点,将生物应力的概念近似于物理学中的应力概念,探讨生物应力状态产生力的来源。在文献的基础上,对这两个概念进行了比较,并对开放系统中的稳态和生物系统中的稳态进行了讨论。利用热力学熵和信息熵的概念,并比较生命系统和非生命系统中的压力,我们试图建立一个基础,将压力视为与物质的适应性属性相关的自然原理,而不是熵。众所周知,在一个复杂系统中可能的微态数量的增加会增加熵。在这种情况下,熵与指定系统的确切物理状态所需的附加信息的数量有关,给定其宏观规格。通过控制代谢过程(分解代谢-合成代谢)来减少熵,压力减少了生命系统可能进化的状态的数量,避免了“生命信息”的丢失,保留了生命的特征,防止了生命的灭绝。生态系统中一个物种的功能丧失或器官中细胞的功能丧失可能表明压力原理的极限被“超越”了。即压力的强度和/或持续时间超过了生物体处理从压力源中提取的信息并重新编程其生理机制的能力,激活其适应过程,同时保持其内部平衡。
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引用次数: 0
DNA Sequencing Modified Method through Effective Regulation of Its Translocation Speed in Aqueous Solution 通过有效调节DNA在水溶液中的易位速度来改进DNA测序方法
Pub Date : 2020-04-26 DOI: 10.4236/ojbiphy.2020.102009
L. Gasparyan, I. Mazo, F. Gasparyan, V. Simonyan
Solid-state nanopore DNA sequencing modified method is developed. Method is based on the tunnel current investigation through the nanogap made on lateral gold electrodes in the form of nanowires or nanoribbons. The movement of DNA in aqueous solution is regulated by the potential applied to reference electrode. The potential applied to the lateral metal electrodes helps to the creation of the molecular junctions. They consist of the nucleosides passing through the pores. Taking into account that DNA moves under gravity, electrophoretic and drag forces, the analytic expression for the DNA translocation speed is calculated and analyzed. The conditions for decreasing the DNA translocation speed or increasing the nucleosides reading time are received. It is shown that one can control value of the DNA molecules bases reading time and the frequency of the bases passes by the choice of magnitude of the potential applied to reference electrode. Our results, therefore potentially suggest a realistic, inherently design-specific, high-throughput nanopore DNA sequencing device/cell as a de-novo alternative to the existing methods.
提出了一种固体纳米孔DNA测序修饰方法。该方法是基于通过纳米线或纳米带形式的横向金电极上的纳米间隙进行隧道电流研究。DNA在水溶液中的运动是由施加在参比电极上的电位调控的。施加在侧面金属电极上的电位有助于分子结的形成。它们由通过孔的核苷组成。考虑DNA在重力、电泳和阻力作用下的运动,计算并分析了DNA易位速度的解析表达式。提出了降低DNA易位速度或增加核苷读取时间的条件。结果表明,通过选择施加在参比电极上的电位的大小,可以控制DNA分子碱基的读数时间和碱基通过的频率。因此,我们的研究结果潜在地提出了一种现实的、固有设计特异性的、高通量的纳米孔DNA测序装置/细胞,作为现有方法的一种从头开始的替代方案。
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引用次数: 2
Exposure of Weak Time-Invariant Electromagnetic Fields to B16-BL6 Cell Cultures Alter Biophoton Emission Profile as a Function of Distance 弱时不变电磁场暴露于B16-BL6细胞培养物中改变生物光子发射曲线作为距离的函数
Pub Date : 2020-02-21 DOI: 10.4236/ojbiphy.2020.102004
Billy C. S. Yearington, Victoria L. Hossack, B. Dotta
Biophoton emission is produced by all living systems; this emission pattern has been shown to be altered by the presence of an electromagnetic field (EMF). Cultures of B16-BL6 cells were exposed to a weak EMF produced by a specially constructed EM generator, called the “Resonator”, for one hour. This EM generator incorporates multiple geometric ratios in its design, including the golden ratio (phi), pi, root 2, root 3, and root 5. It has been used previously to purify water of toxins. There was a significant decrease in mean photon counts from B16-BL6 cells exposed at a distance of 1 m compared to those exposed at 0 m. Alterations in the spectral power density variability were also observed in the 8 - 10 Hz range. The EM generator may have an impact on the viability of the exposed cell cultures, but only at specific distances.
所有生命系统都会产生生物光子;这种发射模式已被证明是改变的存在的电磁场(EMF)。将B16-BL6细胞的培养物暴露在由特殊构造的电磁发生器(称为“谐振器”)产生的弱电磁场中一小时。该电磁发生器在其设计中结合了多种几何比例,包括黄金比例(phi), pi,根号2,根号3和根号5。它以前被用来净化水中的毒素。与暴露在0 m处的细胞相比,暴露在1 m处的B16-BL6细胞的平均光子计数显著减少。在8 - 10 Hz范围内也观察到光谱功率密度变异性的变化。电磁发生器可能对暴露的细胞培养物的生存能力有影响,但仅在特定距离内。
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引用次数: 0
Solar Radiation, Perelman Entropy Mapping, DNA, Viruses etc. 太阳辐射,佩雷尔曼熵图,DNA,病毒等。
Pub Date : 2020-02-21 DOI: 10.4236/ojbiphy.2020.102005
K. W. Wong, P. Fung, W. Chow
A short note based on the homogeneous 5D space-time topological mappings is extended to cover DNAs of viruses and how the body’s immune system can be enhanced to recognize and remove it.
基于齐次5D时空拓扑映射的一个简短注释被扩展到涵盖病毒的DNA,以及如何增强身体的免疫系统来识别和去除它。
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引用次数: 1
期刊
生物物理学期刊(英文)
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