首页 > 最新文献

Journal of Cluster Science最新文献

英文 中文
Silver Nanoparticles and Polydimethylsiloxane-coated Paper for the Simultaneous Detection of Ascorbic Acid and Hydroquinone 用于同时检测抗坏血酸和对苯二酚的银纳米粒子和聚二甲基硅氧烷涂层纸
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-21 DOI: 10.1007/s10876-024-02697-8
Nutthaya Butwong, Siriboon Mukdasai, Pimpanitpa Kunthadong, Kamolwan Rintramee, Thidarat Kunawong

This study developed a novel paper-based sensor for the simultaneous analysis of ascorbic acid (AA) and hydroquinone (HQ). The sensor utilized polyvinyl alcohol (PVA)-stabilized silver nanoparticles (AgNPs-PVA) as the reagent probe and PVA media acted as the filter for separation of the analytes. Polydimethylsiloxane (PDMS) and ethanol serve as the stationary phase and eluent, respectively, exploiting the differences in analyte reactions and solubility to achieve their separation on the filter paper. The circular sensor’s central zone was AA’s detection area, while HQ was detected in the outer ring region. AA induced an immediate color change in the test kit, whereas HQ required a 20-minute elution with ethanol followed by colorimetric analysis. All analytes exhibited relative standard deviations of repeatability and reproducibility below 2.7% and 9.5%, respectively. Under optimal conditions, the linear detection range for HQ was 0.2-2.0 mg⋅L− 1, while AA was 0.1-2.0 mg⋅L− 1. The detection limit was determined to be 0.05 mg⋅L− 1 for AA and 0.1 mg⋅L− 1 for HQ. The recoveries of AA and HQ in cosmetic cream samples ranged from 80 to 110%. The accuracy of the sensor’s measurements was further validated by comparison with the HPLC-DAD method.

本研究开发了一种新型纸基传感器,用于同时分析抗坏血酸(AA)和对苯二酚(HQ)。该传感器利用聚乙烯醇(PVA)稳定银纳米粒子(AgNPs-PVA)作为试剂探针,聚乙烯醇介质作为分离分析物的过滤器。聚二甲基硅氧烷(PDMS)和乙醇分别作为固定相和洗脱剂,利用分析物反应和溶解度的差异实现它们在滤纸上的分离。圆形传感器的中心区域是 AA 的检测区域,而 HQ 则在外圈区域检测。AA 在检测试剂盒中会立即变色,而 HQ 则需要用乙醇洗脱 20 分钟后才能进行比色分析。所有分析物的重复性和再现性的相对标准偏差分别低于 2.7% 和 9.5%。在最佳条件下,HQ 的线性检测范围为 0.2-2.0 mg-L-1,AA 为 0.1-2.0 mg-L-1。AA 和 HQ 的检测限分别为 0.05 mg⋅L- 1 和 0.1 mg⋅L- 1。化妆品膏霜样品中 AA 和 HQ 的回收率为 80% 至 110%。通过与 HPLC-DAD 方法进行比较,进一步验证了传感器测量的准确性。
{"title":"Silver Nanoparticles and Polydimethylsiloxane-coated Paper for the Simultaneous Detection of Ascorbic Acid and Hydroquinone","authors":"Nutthaya Butwong,&nbsp;Siriboon Mukdasai,&nbsp;Pimpanitpa Kunthadong,&nbsp;Kamolwan Rintramee,&nbsp;Thidarat Kunawong","doi":"10.1007/s10876-024-02697-8","DOIUrl":"10.1007/s10876-024-02697-8","url":null,"abstract":"<div><p>This study developed a novel paper-based sensor for the simultaneous analysis of ascorbic acid (AA) and hydroquinone (HQ). The sensor utilized polyvinyl alcohol (PVA)-stabilized silver nanoparticles (AgNPs-PVA) as the reagent probe and PVA media acted as the filter for separation of the analytes. Polydimethylsiloxane (PDMS) and ethanol serve as the stationary phase and eluent, respectively, exploiting the differences in analyte reactions and solubility to achieve their separation on the filter paper. The circular sensor’s central zone was AA’s detection area, while HQ was detected in the outer ring region. AA induced an immediate color change in the test kit, whereas HQ required a 20-minute elution with ethanol followed by colorimetric analysis. All analytes exhibited relative standard deviations of repeatability and reproducibility below 2.7% and 9.5%, respectively. Under optimal conditions, the linear detection range for HQ was 0.2-2.0 mg⋅L<sup>− 1</sup>, while AA was 0.1-2.0 mg⋅L<sup>− 1</sup>. The detection limit was determined to be 0.05 mg⋅L<sup>− 1</sup> for AA and 0.1 mg⋅L<sup>− 1</sup> for HQ. The recoveries of AA and HQ in cosmetic cream samples ranged from 80 to 110%. The accuracy of the sensor’s measurements was further validated by comparison with the HPLC-DAD method.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2837 - 2848"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Advanced Synthesis Strategies and Biomedical Applications of Iron Oxide-Based Nanozymes: A Comprehensive Review 探索氧化铁基纳米酶的先进合成策略和生物医学应用:全面综述
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-21 DOI: 10.1007/s10876-024-02690-1
Tanawish, Nazish Jahan, Kousar Rasheed, Maria Iqbal, Muhammad Atif

The practical usage of natural enzymes is limited due to their sensitivity and need for special conditions. On the other hand, nanozymes provide robust catalytic performance, high stability in challenging conditions, economical production, and versatile surface modification. With these benefits, nanozymes surpass the constraints of natural enzymes and are a better option for a range of applications. Iron oxide-based nanomaterials have attracted significant attention due to their distinctive properties, such as catalase-like function under pH seven and peroxidase enzyme activity at acrid pH values as well as higher enzyme-like activities. This study has explored how synthesis procedures have advanced recently, presenting creative approaches with increased stability, regulated particle sizes, and catalytic activities. The potential of iron oxide nanozymes in a range of domains, such as healthcare, hyperthermia, MRI, optical devices, and anticancer activity, has also been investigated. This critical study provides a comprehensive overview of the synthesis, characterization, and potential uses of iron oxide-based nanozymes, identifies the areas where research is currently lacking, and makes options for future directions to maximize its potential in medicine. Overall, this review expands our understanding of iron oxide nanozymes and is a helpful resource for scientists creating novel medicinal and diagnostic tools.

Graphical Abstract

由于天然酶的敏感性和对特殊条件的要求,其实际用途受到限制。另一方面,纳米酶具有强大的催化性能、在挑战性条件下的高稳定性、经济的生产以及多功能的表面改性。凭借这些优势,纳米酶超越了天然酶的限制,成为一系列应用的更好选择。氧化铁基纳米材料因其独特的性质而备受关注,如在 pH 值为 7 时具有类似催化酶的功能,在刺鼻的 pH 值下具有过氧化物酶的酶活性,以及更高的类似酶的活性。本研究探讨了近来合成程序的发展,提出了具有更高的稳定性、调节粒度和催化活性的创新方法。研究还探讨了氧化铁纳米酶在医疗保健、热疗、核磁共振成像、光学设备和抗癌活性等一系列领域的潜力。这项重要研究全面概述了氧化铁基纳米酶的合成、表征和潜在用途,指出了目前缺乏研究的领域,并为最大限度地发挥其在医学领域的潜力提出了未来发展方向。总之,这篇综述拓展了我们对氧化铁纳米酶的理解,是科学家们创造新型药物和诊断工具的有用资源。图表摘要
{"title":"Exploring the Advanced Synthesis Strategies and Biomedical Applications of Iron Oxide-Based Nanozymes: A Comprehensive Review","authors":"Tanawish,&nbsp;Nazish Jahan,&nbsp;Kousar Rasheed,&nbsp;Maria Iqbal,&nbsp;Muhammad Atif","doi":"10.1007/s10876-024-02690-1","DOIUrl":"10.1007/s10876-024-02690-1","url":null,"abstract":"<div><p>The practical usage of natural enzymes is limited due to their sensitivity and need for special conditions. On the other hand, nanozymes provide robust catalytic performance, high stability in challenging conditions, economical production, and versatile surface modification. With these benefits, nanozymes surpass the constraints of natural enzymes and are a better option for a range of applications. Iron oxide-based nanomaterials have attracted significant attention due to their distinctive properties, such as catalase-like function under pH seven and peroxidase enzyme activity at acrid pH values as well as higher enzyme-like activities. This study has explored how synthesis procedures have advanced recently, presenting creative approaches with increased stability, regulated particle sizes, and catalytic activities. The potential of iron oxide nanozymes in a range of domains, such as healthcare, hyperthermia, MRI, optical devices, and anticancer activity, has also been investigated. This critical study provides a comprehensive overview of the synthesis, characterization, and potential uses of iron oxide-based nanozymes, identifies the areas where research is currently lacking, and makes options for future directions to maximize its potential in medicine. Overall, this review expands our understanding of iron oxide nanozymes and is a helpful resource for scientists creating novel medicinal and diagnostic tools. </p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2637 - 2661"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous Delivery of Dual Anticancer Agents Via pH-Responsive Polymeric Nanoparticles for Enhanced Therapeutic Efficacy Against Breast Cancer Cells 通过 pH 响应性聚合物纳米粒子同时递送双重抗癌剂,增强对乳腺癌细胞的疗效
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-21 DOI: 10.1007/s10876-024-02699-6
Muhammad Haroon, Mehwish Nasim, Asif Nawaz, Naveed Ullah Khan, Sheikh Abdur Rashid, Daulat Haleem Khan, Muhammad Khurshid Alam Shah, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ali A. Shati, Haroon Iqbal

The stated objective of the present research investigation was to use a simultaneous nanodrug delivery approach to optimize the therapeutic effectiveness of anticancer drugs against breast cancer cells. For this purpose, Poly (lactic-co-glycolic acid) nanoparticles with two anticancer drugs; methotrexate (MTX) and doxorubicin (DOX) denoted as DOX/MTX@PLGA NPs was developed by nanoprecipitation method. The developed polymeric DOX/MTX@PLGA NPs exhibited hydrodynamic particle diameter of 170.6 ± 10.0 nm with a poly dispersity index (PDI) of 0.17 and zeta potential value of -9.2 ± 0.31 mV, and spherical geometry analyzed by TEM. Furthermore, the nanoparticles exhibited a pH-responsive drug release profile, outstanding encapsulation efficiency, excellent colloidal stability across various physiological media and pH responsive drug release profile. Additionally, polymeric nanoparticles demonstrated higher cell uptake, in-vitro cytotoxicity, and a high rate of apoptosis in comparison to free DOX and MTX through a synergistic effect, likely as a result of their small particle size. In conclusion, our work presents a novel and distinct approach for boosting the therapeutic efficacy of anticancer drugs by delivering drugs to breast cancer cells simultaneously.

本研究调查的既定目标是采用一种同步纳米给药方法来优化抗癌药物对乳腺癌细胞的治疗效果。为此,采用纳米沉淀法开发了含有两种抗癌药物的聚乳酸-乙醇酸(Poly (lactic-co-glycolic acid) nanoparticles)纳米颗粒,即 DOX/MTX@PLGA NPs。经 TEM 分析,所制备的聚合 DOX/MTX@PLGA NPs 的流体力学粒径为 170.6 ± 10.0 nm,聚分散指数(PDI)为 0.17,zeta 电位值为 -9.2 ± 0.31 mV,呈球形。此外,该纳米粒子还具有 pH 值响应型药物释放特性、出色的封装效率、在各种生理介质中的优异胶体稳定性以及 pH 值响应型药物释放特性。此外,与游离 DOX 和 MTX 相比,聚合物纳米粒子通过协同效应表现出更高的细胞吸收率、体外细胞毒性和高凋亡率,这可能是其粒径较小的结果。总之,我们的研究提出了一种新颖独特的方法,通过同时向乳腺癌细胞递送药物来提高抗癌药物的疗效。
{"title":"Simultaneous Delivery of Dual Anticancer Agents Via pH-Responsive Polymeric Nanoparticles for Enhanced Therapeutic Efficacy Against Breast Cancer Cells","authors":"Muhammad Haroon,&nbsp;Mehwish Nasim,&nbsp;Asif Nawaz,&nbsp;Naveed Ullah Khan,&nbsp;Sheikh Abdur Rashid,&nbsp;Daulat Haleem Khan,&nbsp;Muhammad Khurshid Alam Shah,&nbsp;Mohammad Y. Alfaifi,&nbsp;Serag Eldin I. Elbehairi,&nbsp;Ali A. Shati,&nbsp;Haroon Iqbal","doi":"10.1007/s10876-024-02699-6","DOIUrl":"10.1007/s10876-024-02699-6","url":null,"abstract":"<div><p>The stated objective of the present research investigation was to use a simultaneous nanodrug delivery approach to optimize the therapeutic effectiveness of anticancer drugs against breast cancer cells. For this purpose, Poly (lactic-co-glycolic acid) nanoparticles with two anticancer drugs; methotrexate (MTX) and doxorubicin (DOX) denoted as DOX/MTX@PLGA NPs was developed by nanoprecipitation method. The developed polymeric DOX/MTX@PLGA NPs exhibited hydrodynamic particle diameter of 170.6 ± 10.0 nm with a poly dispersity index (PDI) of 0.17 and zeta potential value of -9.2 ± 0.31 mV, and spherical geometry analyzed by TEM. Furthermore, the nanoparticles exhibited a pH-responsive drug release profile, outstanding encapsulation efficiency, excellent colloidal stability across various physiological media and pH responsive drug release profile. Additionally, polymeric nanoparticles demonstrated higher cell uptake, in-vitro cytotoxicity, and a high rate of apoptosis in comparison to free DOX and MTX through a synergistic effect, likely as a result of their small particle size. In conclusion, our work presents a novel and distinct approach for boosting the therapeutic efficacy of anticancer drugs by delivering drugs to breast cancer cells simultaneously.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2823 - 2836"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Synthesis of Silver Nanoparticles Loaded with Doxorubicin in Polylactide Nanoparticles for Effective Cancer Therapy 在聚乳酸纳米粒子中负载多柔比星的银纳米粒子的绿色合成,用于有效治疗癌症
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-21 DOI: 10.1007/s10876-024-02700-2
Mohyeddin Assali, Anhar Mlitat, Abrar Yacoub, Anagheem Hasson, Ahmed Mousa

Silver nanoparticles (AgNPs) are increasingly recognized as vital nanomaterials in biomedical applications due to their diverse pharmacological properties, including antimicrobial and anti-neoplastic effects, particularly when derived from herbal sources. This study aims to synthesize AgNPs employing a sustainable approach aligned with the principles of the sustainable development goals. The synthesized AgNPs are incorporated with doxorubicin (DOX) and encapsulated within polylactide nanoparticles to enhance their anticancer potency. AgNPs are prepared via the reduction of silver ions using rutin as a reducing agent, with the reaction progress monitored via ultraviolet-visible spectroscopy (UV-vis). Subsequently, the AgNPs are encapsulated into poly(D, L-lactic acid) (PDLLA) nanoparticles alongside doxorubicin. The developed nanoparticles have shown a diameter size of 233 nm with a zeta potential of -21.47 mV. Moreover, the in vitro release profile of the DOX showed a sustained release kinetics over 30 h. Evaluation of the AgNP-DOX-loaded PDLLA nanoparticles reveals enhanced anticancer activity against HeLa and HepG2 cancer cells, highlighting the synergistic efficacy of the combined therapy. These findings underscore the potential of AgNPs-based formulations as promising candidates for advanced cancer therapeutics.

Graphical Abstract

银纳米粒子(AgNPs)具有多种药理特性,包括抗菌和抗肿瘤作用,尤其是从草药中提取的银纳米粒子,因此越来越被认为是生物医学应用中的重要纳米材料。本研究旨在采用符合可持续发展目标原则的可持续方法合成 AgNPs。合成的 AgNPs 与多柔比星(DOX)结合并封装在聚乳酸纳米颗粒中,以增强其抗癌效力。AgNPs 是以芦丁作为还原剂,通过还原银离子来制备的,反应过程通过紫外可见光谱(UV-vis)进行监控。随后,将 AgNPs 与多柔比星一起封装到聚(D,L-乳酸)(PDLLA)纳米粒子中。所开发的纳米颗粒直径为 233 nm,zeta 电位为 -21.47 mV。对 AgNP-DOX 负载 PDLLA 纳米颗粒的评估显示,其对 HeLa 和 HepG2 癌细胞的抗癌活性得到了增强,凸显了联合疗法的协同功效。这些发现凸显了基于AgNPs的制剂作为先进癌症疗法候选药物的潜力。
{"title":"Green Synthesis of Silver Nanoparticles Loaded with Doxorubicin in Polylactide Nanoparticles for Effective Cancer Therapy","authors":"Mohyeddin Assali,&nbsp;Anhar Mlitat,&nbsp;Abrar Yacoub,&nbsp;Anagheem Hasson,&nbsp;Ahmed Mousa","doi":"10.1007/s10876-024-02700-2","DOIUrl":"10.1007/s10876-024-02700-2","url":null,"abstract":"<div><p>Silver nanoparticles (AgNPs) are increasingly recognized as vital nanomaterials in biomedical applications due to their diverse pharmacological properties, including antimicrobial and anti-neoplastic effects, particularly when derived from herbal sources. This study aims to synthesize AgNPs employing a sustainable approach aligned with the principles of the sustainable development goals. The synthesized AgNPs are incorporated with doxorubicin (DOX) and encapsulated within polylactide nanoparticles to enhance their anticancer potency. AgNPs are prepared via the reduction of silver ions using rutin as a reducing agent, with the reaction progress monitored via ultraviolet-visible spectroscopy (UV-vis). Subsequently, the AgNPs are encapsulated into poly(D, L-lactic acid) (PDLLA) nanoparticles alongside doxorubicin. The developed nanoparticles have shown a diameter size of 233 nm with a zeta potential of -21.47 mV. Moreover, the in vitro release profile of the DOX showed a sustained release kinetics over 30 h. Evaluation of the AgNP-DOX-loaded PDLLA nanoparticles reveals enhanced anticancer activity against HeLa and HepG2 cancer cells, highlighting the synergistic efficacy of the combined therapy. These findings underscore the potential of AgNPs-based formulations as promising candidates for advanced cancer therapeutics.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2813 - 2821"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of a High-Performance WO3/g-C3N4 Z-Scheme Photocatalyst for Effective Phenol Degradation and Antibacterial Activity 设计高性能 WO3/g-C3N4 Z-Scheme 光催化剂以实现有效的苯酚降解和抗菌活性
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-06 DOI: 10.1007/s10876-024-02692-z
T. Prabhuraj, Abimannan Gomathi, Arumugam Priyadharsan, Murni Handayani, Sabah Ansar, K. A. Ramesh Kumar, Palanisamy Maadeswaran

An innovative Z-scheme WO3/g-C3N4 composite was efficiently produced via a straightforward hydrothermal method and applied to the photodegradation of phenol. The physiochemical behaviours of WO3, g-C3N4, WO3/g-C3N4 composite was analyzed by various analytical instruments. Compared to WO3, g-C3N4 single counterparts WO3/g-C3N4 Composite exhibits superior charge carriers’ separation efficiency and also Z scheme mechanism promoted the superior pollutant degradation. Subsequently, the WO3/g-C3N4 composite achieving 93% with rate constant 0.0184 min− 1 phenol removal within 100 min. The noteworthy increased photocatalytic bustle of WO3/g-C3N4 composite was attributed to the synergetic effect between the boundary of WO3/g-C3N4. Curiously, WO3/g-C3N4 composite validates exceptional photostability during reusable experiment, accentuating its potential as a functioning photocatalyst for phenol removal. The antimicrobial tests showed that the developed photocatalyst effectively sterilizes both gram-positive Staphylococcus aureus and gram-negative Escherichia coli. Thus, the WO3/g-C3N4 nanocomposites are robust materials suitable for use as antimicrobial agents and photocatalysts activated by sunlight.

通过直接水热法高效制备了一种创新的 Z 型 WO3/g-C3N4 复合材料,并将其应用于苯酚的光降解。各种分析仪器对 WO3、g-C3N4 和 WO3/g-C3N4 复合材料的理化性能进行了分析。与 WO3 相比,g-C3N4 单体对应的 WO3/g-C3N4 复合体表现出更高的电荷载流子分离效率,同时 Z 方案机制也促进了更优越的污染物降解。随后,WO3/g-C3N4 复合材料在 100 分钟内对苯酚的去除率达到 93%,速率常数为 0.0184 min-1。值得注意的是,WO3/g-C3N4 复合材料光催化效率的提高归功于 WO3/g-C3N4 边界之间的协同效应。奇怪的是,WO3/g-C3N4 复合材料在可重复使用的实验中验证了其优异的光稳定性,突出了其作为有效光催化剂去除苯酚的潜力。抗菌测试表明,所开发的光催化剂可有效杀灭革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌。因此,WO3/g-C3N4 纳米复合材料是一种坚固的材料,适合用作抗菌剂和由阳光激活的光催化剂。
{"title":"Design of a High-Performance WO3/g-C3N4 Z-Scheme Photocatalyst for Effective Phenol Degradation and Antibacterial Activity","authors":"T. Prabhuraj,&nbsp;Abimannan Gomathi,&nbsp;Arumugam Priyadharsan,&nbsp;Murni Handayani,&nbsp;Sabah Ansar,&nbsp;K. A. Ramesh Kumar,&nbsp;Palanisamy Maadeswaran","doi":"10.1007/s10876-024-02692-z","DOIUrl":"10.1007/s10876-024-02692-z","url":null,"abstract":"<div><p>An innovative Z-scheme WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was efficiently produced via a straightforward hydrothermal method and applied to the photodegradation of phenol. The physiochemical behaviours of WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub>, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was analyzed by various analytical instruments. Compared to WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub> single counterparts WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> Composite exhibits superior charge carriers’ separation efficiency and also Z scheme mechanism promoted the superior pollutant degradation. Subsequently, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite achieving 93% with rate constant 0.0184 min<sup>− 1</sup> phenol removal within 100 min. The noteworthy increased photocatalytic bustle of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was attributed to the synergetic effect between the boundary of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub>. Curiously, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite validates exceptional photostability during reusable experiment, accentuating its potential as a functioning photocatalyst for phenol removal. The antimicrobial tests showed that the developed photocatalyst effectively sterilizes both gram-positive <i>Staphylococcus aureus</i> and gram-negative <i>Escherichia coli</i>. Thus, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> nanocomposites are robust materials suitable for use as antimicrobial agents and photocatalysts activated by sunlight.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2753 - 2768"},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies 推进自主纳米医学:缩小从概念到潜在临床研究的差距
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-06 DOI: 10.1007/s10876-024-02691-0
Diya Pratish Chohan, Bipasa Dey, Arshia Tarkunde, Vaishnavi Vyas, Srijita De Sarkar, Babitha Kampa Sundara

Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.

Graphical Abstract

自主纳米医学是纳米技术和生物医学科学中的一个新兴领域,通过消除对体内靶向应用的外部干预需求,有望彻底改变医疗保健。本文阐明了自主纳米医学的前景和挑战,强调了它克服化疗和放疗等传统方法局限性的能力。纳米级载体是其疗效的核心,它能在体内自主导航,精确、可控地输送治疗剂。通过将自动化纳米级工具集成到疾病检测过程中,该技术可提供快速和个性化的评估,从而重塑疾病管理模式。要推进自主纳米医学的临床转化,严格的临床前研究势在必行。然而,在确保可重复性和安全性方面仍然存在挑战,阻碍了临床试验的进展。本文探讨了目前有可能转化为临床试验的研究,阐明了对其安全实施至关重要的监管和伦理考虑因素。随着该领域的不断进步,保持创新与安全之间的平衡对于充分发挥自主纳米医学的潜力同时保障患者的福祉仍然至关重要。
{"title":"Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies","authors":"Diya Pratish Chohan,&nbsp;Bipasa Dey,&nbsp;Arshia Tarkunde,&nbsp;Vaishnavi Vyas,&nbsp;Srijita De Sarkar,&nbsp;Babitha Kampa Sundara","doi":"10.1007/s10876-024-02691-0","DOIUrl":"10.1007/s10876-024-02691-0","url":null,"abstract":"<div><p>Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2607 - 2635"},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10876-024-02691-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Nanoparticles Prepared from Starch-Myristic Acid Complex Ethyl Acetate Fraction: Impact on Gene Expression in Human Mesenchymal Stem Cells 更正:用淀粉-肉豆蔻酸复合醋酸乙酯馏分制备纳米颗粒:对人类间充质干细胞基因表达的影响
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-09-03 DOI: 10.1007/s10876-024-02684-z
Mushawah Abdullah Almushawah, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ghedeir Alshammari, Ali A Alshatwi
{"title":"Correction: Nanoparticles Prepared from Starch-Myristic Acid Complex Ethyl Acetate Fraction: Impact on Gene Expression in Human Mesenchymal Stem Cells","authors":"Mushawah Abdullah Almushawah,&nbsp;Jegan Athinarayanan,&nbsp;Vaiyapuri Subbarayan Periasamy,&nbsp;Ghedeir Alshammari,&nbsp;Ali A Alshatwi","doi":"10.1007/s10876-024-02684-z","DOIUrl":"10.1007/s10876-024-02684-z","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"3181 - 3181"},"PeriodicalIF":2.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical Prediction of the Smallest Sized Tricyclic-Boron Oxide B6O62+ 最小尺寸三环氧化硼 B6O62+ 的理论预测
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-08-27 DOI: 10.1007/s10876-024-02687-w
Wen-Juan Tian, Jing-Jing Wang, Hui-Li Chen

The discovery of cyclic boron oxide clusters has prompted investigations into their distinctive structures and bonding characteristics. Notably, the majority of reported cyclic boron oxide structures consist predominantly of four to six-membered rings. In this study, we employ theoretical methods to predict the global-minimum (GM) structure of B6O62+. Our analyses, including global-minimum searches and calculations using B3LYP, PBE, PBE0, and single-point CCSD(T), reveal that the D2h B6O62+ (1Ag) configuration represents a planar and tricyclic structure, resulting from the fusion of B3O2/B4O2/B3O2 units. Remarkably, this structure establishes the B6O62+ cluster as the smallest boron oxide cluster with a planar tricyclic motif. Further bonding analysis indicates that B6O62+ is a weakly antiaromatic system with 12π delocalized electrons. The reported B6O6 has a planar structure with a 6-membered B3O3 ring and 6 π electrons distributed over the ring. Because of the absence of two electrons from the highest occupied molecular orbital (HOMO) of neutral B6O6, the structure of B6O62+ is distinctly different from that of B6O6.

环状氧化硼簇的发现促使人们对其独特的结构和键合特性进行研究。值得注意的是,大多数已报道的环氧化硼结构主要由四到六元环组成。在本研究中,我们采用理论方法预测了 B6O62+ 的全局最小(GM)结构。我们的分析包括全局最小搜索和使用 B3LYP、PBE、PBE0 和单点 CCSD(T) 进行的计算,结果表明 D2h B6O62+ (1Ag) 构型代表了一种平面三环结构,由 B3O2/B4O2/B3O2 单元融合而成。值得注意的是,这种结构使 B6O62+ 团簇成为具有平面三环图案的最小氧化硼团簇。进一步的成键分析表明,B6O62+ 是一个弱反芳香族体系,具有 12π 的脱位电子。所报告的 B6O6 具有平面结构,具有一个 6 元 B3O3 环,环上分布有 6 π 电子。由于中性 B6O6 的最高占位分子轨道(HOMO)上没有两个电子,因此 B6O62+ 的结构与 B6O6 的结构截然不同。
{"title":"Theoretical Prediction of the Smallest Sized Tricyclic-Boron Oxide B6O62+","authors":"Wen-Juan Tian,&nbsp;Jing-Jing Wang,&nbsp;Hui-Li Chen","doi":"10.1007/s10876-024-02687-w","DOIUrl":"10.1007/s10876-024-02687-w","url":null,"abstract":"<div><p>The discovery of cyclic boron oxide clusters has prompted investigations into their distinctive structures and bonding characteristics. Notably, the majority of reported cyclic boron oxide structures consist predominantly of four to six-membered rings. In this study, we employ theoretical methods to predict the global-minimum (GM) structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup>. Our analyses, including global-minimum searches and calculations using B3LYP, PBE, PBE0, and single-point CCSD(T), reveal that the <i>D</i><sub>2<i>h</i></sub> B<sub>6</sub>O<sub>6</sub><sup>2+</sup> (<sup>1</sup>A<sub>g</sub>) configuration represents a planar and tricyclic structure, resulting from the fusion of B<sub>3</sub>O<sub>2</sub>/B<sub>4</sub>O<sub>2</sub>/B<sub>3</sub>O<sub>2</sub> units. Remarkably, this structure establishes the B<sub>6</sub>O<sub>6</sub><sup>2+</sup> cluster as the smallest boron oxide cluster with a planar tricyclic motif. Further bonding analysis indicates that B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is a weakly antiaromatic system with 12π delocalized electrons. The reported B<sub>6</sub>O<sub>6</sub> has a planar structure with a 6-membered B<sub>3</sub>O<sub>3</sub> ring and 6 π electrons distributed over the ring. Because of the absence of two electrons from the highest occupied molecular orbital (HOMO) of neutral B<sub>6</sub>O<sub>6</sub>, the structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is distinctly different from that of B<sub>6</sub>O<sub>6</sub>.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2747 - 2752"},"PeriodicalIF":2.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Wound Healing Activity in Animal Model via Developing and Designing of Self-nano Emulsifying Drug Delivery System (SNEDDS) for the Co-delivery of Hesperidin and Rutin 通过开发和设计用于橙皮甙和芦丁联合给药的自纳米乳化给药系统(SNEDDS)增强动物模型的伤口愈合活性
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-08-25 DOI: 10.1007/s10876-024-02679-w
Ajmal Hayat, Ismail Shah, Abdul Jabbar, Ayman Nafady, Aziz Balouch, Muhammad Raza Shah, Sayyed Ibrahim Shah, Razium Ali Soomro,  Sirajuddin

The aim of this work is to develop a self-nanoemulsifying drug delivery system (SNEDDS) for Hesperidin (HES) and Rutin (RUT) to improve their biopharmaceutical properties. The wound healing potential of HES-RUT-SNEDDS was compared to those of pure HES suspension (HES-s), empty SNEDDS (E-SNEDDS), and standard Fusidic Acid via topical application. To produce various HES-RUT-loaded SNEDDS, aqueous phase titration was used to select cinnamon oil, Labrasol and Tween 80 (surfactants), Transcutol (co-surfactant) from a diverse pool of surfactants, oils and co-surfactants. The thermodynamic stability of HES-RUT-loaded SNEDDS was assessed by examining the globule size, surface morphology, zeta potential, polydispersity index (PDI), and percent (%) transmittance. The improved physicochemical properties of the optimized HES-RUT-SNEDDS (S-N4) formulation included particle size, zeta potential, and % transmittance. Smooth and spherical particles were discovered using Atomic Force Microscopy (AFM). These improved SNEDDS formulations demonstrated enhanced solubility and skin permeation. When compared to HES-s, E-SNEDDS, and standard fusidic acid, the optimized HES-RUT-SNEDDS demonstrated significant wound healing activity following topical application. HES-RUT-SNEDDS is a promising approach for enhancing the wound-healing potential of HES and RUT through topical administration.

这项研究的目的是为橙皮甙(HES)和芦丁(RUT)开发一种自纳米乳化给药系统(SNEDDS),以改善它们的生物制药特性。将 HES-RUT-SNEDDS 的伤口愈合潜力与纯 HES 悬浮液(HES-s)、空 SNEDDS(E-SNEDDS)和标准夫西地酸的伤口愈合潜力进行了比较。为了制备各种 HES-RUT 负载 SNEDDS,采用了水相滴定法,从多种表面活性剂、油和辅助表面活性剂中选择了肉桂油、Labrasol 和吐温 80(表面活性剂)、Transcutol(辅助表面活性剂)。通过检测球形大小、表面形态、ZETA电位、多分散指数(PDI)和透射率百分比,评估了 HES-RUT 负载 SNEDDS 的热力学稳定性。优化后的 HES-RUT-SNEDDS (S-N4) 配方的理化特性得到了改善,包括粒度、zeta 电位和透射率百分比。使用原子力显微镜(AFM)发现了光滑的球形颗粒。这些改进的 SNEDDS 配方显示出更强的溶解性和皮肤渗透性。与 HES-s、E-SNEDDS 和标准夫西地酸相比,优化的 HES-RUT-SNEDDS 在局部应用后具有显著的伤口愈合活性。HES-RUT-SNEDDS 是一种通过局部用药增强 HES 和 RUT 伤口愈合潜力的有效方法。
{"title":"Enhanced Wound Healing Activity in Animal Model via Developing and Designing of Self-nano Emulsifying Drug Delivery System (SNEDDS) for the Co-delivery of Hesperidin and Rutin","authors":"Ajmal Hayat,&nbsp;Ismail Shah,&nbsp;Abdul Jabbar,&nbsp;Ayman Nafady,&nbsp;Aziz Balouch,&nbsp;Muhammad Raza Shah,&nbsp;Sayyed Ibrahim Shah,&nbsp;Razium Ali Soomro,&nbsp; Sirajuddin","doi":"10.1007/s10876-024-02679-w","DOIUrl":"10.1007/s10876-024-02679-w","url":null,"abstract":"<div><p>The aim of this work is to develop a self-nanoemulsifying drug delivery system (SNEDDS) for Hesperidin (HES) and Rutin (RUT) to improve their biopharmaceutical properties. The wound healing potential of HES-RUT-SNEDDS was compared to those of pure HES suspension (HES-s), empty SNEDDS (E-SNEDDS), and standard Fusidic Acid via topical application. To produce various HES-RUT-loaded SNEDDS, aqueous phase titration was used to select cinnamon oil, Labrasol and Tween 80 (surfactants), Transcutol (co-surfactant) from a diverse pool of surfactants, oils and co-surfactants. The thermodynamic stability of HES-RUT-loaded SNEDDS was assessed by examining the globule size, surface morphology, zeta potential, polydispersity index (PDI), and percent (%) transmittance. The improved physicochemical properties of the optimized HES-RUT-SNEDDS (S-N4) formulation included particle size, zeta potential, and % transmittance. Smooth and spherical particles were discovered using Atomic Force Microscopy (AFM). These improved SNEDDS formulations demonstrated enhanced solubility and skin permeation. When compared to HES-s, E-SNEDDS, and standard fusidic acid, the optimized HES-RUT-SNEDDS demonstrated significant wound healing activity following topical application. HES-RUT-SNEDDS is a promising approach for enhancing the wound-healing potential of HES and RUT through topical administration.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2721 - 2734"},"PeriodicalIF":2.7,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescent Nanoprobe Utilizing Tryptophan-Functionalized Silver Nanoclusters for Enhanced Gemcitabine Detection: Optimization and Application in Real Samples 利用色氨酸功能化银纳米簇增强吉西他滨检测的荧光纳米探针:在真实样品中的优化与应用
IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Pub Date : 2024-08-25 DOI: 10.1007/s10876-024-02682-1
Yahya S. Alqahtani, Ashraf M. Mahmoud, Al-Montaser Bellah H. Ali, Mohamed M. El-Wekil

A new “signal-off” probe based on silver nanoclusters modified with tryptophan amino acid (TRP@Ag NCs) has been developed for the sensitive and selective fluorometric detection of the anticancer drug gemcitabine. The probe exhibits a blue-emission at 460 nm upon excitation at 320 nm. Various reaction parameters were optimized to enhance the probe’s performance. The addition of gemcitabine results in a decrease in the fluorescence emission, which is attributed to the aggregation of the TRP@Ag NCs. The interaction between the TRP@Ag NCs and gemcitabine involves multiple types of chemical bonds, including non-covalent hydrogen bonding, Van der Waals, and electrostatic forces. The fluorescence ratio (F°/F) exhibits a linear correlation with gemcitabine concentrations ranging from 0.005 to 60 µM, with a low limit of detection (LOD) of 1.7 nM (S/N = 3). The TRP@Ag NCs probe demonstrates high sensitivity, good selectivity, and reliability. The developed probe was successfully applied for the detection of gemcitabine in authentic samples, including pharmaceutical injections, serum, and urine, with acceptable recovery percentages and low relative standard deviation (RSD), indicating the accuracy and reliability of the probe.

基于色氨酸修饰的银纳米团簇(TRP@Ag NCs)开发了一种新型 "信号关闭 "探针,用于灵敏、选择性地荧光检测抗癌药物吉西他滨。该探针在 320 纳米波长的激发下于 460 纳米波长处发出蓝色荧光。为了提高探针的性能,对各种反应参数进行了优化。加入吉西他滨会导致荧光发射减弱,这归因于 TRP@Ag NCs 的聚集。TRP@Ag NCs 与吉西他滨之间的相互作用涉及多种类型的化学键,包括非共价氢键、范德华力和静电力。荧光比(F°/F)与吉西他滨浓度(0.005 至 60 µM)呈线性相关,检测限(LOD)低至 1.7 nM(S/N = 3)。TRP@Ag NCs 探针具有高灵敏度、良好的选择性和可靠性。所开发的探针被成功应用于药物注射液、血清和尿液等真实样品中吉西他滨的检测,回收率可接受,相对标准偏差(RSD)低,表明该探针准确可靠。
{"title":"Fluorescent Nanoprobe Utilizing Tryptophan-Functionalized Silver Nanoclusters for Enhanced Gemcitabine Detection: Optimization and Application in Real Samples","authors":"Yahya S. Alqahtani,&nbsp;Ashraf M. Mahmoud,&nbsp;Al-Montaser Bellah H. Ali,&nbsp;Mohamed M. El-Wekil","doi":"10.1007/s10876-024-02682-1","DOIUrl":"10.1007/s10876-024-02682-1","url":null,"abstract":"<div><p>A new “signal-off” probe based on silver nanoclusters modified with tryptophan amino acid (TRP@Ag NCs) has been developed for the sensitive and selective fluorometric detection of the anticancer drug gemcitabine. The probe exhibits a blue-emission at 460 nm upon excitation at 320 nm. Various reaction parameters were optimized to enhance the probe’s performance. The addition of gemcitabine results in a decrease in the fluorescence emission, which is attributed to the aggregation of the TRP@Ag NCs. The interaction between the TRP@Ag NCs and gemcitabine involves multiple types of chemical bonds, including non-covalent hydrogen bonding, Van der Waals, and electrostatic forces. The fluorescence ratio (F°/F) exhibits a linear correlation with gemcitabine concentrations ranging from 0.005 to 60 µM, with a low limit of detection (LOD) of 1.7 nM (S/<i>N</i> = 3). The TRP@Ag NCs probe demonstrates high sensitivity, good selectivity, and reliability. The developed probe was successfully applied for the detection of gemcitabine in authentic samples, including pharmaceutical injections, serum, and urine, with acceptable recovery percentages and low relative standard deviation (RSD), indicating the accuracy and reliability of the probe.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2735 - 2745"},"PeriodicalIF":2.7,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Cluster Science
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1