This study developed a novel paper-based sensor for the simultaneous analysis of ascorbic acid (AA) and hydroquinone (HQ). The sensor utilized polyvinyl alcohol (PVA)-stabilized silver nanoparticles (AgNPs-PVA) as the reagent probe and PVA media acted as the filter for separation of the analytes. Polydimethylsiloxane (PDMS) and ethanol serve as the stationary phase and eluent, respectively, exploiting the differences in analyte reactions and solubility to achieve their separation on the filter paper. The circular sensor’s central zone was AA’s detection area, while HQ was detected in the outer ring region. AA induced an immediate color change in the test kit, whereas HQ required a 20-minute elution with ethanol followed by colorimetric analysis. All analytes exhibited relative standard deviations of repeatability and reproducibility below 2.7% and 9.5%, respectively. Under optimal conditions, the linear detection range for HQ was 0.2-2.0 mg⋅L− 1, while AA was 0.1-2.0 mg⋅L− 1. The detection limit was determined to be 0.05 mg⋅L− 1 for AA and 0.1 mg⋅L− 1 for HQ. The recoveries of AA and HQ in cosmetic cream samples ranged from 80 to 110%. The accuracy of the sensor’s measurements was further validated by comparison with the HPLC-DAD method.
{"title":"Silver Nanoparticles and Polydimethylsiloxane-coated Paper for the Simultaneous Detection of Ascorbic Acid and Hydroquinone","authors":"Nutthaya Butwong, Siriboon Mukdasai, Pimpanitpa Kunthadong, Kamolwan Rintramee, Thidarat Kunawong","doi":"10.1007/s10876-024-02697-8","DOIUrl":"10.1007/s10876-024-02697-8","url":null,"abstract":"<div><p>This study developed a novel paper-based sensor for the simultaneous analysis of ascorbic acid (AA) and hydroquinone (HQ). The sensor utilized polyvinyl alcohol (PVA)-stabilized silver nanoparticles (AgNPs-PVA) as the reagent probe and PVA media acted as the filter for separation of the analytes. Polydimethylsiloxane (PDMS) and ethanol serve as the stationary phase and eluent, respectively, exploiting the differences in analyte reactions and solubility to achieve their separation on the filter paper. The circular sensor’s central zone was AA’s detection area, while HQ was detected in the outer ring region. AA induced an immediate color change in the test kit, whereas HQ required a 20-minute elution with ethanol followed by colorimetric analysis. All analytes exhibited relative standard deviations of repeatability and reproducibility below 2.7% and 9.5%, respectively. Under optimal conditions, the linear detection range for HQ was 0.2-2.0 mg⋅L<sup>− 1</sup>, while AA was 0.1-2.0 mg⋅L<sup>− 1</sup>. The detection limit was determined to be 0.05 mg⋅L<sup>− 1</sup> for AA and 0.1 mg⋅L<sup>− 1</sup> for HQ. The recoveries of AA and HQ in cosmetic cream samples ranged from 80 to 110%. The accuracy of the sensor’s measurements was further validated by comparison with the HPLC-DAD method.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2837 - 2848"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1007/s10876-024-02690-1
Tanawish, Nazish Jahan, Kousar Rasheed, Maria Iqbal, Muhammad Atif
The practical usage of natural enzymes is limited due to their sensitivity and need for special conditions. On the other hand, nanozymes provide robust catalytic performance, high stability in challenging conditions, economical production, and versatile surface modification. With these benefits, nanozymes surpass the constraints of natural enzymes and are a better option for a range of applications. Iron oxide-based nanomaterials have attracted significant attention due to their distinctive properties, such as catalase-like function under pH seven and peroxidase enzyme activity at acrid pH values as well as higher enzyme-like activities. This study has explored how synthesis procedures have advanced recently, presenting creative approaches with increased stability, regulated particle sizes, and catalytic activities. The potential of iron oxide nanozymes in a range of domains, such as healthcare, hyperthermia, MRI, optical devices, and anticancer activity, has also been investigated. This critical study provides a comprehensive overview of the synthesis, characterization, and potential uses of iron oxide-based nanozymes, identifies the areas where research is currently lacking, and makes options for future directions to maximize its potential in medicine. Overall, this review expands our understanding of iron oxide nanozymes and is a helpful resource for scientists creating novel medicinal and diagnostic tools.
{"title":"Exploring the Advanced Synthesis Strategies and Biomedical Applications of Iron Oxide-Based Nanozymes: A Comprehensive Review","authors":"Tanawish, Nazish Jahan, Kousar Rasheed, Maria Iqbal, Muhammad Atif","doi":"10.1007/s10876-024-02690-1","DOIUrl":"10.1007/s10876-024-02690-1","url":null,"abstract":"<div><p>The practical usage of natural enzymes is limited due to their sensitivity and need for special conditions. On the other hand, nanozymes provide robust catalytic performance, high stability in challenging conditions, economical production, and versatile surface modification. With these benefits, nanozymes surpass the constraints of natural enzymes and are a better option for a range of applications. Iron oxide-based nanomaterials have attracted significant attention due to their distinctive properties, such as catalase-like function under pH seven and peroxidase enzyme activity at acrid pH values as well as higher enzyme-like activities. This study has explored how synthesis procedures have advanced recently, presenting creative approaches with increased stability, regulated particle sizes, and catalytic activities. The potential of iron oxide nanozymes in a range of domains, such as healthcare, hyperthermia, MRI, optical devices, and anticancer activity, has also been investigated. This critical study provides a comprehensive overview of the synthesis, characterization, and potential uses of iron oxide-based nanozymes, identifies the areas where research is currently lacking, and makes options for future directions to maximize its potential in medicine. Overall, this review expands our understanding of iron oxide nanozymes and is a helpful resource for scientists creating novel medicinal and diagnostic tools. </p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2637 - 2661"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1007/s10876-024-02699-6
Muhammad Haroon, Mehwish Nasim, Asif Nawaz, Naveed Ullah Khan, Sheikh Abdur Rashid, Daulat Haleem Khan, Muhammad Khurshid Alam Shah, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ali A. Shati, Haroon Iqbal
The stated objective of the present research investigation was to use a simultaneous nanodrug delivery approach to optimize the therapeutic effectiveness of anticancer drugs against breast cancer cells. For this purpose, Poly (lactic-co-glycolic acid) nanoparticles with two anticancer drugs; methotrexate (MTX) and doxorubicin (DOX) denoted as DOX/MTX@PLGA NPs was developed by nanoprecipitation method. The developed polymeric DOX/MTX@PLGA NPs exhibited hydrodynamic particle diameter of 170.6 ± 10.0 nm with a poly dispersity index (PDI) of 0.17 and zeta potential value of -9.2 ± 0.31 mV, and spherical geometry analyzed by TEM. Furthermore, the nanoparticles exhibited a pH-responsive drug release profile, outstanding encapsulation efficiency, excellent colloidal stability across various physiological media and pH responsive drug release profile. Additionally, polymeric nanoparticles demonstrated higher cell uptake, in-vitro cytotoxicity, and a high rate of apoptosis in comparison to free DOX and MTX through a synergistic effect, likely as a result of their small particle size. In conclusion, our work presents a novel and distinct approach for boosting the therapeutic efficacy of anticancer drugs by delivering drugs to breast cancer cells simultaneously.
{"title":"Simultaneous Delivery of Dual Anticancer Agents Via pH-Responsive Polymeric Nanoparticles for Enhanced Therapeutic Efficacy Against Breast Cancer Cells","authors":"Muhammad Haroon, Mehwish Nasim, Asif Nawaz, Naveed Ullah Khan, Sheikh Abdur Rashid, Daulat Haleem Khan, Muhammad Khurshid Alam Shah, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ali A. Shati, Haroon Iqbal","doi":"10.1007/s10876-024-02699-6","DOIUrl":"10.1007/s10876-024-02699-6","url":null,"abstract":"<div><p>The stated objective of the present research investigation was to use a simultaneous nanodrug delivery approach to optimize the therapeutic effectiveness of anticancer drugs against breast cancer cells. For this purpose, Poly (lactic-co-glycolic acid) nanoparticles with two anticancer drugs; methotrexate (MTX) and doxorubicin (DOX) denoted as DOX/MTX@PLGA NPs was developed by nanoprecipitation method. The developed polymeric DOX/MTX@PLGA NPs exhibited hydrodynamic particle diameter of 170.6 ± 10.0 nm with a poly dispersity index (PDI) of 0.17 and zeta potential value of -9.2 ± 0.31 mV, and spherical geometry analyzed by TEM. Furthermore, the nanoparticles exhibited a pH-responsive drug release profile, outstanding encapsulation efficiency, excellent colloidal stability across various physiological media and pH responsive drug release profile. Additionally, polymeric nanoparticles demonstrated higher cell uptake, in-vitro cytotoxicity, and a high rate of apoptosis in comparison to free DOX and MTX through a synergistic effect, likely as a result of their small particle size. In conclusion, our work presents a novel and distinct approach for boosting the therapeutic efficacy of anticancer drugs by delivering drugs to breast cancer cells simultaneously.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2823 - 2836"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-21DOI: 10.1007/s10876-024-02700-2
Mohyeddin Assali, Anhar Mlitat, Abrar Yacoub, Anagheem Hasson, Ahmed Mousa
Silver nanoparticles (AgNPs) are increasingly recognized as vital nanomaterials in biomedical applications due to their diverse pharmacological properties, including antimicrobial and anti-neoplastic effects, particularly when derived from herbal sources. This study aims to synthesize AgNPs employing a sustainable approach aligned with the principles of the sustainable development goals. The synthesized AgNPs are incorporated with doxorubicin (DOX) and encapsulated within polylactide nanoparticles to enhance their anticancer potency. AgNPs are prepared via the reduction of silver ions using rutin as a reducing agent, with the reaction progress monitored via ultraviolet-visible spectroscopy (UV-vis). Subsequently, the AgNPs are encapsulated into poly(D, L-lactic acid) (PDLLA) nanoparticles alongside doxorubicin. The developed nanoparticles have shown a diameter size of 233 nm with a zeta potential of -21.47 mV. Moreover, the in vitro release profile of the DOX showed a sustained release kinetics over 30 h. Evaluation of the AgNP-DOX-loaded PDLLA nanoparticles reveals enhanced anticancer activity against HeLa and HepG2 cancer cells, highlighting the synergistic efficacy of the combined therapy. These findings underscore the potential of AgNPs-based formulations as promising candidates for advanced cancer therapeutics.
{"title":"Green Synthesis of Silver Nanoparticles Loaded with Doxorubicin in Polylactide Nanoparticles for Effective Cancer Therapy","authors":"Mohyeddin Assali, Anhar Mlitat, Abrar Yacoub, Anagheem Hasson, Ahmed Mousa","doi":"10.1007/s10876-024-02700-2","DOIUrl":"10.1007/s10876-024-02700-2","url":null,"abstract":"<div><p>Silver nanoparticles (AgNPs) are increasingly recognized as vital nanomaterials in biomedical applications due to their diverse pharmacological properties, including antimicrobial and anti-neoplastic effects, particularly when derived from herbal sources. This study aims to synthesize AgNPs employing a sustainable approach aligned with the principles of the sustainable development goals. The synthesized AgNPs are incorporated with doxorubicin (DOX) and encapsulated within polylactide nanoparticles to enhance their anticancer potency. AgNPs are prepared via the reduction of silver ions using rutin as a reducing agent, with the reaction progress monitored via ultraviolet-visible spectroscopy (UV-vis). Subsequently, the AgNPs are encapsulated into poly(D, L-lactic acid) (PDLLA) nanoparticles alongside doxorubicin. The developed nanoparticles have shown a diameter size of 233 nm with a zeta potential of -21.47 mV. Moreover, the in vitro release profile of the DOX showed a sustained release kinetics over 30 h. Evaluation of the AgNP-DOX-loaded PDLLA nanoparticles reveals enhanced anticancer activity against HeLa and HepG2 cancer cells, highlighting the synergistic efficacy of the combined therapy. These findings underscore the potential of AgNPs-based formulations as promising candidates for advanced cancer therapeutics.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2813 - 2821"},"PeriodicalIF":2.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-06DOI: 10.1007/s10876-024-02692-z
T. Prabhuraj, Abimannan Gomathi, Arumugam Priyadharsan, Murni Handayani, Sabah Ansar, K. A. Ramesh Kumar, Palanisamy Maadeswaran
An innovative Z-scheme WO3/g-C3N4 composite was efficiently produced via a straightforward hydrothermal method and applied to the photodegradation of phenol. The physiochemical behaviours of WO3, g-C3N4, WO3/g-C3N4 composite was analyzed by various analytical instruments. Compared to WO3, g-C3N4 single counterparts WO3/g-C3N4 Composite exhibits superior charge carriers’ separation efficiency and also Z scheme mechanism promoted the superior pollutant degradation. Subsequently, the WO3/g-C3N4 composite achieving 93% with rate constant 0.0184 min− 1 phenol removal within 100 min. The noteworthy increased photocatalytic bustle of WO3/g-C3N4 composite was attributed to the synergetic effect between the boundary of WO3/g-C3N4. Curiously, WO3/g-C3N4 composite validates exceptional photostability during reusable experiment, accentuating its potential as a functioning photocatalyst for phenol removal. The antimicrobial tests showed that the developed photocatalyst effectively sterilizes both gram-positive Staphylococcus aureus and gram-negative Escherichia coli. Thus, the WO3/g-C3N4 nanocomposites are robust materials suitable for use as antimicrobial agents and photocatalysts activated by sunlight.
{"title":"Design of a High-Performance WO3/g-C3N4 Z-Scheme Photocatalyst for Effective Phenol Degradation and Antibacterial Activity","authors":"T. Prabhuraj, Abimannan Gomathi, Arumugam Priyadharsan, Murni Handayani, Sabah Ansar, K. A. Ramesh Kumar, Palanisamy Maadeswaran","doi":"10.1007/s10876-024-02692-z","DOIUrl":"10.1007/s10876-024-02692-z","url":null,"abstract":"<div><p>An innovative Z-scheme WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was efficiently produced via a straightforward hydrothermal method and applied to the photodegradation of phenol. The physiochemical behaviours of WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub>, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was analyzed by various analytical instruments. Compared to WO<sub>3</sub>, g-C<sub>3</sub>N<sub>4</sub> single counterparts WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> Composite exhibits superior charge carriers’ separation efficiency and also Z scheme mechanism promoted the superior pollutant degradation. Subsequently, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite achieving 93% with rate constant 0.0184 min<sup>− 1</sup> phenol removal within 100 min. The noteworthy increased photocatalytic bustle of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite was attributed to the synergetic effect between the boundary of WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub>. Curiously, WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> composite validates exceptional photostability during reusable experiment, accentuating its potential as a functioning photocatalyst for phenol removal. The antimicrobial tests showed that the developed photocatalyst effectively sterilizes both gram-positive <i>Staphylococcus aureus</i> and gram-negative <i>Escherichia coli</i>. Thus, the WO<sub>3</sub>/g-C<sub>3</sub>N<sub>4</sub> nanocomposites are robust materials suitable for use as antimicrobial agents and photocatalysts activated by sunlight.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2753 - 2768"},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.
{"title":"Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies","authors":"Diya Pratish Chohan, Bipasa Dey, Arshia Tarkunde, Vaishnavi Vyas, Srijita De Sarkar, Babitha Kampa Sundara","doi":"10.1007/s10876-024-02691-0","DOIUrl":"10.1007/s10876-024-02691-0","url":null,"abstract":"<div><p>Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2607 - 2635"},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10876-024-02691-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-03DOI: 10.1007/s10876-024-02684-z
Mushawah Abdullah Almushawah, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ghedeir Alshammari, Ali A Alshatwi
{"title":"Correction: Nanoparticles Prepared from Starch-Myristic Acid Complex Ethyl Acetate Fraction: Impact on Gene Expression in Human Mesenchymal Stem Cells","authors":"Mushawah Abdullah Almushawah, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ghedeir Alshammari, Ali A Alshatwi","doi":"10.1007/s10876-024-02684-z","DOIUrl":"10.1007/s10876-024-02684-z","url":null,"abstract":"","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"3181 - 3181"},"PeriodicalIF":2.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1007/s10876-024-02687-w
Wen-Juan Tian, Jing-Jing Wang, Hui-Li Chen
The discovery of cyclic boron oxide clusters has prompted investigations into their distinctive structures and bonding characteristics. Notably, the majority of reported cyclic boron oxide structures consist predominantly of four to six-membered rings. In this study, we employ theoretical methods to predict the global-minimum (GM) structure of B6O62+. Our analyses, including global-minimum searches and calculations using B3LYP, PBE, PBE0, and single-point CCSD(T), reveal that the D2h B6O62+ (1Ag) configuration represents a planar and tricyclic structure, resulting from the fusion of B3O2/B4O2/B3O2 units. Remarkably, this structure establishes the B6O62+ cluster as the smallest boron oxide cluster with a planar tricyclic motif. Further bonding analysis indicates that B6O62+ is a weakly antiaromatic system with 12π delocalized electrons. The reported B6O6 has a planar structure with a 6-membered B3O3 ring and 6 π electrons distributed over the ring. Because of the absence of two electrons from the highest occupied molecular orbital (HOMO) of neutral B6O6, the structure of B6O62+ is distinctly different from that of B6O6.
{"title":"Theoretical Prediction of the Smallest Sized Tricyclic-Boron Oxide B6O62+","authors":"Wen-Juan Tian, Jing-Jing Wang, Hui-Li Chen","doi":"10.1007/s10876-024-02687-w","DOIUrl":"10.1007/s10876-024-02687-w","url":null,"abstract":"<div><p>The discovery of cyclic boron oxide clusters has prompted investigations into their distinctive structures and bonding characteristics. Notably, the majority of reported cyclic boron oxide structures consist predominantly of four to six-membered rings. In this study, we employ theoretical methods to predict the global-minimum (GM) structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup>. Our analyses, including global-minimum searches and calculations using B3LYP, PBE, PBE0, and single-point CCSD(T), reveal that the <i>D</i><sub>2<i>h</i></sub> B<sub>6</sub>O<sub>6</sub><sup>2+</sup> (<sup>1</sup>A<sub>g</sub>) configuration represents a planar and tricyclic structure, resulting from the fusion of B<sub>3</sub>O<sub>2</sub>/B<sub>4</sub>O<sub>2</sub>/B<sub>3</sub>O<sub>2</sub> units. Remarkably, this structure establishes the B<sub>6</sub>O<sub>6</sub><sup>2+</sup> cluster as the smallest boron oxide cluster with a planar tricyclic motif. Further bonding analysis indicates that B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is a weakly antiaromatic system with 12π delocalized electrons. The reported B<sub>6</sub>O<sub>6</sub> has a planar structure with a 6-membered B<sub>3</sub>O<sub>3</sub> ring and 6 π electrons distributed over the ring. Because of the absence of two electrons from the highest occupied molecular orbital (HOMO) of neutral B<sub>6</sub>O<sub>6</sub>, the structure of B<sub>6</sub>O<sub>6</sub><sup>2+</sup> is distinctly different from that of B<sub>6</sub>O<sub>6</sub>.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2747 - 2752"},"PeriodicalIF":2.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-25DOI: 10.1007/s10876-024-02679-w
Ajmal Hayat, Ismail Shah, Abdul Jabbar, Ayman Nafady, Aziz Balouch, Muhammad Raza Shah, Sayyed Ibrahim Shah, Razium Ali Soomro, Sirajuddin
The aim of this work is to develop a self-nanoemulsifying drug delivery system (SNEDDS) for Hesperidin (HES) and Rutin (RUT) to improve their biopharmaceutical properties. The wound healing potential of HES-RUT-SNEDDS was compared to those of pure HES suspension (HES-s), empty SNEDDS (E-SNEDDS), and standard Fusidic Acid via topical application. To produce various HES-RUT-loaded SNEDDS, aqueous phase titration was used to select cinnamon oil, Labrasol and Tween 80 (surfactants), Transcutol (co-surfactant) from a diverse pool of surfactants, oils and co-surfactants. The thermodynamic stability of HES-RUT-loaded SNEDDS was assessed by examining the globule size, surface morphology, zeta potential, polydispersity index (PDI), and percent (%) transmittance. The improved physicochemical properties of the optimized HES-RUT-SNEDDS (S-N4) formulation included particle size, zeta potential, and % transmittance. Smooth and spherical particles were discovered using Atomic Force Microscopy (AFM). These improved SNEDDS formulations demonstrated enhanced solubility and skin permeation. When compared to HES-s, E-SNEDDS, and standard fusidic acid, the optimized HES-RUT-SNEDDS demonstrated significant wound healing activity following topical application. HES-RUT-SNEDDS is a promising approach for enhancing the wound-healing potential of HES and RUT through topical administration.
{"title":"Enhanced Wound Healing Activity in Animal Model via Developing and Designing of Self-nano Emulsifying Drug Delivery System (SNEDDS) for the Co-delivery of Hesperidin and Rutin","authors":"Ajmal Hayat, Ismail Shah, Abdul Jabbar, Ayman Nafady, Aziz Balouch, Muhammad Raza Shah, Sayyed Ibrahim Shah, Razium Ali Soomro, Sirajuddin","doi":"10.1007/s10876-024-02679-w","DOIUrl":"10.1007/s10876-024-02679-w","url":null,"abstract":"<div><p>The aim of this work is to develop a self-nanoemulsifying drug delivery system (SNEDDS) for Hesperidin (HES) and Rutin (RUT) to improve their biopharmaceutical properties. The wound healing potential of HES-RUT-SNEDDS was compared to those of pure HES suspension (HES-s), empty SNEDDS (E-SNEDDS), and standard Fusidic Acid via topical application. To produce various HES-RUT-loaded SNEDDS, aqueous phase titration was used to select cinnamon oil, Labrasol and Tween 80 (surfactants), Transcutol (co-surfactant) from a diverse pool of surfactants, oils and co-surfactants. The thermodynamic stability of HES-RUT-loaded SNEDDS was assessed by examining the globule size, surface morphology, zeta potential, polydispersity index (PDI), and percent (%) transmittance. The improved physicochemical properties of the optimized HES-RUT-SNEDDS (S-N4) formulation included particle size, zeta potential, and % transmittance. Smooth and spherical particles were discovered using Atomic Force Microscopy (AFM). These improved SNEDDS formulations demonstrated enhanced solubility and skin permeation. When compared to HES-s, E-SNEDDS, and standard fusidic acid, the optimized HES-RUT-SNEDDS demonstrated significant wound healing activity following topical application. HES-RUT-SNEDDS is a promising approach for enhancing the wound-healing potential of HES and RUT through topical administration.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2721 - 2734"},"PeriodicalIF":2.7,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-25DOI: 10.1007/s10876-024-02682-1
Yahya S. Alqahtani, Ashraf M. Mahmoud, Al-Montaser Bellah H. Ali, Mohamed M. El-Wekil
A new “signal-off” probe based on silver nanoclusters modified with tryptophan amino acid (TRP@Ag NCs) has been developed for the sensitive and selective fluorometric detection of the anticancer drug gemcitabine. The probe exhibits a blue-emission at 460 nm upon excitation at 320 nm. Various reaction parameters were optimized to enhance the probe’s performance. The addition of gemcitabine results in a decrease in the fluorescence emission, which is attributed to the aggregation of the TRP@Ag NCs. The interaction between the TRP@Ag NCs and gemcitabine involves multiple types of chemical bonds, including non-covalent hydrogen bonding, Van der Waals, and electrostatic forces. The fluorescence ratio (F°/F) exhibits a linear correlation with gemcitabine concentrations ranging from 0.005 to 60 µM, with a low limit of detection (LOD) of 1.7 nM (S/N = 3). The TRP@Ag NCs probe demonstrates high sensitivity, good selectivity, and reliability. The developed probe was successfully applied for the detection of gemcitabine in authentic samples, including pharmaceutical injections, serum, and urine, with acceptable recovery percentages and low relative standard deviation (RSD), indicating the accuracy and reliability of the probe.
{"title":"Fluorescent Nanoprobe Utilizing Tryptophan-Functionalized Silver Nanoclusters for Enhanced Gemcitabine Detection: Optimization and Application in Real Samples","authors":"Yahya S. Alqahtani, Ashraf M. Mahmoud, Al-Montaser Bellah H. Ali, Mohamed M. El-Wekil","doi":"10.1007/s10876-024-02682-1","DOIUrl":"10.1007/s10876-024-02682-1","url":null,"abstract":"<div><p>A new “signal-off” probe based on silver nanoclusters modified with tryptophan amino acid (TRP@Ag NCs) has been developed for the sensitive and selective fluorometric detection of the anticancer drug gemcitabine. The probe exhibits a blue-emission at 460 nm upon excitation at 320 nm. Various reaction parameters were optimized to enhance the probe’s performance. The addition of gemcitabine results in a decrease in the fluorescence emission, which is attributed to the aggregation of the TRP@Ag NCs. The interaction between the TRP@Ag NCs and gemcitabine involves multiple types of chemical bonds, including non-covalent hydrogen bonding, Van der Waals, and electrostatic forces. The fluorescence ratio (F°/F) exhibits a linear correlation with gemcitabine concentrations ranging from 0.005 to 60 µM, with a low limit of detection (LOD) of 1.7 nM (S/<i>N</i> = 3). The TRP@Ag NCs probe demonstrates high sensitivity, good selectivity, and reliability. The developed probe was successfully applied for the detection of gemcitabine in authentic samples, including pharmaceutical injections, serum, and urine, with acceptable recovery percentages and low relative standard deviation (RSD), indicating the accuracy and reliability of the probe.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 8","pages":"2735 - 2745"},"PeriodicalIF":2.7,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}