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Kinetics of Ligand Binding to Receptors in the Presence of Multiplicative Noise 存在乘法噪声时配体与受体的结合动力学
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S106833722470018X
V. B. Arakelyan, S. V. Harutyunyan, S. P. Kocharyan, I. V. Vardanyan, S. G. Haroutiunian, N. S. Ananikian

The binding of ligands with receptors was theoretically studied in the case when the number of ligands in solution fluctuates under the influence of fluctuations of the external environment. A multiplicative stochastic differential equation has been obtained that describes the time change in the number of ligand-receptor complexes. The average number of ligand-receptor complexes and its variance were calculated. An isotherm of the binding of ligands to receptors was obtained. It has been shown that the presence of multiplicative noise leads to the fact that the process of binding of ligands to receptors becomes threshold—in the region of low concentrations of ligands at a certain ratio between the binding parameters and the intensity of the multiplicative noise, the formation of a ligand-receptor complex does not occur. It has been shown that with increasing ligand concentration, the relaxation time of the average number of ligand-receptor complexes decreases, and with increasing noise intensity it increases. It is also shown that at low values of the external noise intensity, the dispersion is proportional to the external noise intensity and increases linearly with increasing noise intensity.

在溶液中配体数量受外部环境波动影响而波动的情况下,配体与受体的结合进行了理论研究。研究得到了一个乘法随机微分方程,该方程描述了配体-受体复合物数量的时间变化。计算了配体-受体复合物的平均数量及其方差。得到了配体与受体结合的等温线。研究表明,乘法噪声的存在导致配体与受体的结合过程成为阈值,在低浓度配体区域,当结合参数与乘法噪声强度达到一定比例时,配体与受体的复合物不会形成。研究表明,随着配体浓度的增加,配体-受体复合物平均数量的弛豫时间减少,而随着噪声强度的增加,弛豫时间增加。研究还表明,在外部噪声强度值较低时,分散度与外部噪声强度成正比,并随着噪声强度的增加而线性增加。
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引用次数: 0
X-Ray Diffraction by Superlattice with Overlapping Stacking Faults 具有重叠堆积断层的超晶格的 X 射线衍射
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S1068337224700294
H. M. Manukyan

A theoretical study of X-ray diffraction on a superlattice with overlapping stacking faults is carried out. Expressions for the X-ray reflection coefficient in the directions of satellites, depending on the wave’s phase jump on the stacking faults and the depth of their occurrence are obtained. For comparison with an ideal superlattice, the relative change in the reflection coefficient is obtained.

对具有重叠堆积断层的超晶格上的 X 射线衍射进行了理论研究。根据波在叠层断层上的相位跃迁及其出现的深度,得到了卫星方向上 X 射线反射系数的表达式。为了与理想超晶格进行比较,还得出了反射系数的相对变化。
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引用次数: 0
Influence of the Target Holder Material on the Cooling Processes of Locally Inclined Targets in the Nirta Solid Compact Target Module 靶架材料对 Nirta 固体紧凑型靶模块中局部倾斜靶冷却过程的影响
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S1068337224700233
R. Dallakyan, N. Dobrovolski, A. Grigoryan, A. Manukyan, I. Sinenko

The results of numerical modeling of thermal processes in locally inclined targets made of pressed molybdenum powder with holders of titanium and copper are presented. The simulation was conducted to determine the suitability of such targets for irradiation with high-intensity proton beams in the “Nirta Solid Compact Model TS06” target module for producing the medical radioisotope Tc-99m. Calculations were carried out using the Fluid Flow (Fluent) engineering package of the ANSYS Workbench software platform on models of targets with axially symmetric corrugations in the irradiation zone. It is shown that the target temperature decreases on locally inclined targets with titanium and copper holders due to corrugation. On targets with copper holders, it is also possible to increase the maximum irradiation current by 1.5 times compared to standard flat targets, comparable with previously obtained results for targets with niobium holders. It has been established that on locally inclined targets with titanium holders, corrugation does not provide a practically significant increase in the maximum irradiation current due to the low thermal conductivity of titanium.

本文介绍了用钛和铜支架压制钼粉制成的局部倾斜靶内热过程的数值建模结果。模拟的目的是确定这种靶是否适合在用于生产医用放射性同位素 Tc-99m 的 "Nirta Solid Compact Model TS06 "靶模块中使用高强度质子束进行辐照。使用 ANSYS Workbench 软件平台的流体流动(Fluent)工程软件包对辐照区内具有轴对称波纹的靶件模型进行了计算。结果表明,在钛和铜支架的局部倾斜靶材上,由于波纹的存在,靶材温度会降低。与标准平面靶相比,铜座靶的最大辐照电流可增加 1.5 倍,这与之前铌座靶的结果相当。在使用钛支架的局部倾斜靶上,由于钛的热传导率较低,波纹并不能显著提高最大辐照电流。
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引用次数: 0
Waveguide-Lens Transitions for Terahertz Range 太赫兹范围的波导透镜转换
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S1068337224700324
V. A. Vardanyan, M. Ts. Ayvazyan

The possibility of applying a dielectric lens as a highly directional antenna in the terahertz range is investigated. Theoretical expressions have been obtained and analyzed that make it possible to compute the shape of the lens profile and the radiation pattern of the created lens antenna. The effectiveness of the proposed lens antenna in the specified range is shown, and the results of experimental studies of the created lens antenna are also presented.

研究了将介质透镜用作太赫兹范围内高指向性天线的可能性。通过获得和分析理论表达式,可以计算透镜轮廓的形状和所创建透镜天线的辐射模式。研究显示了所提出的透镜天线在指定范围内的有效性,并介绍了对所创建的透镜天线进行实验研究的结果。
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引用次数: 0
Assessment of Uncertainty in the Calculation of Neutron Fluence on the VVER-440 Reactor Pressure Vessel Due to Uncertainties in Neutron–Nuclear Interaction Cross-Sections 由于中子-核相互作用截面的不确定性而导致的 VVER-440 反应堆压力容器中子流计算的不确定性评估
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S1068337224700221
S. Bznuni, A. Ugujyan

An assessment of the uncertainty in the calculation of fast neutron fluence on the reactor pressure vessel of the second unit of the Armenian Nuclear Power Plant (ANPP) was conducted, considering uncertainties in neutron–nuclear interaction cross-sections. Using the Monte Carlo method, the most sensitive region of the reactor to changes in neutron interaction cross-sections was identified. The results indicate that the primary source of fluence uncertainty is in the neutron absorption cross-section in the fast neutron energy region, especially in hydrogen. Data received have significant importance for the long-term safety assessment and life extension of these types of reactors.

考虑到中子-核相互作用截面的不确定性,对亚美尼亚核电厂(ANPP)第二机组反应堆压力容器上的快中子通量计算的不确定性进行了评估。利用蒙特卡罗方法,确定了反应堆对中子相互作用截面变化最敏感的区域。结果表明,通量不确定性的主要来源是快中子能量区的中子吸收截面,尤其是氢。获得的数据对这类反应堆的长期安全评估和寿命延长具有重要意义。
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引用次数: 0
Influence of TiO2:ZrO2 Bi-Component Additive on the Mechanical Properties of Glass-Ceramic Material Based on Perlite TiO2:ZrO2 双组分添加剂对基于珍珠岩的玻璃陶瓷材料机械性能的影响
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-11-18 DOI: 10.1134/S1068337224700257
L. N. Grigoryan, P. G. Petrosyan, S. G. Petrosyan

The influence of a two-component TiO2:ZrO2 addition on the mechanical properties of a glass-crystalline material synthesized on the base of perlite has been studied. A relationship has been established between Young’s modulus, microhardness, and the content of the TiO2:ZrO2 addition to the original batch. The kinetics of crystallization of the resulting material were studied using the method of non-isothermal differential thermal analysis (DTA). Based on the results of SEM studies, it was established that the addition of TiO2:ZrO2 results in an increase in the concentration of nucleation sites and a decrease in the size of the resulting crystallites, which ultimately is the physical reason for the increase in the microhardness of the synthesized glass ceramics.

研究了在珍珠岩基础上合成的玻璃晶体材料中添加双组分 TiO2:ZrO2 对其机械性能的影响。在杨氏模量、显微硬度和原始批次中添加的 TiO2:ZrO2 的含量之间建立了关系。使用非等温差热分析(DTA)方法研究了所得材料的结晶动力学。根据扫描电镜研究的结果,确定了添加 TiO2:ZrO2 会导致成核点的浓度增加和所产生的结晶尺寸减小,这最终是合成玻璃陶瓷微硬度增加的物理原因。
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引用次数: 0
Multilayer Energy-Absorbing Substrate for Two-Layer Barriers with an External Ceramic Layer 带外部陶瓷层的多层双层屏障吸能衬底
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-09-09 DOI: 10.1134/S1068337224700099
P. G. Petrosyan, L. N. Grigoryan

A new type of multilayer energy-absorbing substrate has been proposed, the layers of which are stuck together by an elastic glue. When the impactor collides with an obstacle, part of the kinetic energy of this impactor is spent on the displacement of separate layers of the substrate relative to each other, which increases the maximum velocity of penetration of the barrier. The dependence of the maximum velocity of penetration of the barrier on the displacement of the substrate layers, as well as the dependence of the energy spent on sliding layers on the area of the deformed part of the substrate, have been studied. It is shown that, at the same impact energy, the depth of deformation of the proposed substrate is 1.5 times less than that of substrates in which the sliding of layers is absent. The use of the proposed substrate in ceramic protective structures allows one to significantly reduce the surface density of the structure.

摘要 提出了一种新型的多层吸能基板,其各层通过弹性胶粘在一起。当撞击器与障碍物碰撞时,撞击器的部分动能用于使基材的不同层之间产生相对位移,从而提高了障碍物的最大穿透速度。我们研究了障碍物的最大穿透速度与基体各层位移的关系,以及滑动层所消耗的能量与基体变形部分面积的关系。结果表明,在相同的冲击能量下,拟议基底的变形深度是无滑动层基底的 1.5 倍。在陶瓷保护结构中使用拟议的基底,可以大大降低结构的表面密度。
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引用次数: 0
Absorption and Fluorescence Characteristics of the Binding of Ethidium Bromide with Synthetic Single- and Double-Stranded Polyribonucleotides 溴化乙锭与合成单链和双链多核苷酸结合的吸收和荧光特性
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-09-09 DOI: 10.1134/S1068337224700130
A. P. Antonyan, P. O. Vardevanyan, M. S. Mikaelyan, G. H. Kocharyan, G. H. Poghosyan, M. A. Parsadanyan

A comparative study of the complex formation of ethidium bromide (EtBr) and methylene blue (MB) with synthetic single-stranded (ss-) polynucleotides poly(rA) and poly(rU) was conducted. The absorption spectra of these ligands decreased upon interaction with ss-polynucleotides and poly(rA)-poly(rU) formed at their hybridization. In the case of the MB-polynucleotide complexes, the fluorescence intensity decreases, while in the case of EtBr, the fluorescence intensity increases along with the enhancement of concentrations of polynucleotides. Based on the fluorescence spectra analysis of the complexes EtBr with ss- and hybrid ds-polynucleotides, the binding curves in Scatchard coordinates were constructed (r/Cf and r), and the values of the binding parameters of polynucleotides determined, including the binding constant value K and the number of bases n (base pairs at hybridization) per binding site..

摘要 对溴化乙锭(EtBr)和亚甲基蓝(MB)与合成单链(ss-)多核苷酸聚(rA)和聚(rU)形成的复合物进行了比较研究。这些配体与ss-多核苷酸和杂交形成的聚(rA)-聚(rU)相互作用后,其吸收光谱降低。在甲基溴-多核苷酸复合物的情况下,荧光强度会降低,而在乙特溴的情况下,荧光强度会随着多核苷酸浓度的增加而增加。根据 EtBr 与ss-多核苷酸和杂合ds-多核苷酸复合物的荧光光谱分析,构建了 Scatchard 坐标下的结合曲线(r/Cf 和 r),并确定了多核苷酸的结合参数值,包括结合常数 K 值和每个结合位点的碱基数 n(杂交时的碱基对数)。
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引用次数: 0
Features of Microwave Propagation Through a Two-Layer Metasurface Made of Conductive Rods 由导电棒构成的两层元表面的微波传播特性
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-09-09 DOI: 10.1134/S1068337224700142
G. Ohanyan

In a two-layer meta surface consisting of periodically arranged rods, there is a strong dispersion of the transmission coefficient in the microwave region of the spectrum. The observed phenomenon is the result of the resonant interaction of the microwave with the rod, where a standing wave with axial symmetry is formed, as well as the effective electrical interaction between the rods of adjacent layers. The transmission coefficient curve found in the experiment has an acute peak, which allows the structure to be used as a bandpass filter. It was found that the resonant frequency shifts to the low-frequency region as the length of the rods, their diameter, and the distance between the layers increases, which opens up the possibilities of controlling the microwave.

摘要 在一个由周期性排列的棒组成的双层元表面中,光谱的微波区域存在很强的传输系数分散现象。观察到的这一现象是微波与棒的共振相互作用(形成轴对称驻波)以及相邻层的棒之间有效电相互作用的结果。实验中发现的传输系数曲线有一个尖锐的峰值,这使得该结构可以用作带通滤波器。实验发现,随着棒的长度、直径和层间距离的增加,谐振频率会向低频区移动,这为控制微波提供了可能。
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引用次数: 0
Increase in the Resolution of Hard X-Ray Phase-Contrast Imaging in a Device Based on a Triple Laue-Case Interferometer 在基于三重 Laue-Case 干涉仪的设备中提高硬 X 射线相位对比成像的分辨率
IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY Pub Date : 2024-09-09 DOI: 10.1134/S1068337224700166
L. A. Haroutunyan

The possibility of increasing the resolution of X-ray phase-contrast imaging with a device based on a triple Laue-case interferometer is considered. To address one of the drawbacks of this scheme—the distortion of the interference pattern during diffraction of the object wave on the interferometer analyzer—it is proposed to replace the analyzer with two crystalline blocks of equal thickness. These blocks act as a diffraction lens, suppressing the mentioned distortions. Numerical simulations demonstrate that the low coherence of the initial radiation increases the quality of phase-contrast imaging using this method.

摘要 研究考虑了利用基于三重 Laue-case 干涉仪的装置提高 X 射线相位对比成像分辨率的可能性。为了解决该方案的一个缺点--干涉图案在物体波在干涉仪分析器上衍射时发生扭曲--建议用两个等厚的晶体块取代分析器。这些晶体块就像一个衍射透镜,可以抑制上述扭曲现象。数值模拟证明,使用这种方法,初始辐射的低相干性提高了相位对比成像的质量。
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引用次数: 0
期刊
Journal of Contemporary Physics (Armenian Academy of Sciences)
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