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2010 4th International Conference on Bioinformatics and Biomedical Engineering最新文献

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Spatial-Temporal Source Reconstruction of MEG via Variational EM Algorithm 基于变分EM算法的脑磁图时空源重构
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5517755
J. Kan, Richard C. Wilson
Magnetoencephalography(MEG) is a new noninvasive brain imaging technique reconstructed electronic activities of brain by measured the magnetic field surrounding scalp. The aim of this paper is to explore a new method of MEG source spatio-temporal reconstruction based on optimizing the reconstructed MEG source model. We make the assumption that the stimulated electronic activities of the brain are located on a particular part of cortex where we partition it with multiple even voxels. In terms of Biot-Savart Law of electromagnetism, the spatial source model is built with multiple unknown parameters which reflect the information of the source location. Then, we try to solve this parameters optimization as a Maximum-likelihood estimation (MLE) using variational EM algorithm. According to the application of this approach, this paper also addresses that the solution of MEG signal reconstruction should be considered to avoid overlapping the calculation complexity, which may result in too expensive calculation to practice. Whereas, this approach also provides a new possibility and the new angle to solve MEG source reconstruction.
脑磁图(MEG)是一种新的无创脑成像技术,通过测量头皮周围的磁场来重建大脑的电子活动。本文的目的是在优化重构后的MEG源模型的基础上,探索一种新的MEG源时空重构方法。我们假设大脑受刺激的电子活动位于皮层的特定部分,我们将其划分为多个均匀体素。根据电磁比奥-萨瓦定律,建立了包含多个反映源位置信息的未知参数的空间源模型。然后,我们尝试使用变分EM算法将该参数优化求解为最大似然估计(MLE)。根据该方法的应用,本文还提出了应考虑MEG信号重构的解决方案,以避免计算复杂度重叠,从而导致计算成本过高而无法实践。同时,该方法也为解决MEG源重构问题提供了一种新的可能性和新的角度。
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引用次数: 0
Segmentation of White Matter Based on Region Growing and Threshold Theory 基于区域生长和阈值理论的脑白质分割
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516524
Min Li, Hongyan Luo, Renbin He, Wenwu Zhu, L. Tan, Yi Wu
In order to reduce the massive manual intervention involved in the existing segmentation methods for human cross-section slice images, a segmentation algorithm based on the theory of region growing and threshold in normal gray histogram was proposed in this paper, according to the features of slice images of human brain. More exactly, these slice images were initially segmented coarsely by means of the region growing. Then the method of threshold in normal gray histogram was adopted to refine the segmentation. The experimental results indicate that the proposed algorithm can segment white matter accurately and effectively.
为了减少现有人体横切面图像分割方法中大量的人工干预,本文根据人脑横切面图像的特点,提出了一种基于正态灰度直方图区域增长和阈值理论的分割算法。更确切地说,这些切片图像最初是通过区域生长进行粗分割的。然后采用正态灰度直方图阈值法对图像进行细化分割。实验结果表明,该算法能准确有效地分割脑白质。
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引用次数: 1
Textural Feature Analysis for Ultrasound Breast Tumor Images 乳腺超声肿瘤图像的纹理特征分析
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516918
Qiuxia Chen, Qi Liu
Texture is one of the important characteristics used in identifying objects or regions of interest in an image. This paper describes some textural features based on integrated spatial gray level co-occurrence matrix, and illustrates the effectiveness of four textural features in categorizing ultrasound breast tumor images by means of Fuzzy C-means and K-medoid clustering algorithms respectively. The experimental identification accuracy is 72.6415 percent. These results indicate that textural features probably have a general applicability for classification of breast tumors.
纹理是用于识别图像中感兴趣的物体或区域的重要特征之一。本文描述了基于集成空间灰度共生矩阵的一些纹理特征,并分别用模糊C-means和k - medium聚类算法说明了四种纹理特征在超声乳腺肿瘤图像分类中的有效性。实验识别准确率为72.6415%。这些结果表明,纹理特征可能对乳腺肿瘤的分类具有普遍的适用性。
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引用次数: 6
NOR1 Enhanced CB1954 Induced Cell Cytotoxicity in HepG2 Is Dependent on Grb2 Mediated MAPK Pathway NOR1增强CB1954诱导的HepG2细胞毒性依赖于Grb2介导的MAPK通路
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516376
R. Gui, Jing Liu, Deng-qing Li, Hua Tang, Zhenqian Feng, X. Nie
Nitroreductase gene NOR1 is possibly involved in the chemical carcinogenesis of hepatic cancer and nasopharyngeal carcinoma. We have demonstrted that NOR1 overexpression could convert monofunction alalkylating agent, CB1954 ([5-aziridin-1-yl]-2,4-dinitrobenzamide) into a toxic form by reduction of the 4-nitro group of CB1954 and enhancing cell killing in nasopharyngeal carcinoma(NPC) cell line CNE1. However, the mechanisms are not known.Using cDNA microarrys and quantitative Real-time PCR, we previously found that NOR1 increased the expression of Grb2 mRNA by 4.8 fold in hepatic cancer cell HepG2. In the present study, we found that NOR1 increased the Grb2 protein expression by 3 fold and enhanced the CB1954 induced cell killing in HepG2 cells ,and the cell cytotoxicity could be inhibited by adding tyrosine kinase inhibitor genestein or by stable transfection of Grb2 shRNA (pU6+27-shGrb2) to silence the expression of Grb2. Western blot analysis showed that Grb2 downexpression could reduce the activity of MAPK. Moreover, inhibiting the activatiton of MAPK by MEK inhibtor PD98059 suppressed CB1954 induced cell killing. These results suggested that NOR1 gene enhanced CB1954 cell cytotoxicity through upregulating expression of Grb2 and activiation of MAPK signal transduction in HepG2 cells.
硝基还原酶基因NOR1可能参与了肝癌和鼻咽癌的化学致癌作用。我们已经证明,NOR1过表达可以通过减少CB1954的4-硝基基团并增强鼻咽癌(NPC)细胞系CNE1的细胞杀伤能力,将单功能烷基化剂CB1954 ([5-aziridin-1-yl]-2,4-二硝基苯酰胺)转化为有毒形式。然而,其机制尚不清楚。利用cDNA芯片和实时荧光定量PCR技术,我们发现NOR1使肝癌细胞HepG2中Grb2 mRNA的表达增加了4.8倍。在本研究中,我们发现NOR1使Grb2蛋白的表达增加了3倍,并增强了CB1954诱导的HepG2细胞的杀伤作用,并且可以通过添加酪氨酸激酶抑制剂基因蛋白或稳定转染Grb2 shRNA (pU6+27-shGrb2)沉默Grb2的表达来抑制细胞毒性。Western blot分析显示,Grb2的下调可降低MAPK的活性。此外,MEK抑制剂PD98059抑制MAPK的激活可以抑制CB1954诱导的细胞杀伤。这些结果表明,NOR1基因通过上调HepG2细胞中Grb2的表达和激活MAPK信号转导,增强了CB1954细胞的毒性。
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引用次数: 1
Preparation of a Composite Plate Using Nonmetallic Materials Powder from the Waste Printed Circuit Boards 利用废旧印刷电路板中的非金属材料粉末制备复合板
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516729
Yin Jin, Guangming Li, Wenzhi He
With the production of electrical and electronic equipment (EEE) being one of the fastest growing markets in the world, the steep increasing amount of waste electrical and electronic equipment (WEEE) has triggered off a serious environmental crisis. A composite plate produced by using nonmetallic materials of pulverized waste printed circuit boards(PCBs) obtained after air classification as filler was prepared. The main mechanical properties of composite plate such as tensile strength, bending and impact strength were compared according to different filler particle size, dosage, and modifier and the inner structure of the composite plate was investigated by fractography study. The results indicated that using polypropylene S700 as the base resin and maleic anhydride grafted polypropylene (MAH-g-PP) as a modifier, the mechanical properties of composite plate were excellent when non-metallic materials with particle size from 0.125 to 0.3mm adding amount was 20 wt%. This technique of recycling waste PCBs offers a new way for the improvement of recovery and treatment system of WEEE and possesses wide application prospects.
随着电子电气设备(EEE)的生产成为世界上增长最快的市场之一,废弃电子电气设备(WEEE)数量的急剧增加引发了严重的环境危机。以空气分级后得到的废旧印刷电路板粉碎后的非金属材料为填料,制备了复合板。对比了不同填料粒径、用量和改性剂对复合板材的抗拉强度、抗弯强度、冲击强度等主要力学性能的影响,并通过断口形貌研究了复合板材的内部组织。结果表明,以聚丙烯S700为基体树脂,马来酸酐接枝聚丙烯(MAH-g-PP)为改性剂,当粒径为0.125 ~ 0.3mm的非金属材料添加量为20 wt%时,复合板材的力学性能优异。该技术为完善报废电子电气设备回收处理系统提供了一条新的途径,具有广阔的应用前景。
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引用次数: 3
On the Integration of Different Physiological Model Systems 论不同生理模型系统的整合
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516509
J. Kretschmer, A. Wahl, K. Moller
A versatile software for dynamic generation of physiological model systems is proposed. Via a graphical user interface the user can choose and combine models of varying abstraction level and complexity from the following three model families: respiratory mechanics, gas exchange and cardiovascular dynamics. Tests of different simulation runs showed results and model delay times consistent with human physiology.
提出了一种用于生理模型系统动态生成的多功能软件。通过图形用户界面,用户可以从以下三个模型族中选择和组合不同抽象级别和复杂程度的模型:呼吸力学、气体交换和心血管动力学。不同模拟运行的测试结果和模型延迟时间与人体生理学一致。
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引用次数: 1
Acute Toxicity Test of Landfill Leachates Using Protozoan Communities 利用原生动物群落进行垃圾渗滤液急性毒性试验
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5515286
Ting Liu, Zhulei Chen, Qianwen Fu, B. Shi, Lie Yang
Leachate contains high concentrations of organic matter, ammonia, metals, and other toxic compounds, which may pose serious risks to ecosystems and human health. In order to set up the appropriate toxicological criteria for the leachate, leachate toxicity tests with various organisms need to be conducted. The objective of this investigation was to evaluate the toxicity of leachate using the protozoan community, and the toxic effects of varies seasonal leachates were also compared. Leachates from two municipal solid waste landfills in Wuhan, China were used to develop short-term acute toxicity testing. Bioassays were conducted recording toxicity against various seasonal protozoan communities as median effective concentrations (EC50 values) of species after 24 h exposure. Various seasonal protozoan communities were all sensitive to the leachate samples and the species of the communities decreased with an increase in the leachates concentrations. The EC50 values of Landfill A oscillated between 1.03% and 2.24%, and the EC50 values of Landfill B were between 2.79% and 6.60%. Fluctuation of physicochemical parameters and EC50s of leachates depended rather on landfill age than season of the year (seasonal variations). The results from the bivariate correlation analyses between EC50s and physicochemical parameters implied that the toxicity of leachate might reliably depend on the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N).
渗滤液含有高浓度的有机物、氨、金属和其他有毒化合物,可能对生态系统和人类健康构成严重风险。为了为渗滤液制定适当的毒理学标准,需要对渗滤液进行不同生物的毒性试验。本研究的目的是利用原生动物群落评价渗滤液的毒性,并比较不同季节渗滤液的毒性效应。利用武汉市两个城市生活垃圾填埋场的渗滤液进行短期急性毒性试验。生物测定法记录了暴露24 h后各物种对不同季节原生动物群落的毒性,并以此作为中位有效浓度(EC50值)。各季节原生动物群落均对渗滤液样品敏感,群落种类随渗滤液浓度的增加而减少。A填埋场的EC50值在1.03% ~ 2.24%之间波动,B填埋场的EC50值在2.79% ~ 6.60%之间波动。渗滤液理化参数和ec50的波动与填埋年限的关系大于与季节的关系(季节变化)。ec50与理化参数的双变量相关分析结果表明,渗滤液的毒性可能与化学需氧量(COD)和氨氮(NH4+-N)有关。
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引用次数: 1
Pollutants Removal from Municipal Wastewater Using Vertical Multilevel Soil Infiltration System 垂直多层土壤渗透系统去除城市污水中的污染物
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5517425
Shengjiong Yang, Chuanping Feng, L. Hou, Chun-bo Hao
In this study, we have investigated the effect of pollutants removal of a vertical multilevel soil infiltration (VMSI) system on municipal wastewater treatment. The VMSI was of 30cm*20cm*50cm column, in which combined stuffing consisted of soil, quartz sand, active carbon and scrap irons were packed. As a result, VMSI system exhibited excellent removal efficiency with 91.7% of COD, 98.4% of NH4+-N, 81.0% of TN and 97.3% of TP. Moreover, the proportion of biological and abiological effects in pollutants removal was also investigated through different reactor, and abiological effect against organic removal was 53-62%. In a long-term performance, the VMSI system exhibited excellent ability and stability in pollutants removal.
在本研究中,我们研究了垂直多层土壤渗透(VMSI)系统去除污染物对城市污水处理的影响。VMSI为30cm*20cm*50cm圆柱,采用土壤、石英砂、活性炭、废铁组合填料填充。结果表明,VMSI体系的COD去除率为91.7%,NH4+-N去除率为98.4%,TN去除率为81.0%,TP去除率为97.3%。此外,还通过不同的反应器考察了生物和非生物效应在污染物去除中的比例,非生物效应对有机物去除的影响为53-62%。在长期运行中,VMSI系统表现出优异的污染物去除能力和稳定性。
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引用次数: 0
Agricultural Burning Detection Using Remote Sensing: A Case Study in Zhejiang Province, China 基于遥感技术的农业燃烧探测——以浙江省为例
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516543
Zili Zhang, H. Yu, Zunying Hu, Bin Zhou, Mingchun Han
Random agricultural burning such as crop straw fire, especial during the harvest seasons of summer and autumn, is a very common phenomenon in rural or suburban cities in China. However, several pollutions may caused by this kind of biomass burning including climate-destructive aerosols and carbon fluxes which decrease seriously regional air quality and may have an negative impact on public human health leading to respiratory illness. Using remote sensing is an available method to detect and monitor agricultural burning arbitrarily with its better time and spatial effectiveness. As a part of EOS mission, MODIS was suitable for fire detection as some high-temperature-sensitive bands of the sensor had been improved. A hybrid algorithm presented by the paper had archived two major advancements on adjusting the potential thresholds to suit lower temperature of crop straw burning than forest fires and introducing latest land cover data to exclude fake agriculture burning fire points which not located in croplands. The results had been validated by FIRMS's active fire production suggesting that the modified algorithm works well for agriculture burning under complex land characteristic of eastern China, especially in Zhejiang province. A very large potential for satellite data as an efficient method to detect agriculture burning was also demonstrated in the study.
农作物秸秆随意焚烧是中国农村和郊区城市普遍存在的现象,特别是在夏秋两季收获季节。然而,这种生物质燃烧可能造成几种污染,包括破坏气候的气溶胶和碳通量,严重降低区域空气质量,并可能对公众健康产生负面影响,导致呼吸系统疾病。利用遥感技术对农业焚烧进行任意检测和监测是一种可行的方法,具有较好的时间和空间有效性。作为EOS任务的一部分,MODIS对传感器的一些高温敏感波段进行了改进,适合于火灾探测。本文提出的混合算法在调整潜在阈值以适应比森林火灾更低的农作物秸秆燃烧温度和引入最新的土地覆盖数据以排除非农田的假农业燃烧火点方面取得了两大进展。结果表明,改进后的算法对中国东部特别是浙江省复杂土地特征下的农业燃烧具有良好的效果。该研究还证明了卫星数据作为探测农业燃烧的有效方法的巨大潜力。
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引用次数: 1
Disinfection for Removal of Zooplankton with Chlorine Dioxide 二氧化氯消毒去除浮游动物
Pub Date : 2010-06-18 DOI: 10.1109/ICBBE.2010.5516154
Tao Lin, S. Fan, Wei Chen
The disinfection effect of Copepod of zooplankton with chlorine dioxide was compared with that of chlorine. The experimental results showed that chlorine dioxide was more effective to kill Copepod. Copepod was completely killed by 1.0mg/L of chlorine dioxide for contacting 30 min but the required dosage were about 2.0mg/L of liquid chlorine. The body structure variety of Copepod indicated that the direct oxidation on structure surface was the main reason for chlorine dioxide causing the death of Copepod. As for chlorine, disinfection of Copepod mainly depended on hypochlorous acid (HOCl) permeation to destroy inner cellular protein. The exterior factors of organic precursors and temperature had a negative influence on disinfection rate of Copepod. There was high oxidizability and prone selectivity to kill Copepod during chlorine dioxide. Therefore, the disinfection effect of chlorine dioxide may be less influenced by extraneous factors than that of chlorine. The GC-MS examination showed that the sort and amount of organic substances in treated water by chlorine dioxide were less than that by chlorination.
比较了二氧化氯和氯对浮游动物桡足类的消毒效果。实验结果表明,二氧化氯对桡足类动物的杀伤效果较好。1.0mg/L的二氧化氯可使桡足类接触30 min,但所需液氯用量约为2.0mg/L。桡足类动物身体结构的变化表明,结构表面的直接氧化是二氧化氯导致桡足类动物死亡的主要原因。氯方面,桡足类动物的消毒主要依靠次氯酸(HOCl)渗透破坏细胞内蛋白质。有机前体和温度等外部因素对桡足类动物的消毒率有不利影响。在二氧化氯作用下,桡足类动物具有较高的氧化性和选择性。因此,与氯相比,二氧化氯的消毒效果受外来因素的影响较小。气相色谱-质谱分析表明,二氧化氯处理后的水中有机物的种类和数量比氯化处理后的水少。
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引用次数: 1
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2010 4th International Conference on Bioinformatics and Biomedical Engineering
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