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Chinese Journal of Plastic and Reconstructive Surgery最新文献

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Classification and reconstructive algorithm for nasal alar defect in Asians 亚洲人鼻骨缺损的分类和重建算法
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.003
Renpeng Zhou, Dongze Lyu, Chen Wang, Danru Wang

Background

The nasal alar defect in Asians remains a challenging issue, as do clear classification and algorithm guidance, despite numerous previously described surgical techniques. The aim of this study is to propose a surgical algorithm that addresses the appropriate surgical procedures for different types of nasal alar defects in Asian patients.

Methods

A retrospective case note review was conducted on 32 patients with nasal alar defect who underwent reconstruction between 2008 and 2022. Based on careful analysis and our clinical experience, we proposed a classification system for nasal alar defects and presented a reconstructive algorithm. Patient data, including age, sex, diagnosis, surgical options, and complications, were assessed. The extent of surgical scar formation was evaluated using standard photography based on a 4-grade scar scale.

Results

Among the 32 patients, there were 20 males and 12 females with nasal alar defects. The predominant cause of trauma in China was industrial factors. The majority of alar defects were classified as type I C (n=8, 25%), comprising 18 cases (56.2%); there were 5 cases (15.6%) of type II defect, 7 (21.9%) of type III defect, and 2 (6.3%) of type IV defect. The most common surgical option was auricular composite graft (n=8, 25%), followed by bilobed flap (n=6, 18.8%), free auricular composite flap (n=4, 12.5%), and primary closure (n=3, 9.4%). Satisfactory improvements were observed postoperatively.

Conclusion

Factors contributing to classifications were analyzed and defined, providing a framework for the proposed classification system. The reconstructive algorithm offers surgeons appropriate procedures for treating nasal alar defect in Asians.

背景亚洲人的鼻甲缺损仍然是一个具有挑战性的问题,尽管之前有许多描述过的手术技术,但没有明确的分类和算法指导。本研究的目的是提出一种手术算法,针对亚洲患者不同类型的鼻骨缺损采取适当的手术方法。方法对 2008 年至 2022 年期间接受鼻骨缺损重建手术的 32 例鼻骨缺损患者进行了回顾性病例回顾。根据仔细分析和我们的临床经验,我们提出了鼻骨缺损的分类系统,并介绍了重建算法。我们评估了患者的数据,包括年龄、性别、诊断、手术方案和并发症。结果 32 例鼻骨缺损患者中,男性 20 例,女性 12 例。在中国,造成创伤的主要原因是工业因素。大部分鼻翼缺损属于 I C 型(8 例,25%),共 18 例(56.2%);II 型缺损 5 例(15.6%),III 型缺损 7 例(21.9%),IV 型缺损 2 例(6.3%)。最常见的手术方式是耳廓复合移植(8例,25%),其次是双叶皮瓣(6例,18.8%)、游离耳廓复合皮瓣(4例,12.5%)和原发性闭合(3例,9.4%)。结论分析并定义了导致分类的因素,为拟议的分类系统提供了一个框架。重建算法为外科医生提供了治疗亚洲人鼻骨缺损的适当程序。
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引用次数: 0
Ultrasound-assisted isolation: A new method to isolate stromal vascular fraction 超声辅助分离:分离基质血管部分的新方法
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.001
Yiming Gao , Xiaojie Zhang , Poh-Ching Tan , Yun Xie , Peiqi Zhang , Tianyu Zhang , Qingfeng Li , Shuangbai Zhou

Background

The stromal vascular fraction (SVF), a cluster of stem and progenitor cells isolated from adipose tissue, holds significant promise for application in regenerative medicine. However, the existing methods for SVF isolation are time-consuming and expensive. Thus, in this study, we explored a new method of SVF extraction—ultrasound-assisted SVF isolation (USASI)—and compared the viability and characteristics of SVF isolated using different methods.

Methods

SVF extraction methods using different combinations of ultrasound power, ultrasound time, collagenase dosage, and collagenase digestion time were compared with those of the control group (collagenase digestion method). The cell yield and vitality of the SVF were evaluated via cell counting and trypan blue staining. The cell components and immunophenotypes of freshly isolated SVF were analyzed using flow cytometry. The proliferative capacity and differentiation potential of the SVF were also identified.

Results

Ultrasonication at 95 ​W-20 kHz for 30 ​s followed by digestion with 0.15% collagenase for 30 ​min was identified as the most suitable parameter for the USASI method in isolating SVF, as recommended based on the evaluation of various tested conditions. The USASI method significantly reduced the collagenase dosage and shortened the digestion time. Compared to the collagenase digestion method, the USASI method had a higher cell yield and cell viability, with no adverse effects on cell components, proliferative capacity, or multipotential differentiation capacity.

Conclusion

With reduced processing time, lower collagenase dosage, and increased cell yield without impairing the viability and characteristics of SVF, USASI holds the potential to emerge as a time-saving and cost-effective method for future clinical applications.

背景基质血管成分(SVF)是从脂肪组织中分离出来的干细胞和祖细胞群,它在再生医学中的应用前景十分广阔。然而,现有的 SVF 分离方法既费时又昂贵。因此,在本研究中,我们探索了一种新的 SVF 提取方法--超声辅助 SVF 分离(USASI),并比较了用不同方法分离的 SVF 的活力和特征。方法将不同超声功率、超声时间、胶原酶剂量和胶原酶消化时间组合的 SVF 提取方法与对照组(胶原酶消化法)的 SVF 提取方法进行了比较。通过细胞计数和胰蓝染色评估了 SVF 的细胞产量和活力。流式细胞术分析了新鲜分离 SVF 的细胞成分和免疫分型。结果根据对各种测试条件的评估,确定 95 W-20 kHz 超声波 30 秒,然后用 0.15% 胶原酶消化 30 分钟是 USASI 法分离 SVF 的最合适参数。USASI 法大大减少了胶原酶的用量,缩短了消化时间。与胶原酶消化法相比,USASI 法具有更高的细胞产量和细胞活力,对细胞成分、增殖能力和多潜能分化能力没有不良影响。
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引用次数: 0
Advances in the study of epicanthus correction 上睑下垂矫正研究进展
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.004
Xiuxia Wang , Jingyan Huang , Rui Jin, Xusong Luo

Epicanthus is a half-moon-shaped skin fold diagonally or vertically distributed in front of the medial canthus. In mild cases, it affects aesthetics, whereas in severe cases, it may obscure the patient’s field of vision and even affect the functional development of the eyes in children. Until now, surgery has been the only corrective measure for epicanthus and a bewildering number of epicanthus-related surgical procedures have been reported; however, there is no standardized classification to guide inexperienced plastic surgeons in their study or case selection. Therefore, this review aimed to classify epicanthus accordingly and introduce its corresponding and appropriate surgical treatment modalities.

内眦赘皮是一种半月形皮肤皱褶,斜向或垂直分布在内侧眦角前方。轻者影响美观,重者会遮挡视野,甚至影响儿童眼睛的功能发育。迄今为止,手术一直是上眼睑外翻的唯一矫正措施,与上眼睑外翻相关的手术方法也层出不穷,但却没有一个标准的分类方法来指导经验不足的整形外科医生进行研究或选择病例。因此,本综述旨在对上睑下垂进行相应的分类,并介绍其相应和适当的手术治疗方式。
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引用次数: 0
Reconstructive surgery for phantom and residual limb pain in post-conflict settings 冲突后环境中幻肢痛和残肢痛的重建手术
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.006
Damián Palafox

Traumatic amputations remain one of the most frequent and disturbing wounds of armed conflict. In this scenario, most amputees develop residual and phantom limb pain, impacting their quality of life. There are several elective surgical procedures available for both conditions, such as neuroma excision followed by nerve reconstruction, nerve relocation, e.g., surgically implanting a transected nerve into a muscle, nerve transfers in cases of associated paralysis, and most recently, regenerative peripheral nerve interface surgery. Whenever possible in the post-conflict phase, a coordinated effort between traveling humanitarian surgeons specializing in reconstructive microsurgery and local healthcare providers is essential for successfully treating phantom and chronic residual limb pain in post-conflict amputees. While providing a detailed logistical framework for global humanitarian missions is beyond the scope of this article, we provide a brief perspective on a topic of utmost importance for reconstructive surgeons worldwide: the high-quality care and treatment of refugees and those whose lives have been impacted by conflict, disaster, or displacement.

创伤性截肢仍然是武装冲突中最常见、最令人不安的创伤之一。在这种情况下,大多数截肢者会出现残肢和幻肢痛,影响他们的生活质量。针对这两种情况,有多种选择性外科手术可供选择,如神经瘤切除后的神经重建术、神经移位术(如通过手术将横断的神经植入肌肉)、伴有瘫痪时的神经转移术,以及最近出现的外周神经接口再生手术。在冲突后阶段,只要有可能,专门从事显微外科重建手术的人道主义外科医生和当地医疗服务提供者之间的协调努力对于成功治疗冲突后截肢者的幻肢痛和慢性残肢痛至关重要。虽然为全球人道主义任务提供详细的后勤框架不在本文的讨论范围之内,但我们还是就全球重建外科医生最为重视的一个话题提供了一个简短的视角:为难民和那些生活受到冲突、灾难或流离失所影响的人们提供高质量的护理和治疗。
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引用次数: 0
Adaptability of bipedicled scalp advancement flap for coverage of huge scalp defects after tumor resection 双髁头皮推进瓣覆盖肿瘤切除术后巨大头皮缺损的适应性
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.02.003
Waleed Aldabaany

Background

Several reconstructive techniques have been used to reconstruct scalp defects. Numerous researchers have studied the utilization of bipedicled scalp advancement flaps for scalp defect coverage. In this study, we will assess the adaptability of a bipedicled scalp advancement flap for coverage of huge scalp defects after tumor resection.

Methods

This study was performed at the Plastic Surgery Department, Fayoum University Hospital, on 20 patients with huge scalp tumors treated by adequate excision and reconstructed using a bipedicled scalp advancement flap from December 2021 to July 2023.

Results

The study was conducted on 20 patients: 16 (80%) were men and 4 (20%) were women presenting with large scalp tumors. The mean age was 57.4 years (33–68 years). The sites of the tumors were 10 (50%) occipital, 6 (30%) parietal, and 4 (20%) parieto-occipital. No major complications occurred postoperatively, and the bipedicled flaps survived well in all cases, with no necrosis.

Conclusion

Huge scalp defects after tumor resection can be safely reconstructed with a large versatile bipedicled advancement scalp flap, either transversely or longitudinally oriented, with favorable functional results and accepted aesthetic results, apart from the alopecic area over the grafted donor site, which can be treated by tissue expansion if desired later.

背景已有多种重建技术用于重建头皮缺损。许多研究人员已对利用双夹头皮瓣覆盖头皮缺损进行了研究。在本研究中,我们将评估双带头皮推进瓣在肿瘤切除术后覆盖巨大头皮缺损方面的适应性:16例(80%)为男性,4例(20%)为女性。平均年龄为 57.4 岁(33-68 岁)。肿瘤部位分别为枕部 10 例(50%)、顶叶 6 例(30%)和顶枕部 4 例(20%)。结论肿瘤切除后的巨大头皮缺损可通过横向或纵向的大型多功能双面推进头皮瓣安全地重建,除了移植供体部位的脱发区外,功能效果良好,美观效果也可接受,如果需要,以后可通过组织扩张进行治疗。
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引用次数: 0
A treatment recommendation for trichoepithelioma: Thoughts on selection of treatment timing and method 三表皮细胞瘤的治疗建议:关于选择治疗时机和方法的思考
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.002
Shenying Luo, Shuchen Gu, Ruoqing Xu, En Yang, Liying Tu, Hsin Liang, Xin Huang, Jieyi Ren, Tao Zan

In this report, we present the case of a 55-year-old woman with a 30-year history of multiple familial trichoepithelioma (MFT), with facial surface tumors that progressively worsened, causing ventilation disorders. In order to improve the patient’s appearance and functional impairment, we performed a two-step surgical excision and skin grafting procedure post diagnosis through genetic testing. The 18-month follow-up confirmed that the effect was satisfactory without obvious recurrence. Based on this outcome, we have developed a diagnosis and treatment process for patients with MFT, aiming to provide a reference for standardized treatment of this rare disease.

在本报告中,我们介绍了一名 55 岁女性的病例,她有 30 年的多发性家族性三上皮细胞瘤(MFT)病史,面部表面肿瘤逐渐恶化,导致通气障碍。为了改善患者的外观和功能障碍,我们在通过基因检测确诊后为其实施了两步手术切除和植皮术。18 个月的随访证实效果满意,无明显复发。根据这一结果,我们制定了 MFT 患者的诊断和治疗流程,旨在为这一罕见疾病的规范化治疗提供参考。
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引用次数: 0
Vascularized lymph node transfer using axilla as recipient site restores lymphatic flow in upper limb lymphedema: Evidence from magnetic resonance lymphangiography 以腋窝为受体部位的血管淋巴结转移可恢复上肢淋巴水肿患者的淋巴流动:磁共振淋巴管造影的证据
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.02.001
Zhaohua Jiang , Ziyou Yu , Shengli Li

Background

Lymphedema is a debilitating condition that frequently occurs after breast cancer treatment. Vascularized lymph node transfer (VLNT) is a promising approach to reduce lymphedema. This study used magnetic resonance lymphangiography (MRL) to assess lymphatic reconnections post-VLNT in patients with breast cancer-related lymphedema (BCRL).

Methods

The clinical records of six female patients with unilateral upper limb BCRL who underwent VLNT (4 cases) or VLNT combined with breast reconstruction (2 cases) were retrospectively reviewed. All patients were examined using MRL preoperatively and at the 1-year follow-up. The morphological characteristics of the lymphatic network, dermal backflow patterns, and architecture of the lymph nodes were evaluated. Clinical outcomes, patient satisfaction, and complications were assessed.

Results

At the 1-year follow-up, reduction in tissue edema and limb circumference was achieved in all six patients. In MRL, the implanted lymph nodes in the axillary region of the affected upper arm were enhanced and visualized in all six patients. Reconnected lymphatic vessels in the subcutaneous tissue associated with the implanted lymph nodes were observed in four patients. Decreased dermal backflow and lymphatic vessel dilation of the affected limbs were observed in all six patients. No disruption of the lymph flow in the donor area was detected.

Conclusion

This is the first study to provide direct imaging evidence for the reconnection of afferent lymphatic channels between implanted lymph nodes and the recipient lymphatic system in patients with BCRL. Overall, our study demonstrates the mechanism and efficacy of VLNT in reducing lymphedema.

背景淋巴水肿是乳腺癌治疗后经常出现的一种使人衰弱的症状。血管化淋巴结转移(VLNT)是一种很有希望减轻淋巴水肿的方法。本研究使用磁共振淋巴管造影(MRL)评估乳腺癌相关淋巴水肿(BCRL)患者VLNT术后的淋巴重新连接情况。方法回顾性研究了6例单侧上肢BCRL女性患者的临床记录,这些患者接受了VLNT(4例)或VLNT联合乳房重建(2例)。所有患者均在术前和随访一年时接受了 MRL 检查。对淋巴管网的形态特征、真皮回流模式和淋巴结的结构进行了评估。结果随访一年时,所有六名患者的组织水肿和肢体周长都有所减轻。在 MRL 中,所有六名患者患侧上臂腋窝区域的植入淋巴结都得到了增强和可视化。在四名患者中观察到与植入淋巴结相关的皮下组织淋巴管重新连接。所有六名患者的患肢真皮回流减少,淋巴管扩张。结论:这是第一项为 BCRL 患者植入淋巴结与受体淋巴系统之间传入淋巴通道重新连接提供直接成像证据的研究。总之,我们的研究证明了 VLNT 减轻淋巴水肿的机制和疗效。
{"title":"Vascularized lymph node transfer using axilla as recipient site restores lymphatic flow in upper limb lymphedema: Evidence from magnetic resonance lymphangiography","authors":"Zhaohua Jiang ,&nbsp;Ziyou Yu ,&nbsp;Shengli Li","doi":"10.1016/j.cjprs.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.cjprs.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>Lymphedema is a debilitating condition that frequently occurs after breast cancer treatment. Vascularized lymph node transfer (VLNT) is a promising approach to reduce lymphedema. This study used magnetic resonance lymphangiography (MRL) to assess lymphatic reconnections post-VLNT in patients with breast cancer-related lymphedema (BCRL).</p></div><div><h3>Methods</h3><p>The clinical records of six female patients with unilateral upper limb BCRL who underwent VLNT (4 cases) or VLNT combined with breast reconstruction (2 cases) were retrospectively reviewed. All patients were examined using MRL preoperatively and at the 1-year follow-up. The morphological characteristics of the lymphatic network, dermal backflow patterns, and architecture of the lymph nodes were evaluated. Clinical outcomes, patient satisfaction, and complications were assessed.</p></div><div><h3>Results</h3><p>At the 1-year follow-up, reduction in tissue edema and limb circumference was achieved in all six patients. In MRL, the implanted lymph nodes in the axillary region of the affected upper arm were enhanced and visualized in all six patients. Reconnected lymphatic vessels in the subcutaneous tissue associated with the implanted lymph nodes were observed in four patients. Decreased dermal backflow and lymphatic vessel dilation of the affected limbs were observed in all six patients. No disruption of the lymph flow in the donor area was detected.</p></div><div><h3>Conclusion</h3><p>This is the first study to provide direct imaging evidence for the reconnection of afferent lymphatic channels between implanted lymph nodes and the recipient lymphatic system in patients with BCRL. Overall, our study demonstrates the mechanism and efficacy of VLNT in reducing lymphedema.</p></div>","PeriodicalId":65600,"journal":{"name":"Chinese Journal of Plastic and Reconstructive Surgery","volume":"6 1","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2096691124000128/pdfft?md5=5e61585747f65e591f0005fd1d23b564&pid=1-s2.0-S2096691124000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classification and a decade-long follow-up of rat bite injuries in the nasal region 鼻部鼠咬伤的分类和长达十年的跟踪调查
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.03.005
Chu-Hsin Chen , Yahong Chen , Peng Xu , Kai Liu

Background

Nasal defects due to rat bites are frequently encountered in rural regions of China. In addition to serving as disease vectors, rats can also inflict bite injuries. In this study, we delineated the characteristics of rat bite injuries in the nasal region and discussed the clinical features observed during a 10-year follow-up period.

Methods

We retrospectively reviewed hospital records for patients admitted due to rat bites. This study outlines the demographics, clinical features, and follow-up outcomes supported by comprehensive photo documentation of the patients’ progress.

Results

Twenty-five patients, with a mean age of 29 years, were admitted due to rat bites. Treatment was provided for three distinct types of injuries: nasal tip defect (type I), nasal defect (type II), and full-thickness nasal defect with loss of surrounding tissues (type III). All patients recovered fully.

Conclusions

The treatment for rat bites should be based on the wound type. The long-term follow-up outcomes are more favorable when fewer subunits of the nose affected. We recommend early surgical intervention, along with psychological therapy, to prevent interference with growth and development.

背景在中国农村地区,经常会遇到因老鼠咬伤而导致鼻腔缺损的情况。老鼠除了是疾病的传播媒介外,还可能造成咬伤。在本研究中,我们描述了老鼠咬伤鼻部的特征,并讨论了 10 年随访期间观察到的临床特征。本研究概述了患者的人口统计学特征、临床特征和随访结果,并提供了患者病情进展的全面照片记录。结果25 名患者因老鼠咬伤入院,平均年龄 29 岁。治疗针对三种不同类型的损伤:鼻尖缺损(I 型)、鼻腔缺损(II 型)和周围组织缺失的全厚鼻腔缺损(III 型)。所有患者均完全康复。被老鼠咬伤的治疗应根据伤口类型进行,如果鼻子受影响的亚单位较少,则长期随访结果更佳。我们建议及早进行手术干预,同时进行心理治疗,以防影响生长发育。
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引用次数: 0
Current practice in autologous rib and costal-cartilage harvest for rhinoplasty: A systematic review 自体肋骨和肋软骨采集用于鼻整形术的当前实践:系统回顾
Pub Date : 2024-03-01 DOI: 10.1016/j.cjprs.2024.02.002
Mengyuan Jiang , Haizhong Huo , Lu Zhang

Background

Autologous costal grafts are used universally in clinical practice for rhinoplasty and reconstruction. However, surgeons worldwide have not agreed on the details of graft harvesting, including rib selection, side preference, operation mode, cutting methods, and handling of the periosteum and perichondrium. This study aimed to provide an overview of the novel techniques used for auto-rib harvesting in rhinoplasty within the past 5 years and identify potential avenues for future research.

Methods

We searched for related articles in PubMed, Embase, and Web of Science from 2019 to 2023, summarized crucial but controversial steps in recent practice, and analyzed their theoretical basis and clinical feasibility.

Results

Auto-rib and cartilage open harvest is still mainstream in rhinoplasty and reconstruction, with the 5th to 8th ribs and cartilage being the most used. The laparoscopic harvest is gaining attention, being second only to the open harvest, with the 9th/10th ribs and cartilages being particularly convenient. The clinical applications of full-cut and split-cut methods differ in their advantages. Except for some special reasons, almost all studies tended to preserve the periosteum and perichondrium in situ, and few surgeons chose to harvest the grafts on the left side.

Conclusion

Multiple techniques have emerged, requiring surgeons to balance the benefits and risks of various strategies at each step. New theories and techniques should be fully tested promptly and in clinical practice before wide application. Overall, a professional consensus is needed for better directivity, precision, and stability in clinical practice.

背景自体肋骨移植物被普遍用于鼻整形和鼻重建的临床实践中。然而,世界各地的外科医生对移植物采集的细节,包括肋骨的选择、偏好的一侧、操作模式、切割方法以及骨膜和软骨膜的处理等,尚未达成一致意见。本研究旨在概述过去 5 年中用于鼻整形术中自体肋骨采集的新技术,并确定未来研究的潜在途径。方法我们在 PubMed、Embase 和 Web of Science 中检索了 2019 年至 2023 年的相关文章,总结了近期实践中关键但有争议的步骤,并分析了其理论基础和临床可行性。结果自体肋骨和软骨开放式采集仍是鼻整形和重建的主流,其中第 5 至第 8 根肋骨和软骨使用最多。腹腔镜取材越来越受到重视,仅次于开放式取材,其中第 9/10 肋骨和软骨的取材尤为方便。全切法和分切法的临床应用优势各不相同。除一些特殊原因外,几乎所有的研究都倾向于原位保留骨膜和软骨周围,很少有外科医生选择在左侧采集移植物。新理论和新技术在广泛应用之前,应及时在临床实践中进行充分检验。总之,要想在临床实践中获得更好的指导性、精确性和稳定性,需要达成专业共识。
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引用次数: 0
Revolutionizing diabetic wound healing: The power of microneedles 糖尿病伤口愈合的革命:微针的力量
Pub Date : 2023-12-01 DOI: 10.1016/j.cjprs.2023.12.004
Chun Liang , Ren Wang , Tian He , Dongsheng Chen , Guangliang Zhang , Xiangye Yin , Hongyu Wang , Jiale Xie , Yujing Li , Youbai Chen
Diabetic wounds significantly affect patient quality of life. Microneedles are a promising treatment to accelerate wound healing owing to their high drug-loading capacity and efficient drug delivery; however, few studies to date have comprehensively reviewed microneedles for diabetic wound healing. This up-to-date review summarizes the research progress in microneedles for diabetic wound healing, including manufacturing materials and techniques, structures, designs, release mechanisms, delivery substances, and their specific effects. This study showed that most microneedles designed for diabetic wounds are made of synthetic polymers and/or natural materials using polydimethylsiloxane micromolding. The geometric structure and design directly influence penetration ability and drug delivery capacity. Microneedles can deliver antibiotics, hypoglycemic agents, traditional Chinese medicines, metal ions, growth factors, exosomes, stem cells, and microorganisms, thus promoting diabetic wound healing through diverse mechanisms, such as antibacterial, anti-inflammatory, antioxidant, hypoglycemic, and angiogenic activities, at different stages of the healing process. In conclusion, microneedles are promising drug delivery systems for the treatment of diabetic wounds.
糖尿病伤口对患者的生活质量有显著影响。微针因其高载药能力和高效给药而成为一种很有前景的加速伤口愈合的治疗方法;然而,迄今为止,很少有研究全面回顾了微针在糖尿病伤口愈合中的应用。本文综述了用于糖尿病创面愈合的微针的最新研究进展,包括制备材料和技术、结构、设计、释放机制、递送物质及其特异性作用。这项研究表明,大多数设计用于糖尿病伤口的微针是由合成聚合物和/或天然材料使用聚二甲基硅氧烷微成型制成的。其几何结构和设计直接影响渗透能力和给药能力。微针可以输送抗生素、降糖药、中药、金属离子、生长因子、外泌体、干细胞、微生物等,从而在愈合过程的不同阶段通过抗菌、抗炎、抗氧化、降血糖、血管生成等多种机制促进糖尿病创面愈合。总之,微针是治疗糖尿病伤口的一种很有前途的给药系统。
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引用次数: 0
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Chinese Journal of Plastic and Reconstructive Surgery
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