Amblyopia is a common visual related eye disease in childhood. Although traditional treatment to amblyopia is effective, there are still some disadvantages, such as poor compliance, easily leading to the healthy eyesight problem, the poor recovery of binocular and stereoscopy vision, the lack of objective parameter guidance, etc. Therefore, a new personalized amblyopia treatment solution is put forward to solve these problems combined with Pattern Visual Evoked Potential (P_VEP). A complete software system is built, including diagnosis module, treatment module, data management module and expert module. The EEG data acquisition and synchronized trigger circuit are designed using ADS 1299 EEG Front-End and 10 data collecting card to collect the raw EEG signal. Digital filtering algorithm, average superposition algorithm and wavelet algorithm are used to extract P_VEP from the raw EEG data acquired by the hardware circuit. The latency and peak of P_VEP wave is measured. The best spatial frequency is searched and obtained from the treatment training curve. It is updated automatically as treatment continues.
{"title":"Study of a new amblyopia diagnostic and therapeutic method along with the system implementation","authors":"Yin Tao, Jia Chen, Xiaoli Liu, Zhen Fang, Dalong Zhang, Qinwu Zhou, Bo Zhang","doi":"10.2316/P.2017.852-014","DOIUrl":"https://doi.org/10.2316/P.2017.852-014","url":null,"abstract":"Amblyopia is a common visual related eye disease in childhood. Although traditional treatment to amblyopia is effective, there are still some disadvantages, such as poor compliance, easily leading to the healthy eyesight problem, the poor recovery of binocular and stereoscopy vision, the lack of objective parameter guidance, etc. Therefore, a new personalized amblyopia treatment solution is put forward to solve these problems combined with Pattern Visual Evoked Potential (P_VEP). A complete software system is built, including diagnosis module, treatment module, data management module and expert module. The EEG data acquisition and synchronized trigger circuit are designed using ADS 1299 EEG Front-End and 10 data collecting card to collect the raw EEG signal. Digital filtering algorithm, average superposition algorithm and wavelet algorithm are used to extract P_VEP from the raw EEG data acquired by the hardware circuit. The latency and peak of P_VEP wave is measured. The best spatial frequency is searched and obtained from the treatment training curve. It is updated automatically as treatment continues.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"25 12","pages":"121-124"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91546803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adria Romero Lopez, Xavier Giró-i-Nieto, Jack Burdick, Oge Marques
The recent emergence of deep learning methods for medical image analysis has enabled the development of intelligent medical imaging-based diagnosis systems that can assist the human expert in making better decisions about a patients health. In this paper we focus on the problem of skin lesion classification, particularly early melanoma detection, and present a deep-learning based approach to solve the problem of classifying a dermoscopic image containing a skin lesion as malignant or benign. The proposed solution is built around the VGGNet convolutional neural network architecture and uses the transfer learning paradigm. Experimental results are encouraging: on the ISIC Archive dataset, the proposed method achieves a sensitivity value of 78.66%, which is significantly higher than the current state of the art on that dataset.
{"title":"Skin lesion classification from dermoscopic images using deep learning techniques","authors":"Adria Romero Lopez, Xavier Giró-i-Nieto, Jack Burdick, Oge Marques","doi":"10.2316/P.2017.852-053","DOIUrl":"https://doi.org/10.2316/P.2017.852-053","url":null,"abstract":"The recent emergence of deep learning methods for medical image analysis has enabled the development of intelligent medical imaging-based diagnosis systems that can assist the human expert in making better decisions about a patients health. In this paper we focus on the problem of skin lesion classification, particularly early melanoma detection, and present a deep-learning based approach to solve the problem of classifying a dermoscopic image containing a skin lesion as malignant or benign. The proposed solution is built around the VGGNet convolutional neural network architecture and uses the transfer learning paradigm. Experimental results are encouraging: on the ISIC Archive dataset, the proposed method achieves a sensitivity value of 78.66%, which is significantly higher than the current state of the art on that dataset.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"26 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72623756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We analyzed the characteristics of diabetes-related macrovascular complications with the objective of more effectively preventing later lethal complications involving cerebral infarction. The associated diseases of approximately 8,000 diabetic patients and >50,000 non-diabetic individuals were evaluated. The distribution characteristics of the four major vascular complications, hypertension, hyperlipemia, coronary heart disease and cerebral infarction in different gender and age groups, together with the relationship among these complications, were investigated. Statistical analysis entailing >600 clinical detection indices in the two major populations (diabetic patients with or without the four major complications listed above) were performed. It is found that in southern Zhejiang Province, China, macroangiopathy is the major complication of diabetes. The most relevant four vascular diseases are hypertension, hyperlipemia, coronary heart disease and cerebral infarction. There is a clear peak prevalence of these four complications in women with diabetes around the age of 65–70 years. There were significant differences in uric acid, triglyceride, creatinine, total cholesterol, serum sodium and other indices (P < 0.05) between the diabetic populations with and without the four complications.
{"title":"Evaluation of the relationship between diabetes and large blood vessel disease","authors":"Peihua Chen, Chuandi Pan","doi":"10.2316/P.2017.852-008","DOIUrl":"https://doi.org/10.2316/P.2017.852-008","url":null,"abstract":"We analyzed the characteristics of diabetes-related macrovascular complications with the objective of more effectively preventing later lethal complications involving cerebral infarction. The associated diseases of approximately 8,000 diabetic patients and >50,000 non-diabetic individuals were evaluated. The distribution characteristics of the four major vascular complications, hypertension, hyperlipemia, coronary heart disease and cerebral infarction in different gender and age groups, together with the relationship among these complications, were investigated. Statistical analysis entailing >600 clinical detection indices in the two major populations (diabetic patients with or without the four major complications listed above) were performed. It is found that in southern Zhejiang Province, China, macroangiopathy is the major complication of diabetes. The most relevant four vascular diseases are hypertension, hyperlipemia, coronary heart disease and cerebral infarction. There is a clear peak prevalence of these four complications in women with diabetes around the age of 65–70 years. There were significant differences in uric acid, triglyceride, creatinine, total cholesterol, serum sodium and other indices (P < 0.05) between the diabetic populations with and without the four complications.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"20 1","pages":"200-207"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83109208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A circularly polarized implanted antenna is designed and numerically analyzed for in-body communication. The turn-style like antenna consists of two orthogonal conformal dipoles located on the bone which contains a conical implant made up by a bio-metallic alloy. The return losses at the central frequency of the Industrial, Scientific and Medical (ISM) band (i.e., ƒ=2.45 GHz) of the two dipoles in stand-alone configurations are −46.1 dB and −57.9 dB, respectively. When both radiators are present to generate a circular polarized radiated field, the dimensions of the dipoles have been redesigned to get resonance close to 2.45 GHz. Numerical results show that circular polarization can be achieved in an angular range of 163° × 23°.
{"title":"Circularly polarized implanted antenna with conical bio-metallic ground plane","authors":"Jingjing Li, I. Peter, L. Matekovits","doi":"10.2316/P.2017.852-058","DOIUrl":"https://doi.org/10.2316/P.2017.852-058","url":null,"abstract":"A circularly polarized implanted antenna is designed and numerically analyzed for in-body communication. The turn-style like antenna consists of two orthogonal conformal dipoles located on the bone which contains a conical implant made up by a bio-metallic alloy. The return losses at the central frequency of the Industrial, Scientific and Medical (ISM) band (i.e., ƒ=2.45 GHz) of the two dipoles in stand-alone configurations are −46.1 dB and −57.9 dB, respectively. When both radiators are present to generate a circular polarized radiated field, the dimensions of the dipoles have been redesigned to get resonance close to 2.45 GHz. Numerical results show that circular polarization can be achieved in an angular range of 163° × 23°.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"194 ","pages":"265-269"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91467262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thananya Khienwad, R. Deepankaew, Praemai Wannawat, P. Naiyanetr
The variable of connecting tube length (CTL) in rotary blood pumps (RBPs) is normally existed for the external circulatory support and thus eventually incurs the different outcome as compared to the internal circulatory support. This study aims to determine the effect of the various CTL on the measured parameters from RBP. To serve this purpose, a derived indexes from RBP under mock circulatory loop (MCL) were examined. IQ which is a slope of the linear regression between the maximal time derivative of pump flow, dQ/dtmax, and its peak to peak, QP2P, was determined to evaluate the effect of 3 different CTLs; 130, 50 and 10 cm (length of inlet tube), and 130, 50 and 50 cm (length of outlet tube). Moreover, the parameters dH/dtmax, which are the maximal time derivative of pressure head (H); AOP-LVP, and its peak to peak were derived. The slope of a linear regression between dQ/dtmax and dH/dtmax decreased during reduce CTL in contrast to IQ index. Thus, this study proved that IQ index was not significant influenced by a hydraulic resistance (including CTL) and therefore can be used to monitor the cardiac function in case of both external and internal RBP support.
{"title":"Effect of tubing length pump on flow derived index during rotary blood pump support","authors":"Thananya Khienwad, R. Deepankaew, Praemai Wannawat, P. Naiyanetr","doi":"10.2316/P.2017.852-034","DOIUrl":"https://doi.org/10.2316/P.2017.852-034","url":null,"abstract":"The variable of connecting tube length (CTL) in rotary blood pumps (RBPs) is normally existed for the external circulatory support and thus eventually incurs the different outcome as compared to the internal circulatory support. This study aims to determine the effect of the various CTL on the measured parameters from RBP. To serve this purpose, a derived indexes from RBP under mock circulatory loop (MCL) were examined. IQ which is a slope of the linear regression between the maximal time derivative of pump flow, dQ/dtmax, and its peak to peak, QP2P, was determined to evaluate the effect of 3 different CTLs; 130, 50 and 10 cm (length of inlet tube), and 130, 50 and 50 cm (length of outlet tube). Moreover, the parameters dH/dtmax, which are the maximal time derivative of pressure head (H); AOP-LVP, and its peak to peak were derived. The slope of a linear regression between dQ/dtmax and dH/dtmax decreased during reduce CTL in contrast to IQ index. Thus, this study proved that IQ index was not significant influenced by a hydraulic resistance (including CTL) and therefore can be used to monitor the cardiac function in case of both external and internal RBP support.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"33 1","pages":"270-276"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88890992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aims to determine the effect of professional sailing on the balancing ability compared to a control group using ultrasound-based provocation tests on a moving platform. The balancing capacity after sudden unidirectional perturbation is characterized by following parameters: the damping time (T), the Lehr's damping ratio (D), the orientation ratio (R) and the HeadPath during double-limb standing with eyes open and eyes closed. Significant differences showed between the 4- and 8 spring setting in the case of the control group, but not in the case of the sailor group. This new finding allows us to state, that the professional practice of sailing can change the method and the efficiency of balancing. A new practice for characterizing the balancing ability, the measurement of the head movement, was involved in the research.
{"title":"Examination of sailors' balancing ability with means of motion analysing system","authors":"B. Kiss, Gergely Nagymáté, R. Kiss","doi":"10.2316/P.2017.852-050","DOIUrl":"https://doi.org/10.2316/P.2017.852-050","url":null,"abstract":"The present study aims to determine the effect of professional sailing on the balancing ability compared to a control group using ultrasound-based provocation tests on a moving platform. The balancing capacity after sudden unidirectional perturbation is characterized by following parameters: the damping time (T), the Lehr's damping ratio (D), the orientation ratio (R) and the HeadPath during double-limb standing with eyes open and eyes closed. Significant differences showed between the 4- and 8 spring setting in the case of the control group, but not in the case of the sailor group. This new finding allows us to state, that the professional practice of sailing can change the method and the efficiency of balancing. A new practice for characterizing the balancing ability, the measurement of the head movement, was involved in the research.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"14 1","pages":"195-199"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74906705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brain computer interface (BCI) systems have ushered a new era of neural engineering research. At the core of BCIi research is development of data acquisition, filtration and classification techniques that can accurately decode the brain activity that occurs while performing a motor task. In this study, we investigate the classification accuracy of lda, QDA, Naïve Bayes, quadratic SVM and RBF SVM classifiers for classifying the flexion/extension of forearm and wrist. Moreover, hjorth parameters and PSD are employed as feature extraction techniques to derive four different feature vectors that are later used to train our classifiers. At the culmination of this study, it is shown that QDA classifier trained with PSD feature vector has the highest classification accuracy at 77.37% followed by q-SVM trained with activity feature vector at 73.97%. Apart from enhancing accuracy of classifying the four fundamental upper limb movements, this study will eventually contribute towards developing better controllers for neuro-prosthetic devices. The study has been performed experimentally with Emotiv headsets equipped with 14 electrodes to acquire EEG data from two human test subjects in synchronous mode. Classification and data analysis has been performed offline however in future the study will be extended to an online BCI system.
{"title":"A new approach to classification of upper limb and wrist movements using EEG signals","authors":"M. A. Gull, H. Elahi, M. Marwat, Saad Waqar","doi":"10.2316/P.2017.852-049","DOIUrl":"https://doi.org/10.2316/P.2017.852-049","url":null,"abstract":"Brain computer interface (BCI) systems have ushered a new era of neural engineering research. At the core of BCIi research is development of data acquisition, filtration and classification techniques that can accurately decode the brain activity that occurs while performing a motor task. In this study, we investigate the classification accuracy of lda, QDA, Naïve Bayes, quadratic SVM and RBF SVM classifiers for classifying the flexion/extension of forearm and wrist. Moreover, hjorth parameters and PSD are employed as feature extraction techniques to derive four different feature vectors that are later used to train our classifiers. At the culmination of this study, it is shown that QDA classifier trained with PSD feature vector has the highest classification accuracy at 77.37% followed by q-SVM trained with activity feature vector at 73.97%. Apart from enhancing accuracy of classifying the four fundamental upper limb movements, this study will eventually contribute towards developing better controllers for neuro-prosthetic devices. The study has been performed experimentally with Emotiv headsets equipped with 14 electrodes to acquire EEG data from two human test subjects in synchronous mode. Classification and data analysis has been performed offline however in future the study will be extended to an online BCI system.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"30 1","pages":"181-194"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74030045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a system engineering approach to a problem of DNA damage-repair in human cells. We discuss chosen control systems existing in the cells and demonstrate that they constitute an almost perfect fault tolerant system. We discuss the consequences of gaps in this system and explain why it cannot be completely perfect.
{"title":"Is cell cycle a perfect fault tolerant control system? - System engineering point of view","authors":"A. Świerniak, R. Jaksik, J. Śmieja","doi":"10.2316/P.2017.852-005","DOIUrl":"https://doi.org/10.2316/P.2017.852-005","url":null,"abstract":"We present a system engineering approach to a problem of DNA damage-repair in human cells. We discuss chosen control systems existing in the cells and demonstrate that they constitute an almost perfect fault tolerant system. We discuss the consequences of gaps in this system and explain why it cannot be completely perfect.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"24 1","pages":"108-113"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83076423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
According to the world health organization, 40 billion people travel to regions of high altitudes every year. One the most dangerous diseases according to high altitudes is the acute mountain sickness, caused, inter alia, by reduced partial oxygen pressure. This work reflects the possibilities of a cardio-respiratory acute mountain sickness monitoring with wearable photoplethysmography sensors. Since common photoplethysmographic systems are often applied to peripherals, these systems are affected to hypothermia that may inhibit accurate measurement in critical situations. Therefore, we discuss the usability of the in-ear pulse oximetry for vital monitoring during high altitude activities. For this, we present an in-ear pulse oximeter system for continuous measurement of vital signs. The system is evaluated during a cold-pressure-test to simulate low temperature exposition or to stimulate the endogenous centralization, respectively. Furthermore, high altitude is simulated by reduces partial oxygen pressure in 10 healthy subject (up to 8500m equivalent, ideal conditions). It could be proved, that the sub-dermal perfusion in the inner ear channel is not affected by centralization and thus, enables stable measurement during hypothermia. Blood oxygen saturation (hypoxia) could be measured with high accuracy. Furthermore, the system was tested under a realistic scenario at approximately 3000m in Switzerland with promising results.
{"title":"In-ear pulse oximetry in high altitude mountaineering","authors":"B. Venema, S. Leonhardt","doi":"10.2316/P.2017.852-044","DOIUrl":"https://doi.org/10.2316/P.2017.852-044","url":null,"abstract":"According to the world health organization, 40 billion people travel to regions of high altitudes every year. One the most dangerous diseases according to high altitudes is the acute mountain sickness, caused, inter alia, by reduced partial oxygen pressure. This work reflects the possibilities of a cardio-respiratory acute mountain sickness monitoring with wearable photoplethysmography sensors. Since common photoplethysmographic systems are often applied to peripherals, these systems are affected to hypothermia that may inhibit accurate measurement in critical situations. Therefore, we discuss the usability of the in-ear pulse oximetry for vital monitoring during high altitude activities. For this, we present an in-ear pulse oximeter system for continuous measurement of vital signs. The system is evaluated during a cold-pressure-test to simulate low temperature exposition or to stimulate the endogenous centralization, respectively. Furthermore, high altitude is simulated by reduces partial oxygen pressure in 10 healthy subject (up to 8500m equivalent, ideal conditions). It could be proved, that the sub-dermal perfusion in the inner ear channel is not affected by centralization and thus, enables stable measurement during hypothermia. Blood oxygen saturation (hypoxia) could be measured with high accuracy. Furthermore, the system was tested under a realistic scenario at approximately 3000m in Switzerland with promising results.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"30 1","pages":"254-259"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89470492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reliable mechanical properties of trabecuale are needed at the tissue-level for prediction of mechanical behavior of the overall trabecular structure using Finite element analysis (FEA). The aim of this study was to develop a set-up to test trabeculae in tension in a close to physiological environment, and to determine reliable tissue-level properties. Ten bovine trabeculae were tested until failure. Tissue-stress can only be indirectly determined, since it is based on a defined cross-sectional area. Different geometrical assumptions for the cross-section were compared. The mean tissue Youngs modulus, based on the assumption of an elliptical cross-sectional area, was 9.9 ± 3.4GPa, the mean tissue ultimate tissue strain 9.8 ± 3.9%. Back-calculation of the tissue Youngs modulus by means of FEA illustrated a significant reduction to 8.2 ± 2.4GPa (p < 0.001). However, with simple geometric assumptions, it is possible to estimate a reasonable upper and lower boundary for the tissue Young's modulus. Full-field strain measurements were done to detect localization of strain. It was shown that local strain peaks occur already early after yielding, with a local strain at fracture of 19.7 ± 6.6%. These findings clearly show that individual trabeculae can withstand much higher tissue strains as previously reported.
{"title":"Mechanical properties of individual trabeculae in a physiological environment","authors":"Martin Frank, Dorothee Marx, D. Pahr, P. Thurner","doi":"10.2316/P.2017.852-023","DOIUrl":"https://doi.org/10.2316/P.2017.852-023","url":null,"abstract":"Reliable mechanical properties of trabecuale are needed at the tissue-level for prediction of mechanical behavior of the overall trabecular structure using Finite element analysis (FEA). The aim of this study was to develop a set-up to test trabeculae in tension in a close to physiological environment, and to determine reliable tissue-level properties. Ten bovine trabeculae were tested until failure. Tissue-stress can only be indirectly determined, since it is based on a defined cross-sectional area. Different geometrical assumptions for the cross-section were compared. The mean tissue Youngs modulus, based on the assumption of an elliptical cross-sectional area, was 9.9 ± 3.4GPa, the mean tissue ultimate tissue strain 9.8 ± 3.9%. Back-calculation of the tissue Youngs modulus by means of FEA illustrated a significant reduction to 8.2 ± 2.4GPa (p < 0.001). However, with simple geometric assumptions, it is possible to estimate a reasonable upper and lower boundary for the tissue Young's modulus. Full-field strain measurements were done to detect localization of strain. It was shown that local strain peaks occur already early after yielding, with a local strain at fracture of 19.7 ± 6.6%. These findings clearly show that individual trabeculae can withstand much higher tissue strains as previously reported.","PeriodicalId":6635,"journal":{"name":"2017 13th IASTED International Conference on Biomedical Engineering (BioMed)","volume":"48 1","pages":"141-146"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80190222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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