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2017 13th IASTED International Conference on Biomedical Engineering (BioMed)最新文献

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A physical simulation to investigate the effect of anorectal angle on continence 物理模拟研究肛肠角对尿失禁的影响
Pub Date : 2017-04-06 DOI: 10.2316/P.2017.852-046
W. E. Stokes, D. Jayne, A. Alazmani, P. Culmer
This paper investigates the effect of the anorectal angle on continence using a physical model of the anatomical system. A method to fabricate, measure and control a physical model for the simulation of human faecal continence is presented. A model rectum and associated soft tissues, based on geometry from an anonymised CT dataset, was fabricated from silicone and showed behavioural realism to ex vivo tissue. Simulated stool matter with similar rheological properties to human faeces was developed. Instrumentation and control hardware are used to regulate injection of simulated stool into the system, define the anorectal angle and monitor stool flow rate, intra-rectal pressure and puborectalis force. A study was then conducted in which simulated stool was introduced to the system for anorectal angles between 80° and 100°. Results obtained from the study give insight into the effect of the anorectal angle on continence. Stool leakage was reduced as the angle became more acute. Conversely, intra-rectal pressure increased. These data demonstrate that the anorectal angle is fundamental in maintaining continence. This work is valuable in helping improve our understanding of the physical behaviour of the faecal system. It has particular relevance facilitating improved technologies to treat or manage severe faecal incontinence.
本文利用解剖系统的物理模型探讨了肛肠角对尿失禁的影响。介绍了一种制作、测量和控制人体大便失禁的物理模型的方法。基于匿名CT数据集的几何形状,用硅胶制作了一个模型直肠和相关的软组织,并显示了离体组织的行为真实性。模拟大便物质具有与人类粪便相似的流变学特性。仪器和控制硬件用于调节模拟粪便注入系统,定义肛门直肠角度,监测粪便流速,直肠内压力和耻骨直肠力。然后进行了一项研究,将模拟粪便引入系统,肛肠角度在80°到100°之间。本研究的结果对肛肠角度对尿失禁的影响有了深入的了解。粪便漏出随着角度的增大而减少。相反,直肠内压升高。这些数据表明肛肠角是维持尿失禁的基础。这项工作有助于提高我们对粪便系统物理行为的理解。它具有特别的相关性,促进改进技术,以治疗或管理严重的大便失禁。
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引用次数: 2
Effect of anatomical landmark placement variation on the angular parameters of the lower extremities 解剖标记位置变化对下肢角参数的影响
Pub Date : 2017-04-05 DOI: 10.2316/P.2017.852-037
Kristóf Rácz, Gergely Nagymáté, R. Kiss
Gait analysis gets more accessible, accurate, and simple to use as technology advances. The goal of this paper is to explore the accuracy of an advanced optical motion analysis system, where marker clusters mounted on rigid shapes are used to track the movement of body segments. It aims to examine the magnitude and nature of variation of the angular gait parameters of the lower extremities, caused by inaccuracy of the anatomical landmark placement. These landmarks are defined in the local coordinate systems of the rigid clusters through a calibration procedure, eliminating the need for skin-mounted markers. The used protocol makes it possible to evaluate the exact same motion using different calibrations, eliminating any other possible source for the variation of results. As a conclusion, a good estimation for the accuracy of the usual angular parameters in gait analysis is given. Mean anatomical landmark placement variation was found to be around 8.5 mm. The biggest standard deviations were found in the left hip flexion angle, with an average of 4.38°.
随着技术的进步,步态分析变得更加容易获取、准确和简单。本文的目标是探索一种先进的光学运动分析系统的准确性,其中安装在刚性形状上的标记簇用于跟踪身体部分的运动。它的目的是检查的大小和变化的角度步态参数的下肢的性质,引起的不准确的解剖地标放置。通过校准程序在刚性集群的局部坐标系中定义这些地标,从而消除了对皮肤安装标记的需要。使用的协议使得使用不同的校准来评估完全相同的运动成为可能,消除了结果变化的任何其他可能的来源。最后给出了步态分析中常用角度参数的精度估计。解剖标记位置的平均变异在8.5 mm左右。左髋关节屈曲角度标准差最大,平均为4.38°。
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引用次数: 2
Balancing strategy differences in bilateral knee osteoarthritis patients 双侧膝骨关节炎患者平衡策略的差异
Pub Date : 2017-04-05 DOI: 10.2316/P.2017.852-016
Gergely Nagymáté, R. Kiss
Knee osteoarthritis (OA) is one of the most widespread orthopedic disease that affects the elderly. The present study aims to evaluate the biomechanical effects of bilateral osteoarthritis on elderly patients compared to a control group using stabilometry parameters. The used parameters were center of pressure (CoP) 95% confidence ellipse area, CoP path length and maximum path velocity, CoP range ratio and spectral power ratio in anteroposterior (AP) and mediolateral (ML) directions, load distribution between legs, largest amplitudes in AP and ML direction during a 30s bilateral quite standing trial on a Zebris FDM-S force distribution plate. Significant differences to the control group in path length, ML largest amplitude and spectral power ratio showed that bilaterally involved OA degrades postural stability as reported earlier, but new finding is that more intense CoP motions can be observed in ML direction in case of bilateral knee osteoarthritis.
膝关节骨关节炎(OA)是影响老年人最普遍的骨科疾病之一。本研究旨在评估双侧骨关节炎对老年患者的生物力学影响,并使用稳定测量参数与对照组进行比较。使用的参数是在Zebris FDM-S力分布板上进行的30秒双侧站立试验中,压力中心(CoP) 95%置信度椭圆面积、CoP路径长度和最大路径速度、正前方(AP)和中外侧(ML)方向的CoP范围比和频谱功率比、腿间负荷分布、AP和ML方向的最大振幅。与对照组相比,路径长度、ML最大振幅和频谱功率比的显著差异表明,如先前报道的那样,双侧受累的OA降低了姿势稳定性,但新的发现是,在双侧膝骨关节炎的情况下,在ML方向可以观察到更强烈的CoP运动。
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引用次数: 2
Controlled permeation of lidocaine hydrochloride using a smart drug delivery system 智能给药系统控制盐酸利多卡因的渗透
Pub Date : 2017-02-20 DOI: 10.2316/P.2017.852-024
Yassine Talbi, Damien Brulin, E. Campo, J. Fourniols
Transdermal administration might be an interesting alternative to current routes of administration. It is non-invasive, avoids gastric side effects, and improves bioavailability of the molecules. However, due to the low permeability of the stratum corneum, a permeation enhancement strategy is required to make a large number of molecules suitable to this mode of administration. To overcome those limitations and deliver controlled drugs, a smart transdermal drug delivery system is designing. This paper focusses on the study of transdermal iontophoresis permeation of lidocaine hydrochloride (2%, w/w) across pig ear skin. In vitro iontophoresis experiments were conducted using Franz diffusion cells. Anodal iontophoresis was applied for 30 minutes at different current densities. Samples (1 mL) were withdrawn every 30 minutes from the receptor compartment and replaced with a fresh buffer and then analyzed using High Performance Liquid Chromatography (HPLC). Results highlight the relationship between current density, time of stimulation, and amount of lidocaine permeated.
透皮给药可能是一个有趣的替代目前的给药途径。它是非侵入性的,避免了胃的副作用,并提高了分子的生物利用度。然而,由于角质层的渗透性较低,需要一种渗透性增强策略来使大量分子适合这种给药模式。为了克服这些限制并提供受控药物,一种智能透皮给药系统正在设计中。本文研究了盐酸利多卡因(2%,w/w)在猪耳皮肤上的透皮离子透渗作用。体外离子导入实验采用Franz扩散池进行。在不同电流密度下阳极离子电泳30分钟。每30分钟从受体室中取出样品(1ml),并用新鲜缓冲液替换,然后使用高效液相色谱(HPLC)进行分析。结果强调了电流密度、刺激时间和利多卡因渗透量之间的关系。
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引用次数: 4
Comparison of single ended and differential signalling for wired biomedical implants using SPI communication with Reed Solomon Error Correction codes 有线生物医学植入物单端和差分信号的比较使用SPI通信与里德所罗门纠错码
Pub Date : 2017-02-01 DOI: 10.2316/P.2017.852-001
C. Gümüş, Andreas Bahr, L. A. Saleh, D. Schroeder, W. Krautschneider
For an implantable system for the recording of brain signals from neonatal mice the design specifications for the weight and the size of a implantable system are very tough. The animals are very small and light weight (1–3 cm, 2– 3 g) and the recording data rate is very high (3,5 Mbit/s). Thus, the system has to be extremely small. With state of the art technique it is not possible to set up a wireless implantable system that is suitable for a neonatal mouse. Thus a wired system is developed. For the wired system the connector is a size limiting factor. In wired transmission systems single ended and differential signalling are available. Differential signalling is more robust against noise disturbances, single ended transmission is beneficial with respect to a minimum number of wires and chip area. A detailed comparison of the suitability of both transmission types for wired implantable systems has been performed. A Serial Peripheral Interface connection with Reed Solomon Encoder connection has been implemented. Reed Solomon Error Correction is used to correct the errors occurring on the wired transmission line. Measurements of data rate and error rate for single ended and differential signalling have been performed for long cables (up to 1.8 m). It could be shown that single ended transmission is favourable for the desired application. For the detection and correction of errors occurring on high speed Serial Peripheral Interface Reed Solomon decoding on FPGA was used. This particular decoder design has capability of correcting up to 2 symbol errors on a packet of data composed of 9 symbols where each symbol is 4 bits long. Complete error correction takes about 65 clock cycles on a speed up to 100 MHz.
对于一种用于记录新生小鼠大脑信号的植入式系统来说,其重量和尺寸的设计规范是非常严格的。动物非常小,重量很轻(1-3厘米,2 - 3克),记录数据速率非常高(3.5 Mbit/s)。因此,系统必须非常小。以目前的技术水平,还不可能建立一个适合新生老鼠的无线植入式系统。这样,有线系统就被开发出来了。对于有线系统,连接器是一个尺寸限制因素。在有线传输系统中,单端和差分信号是可用的。差分信号对噪声干扰具有更强的鲁棒性,单端传输相对于最小数量的导线和芯片面积是有益的。详细比较了两种传输类型对有线植入式系统的适用性。一个串行外设接口连接与里德所罗门编码器连接已实现。里德所罗门纠错是用来纠正有线传输线上发生的错误。对长电缆(最长1.8米)进行了单端和差分信号的数据速率和错误率测量。可以表明,单端传输有利于预期的应用。为了检测和纠正高速串行外设接口上出现的错误,采用了FPGA上的里德索罗门解码。这种特殊的解码器设计能够在由9个符号组成的数据包上纠正最多2个符号错误,每个符号长4位。在高达100 MHz的速度下,完全纠错大约需要65个时钟周期。
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引用次数: 0
Patient-specific ECG classification based on recurrent neural networks and clustering technique 基于递归神经网络和聚类技术的患者心电分类
Pub Date : 2017-01-01 DOI: 10.2316/P.2017.852-029
Chenshuang Zhang, Guijin Wang, Jingwei Zhao, Pengfei Gao, Jianping Lin, Huazhong Yang
In this paper, we propose a novel patient-specific electrocardiogram (ECG) classification algorithm based on the recurrent neural networks (RNN) and density based clustering technique. We use RNN to learn time correlation among ECG signal points and to classify ECG beats with different heart rates. Morphology information including the present beat and the T wave of former beat is fed into RNN to learn underlying features automatically. Clustering method is employed to find representative beats as the training data. Evaluated on the MIT-BIH Arrhythmia Database, the experimental results show that proposed algorithm achieves the state-of-the-art classification performance.
本文提出了一种基于递归神经网络(RNN)和密度聚类技术的患者特异性心电图(ECG)分类算法。利用RNN学习心电信号点之间的时间相关性,对不同心率下的心电跳动进行分类。将当前拍和前拍的T波等形态学信息输入到RNN中,自动学习底层特征。采用聚类方法寻找具有代表性的节拍作为训练数据。在MIT-BIH心律失常数据库上进行的实验结果表明,该算法达到了最先进的分类性能。
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引用次数: 78
Intelligent pillbox: Automatic and programmable Assistive Technology device 智能药箱:自动和可编程的辅助技术设备
Pub Date : 2017-01-01 DOI: 10.2316/P.2017.852-051
Juan Parra, Wilson Valdez, Andrea Guevara, Priscila Cedillo, Jose Ortíz-Segarra
Assistive Technology (AT) maintains and improves the individual's functioning and independence, thereby promoting their well-being. But today only 1 from each 10 people in need have access to AT due to high costs and a lack of awareness, availability, personal training, policy and financing. By 2050, more than 2 billion people will need at least 1 assistive product with many elderly needing 2 or more. Elderly make important contributions to the society. Though some people aged well, other become frail, with a high risk of disease. In this paper, we propose a first approach related the design of AT device. This uses open source technologies and gives a new choice in taking medication dosages. “The Intelligent PillBox” allows the organization of several medication schedules that health disorders presented in elderly need basically. Arduino Mega 2560 was took as the principal controller. This prototype contains; a programmable alarm system with an automatic opening and closing system, an interactive user interface and a notification system through GSM network. The development of this device is focused in the support of elderly people and other vulnerable groups that may need for an assisted care.
辅助技术(AT)维持和改善个人的功能和独立性,从而促进他们的福祉。但今天,由于成本高昂以及缺乏认识、可获得性、个人培训、政策和资金,每10个有需要的人中只有1人能够获得辅助治疗。到2050年,将有超过20亿人需要至少一种辅助产品,许多老年人需要两种或更多。老年人对社会做出了重要贡献。虽然有些人老得很好,但其他人变得虚弱,患病的风险很高。在本文中,我们提出了一种与AT器件设计相关的第一种方法。它使用了开源技术,并在服用药物剂量方面提供了新的选择。“智能药盒”允许组织老年人健康障碍基本需要的几种药物时间表。采用Arduino Mega 2560作为主控制器。这个原型包含;具有自动启闭系统、交互式用户界面和通过GSM网络的通知系统的可编程报警系统。该设备的开发重点是为老年人和其他可能需要辅助护理的弱势群体提供支持。
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引用次数: 20
Automated therapeutic anticoagulation: A closed-loop approach using a modified measurement device 自动抗凝治疗:一种使用改良测量装置的闭环方法
Pub Date : 2017-01-01 DOI: 10.15496/PUBLIKATION-25167
Jörg Peter, M. Spüler, W. Rosenstiel, Wilfried Klingert, A. Königsrainer, M. Schenk
Measurement of the activated clotting time (ACT) is an important and regularly performed task in hospitals for thrombosis prevention. Required adjustments of anticoagulation therapy are most often done manually by using a therapeutic look-up table adapted to patient weight. This process is prone to human errors and an automated solution for calculating the required change and readjusting the individual infusion rate of an anticoagulant therefore would provide benefits. Currently no automated blood anticoagulation system is available and we thus decided to expand an existing ACT measurement device with real-time reporting capabilities. We intercepted the electrical signals to the device's seven segment displays and converted the electrical signals of the numbers using a Raspberry Pi. Then an automated closed-loop heparinization following a look-up table approach as used in clinical practice was implemented. To prove the feasibility of the system, a successful test for 96 hours in an anaesthetized animal was performed. While this study has shown that automatic closed-loop adaptation in a medical environment is feasible, we discuss possible implications of this approach, outline open problems and address issues that need to be solved towards a more automated and better medical care in general.
活化凝血时间(ACT)的测定是医院预防血栓形成的一项重要的常规工作。抗凝治疗所需的调整通常是通过使用适合患者体重的治疗查找表手动完成的。这一过程容易出现人为错误,因此,用于计算所需变化和重新调整抗凝剂个人输注速率的自动化解决方案将提供好处。目前没有自动血液抗凝系统可用,因此我们决定扩展现有的具有实时报告功能的ACT测量设备。我们截取了设备的7段显示的电信号,并使用树莓派转换了数字的电信号。然后在临床实践中采用查找表方法实施自动闭环肝素化。为了证明该系统的可行性,在麻醉动物身上进行了96小时的成功测试。虽然这项研究表明,在医疗环境中自动闭环适应是可行的,但我们讨论了这种方法的可能含义,概述了开放的问题,并解决了需要解决的问题,以实现更自动化和更好的医疗保健。
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引用次数: 0
Instrumented spinal cord surrogate using optical fiber: Role of the fiber's location 使用光纤仪器化脊髓替代物:光纤位置的作用
Pub Date : 2017-01-01 DOI: 10.2316/P.2017.852-028
Yann Facchinello, E. Wagnac, B. Ung, Y. Petit, Prabin Pradhan, Louis-Marie Peyrache, J. Mac-Thiong
In vitro replication of traumatic spinal cord injury is necessary to understand its biomechanics and to improve prevention devices and care. During the trauma, the spinal cord withstands an impaction at high velocity. In order to fully assess spinal cord compression, a physical spinal cord surrogate instrumented with bare optical fibers is a promising avenue. The sensing is based on light transmission loss observed in optical fibers subjected to bending. In this paper, the role of the fibers' position within the surrogate is presented and discussed. The closer the fiber from the surface of the spinal cord, the more sensitive it is to small compression magnitude. A threshold value of 15 % was observed for the fiber located at the upper surface of the surrogate. However, this fiber was not able to record compression over 40 %. Another fiber located in the middle of the surrogate was needed to record compression between 40 % to 85 %. Using two fibers allows continuous recording of compressions ranging from 15 % to 85 %. This study shows the relevance of using multiple fibers in order to fully assess the compression of the spinal cord surrogate.
体外复制外伤性脊髓损伤是了解其生物力学和改进预防装置和护理的必要条件。在创伤过程中,脊髓承受高速撞击。为了充分评估脊髓压迫,裸光纤物理脊髓替代仪器是一种很有前途的途径。传感是基于在光纤中观察到的受弯曲的光传输损耗。在本文中,纤维的位置在代理提出和讨论的作用。纤维离脊髓表面越近,对小的压缩幅度越敏感。对于位于代孕体上表面的纤维,观察到的阈值为15%。然而,这种纤维不能记录超过40%的压缩。另一根位于代孕体中间的纤维需要记录40%到85%的压缩。使用两根纤维可以连续记录从15%到85%的压缩。这项研究表明,为了充分评估脊髓替代物的压迫,使用多种纤维的相关性。
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引用次数: 1
Performance feedback assists practice driven plasticity 表现反馈有助于实践驱动的可塑性
Pub Date : 2017-01-01 DOI: 10.2316/P.2017.852-009
Aqsa Shakeel, Hafsah Ahmad, M. S. Navid, Amnah Mahroo, M. N. Anwar
Motor skills are generally acquired by means of practice. This procedure comprised of acquiring particular task requirements by overruling intrinsic tendencies. The objectives of the present study were; to induce plasticity through bimanual finger tapping task; and to determine the influence of presence or absence of performance feedback on training. Behavioural data from 16 healthy subjects was recorded. They were randomly divided into two equal groups. First group performed bimanual finger tapping task according to 2∶1 mode with feedback (TF). Second group performed bimanual finger tapping task according to 2∶1 mode without feedback (TNF). All subjects performing Tapping task either with or without feedback improved their performance at the end of practice. However, TF performed better than TNF, F (1,14) = 22.378, p<0.01. The results illustrate that practice of 2∶1 task with feedback leads to augmented motor experience reflecting better practice driven plasticity.
运动技能一般是通过练习获得的。这个过程包括通过推翻内在倾向来获得特定的任务要求。本研究的目的是:通过双手手指敲击任务诱导可塑性;并确定是否存在绩效反馈对培训的影响。记录16名健康受试者的行为数据。他们被随机分成两组。第一组按2∶1反馈模式进行双手手指敲击任务。第二组按2∶1无反馈模式(TNF)进行双手手指轻敲任务。在练习结束时,所有受试者在有或没有反馈的情况下进行敲击任务,他们的表现都有所提高。但TF优于TNF, F (1,14) = 22.378, p<0.01。结果表明,2∶1任务反馈练习导致运动体验增强,反映出较好的练习驱动可塑性。
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引用次数: 1
期刊
2017 13th IASTED International Conference on Biomedical Engineering (BioMed)
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