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第二军医大学学报最新文献

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Application of heart rate and rating of perceived exertion scale in monitoring physical fatigue in divers during heliox saturation diving 心率和感知运动量表在监测饱和螺旋潜水时身体疲劳中的应用
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.00978
Yu-min Huang, Ming-yue Zhang, Rui Chen, Xiangqin Han, Li Chen, Xuan Zhang
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引用次数: 0
Comparison of diagnosis efficacies between real-time tissue elastography and serum markers for liver cirrhosis 实时组织弹性成像与血清标志物对肝硬化诊断效果的比较
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.00957
Meng-lin Zheng, W. Shen, Jia Guo, B. Tan, Wan-bin Li, Jie-wen Lei
{"title":"Comparison of diagnosis efficacies between real-time tissue elastography and serum markers for liver cirrhosis","authors":"Meng-lin Zheng, W. Shen, Jia Guo, B. Tan, Wan-bin Li, Jie-wen Lei","doi":"10.3724/SP.J.1008.2015.00957","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00957","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69857109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Relationship of endocrine disruptors (bisphenol A and diethyl phthalate) with premature thelarche in infant girls 内分泌干扰物(双酚A和邻苯二甲酸二乙酯)与女婴早产的关系
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.01021
Yan Zeng, Hong-tao Hu
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引用次数: 0
Screen and preliminary function study of fetal liver specific oncofetal RNA AK003710 胎肝特异性癌胎RNA AK003710的筛选及初步功能研究
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.00233
Shao-bing Wang, Shuhan Sun, F. Wang
Objective To screen for a fetal liver specific oncofetal RNA and to study its effect on the proliferation and mobility of hepatocellular carcinoma(HCC)cells.Methods By overlapping the microarray results of mouse fetal liver and regenerated liver following partial hepatectomy(PH),we obtained several candidate lncRNAs which were highly expressed in both fetal liver and regenerated liver tissues,and then the expression of these candidate lncRNAs in HCC tissue were also detected.The most differentially expressed lncRNA in the mouse HCC tissues as detected by real-time PCR were chosen for further research.By real-time PCR,the expression of those lncRNA in fetal liver and regenerated liver tissue was verified.For the function study,EdU labeling system and Transwell experiment were carried out to determine the proliferation ability and mobility after knocking down the lncRNA by siRNA transfection in HCC cell line Hepa1-6.Results Seven candidate lncRNAs which were highly expressed in both fetal liver and regenerated liver tissues were obtained;3of them were overexpressed in HCC tissues compared with normal liver tissues,3had no differential expression,and 1 was undetectable.Among the 3overexpressed lncRNAs,lncRNA-AK003710 was the most differentially expressed lncRNA according to microarray and realtime PCR results.And then we detected that lncRNA-AK003710 was overexpressed in the fetal liver and 3kinds of injured liver tissues.Furthermore,the proliferation ability and mobility of Hepa1-6were impaired after knocking down lncRNA-AK003710 in HCC cell line Hepa1-6.Conclusion lncRNA-AK003710 is overexpressed in the fetal liver,regenerated liver tissues,and HCC tissues;therefore it is an oncofetal RNA that can regulate the proliferation and invasion of HCC cells and may be a potential therapeutic target for HCC.
目的筛选胎儿肝特异性癌胎RNA,研究其对肝细胞癌(HCC)细胞增殖和移动性的影响。方法将部分肝切除(PH)后小鼠胎肝和再生肝的微阵列结果进行重叠,获得在胎肝和再生肝组织中均高表达的几个候选lncRNAs,并检测这些候选lncRNAs在HCC组织中的表达。选择real-time PCR检测到的小鼠HCC组织中差异表达最多的lncRNA进行进一步研究。通过实时荧光定量PCR验证了这些lncRNA在胎肝和再生肝组织中的表达。在功能研究方面,我们通过EdU标记系统和Transwell实验,检测转染siRNA敲低lncRNA后肝癌细胞株Hepa1-6的增殖能力和迁移能力。结果获得7个候选lncrna,在胎肝和再生肝组织中均有高表达,其中3个在HCC组织中与正常肝组织相比过表达,3个无差异表达,1个未检出。在这3个过表达的lncRNA中,根据微阵列和实时PCR结果,lncRNA- ak003710是差异表达最多的lncRNA。然后我们检测到lncRNA-AK003710在胎儿肝脏和3种损伤肝组织中过表达。此外,敲低lncRNA-AK003710后,肝癌细胞系Hepa1-6的增殖能力和移动性受到损害。结论lncRNA-AK003710在胎肝、再生肝组织和HCC组织中均有过表达,是一种能调控HCC细胞增殖和侵袭的癌胎RNA,可能是HCC潜在的治疗靶点。
{"title":"Screen and preliminary function study of fetal liver specific oncofetal RNA AK003710","authors":"Shao-bing Wang, Shuhan Sun, F. Wang","doi":"10.3724/SP.J.1008.2015.00233","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00233","url":null,"abstract":"Objective To screen for a fetal liver specific oncofetal RNA and to study its effect on the proliferation and mobility of hepatocellular carcinoma(HCC)cells.Methods By overlapping the microarray results of mouse fetal liver and regenerated liver following partial hepatectomy(PH),we obtained several candidate lncRNAs which were highly expressed in both fetal liver and regenerated liver tissues,and then the expression of these candidate lncRNAs in HCC tissue were also detected.The most differentially expressed lncRNA in the mouse HCC tissues as detected by real-time PCR were chosen for further research.By real-time PCR,the expression of those lncRNA in fetal liver and regenerated liver tissue was verified.For the function study,EdU labeling system and Transwell experiment were carried out to determine the proliferation ability and mobility after knocking down the lncRNA by siRNA transfection in HCC cell line Hepa1-6.Results Seven candidate lncRNAs which were highly expressed in both fetal liver and regenerated liver tissues were obtained;3of them were overexpressed in HCC tissues compared with normal liver tissues,3had no differential expression,and 1 was undetectable.Among the 3overexpressed lncRNAs,lncRNA-AK003710 was the most differentially expressed lncRNA according to microarray and realtime PCR results.And then we detected that lncRNA-AK003710 was overexpressed in the fetal liver and 3kinds of injured liver tissues.Furthermore,the proliferation ability and mobility of Hepa1-6were impaired after knocking down lncRNA-AK003710 in HCC cell line Hepa1-6.Conclusion lncRNA-AK003710 is overexpressed in the fetal liver,regenerated liver tissues,and HCC tissues;therefore it is an oncofetal RNA that can regulate the proliferation and invasion of HCC cells and may be a potential therapeutic target for HCC.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of 320 rows spiral CT for multiple rib fractures 320排螺旋CT对多发肋骨骨折的诊断价值
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.00927
Chongfeng Bai, Yun Wang, Qian Luo, S. Fan, Taotao Li
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引用次数: 1
Clinical characteristics of patients with early hypothyroidism after131I therapy and patients with refractory hyperthyroidism 131i治疗后早期甲状腺功能减退患者与难治性甲状腺功能亢进患者的临床特点
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.01012
Jingzhu Cao, Ming Ji, D. Zou
{"title":"Clinical characteristics of patients with early hypothyroidism after131I therapy and patients with refractory hyperthyroidism","authors":"Jingzhu Cao, Ming Ji, D. Zou","doi":"10.3724/SP.J.1008.2015.01012","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01012","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69857668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choice of diagnostic and therapeutic strategy for young patients with acute myocardial infarction: a report of 36 cases 青年急性心肌梗死36例诊治策略的选择
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.00905
Song-qun Huang, Wen-Wen Li, Xianxian Zhao, Li-ping Ma
{"title":"Choice of diagnostic and therapeutic strategy for young patients with acute myocardial infarction: a report of 36 cases","authors":"Song-qun Huang, Wen-Wen Li, Xianxian Zhao, Li-ping Ma","doi":"10.3724/SP.J.1008.2015.00905","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00905","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69855668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adalimumab for treatment of moderate to severe plaque psoriasis: observation of efficacy and changes of serum vitamin D level 阿达木单抗治疗中重度斑块型银屑病:疗效观察及血清维生素D水平变化
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.01003
Xin Zhou, X. Bi, J. Gu
{"title":"Adalimumab for treatment of moderate to severe plaque psoriasis: observation of efficacy and changes of serum vitamin D level","authors":"Xin Zhou, X. Bi, J. Gu","doi":"10.3724/SP.J.1008.2015.01003","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01003","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69857922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal disinfection before cesarean delivery in preventing postoperative infections:a meta-analysis 剖宫产前阴道消毒预防术后感染:荟萃分析
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.01080
Yinan Meng, Qing Wan, D. Hu
Objective To analyze the efficacy of vaginal disinfection with povidone-iodine before cesarean delivery in preventing postoperative infections.Methods Randomized controlled trials,identified from a systematic search of relevant databases including PubMed,EMBASE,CBM,CNKI,and CQVIP,were screened and evaluated according to standardized criteria.RevMan 5.2software was used to do the meta-analysis.Results A total of 9randomized controlled trials with 3 024 participants,with 1 508 in the vaginal cleansing group and 1 516 in the control group,were included in this meta-analysis.The analysis result showed that vaginal disinfection with povidone-iodine before cesarean delivery reduced the incidence of postcesarean endometritis(RR=0.55,95% CI 0.36-0.85,P =0.007).The incidence of post-cesarean endometritis was significantly reduced in women with ruptured membranes(RR=0.29,95%CI:0.16-0.52,P0.000 1)and women in labor(RR=0.63,95%CI 0.41-0.96,P=0.03),but not significantly reduced in the women with intact membranes(RR=0.73,95%CI 0.50-1.08,P=0.11)or women not in labor(RR=0.79,95%CI 0.53-1.17,P=0.24).Vaginal disinfection could not help to reduce the incidence of postoperative wound infection(RR=0.80,95%CI 0.53-1.22,P=0.30)or postoperative fever(RR=0.92,95%CI 0.76-1.11,P=0.37).Conclusion Vaginal disinfection with povidone-iodine before cesarean delivery can decrease the risk of post-cesarean endometritis,especially for women undergoing cesarean delivery with ruptured membranes or in labor,but vaginal disinfection do not reduce the risk of postoperative wound infection or fever.
目的分析剖宫产前用聚维酮碘消毒阴道对预防术后感染的效果。方法系统检索PubMed、EMBASE、CBM、CNKI、CQVIP等相关数据库,筛选随机对照试验,按照标准化标准进行评价。采用RevMan 5.2软件进行meta分析。结果共纳入9项随机对照试验3 024例,其中阴道清洁组1 508例,对照组1 516例。分析结果显示,剖宫产前阴道消毒聚维酮碘可降低剖宫产后子宫内膜炎的发生率(RR=0.55,95% CI 0.36 ~ 0.85,P =0.007)。剖宫产后子宫内膜炎的发生率在胎膜破裂妇女(RR=0.29,95%CI:0.16-0.52,P = 0.0001)和产程妇女(RR=0.63,95%CI 0.41-0.96,P=0.03)中显著降低,但在胎膜完整妇女(RR=0.73,95%CI 0.50-1.08,P=0.11)和非产程妇女(RR=0.79,95%CI 0.53-1.17,P=0.24)中无显著降低。阴道消毒不能降低术后创面感染(RR=0.80,95%CI 0.53 ~ 1.22,P=0.30)和术后发热(RR=0.92,95%CI 0.76 ~ 1.11,P=0.37)的发生率。结论剖宫产前阴道消毒聚维酮碘可降低剖宫产后子宫内膜炎的发生风险,尤其是剖宫产伴破膜或产程产妇,但阴道消毒不能降低术后伤口感染和发热的发生风险。
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引用次数: 0
Correlation of fluid resuscitation volume with intra-abdominal hypertension and renal injury in patients with severe acute pancreatitis 重症急性胰腺炎患者腹腔高压及肾损伤与液体复苏量的关系
Q4 Medicine Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1008.2015.01152
Xiao-ying Chen, Xi Shi
Objective To investigate the correlation of fluid resuscitation volume with intra-abdominal hypertension(IAH)and renal injury in patients with severe acute pancreatitis(SAP).Methods Totally 60 patients with SAP from our ICU were recruited in the present study.The intra-abdominal pressure(IAP)was measured by method AbViser.The patients were divided into the following 3groups according to the different of IAP:the normal group,IAH group and abdominal compartment syndrome(ACS)group.The general information,mortality rate,fluid resuscitation volumes and renal injury were analyzed and compared in the 3groups.Results(1)The incidence rates of IAH and ACS in our study were 31.67%(19/60)and 11.67%(7/60),respectively.The mortality rates of normal group,IAH group and ACS group were 5.88%(2/34),21.05%(4/19)and 57.14%(4/7),respectively.The mortality rate of ACS group was significantly higher than that of normal group(P=0.007).(2)The fluid balance volumes of normal group,IAH group and ACS group were(4 350±892),(5 512±1 246)and(5 974±1 765)mL,respectively,with significant differences found among the 3groups(P0.001);the total cumulative fluid volumes of the 3groups were(8 530±2 384),(9 403±2 064)and(13 172±2 409)mL,respectively,also with significant differences found among the 3groups(P0.001).ACS group had the highest fluid balance and total cumulative fluid volumes in the first 3days.(3)There were significant differences in the levels of blood creatinine and urea nitrogen among the 3groups(P0.001).The levels of blood creatinine and urea nitrogen of ACS group was significantly higher than those of normal group and IAH group(P0.05).Conclusion The cumulative fluid of the first 3days is associated with IAH and even ACS in pateints with SAP,and IAH can further lead to renal injury in patients with SAP.
目的探讨重症急性胰腺炎(SAP)患者腹腔内高压(IAH)和肾损伤与液体复苏量的关系。方法选取我院ICU收治的60例SAP患者作为研究对象。采用AbViser法测定腹内压(IAP)。根据IAP的不同将患者分为正常组、IAH组和腹腔隔室综合征(ACS)组。分析比较3组患者的一般情况、死亡率、液体复苏量及肾损伤情况。结果(1)本组IAH和ACS的发生率分别为31.67%(19/60)和11.67%(7/60)。正常组、IAH组和ACS组的死亡率分别为5.88%(2/34)、21.05%(4/19)和57.14%(4/7)。ACS组死亡率显著高于正常组(P=0.007)。(2)正常组、IAH组和ACS组体液平衡体积分别为(4 350±892)、(5 512±1 246)和(5 974±1 765)mL, 3组间差异有统计学意义(P0.001); 3组总累积体液体积分别为(8 530±2 384)、(9 403±2 064)和(13 172±2 409)mL, 3组间差异也有统计学意义(P0.001)。ACS组前3d的体液平衡和总累积体液体积最高。(3)3组间血肌酐、尿素氮水平差异有统计学意义(P0.001)。ACS组血肌酐、尿素氮水平显著高于正常组和IAH组(P0.05)。结论SAP患者前3天积液与IAH甚至ACS相关,IAH可进一步导致SAP患者肾损伤。
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