{"title":"Population pharmacokinetics in individualized drug dosage regimes of valproate","authors":"Chunhua You, Yunlei Yun, Shouhong Gao, Feng Zhang, Wansheng Chen, Xiaojuan Xiong","doi":"10.3724/SP.J.1008.2015.01329","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01329","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"1329"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.01370
Jing-hua Wang, Sheng-li Zhou, Ling-na Mao, Gui-feng Wang, Zhen-ya Song
{"title":"Effects of systemic inflammation on basal ganglia damage in diabetic mice and the underlying mechanisms","authors":"Jing-hua Wang, Sheng-li Zhou, Ling-na Mao, Gui-feng Wang, Zhen-ya Song","doi":"10.3724/SP.J.1008.2015.01370","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.01370","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"1370"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.1192
Lin Wang, L. Duan, Yuan Feng, Huaning Wang, Xiaofei Wu, Xiaoyan Wang
{"title":"Ciclopirox olamine in treatment of vulvovaginal candidiasis: a randomized controlled study","authors":"Lin Wang, L. Duan, Yuan Feng, Huaning Wang, Xiaofei Wu, Xiaoyan Wang","doi":"10.3724/SP.J.1008.2015.1192","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.1192","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"1192"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.1270
Jian Zhang, Fengsen Li, Jing Wang, H. Bilal
Objective To compare the urine aquaporin 2(AQP2)levels between asthmatic patients and healthy participants,explore the AQP2 levels in patients with asthma of different clinical control levels and its relationship with inflammatory factors.Methods Urine AQP2 levels were examined by ELISA in 60 patients with asthma and 21 healthy participants;plasma interleukin(IL)-4,IL-6,tumor necrosis factor(TNF)-αand interferon(IFN)-γlevels were determined by by CBA method.Results The levels of urine AQP2 in clinical uncontrolled asthma group(ACT below 19)and partially controlled asthma group(ACT 20~24)were significantly higher than that in the healthy control group(P0.01),and the level in the uncontrolled group was(174.28±40.81)pg/mL.The plasma IL-4level in uncontrolled group was(1.10±0.25)pg/mL,which was significantly higher than those in the other two groups(P0.01).The plasma IL-6level in uncontrolled asthma group was the highest but showing no significant difference when compared with the other two groups(P=0.058).The TNF-αlevel in asthma patients was significantly higher than that in healthy controls(P0.05).Urine AQP2 was found significantly correlated with plasma IL-4and IL-6levels(P=0.049,P=0.010);plasma IL-4level was significantly correlated with IFN-γlevel(P=0.019);IL-6was significantly correlated with TNF-αlevel(P=0.010);and IL-10 was significantly correlated with IFN-γlevle(P=0.005).Conclusion Urine AQP2 level of asthma patients is increased,and it is significantly correlated with plasma levels of inflammatory factors IL-4and IL-6.The role of AQP2 in the pathogenesis of bronchial asthma is worth further studying.
{"title":"Urine AQP2 change in patients with asthma controlled to different clinical levels and its relationship with inflammatory factors","authors":"Jian Zhang, Fengsen Li, Jing Wang, H. Bilal","doi":"10.3724/SP.J.1008.2015.1270","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.1270","url":null,"abstract":"Objective To compare the urine aquaporin 2(AQP2)levels between asthmatic patients and healthy participants,explore the AQP2 levels in patients with asthma of different clinical control levels and its relationship with inflammatory factors.Methods Urine AQP2 levels were examined by ELISA in 60 patients with asthma and 21 healthy participants;plasma interleukin(IL)-4,IL-6,tumor necrosis factor(TNF)-αand interferon(IFN)-γlevels were determined by by CBA method.Results The levels of urine AQP2 in clinical uncontrolled asthma group(ACT below 19)and partially controlled asthma group(ACT 20~24)were significantly higher than that in the healthy control group(P0.01),and the level in the uncontrolled group was(174.28±40.81)pg/mL.The plasma IL-4level in uncontrolled group was(1.10±0.25)pg/mL,which was significantly higher than those in the other two groups(P0.01).The plasma IL-6level in uncontrolled asthma group was the highest but showing no significant difference when compared with the other two groups(P=0.058).The TNF-αlevel in asthma patients was significantly higher than that in healthy controls(P0.05).Urine AQP2 was found significantly correlated with plasma IL-4and IL-6levels(P=0.049,P=0.010);plasma IL-4level was significantly correlated with IFN-γlevel(P=0.019);IL-6was significantly correlated with TNF-αlevel(P=0.010);and IL-10 was significantly correlated with IFN-γlevle(P=0.005).Conclusion Urine AQP2 level of asthma patients is increased,and it is significantly correlated with plasma levels of inflammatory factors IL-4and IL-6.The role of AQP2 in the pathogenesis of bronchial asthma is worth further studying.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"1270"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69860573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00108
Guang-yu Yu, Q. Bian, Xue-Li Lai, D. Jiang, Zhi-Yong Guo, R. Cui
{"title":"Gross hematuria, proteinuria, fever, and acute kidney injury (the 52edcase)","authors":"Guang-yu Yu, Q. Bian, Xue-Li Lai, D. Jiang, Zhi-Yong Guo, R. Cui","doi":"10.3724/SP.J.1008.2015.00108","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00108","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"108"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00112
Junjie Zhao, Bo Yang, Zhensheng Zhang, Yang Wang, Yinghao Sun, X. Chuanliang
{"title":"Secondary cavernous hemangioma of urinary bladder following pelvic radiation therapy: a case report","authors":"Junjie Zhao, Bo Yang, Zhensheng Zhang, Yang Wang, Yinghao Sun, X. Chuanliang","doi":"10.3724/SP.J.1008.2015.00112","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00112","url":null,"abstract":"","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00131
Guan‐xin Zhang, B. Cong, Jiajun Zhang, Chong Wang, Yang Yuan, Guo-Kun Wang, Lin Han, Xu Zhiyun
Objective To study the regulatory effects of long non-coding RNA HIF1A-AS1 on the myocardial ischemia reperfusion(I/R)injury and the related mechanism.Methods Myocardial I/R injury model was established with SD rats,and hypoxia reoxygenation(H/R)model was established with rat cardiac myocytes.si-HIF1A-AS1 was used to inhibit HIF1A-AS1 expression in the cardiac myoctyes.Then the mRNA expression of HIF1A-AS1 was detected by real-time PCR,the growth vitality of cardiac myocytes was investigated by MTT assay,the concentration of lactate dehydrogenase(LDH)in the culture media was detected by ELISA,and the autophagy-associated protein Beclin-1expression was observed by Western blotting analysis.Results HIF1A-AS1 expression was increased in cardiac muscle of rat I/R model and rat cardiac myocytes of H/R model.Inhibition of HIF1A-AS1 by siRNA protected the cardiomyocytes against H/R injuries,reversing the decreased growth vitality of cardiac myoctyes,increased LDH level in the culture media,and increased expression of autophagy-related protein Beclin-1induced by H/R stimulation.Conclusion Inhibition of long non-coding RNA HIF1A-AS1 might play aprotective role in I/R injury of cardiac myoctyes by inhibiting the excessive autophagy of cardiomyocytes.
{"title":"Regulatory effects of long non-coding RNA HIF1A-AS1 on ischemic myocardial reperfusion injury in rats","authors":"Guan‐xin Zhang, B. Cong, Jiajun Zhang, Chong Wang, Yang Yuan, Guo-Kun Wang, Lin Han, Xu Zhiyun","doi":"10.3724/SP.J.1008.2015.00131","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00131","url":null,"abstract":"Objective To study the regulatory effects of long non-coding RNA HIF1A-AS1 on the myocardial ischemia reperfusion(I/R)injury and the related mechanism.Methods Myocardial I/R injury model was established with SD rats,and hypoxia reoxygenation(H/R)model was established with rat cardiac myocytes.si-HIF1A-AS1 was used to inhibit HIF1A-AS1 expression in the cardiac myoctyes.Then the mRNA expression of HIF1A-AS1 was detected by real-time PCR,the growth vitality of cardiac myocytes was investigated by MTT assay,the concentration of lactate dehydrogenase(LDH)in the culture media was detected by ELISA,and the autophagy-associated protein Beclin-1expression was observed by Western blotting analysis.Results HIF1A-AS1 expression was increased in cardiac muscle of rat I/R model and rat cardiac myocytes of H/R model.Inhibition of HIF1A-AS1 by siRNA protected the cardiomyocytes against H/R injuries,reversing the decreased growth vitality of cardiac myoctyes,increased LDH level in the culture media,and increased expression of autophagy-related protein Beclin-1induced by H/R stimulation.Conclusion Inhibition of long non-coding RNA HIF1A-AS1 might play aprotective role in I/R injury of cardiac myoctyes by inhibiting the excessive autophagy of cardiomyocytes.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"131"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00221
Xiang-qin Huang, Hong-ai Zhang, Qin Huang
Objective To investigate the prevalence of thyroid nodules in elderly patients(age≥80years)with type 2diabetes mellitus(T2DM),and to analyze the correlation between thyroid nodules and type 2diabetes mellitus.Methods The study included two groups:one group included 103 patients with T2DM(diabetic group)and the other group included 103 patients without T2DM(control group).Information including clinical history,fasting plasma glucose(FPG),thyroid hormone,and ultrasonic finding of thyroid glands was collected for both groups.The clinical features of thyroid nodules were compared between the two groups and their relationship with other indices was analyzed.Results(1)The prevalence rate of thyroid nodules in diabetic group was greatly higher than that of the control group(84.47% vs 70.59%).The proportion of patients with multiple nodules was as high as 80.46% in the diabetic group.Presence of thyroid nodule was significantly associated with patient ages(χ2=7.060,P0.05),but not with gender,body mass index(BMI),or serum glucose level.(2)The positive rate of thyroid dysfunction in the diabetic group was significantly higher than that in the control group(15.53% vs6.80%,P0.05).The prevalence rates of sub-clinical hypothyroidism were similar between the two groups.T3 and T4levels of thyroid function in the diabetic group were significantly lower than those in the control group(P0.05),and the thyroid stimulating hormone(TSH)levels were similar between the two groups.Conclusion Elderly patients(age≥80years)have a higher liability for thyroid disease,which may affect the control and prognosis of diabetes.It is recommended for those patients to receive regular check-up for thyroid function and morphology changes.
目的调查老年(≥80岁)2型糖尿病(T2DM)患者甲状腺结节的患病率，并分析甲状腺结节与2型糖尿病的相关性。方法研究分为两组，一组103例T2DM患者(糖尿病组)，另一组103例非T2DM患者(对照组)。收集两组患者的临床病史、空腹血糖(FPG)、甲状腺激素、甲状腺超声检查结果。比较两组患者甲状腺结节的临床特征，并分析其与其他指标的关系。结果(1)糖尿病组甲状腺结节患病率明显高于对照组(84.47% vs 70.59%)。糖尿病组多发结节患者比例高达80.46%。甲状腺结节的存在与患者年龄有显著相关性(χ2=7.060,P0.05)，与性别、体重指数(BMI)、血糖水平无显著相关性。(2)糖尿病组甲状腺功能障碍阳性率显著高于对照组(15.53% vs6.80%，P0.05)。两组亚临床甲状腺功能减退的患病率相似。糖尿病组甲状腺功能T3、t4水平显著低于对照组(P0.05)，两组促甲状腺激素(TSH)水平相近。结论老年患者(≥80岁)甲状腺疾病易感性较高，可能影响糖尿病的控制和预后。建议定期检查甲状腺功能和形态变化。
{"title":"Correlation analysis between type 2 diabetes mellitus and thyroid nodules in elderly patients","authors":"Xiang-qin Huang, Hong-ai Zhang, Qin Huang","doi":"10.3724/SP.J.1008.2015.00221","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00221","url":null,"abstract":"Objective To investigate the prevalence of thyroid nodules in elderly patients(age≥80years)with type 2diabetes mellitus(T2DM),and to analyze the correlation between thyroid nodules and type 2diabetes mellitus.Methods The study included two groups:one group included 103 patients with T2DM(diabetic group)and the other group included 103 patients without T2DM(control group).Information including clinical history,fasting plasma glucose(FPG),thyroid hormone,and ultrasonic finding of thyroid glands was collected for both groups.The clinical features of thyroid nodules were compared between the two groups and their relationship with other indices was analyzed.Results(1)The prevalence rate of thyroid nodules in diabetic group was greatly higher than that of the control group(84.47% vs 70.59%).The proportion of patients with multiple nodules was as high as 80.46% in the diabetic group.Presence of thyroid nodule was significantly associated with patient ages(χ2=7.060,P0.05),but not with gender,body mass index(BMI),or serum glucose level.(2)The positive rate of thyroid dysfunction in the diabetic group was significantly higher than that in the control group(15.53% vs6.80%,P0.05).The prevalence rates of sub-clinical hypothyroidism were similar between the two groups.T3 and T4levels of thyroid function in the diabetic group were significantly lower than those in the control group(P0.05),and the thyroid stimulating hormone(TSH)levels were similar between the two groups.Conclusion Elderly patients(age≥80years)have a higher liability for thyroid disease,which may affect the control and prognosis of diabetes.It is recommended for those patients to receive regular check-up for thyroid function and morphology changes.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"221"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/SP.J.1008.2015.00161
Yi Ren, Xiao-guang Yang, Yu Zhang, Xue-zhi Li
Objective To observe the effect of electro-acupuncture on reproductive endocrine and renal contents of superoxide dismutase(SOD)and malondialdehyde(MDA)in aging male(PADAM)rats with partial androgen deficiency.Methods Forty male rats were randomly divided into normal control group(n=10)and model group(n=30).Rats in the model group were injected with cyclophosphamide 20mg/(kg·d)into the abdominal cavities to establish PADAM model.The24 successful model rats were further randomized into electro-acupuncture,androlin treatment and blank groups;rats received corresponding treatment for 8weeks.The general conditions of the animals were observed before and 1day after modeling and at the end of treatment.Tail suspension experiments and exhaustion swimming tests were performed;and the serum total testosterone(TT)and free testosterone(FT)levels were determined.The contents of SOD and MDA in renal tissues were examined at the end of the experiments by hydroxylamine method.Results After treatment with cyclophosphamide,the serum levels of TT and FT in rats were significantly decreased(P0.01),being lower than the 99%confidence interval of the normal control group,and the animals developed behaviors similar to those of PADAM,indicating successful modeling.The serum TT and FT levels in electro-acupuncture group and androlin group were significantly higher than those in the pre-therapy and blank control groups(P0.01);the duration of immobility and exhaustion swimming were also significantly improved in the two treatment groups(P0.01);and SOD activities in the kidney were significantly increased(P0.01)and MDA contents were significantly decreased(P0.01)in electro-acupuncture group and androlin group;while no significant differences were found between electro-acupuncture group and androlin group(P0.05).Conclusion Electro-acupuncture can increase serum TT and FT levels in PADAM rats,improve the depression state,myodynamia and energy in the aging rats,with its effect being equivalent to that of testosterone propionate.Electro-acupuncture can increase SOD level and decease MDA level in PADAM rats,indicating that electro-acupuncture may function by improving the free radicals system of PADAM rats.
{"title":"Effect of electro-acupuncture on reproductive endocrine and renal contents of SOD and MDA in aging male rats with partial androgen deficiency","authors":"Yi Ren, Xiao-guang Yang, Yu Zhang, Xue-zhi Li","doi":"10.3724/SP.J.1008.2015.00161","DOIUrl":"https://doi.org/10.3724/SP.J.1008.2015.00161","url":null,"abstract":"Objective To observe the effect of electro-acupuncture on reproductive endocrine and renal contents of superoxide dismutase(SOD)and malondialdehyde(MDA)in aging male(PADAM)rats with partial androgen deficiency.Methods Forty male rats were randomly divided into normal control group(n=10)and model group(n=30).Rats in the model group were injected with cyclophosphamide 20mg/(kg·d)into the abdominal cavities to establish PADAM model.The24 successful model rats were further randomized into electro-acupuncture,androlin treatment and blank groups;rats received corresponding treatment for 8weeks.The general conditions of the animals were observed before and 1day after modeling and at the end of treatment.Tail suspension experiments and exhaustion swimming tests were performed;and the serum total testosterone(TT)and free testosterone(FT)levels were determined.The contents of SOD and MDA in renal tissues were examined at the end of the experiments by hydroxylamine method.Results After treatment with cyclophosphamide,the serum levels of TT and FT in rats were significantly decreased(P0.01),being lower than the 99%confidence interval of the normal control group,and the animals developed behaviors similar to those of PADAM,indicating successful modeling.The serum TT and FT levels in electro-acupuncture group and androlin group were significantly higher than those in the pre-therapy and blank control groups(P0.01);the duration of immobility and exhaustion swimming were also significantly improved in the two treatment groups(P0.01);and SOD activities in the kidney were significantly increased(P0.01)and MDA contents were significantly decreased(P0.01)in electro-acupuncture group and androlin group;while no significant differences were found between electro-acupuncture group and androlin group(P0.05).Conclusion Electro-acupuncture can increase serum TT and FT levels in PADAM rats,improve the depression state,myodynamia and energy in the aging rats,with its effect being equivalent to that of testosterone propionate.Electro-acupuncture can increase SOD level and decease MDA level in PADAM rats,indicating that electro-acupuncture may function by improving the free radicals system of PADAM rats.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"36 1","pages":"161"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69844918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3724/sp.j.1008.2015.00362
Ding Yi-b
The development and progression of colorectal cancer(CRC)is a process that accumulates the driver somatic mutations elicited by chronic inflammation.Epigenetic modifications and genetic mutations play key roles in the whole evolutionary process of chronic inflammation-induced CRC. Adenoma gradually progresses into adenocarcinoma via accumulating genetic mutations stimulated by cancer promoting stimulations.The next generation sequencing technology provides an effective way to identify the"driver"mutations and fusion genes in the carcinogenesis,providing molecular evidences for cancer evolution.The most significant genetic changes during malignant transformation from adenoma to adenocarcinoma are the significant increases in microsatellite instability and chromosome instability.The main purpose of investigating the evolutionary process of CRC,especially somatic mutations,is to identify the related signaling pathways,which are the key steps to explore early effective intervention strategies and targeted therapies for CRC.
{"title":"Role of non-resolving inflammation,epigenetic and genetic alterations in carcinogenesis and invasion of colorectal carcinoma","authors":"Ding Yi-b","doi":"10.3724/sp.j.1008.2015.00362","DOIUrl":"https://doi.org/10.3724/sp.j.1008.2015.00362","url":null,"abstract":"The development and progression of colorectal cancer(CRC)is a process that accumulates the driver somatic mutations elicited by chronic inflammation.Epigenetic modifications and genetic mutations play key roles in the whole evolutionary process of chronic inflammation-induced CRC. Adenoma gradually progresses into adenocarcinoma via accumulating genetic mutations stimulated by cancer promoting stimulations.The next generation sequencing technology provides an effective way to identify the\"driver\"mutations and fusion genes in the carcinogenesis,providing molecular evidences for cancer evolution.The most significant genetic changes during malignant transformation from adenoma to adenocarcinoma are the significant increases in microsatellite instability and chromosome instability.The main purpose of investigating the evolutionary process of CRC,especially somatic mutations,is to identify the related signaling pathways,which are the key steps to explore early effective intervention strategies and targeted therapies for CRC.","PeriodicalId":6893,"journal":{"name":"Academic Journal of Second Military Medical University","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69845958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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