Pub Date : 2020-05-09DOI: 10.29413/abs.2020-5.2.12
A. Lisovtsov, Ya. A. Leschenko
The industrial cities of Irkutsk region are a type of socio-ecological systems, the population of which for a long time lives under the combined influence of adverse technogenic and socio-economic factors. The aim of the study was to assess the characteristics of the general incidence of the population of industrial cities in the Irkutsk region (Angarsk, Shelekhov) in the first and second decades of the XXI century. Methods. The morbidity indicators for the appeal of the population for medical care presented by healthcare institu- tions in statistical form N 12 were analyzed. We evaluated the characteristics of diseases detected for the first time inlife (primary incidence). To identify trends in the dynamics of morbidity indicators, the method of regression analysis (linear and quadratic functions with a free term) was used. Results. In the dynamics of the general indicator of the primary incidence in both studied cities, no tendencies for steady growth or decrease were revealed. At the same time, in the dynamics of indicators for some classes of diseases, there were statistically significant trends in the increase in incidence (classes of diseases of the musculoskeletal system, diseases of the genitourinary system, respiratory diseases), as well as trends in the decrease in incidence (classes of infectious diseases, neoplasms and skin diseases). Conclusion. The changes in the structure of primary morbidity that have occurred over 14 years indicate pathomor- phism of the pathology, for which the population is seeking medical help. An increase in the prevalence of diseases of the musculoskeletal system, diseases of the genitourinary organs and others among the population can be caused by both the aging processes of the population and changes in lifestyle (especially young people) that occur under the influence of negative factors of the sociocultural environment and others.
{"title":"Description of the Incidence among Population of Industrial Cities in the Irkutsk Region","authors":"A. Lisovtsov, Ya. A. Leschenko","doi":"10.29413/abs.2020-5.2.12","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.12","url":null,"abstract":"The industrial cities of Irkutsk region are a type of socio-ecological systems, the population of which for a long time lives under the combined influence of adverse technogenic and socio-economic factors. The aim of the study was to assess the characteristics of the general incidence of the population of industrial cities in the Irkutsk region (Angarsk, Shelekhov) in the first and second decades of the XXI century. Methods. The morbidity indicators for the appeal of the population for medical care presented by healthcare institu- tions in statistical form N 12 were analyzed. We evaluated the characteristics of diseases detected for the first time inlife (primary incidence). To identify trends in the dynamics of morbidity indicators, the method of regression analysis (linear and quadratic functions with a free term) was used. Results. In the dynamics of the general indicator of the primary incidence in both studied cities, no tendencies for steady growth or decrease were revealed. At the same time, in the dynamics of indicators for some classes of diseases, there were statistically significant trends in the increase in incidence (classes of diseases of the musculoskeletal system, diseases of the genitourinary system, respiratory diseases), as well as trends in the decrease in incidence (classes of infectious diseases, neoplasms and skin diseases). Conclusion. The changes in the structure of primary morbidity that have occurred over 14 years indicate pathomor- phism of the pathology, for which the population is seeking medical help. An increase in the prevalence of diseases of the musculoskeletal system, diseases of the genitourinary organs and others among the population can be caused by both the aging processes of the population and changes in lifestyle (especially young people) that occur under the influence of negative factors of the sociocultural environment and others.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79183994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Criteria for Macular Edema Associated with Venous Occlusions","authors":"A. Shchuko, V. Bukina, A. V. Borisova, T. Iureva","doi":"10.29413/abs.2020-5.2.8","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.8","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75317431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Potapov, Z. Koshkareva, A. Zhivotenko, A. Gorbunov, V. Sorokovikov
{"title":"Puncture Surgical Technologies in the Treatment of Facet Syndrome for Spondylarthrosis in the Lumbar Spine (Literature Review)","authors":"V. Potapov, Z. Koshkareva, A. Zhivotenko, A. Gorbunov, V. Sorokovikov","doi":"10.29413/abs.2020-5.2.6","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.6","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86795855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gorbunov, Z. Koshkareva, A. Zhivotenko, V. Potapov, O. Sklyarenko, B. Damdinov, S. D. Glotov
{"title":"The Effectiveness of Laser Vaporization in the Treatment of Intervertebral Hernias of the Lumbar Spine","authors":"A. Gorbunov, Z. Koshkareva, A. Zhivotenko, V. Potapov, O. Sklyarenko, B. Damdinov, S. D. Glotov","doi":"10.29413/abs.2020-5.2.7","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.7","url":null,"abstract":"","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86084245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Osteochondrosis of the cervical spine is a very common disease that causes a significant decrease in the quality of life of patients. In the case of pronounced changes in the cervical spine with osteochondrosis, there is a violation of blood circulation in the cerebral cortex, which leads to pronounced clinical symptoms. ActA BiomedicA ScientificA, 2020, Том 5, No 2 Неврология и нейрохирургия 29 The aim of this study was to identify a correlation between bioelectrical activity and cerebral hemodynamics in patients with osteochondrosis of the cervical spine. Materials and methods. The examination involved 25 patients of the neurosurgical department who received conservative treatment for exacerbation of osteochondrosis of the cervical spine, and 25 volunteers without a history of diseases of the spine and joints. The cerebral bioelectrical activity and blood flow indicators were recorded in the pool of the common carotid and vertebral arteries. Results. In the main group and the clinical comparison group, the rheographic index and the peripheral vascular resistance index were studied, which characterize both the volume pulse blood filling of the vascular bed and the tone of small and medium caliber arteries. At the same time, the EEG rhythm indices were analyzed: α-, β-, δ-, and θ-waves. An analysis of the intersystem interaction of blood flow indices and the biopotentials of the cortical rhythm of the brain in the main group showed a mismatch in the intra-system connections, which corresponds to the period of the general stress of the body. An analysis of the correlation between the indicators of electroencephalography and rheoencephalography in the control group revealed a stable system of correlation between the indicators, showing intersystem and intrasystem consistency and reflecting a high level of reserve capacity of the body and the state of steady adaptation to adverse factors. Conclusion. The use of simultaneous recording of cerebral hemodynamics and brain biopotentials in patients with osteochondrosis of the cervical spine will allow clinicians to correctly assess the functional state of the central nervous system and to prescribe adequate treatment in a timely manner.
介绍。颈椎骨软骨病是一种非常常见的疾病，会导致患者的生活质量显著下降。如果颈椎出现明显的改变并伴有骨软骨病，则大脑皮层的血液循环受到破坏，从而导致明显的临床症状。生物医学学报，2020，Том 5, No . 2 Неврология * нейрохирургия 29本研究的目的是确定颈椎骨软骨病患者的生物电活动与脑血流动力学之间的相关性。材料和方法。检查对象为25例因颈椎骨软骨病加重而接受保守治疗的神经外科患者和25例无脊柱、关节疾病史的志愿者。记录颈总动脉池和椎动脉池的脑生物电活动和血流指标。结果。主要组和临床对照组分别研究表征血管床容积脉搏充血和中小口径动脉张力的流变学指数和外周血管阻力指数。同时分析脑电图节律指标:α-、β-、δ-、θ-波。对主组血流量指数和脑皮层节律生物电位的系统间相互作用的分析显示，系统内连接不匹配，这与身体的一般应激期相对应。通过对对照组脑电图与脑流变图指标的相关性分析，发现指标间存在稳定的系统相关性，表现出系统间和系统内的一致性，反映了机体的高水平储备能力和对不利因素的稳定适应状态。结论。同时记录颈椎骨软骨病患者的脑血流动力学和脑生物电位将使临床医生能够正确评估中枢神经系统的功能状态，并及时制定适当的治疗方案。
{"title":"Relationship of Cerebral Hemodynamics and Cerebral Bioelectrical Activity in Patients with Cervical Osteochondrosis","authors":"I. N. Kinash, T. K. Verkhozina, E. G. Ippolitova","doi":"10.29413/abs.2020-5.2.5","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.5","url":null,"abstract":"Introduction. Osteochondrosis of the cervical spine is a very common disease that causes a significant decrease in the quality of life of patients. In the case of pronounced changes in the cervical spine with osteochondrosis, there is a violation of blood circulation in the cerebral cortex, which leads to pronounced clinical symptoms. ActA BiomedicA ScientificA, 2020, Том 5, No 2 Неврология и нейрохирургия 29 The aim of this study was to identify a correlation between bioelectrical activity and cerebral hemodynamics in patients with osteochondrosis of the cervical spine. Materials and methods. The examination involved 25 patients of the neurosurgical department who received conservative treatment for exacerbation of osteochondrosis of the cervical spine, and 25 volunteers without a history of diseases of the spine and joints. The cerebral bioelectrical activity and blood flow indicators were recorded in the pool of the common carotid and vertebral arteries. Results. In the main group and the clinical comparison group, the rheographic index and the peripheral vascular resistance index were studied, which characterize both the volume pulse blood filling of the vascular bed and the tone of small and medium caliber arteries. At the same time, the EEG rhythm indices were analyzed: α-, β-, δ-, and θ-waves. An analysis of the intersystem interaction of blood flow indices and the biopotentials of the cortical rhythm of the brain in the main group showed a mismatch in the intra-system connections, which corresponds to the period of the general stress of the body. An analysis of the correlation between the indicators of electroencephalography and rheoencephalography in the control group revealed a stable system of correlation between the indicators, showing intersystem and intrasystem consistency and reflecting a high level of reserve capacity of the body and the state of steady adaptation to adverse factors. Conclusion. The use of simultaneous recording of cerebral hemodynamics and brain biopotentials in patients with osteochondrosis of the cervical spine will allow clinicians to correctly assess the functional state of the central nervous system and to prescribe adequate treatment in a timely manner.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86993390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vibration disease occupies one of the leading places among occupational diseases. The development and course of vi - bration disease is accompanied by disorders in immune system. Aim of the study is to provide a comparative assessment of cells with markers of the early (CD25+) and late (CD95+) stage of lymphocyte activation and to compare them with the phenotypic composition of lymphocytes in patients with vibration disease. Materials and methods. The study includes men aged 36–60 years with vibration disease from exposure to local vibration (26 people) and from combined exposure to local and general vibration (28 people). Results. The most pronounced changes in the system of lymphocyte apoptosis are observed in patients with vibration disease from the combined effects of local and general vibration, manifested by the increase in the number of CD25+ and CD95+-lymphocytes. Increase of quantity of CD25+ at patients with a vibration disease from impact of local vibra tion and from the combined impact of local and general vibration is caused by increase in their number on lymphocytes what the direct correlation dependence between quantity of CD25+-lymphocytes and the number of CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes testifies to. Conclusions. In patients with vibration disease from the combined effects of local and general vibration, the increase in the number of CD95+ is due to an increase in their density on mature T-lymphocytes, as evidenced by the inverse relationship between the level of CD95+ and the CD3+-lymphocytes. The obtained data should be taken into account in order to develop new effective methods of prevention, treatment and prediction of the course of vibration pathology.
{"title":"Expression of CD25+ and CD95+ Surface Markers on Peripheral Blood Lymphocytes in Patients with Vibration Disease","authors":"S. Kurchevenko, G. Bodienkova","doi":"10.29413/abs.2020-5.2.4","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.4","url":null,"abstract":"Vibration disease occupies one of the leading places among occupational diseases. The development and course of vi - bration disease is accompanied by disorders in immune system. Aim of the study is to provide a comparative assessment of cells with markers of the early (CD25+) and late (CD95+) stage of lymphocyte activation and to compare them with the phenotypic composition of lymphocytes in patients with vibration disease. Materials and methods. The study includes men aged 36–60 years with vibration disease from exposure to local vibration (26 people) and from combined exposure to local and general vibration (28 people). Results. The most pronounced changes in the system of lymphocyte apoptosis are observed in patients with vibration disease from the combined effects of local and general vibration, manifested by the increase in the number of CD25+ and CD95+-lymphocytes. Increase of quantity of CD25+ at patients with a vibration disease from impact of local vibra tion and from the combined impact of local and general vibration is caused by increase in their number on lymphocytes what the direct correlation dependence between quantity of CD25+-lymphocytes and the number of CD3+, CD4+, CD8+, CD16+, CD20+-lymphocytes testifies to. Conclusions. In patients with vibration disease from the combined effects of local and general vibration, the increase in the number of CD95+ is due to an increase in their density on mature T-lymphocytes, as evidenced by the inverse relationship between the level of CD95+ and the CD3+-lymphocytes. The obtained data should be taken into account in order to develop new effective methods of prevention, treatment and prediction of the course of vibration pathology.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80025994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Nikolaev, S. Sofronova, E. Rumyantsev, Z. Alekseeva, N. Chirikova, N. A. Sleptsova, S. A. Fedorova
Pathological processes in the pre-reactive period of cold injury have not been studied. The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury. Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase, glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19. Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly. Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes.
{"title":"Lipid Peroxidation in the Pre-Reactive Period of Cold Injury","authors":"V. Nikolaev, S. Sofronova, E. Rumyantsev, Z. Alekseeva, N. Chirikova, N. A. Sleptsova, S. A. Fedorova","doi":"10.29413/abs.2020-5.2.1","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.1","url":null,"abstract":"Pathological processes in the pre-reactive period of cold injury have not been studied. The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury. Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase, glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19. Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly. Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83897149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Shamrikova, E. Sorokina, E. Dubrovskaya, Y. A. Krakhaleva, E. A. Kurniavkina, Y. Krinitsyna, A. Yakubovich, I. Sergeeva
Background. High predisposition to sunburn in childhood and associated increased risk of malignant skin tumors development, decrease with age. There is a likelihood of a relationship between the described trends and dynamic age related changes in functional state of melanocytes and melanin. Aim: to evaluate the level of melanin in the skin in children of different age. Materials and methods. The study involved 78 children aged from 7 to 17 years, without any disorders of skin pig - mentation. Three groups of observations were formed: Group 1 – 28 children from 7 to 9 years, Group 2 – 25 children from 10 to 12 years, Group 3 – 25 children from 16 to 17 years. The melanin level was evaluated in the skin of face, body and extremities using mexametry. Results. The highest level of skin melanin was observed in forearms and lower legs in all age groups (up to 28.3 ± 10.8, 23.3 ± 8.6 and 26.7 ± 10.6 c.u. in Group 1, 2 and 3 respectively), the lowest – in cheeks and chest (up to 8.0 ± 4.7, 4.4 ± 3.4 and 9.5 ± 4.1 c.u. in Group 1, 2 and 3 respectively). There were relationships between skin site and level of melanin, but no relationships between level of melanin and gender or age. Findings. The level of melanin in the skin in children aged from 7 to 17 years is individual and depends on the location of the skin area, but does not depend on gender or age. The distribution of melanin in the skin is stable and does not change over time. of Melanin
{"title":"Mexametric Assessment of Melanin Level in Children's Skin","authors":"V. Shamrikova, E. Sorokina, E. Dubrovskaya, Y. A. Krakhaleva, E. A. Kurniavkina, Y. Krinitsyna, A. Yakubovich, I. Sergeeva","doi":"10.29413/abs.2020-5.2.2","DOIUrl":"https://doi.org/10.29413/abs.2020-5.2.2","url":null,"abstract":"Background. High predisposition to sunburn in childhood and associated increased risk of malignant skin tumors development, decrease with age. There is a likelihood of a relationship between the described trends and dynamic age related changes in functional state of melanocytes and melanin. Aim: to evaluate the level of melanin in the skin in children of different age. Materials and methods. The study involved 78 children aged from 7 to 17 years, without any disorders of skin pig - mentation. Three groups of observations were formed: Group 1 – 28 children from 7 to 9 years, Group 2 – 25 children from 10 to 12 years, Group 3 – 25 children from 16 to 17 years. The melanin level was evaluated in the skin of face, body and extremities using mexametry. Results. The highest level of skin melanin was observed in forearms and lower legs in all age groups (up to 28.3 ± 10.8, 23.3 ± 8.6 and 26.7 ± 10.6 c.u. in Group 1, 2 and 3 respectively), the lowest – in cheeks and chest (up to 8.0 ± 4.7, 4.4 ± 3.4 and 9.5 ± 4.1 c.u. in Group 1, 2 and 3 respectively). There were relationships between skin site and level of melanin, but no relationships between level of melanin and gender or age. Findings. The level of melanin in the skin in children aged from 7 to 17 years is individual and depends on the location of the skin area, but does not depend on gender or age. The distribution of melanin in the skin is stable and does not change over time. of Melanin","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86531984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation in animal models are presented, indicating the dependence of processes on the duration of sleep deprivation. The largest number of studies of free radical processes in a person with somnological pathology was carried out in the study of OSAS. Blood, urine, saliva, condensate of exhaled air can be biomaterial for determining the parameters of free radical oxidation. It was shown that the intensity of oxidative stress depends on the severity of OSAS, as evidenced by the positive correlation of the level of active products of thiobarbituric acid, the products of oxidation of proteins and carbonyl groups with the apnea/hypopnea index, determining the development of not only oxidative, but also carbonyl stress in patients with a severe degree OSAS. Biomarkers such as thioredoxin, malondialdehyde, superoxide dismutase, and reduced iron have shown a more stable relationship between increased oxidative stress and OSA. Despite the results obtained, the question of the association of oxidative stress and hypoxia in OSA remains debatable, which is associated with the opposite results of some studies. Insomnia, which occurs mainly in females, is accompanied by a high level of end products of lipid peroxidation with a decrease in the activity of antioxidants such as paraoxonase, an enzymatic component of the glutathione system. Along with this, menopausal women present low levels of uric acid, which correlates with high scores of the Pittsburgh sleep quality index questionnaire. Recent studies have identified an association between the activity of the «lipoperoxidation – antioxidants» system and the Clock 3111T/C gene polymorphism in menopausal Caucasian women, indicating the protective role of the minor allele.
{"title":"Free Radical Oxidation and Sleep Disorders in Andro- and Menopause (Literature Review)","authors":"N. Semenova, I. Madaeva, L. Kolesnikova","doi":"10.29413/abs.2020-5.1.4","DOIUrl":"https://doi.org/10.29413/abs.2020-5.1.4","url":null,"abstract":"This review presents data on changes in the physiology of sleep during reproductive aging. It is noted that insomnia and obstructive sleep apnea syndrome (OSAS) are the main sleep disorders. The results of foreign and domestic studies in the field of free radical oxidation during sleep deprivation in animal models are presented, indicating the dependence of processes on the duration of sleep deprivation. The largest number of studies of free radical processes in a person with somnological pathology was carried out in the study of OSAS. Blood, urine, saliva, condensate of exhaled air can be biomaterial for determining the parameters of free radical oxidation. It was shown that the intensity of oxidative stress depends on the severity of OSAS, as evidenced by the positive correlation of the level of active products of thiobarbituric acid, the products of oxidation of proteins and carbonyl groups with the apnea/hypopnea index, determining the development of not only oxidative, but also carbonyl stress in patients with a severe degree OSAS. Biomarkers such as thioredoxin, malondialdehyde, superoxide dismutase, and reduced iron have shown a more stable relationship between increased oxidative stress and OSA. Despite the results obtained, the question of the association of oxidative stress and hypoxia in OSA remains debatable, which is associated with the opposite results of some studies. Insomnia, which occurs mainly in females, is accompanied by a high level of end products of lipid peroxidation with a decrease in the activity of antioxidants such as paraoxonase, an enzymatic component of the glutathione system. Along with this, menopausal women present low levels of uric acid, which correlates with high scores of the Pittsburgh sleep quality index questionnaire. Recent studies have identified an association between the activity of the «lipoperoxidation – antioxidants» system and the Clock 3111T/C gene polymorphism in menopausal Caucasian women, indicating the protective role of the minor allele.","PeriodicalId":6986,"journal":{"name":"Acta Biomedica Scientifica (East Siberian Biomedical Journal)","volume":"209 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77760893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-17DOI: 10.29413/abs.2020-5.1.10
V. .. Dubrovina, T. P. Starovoitova, E. V. Kravets, T. Ivanova, Z. F. Dugarzhapova, O. Gavrilova, O. V. Yur’eva, T. T. Shkaruba, S. Balakhonov
Background. Detection of the pathogenicity factors is one of the actual directions in studying of the anthrax causative agent. First of all, it includes the presence of tripartite toxin, capsule and the related structural and regulatory genes. Their presence or absence is defined by structural changes in cellular structure of blood and immunocomplex organs of a macroorganism.Objective: To conduct a comparative analysis of subpopulational structure of marrow and peripheral blood cells at anthrax infection in experimental animals and to trace dynamics of the infectious process caused by Bacillus anthracis of different genotypes.Methods. Comparative examination of subpopulational structure of red marrow and peripheral blood cells of white mice in dynamics of the infectious process caused by B. anthracis of different genotypes was conducted. Also, neutrophil maturing index and leucoerythrocytic correlation were calculated in red marrow. Degree of manifestation of neutrophil pathological granularity was revealed in peripheral blood smears stained by the Freifeld’s method. Statistical processing of the received data was conducted using the computer program “Statistics”, version 6 (Novosibirsk). Authentic results were considered if the error probability was less than 0.05 (р < 0.05) in relation to the control.Results. It is revealed that alterations in white mice infected by B. anthracis strains with the same set of plasmids are significantly various.Conclusion. The resulted data permit to assume that the distinction of pathological alterations in peripheral blood and red marrow is probably connected with the other factors of the pathogen invasiveness like enzymatic activity, ability to adhesion and many others.
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